GB1016959A - Substituted steroid hormones - Google Patents

Substituted steroid hormones

Info

Publication number
GB1016959A
GB1016959A GB14160/63A GB1416063A GB1016959A GB 1016959 A GB1016959 A GB 1016959A GB 14160/63 A GB14160/63 A GB 14160/63A GB 1416063 A GB1416063 A GB 1416063A GB 1016959 A GB1016959 A GB 1016959A
Authority
GB
United Kingdom
Prior art keywords
amine
haloethyl
chloroethyl
reacting
chloroformyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB14160/63A
Inventor
Knut Bertil Hogberg
Hans Jakob Fex
Imre Konyves
Paul Hans Otto Josef Kneip
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo AB
Original Assignee
Leo AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo AB filed Critical Leo AB
Priority to GB14160/63A priority Critical patent/GB1016959A/en
Priority to US356666A priority patent/US3299104A/en
Priority to BR158190/64A priority patent/BR6458190D0/en
Priority to CH442864A priority patent/CH452514A/en
Priority to NL646403756A priority patent/NL139308B/en
Priority to DK173064AA priority patent/DK117225B/en
Priority to ES0298429A priority patent/ES298429A1/en
Priority to FR970258A priority patent/FR3331M/en
Priority to SE4376/64A priority patent/SE314977B/xx
Priority to NO152768A priority patent/NO123943B/no
Priority to BE646319A priority patent/BE646319A/xx
Priority to FI0747/64A priority patent/FI41742B/fi
Priority claimed from BE646319A external-priority patent/BE646319A/xx
Publication of GB1016959A publication Critical patent/GB1016959A/en
Priority to US05/708,921 priority patent/USRE29199E/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C19/00—Apparatus specially adapted for applying particulate materials to surfaces
    • B05C19/02—Apparatus specially adapted for applying particulate materials to surfaces using fluidised-bed techniques
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises esters of various estrogenic, androgenic and corticoid steroid hormones and N,N-di-(b -haloethyl)-carbamic acids wherein the halogen is chlorine or bromine, and their preparation by (a) reacting either the corresponding steroid alcohol or an N,N-di-(b -haloethyl)-amine with carbonyl chloride or bromide to give the corresponding chloroformyl ester or amide and reacting this intermediate with the other starting material, or (b) esterifying a free hydroxyl group in a product of (a) with a pharmaceutically acceptable organic or inorganic acid. N - Chloroformyl - N,N - di - (b - chloroethyl) - amine is prepared by reaction of N,N-di-(b - chloroethyl)-amine with phosgene. The compounds of the invention have antitumou activity and may be used in combination with a pharmaceutical carrier in forms suitable for oral or parental administration, e.g. as tablets, capsules, solutions or suspensions.
GB14160/63A 1963-04-09 1963-04-09 Substituted steroid hormones Expired GB1016959A (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
GB14160/63A GB1016959A (en) 1963-04-09 1963-04-09 Substituted steroid hormones
US356666A US3299104A (en) 1963-04-09 1964-04-01 Certain steroid nu-bis-(haloethyl)-carbamates
BR158190/64A BR6458190D0 (en) 1963-04-09 1964-04-07 PROCESS TO PRODUCE MONO AND POLYESTERES OF HORMONES
CH442864A CH452514A (en) 1963-04-09 1964-04-08 Process for the production of new mono- and polyesters of steroid hormones
NL646403756A NL139308B (en) 1963-04-09 1964-04-08 PROCESS FOR PREPARING A HORMONAL SUBSTANCE WITH ANTI-TUMOR EFFICACY.
DK173064AA DK117225B (en) 1963-04-09 1964-04-08 Process for the preparation of mono- or di-N-bis- (β-chloro- or bromoethyl) -urea acid esters of estrane, androstane or pregnane compounds.
ES0298429A ES298429A1 (en) 1963-04-09 1964-04-08 Certain steroid N-bis-(haloethyl)-carbamates
FR970258A FR3331M (en) 1963-04-09 1964-04-09 Medicinal product containing a derivative of steroid hormone.
SE4376/64A SE314977B (en) 1963-04-09 1964-04-09
NO152768A NO123943B (en) 1963-04-09 1964-04-09
BE646319A BE646319A (en) 1963-04-09 1964-04-09
FI0747/64A FI41742B (en) 1963-04-09 1964-04-09
US05/708,921 USRE29199E (en) 1963-04-09 1976-07-30 Certain steroid N-bis-(haloethyl)-carbamates

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB14160/63A GB1016959A (en) 1963-04-09 1963-04-09 Substituted steroid hormones
BE646319A BE646319A (en) 1963-04-09 1964-04-09

Publications (1)

Publication Number Publication Date
GB1016959A true GB1016959A (en) 1966-01-12

Family

ID=25655810

Family Applications (1)

Application Number Title Priority Date Filing Date
GB14160/63A Expired GB1016959A (en) 1963-04-09 1963-04-09 Substituted steroid hormones

Country Status (2)

Country Link
GB (1) GB1016959A (en)
NL (1) NL139308B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2629657A1 (en) * 1975-07-07 1977-01-27 Leo Ab PROCESS FOR THE CARBAMOYLATION OF PHENOLIC HYDROXY GROUPS FOR THE PRODUCTION OF PHENOLIC N-DISUBSTITUTED CARBAMATE STARS AND THE ION PAIR SOLUTIONS USED THEREFORE
US4332797A (en) * 1978-08-14 1982-06-01 Kureha Kagaku Kogyo Kabushiki Kaisha Chlorambucil derivatives
EP0138153A2 (en) * 1983-10-12 1985-04-24 Ab Leo A selective acylation process
US4938897A (en) * 1985-06-21 1990-07-03 Kureha Kagaku Kogyo Kabushiki Kaisha Chlorambucil derivatives and cell-discriminating agent containing the same
WO2004106358A1 (en) * 2003-05-30 2004-12-09 Trin Gmbh Target-oriented chemotherapy for treating tumors of the sexual organs

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2629657A1 (en) * 1975-07-07 1977-01-27 Leo Ab PROCESS FOR THE CARBAMOYLATION OF PHENOLIC HYDROXY GROUPS FOR THE PRODUCTION OF PHENOLIC N-DISUBSTITUTED CARBAMATE STARS AND THE ION PAIR SOLUTIONS USED THEREFORE
US4081461A (en) * 1975-07-07 1978-03-28 Aktiebolaget Leo Acylation process for the preparation of phenolic N-disubstituted carbamate esters, and ion pair solution for use in the process
US4082779A (en) * 1975-07-07 1978-04-04 Aktiebolaget Leo Acylation process for the preparation of steroid phenolic n-disubstituted carbamate esters, and ion pair solution for use in the process
US4332797A (en) * 1978-08-14 1982-06-01 Kureha Kagaku Kogyo Kabushiki Kaisha Chlorambucil derivatives
EP0138153A2 (en) * 1983-10-12 1985-04-24 Ab Leo A selective acylation process
EP0138153A3 (en) * 1983-10-12 1986-04-09 Ab Leo A selective acylation process
US4938897A (en) * 1985-06-21 1990-07-03 Kureha Kagaku Kogyo Kabushiki Kaisha Chlorambucil derivatives and cell-discriminating agent containing the same
WO2004106358A1 (en) * 2003-05-30 2004-12-09 Trin Gmbh Target-oriented chemotherapy for treating tumors of the sexual organs

Also Published As

Publication number Publication date
NL139308B (en) 1973-07-16
NL6403756A (en) 1964-10-12

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