GB949719A - Steroid-3-enolacylates and the preparation thereof - Google Patents
Steroid-3-enolacylates and the preparation thereofInfo
- Publication number
- GB949719A GB949719A GB20433/61A GB2043361A GB949719A GB 949719 A GB949719 A GB 949719A GB 20433/61 A GB20433/61 A GB 20433/61A GB 2043361 A GB2043361 A GB 2043361A GB 949719 A GB949719 A GB 949719A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- enol
- mixture
- carboxylic acid
- organic base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises steroids of the general formula: <FORM:0949719/C2/1> wherein R1 represents H, CH3, F or Cl, Z represents H(H) or =CH2, and R3 represents an aliphatic acyl radical containing not more than 6 carbon atoms, and the preparation thereof by reacting a 3-keto -4, 6-diene steroid of the general formula: <FORM:0949719/C2/2> wherein R1, R2 and Z have the above significance, with the required enol acylating agent such as a mixture of the required carboxylic acid anhydride and acid chloride with or without the presence of an organic base, or a mixture of the required carboxylic acid anhydride and an organic base, or isopropenyl acetate. A free 17a -hydroxyl group in the reactant is concurrently esterified with the enol ocylation. Therapeutic compositions having a progestational action on oral application contain as the active ingredient steroids of the first general formula above. They may take the form of pills, tablets, dragees, solutions or emulsions.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEM45602A DE1157609B (en) | 1960-06-11 | 1960-06-11 | Process for the preparation of gestagenic steroid 3-enol acylates with increased oral effectiveness |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB949719A true GB949719A (en) | 1964-02-19 |
Family
ID=7305341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB20433/61A Expired GB949719A (en) | 1960-06-11 | 1961-06-06 | Steroid-3-enolacylates and the preparation thereof |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE604366A (en) |
| CH (1) | CH388952A (en) |
| DE (1) | DE1157609B (en) |
| FR (1) | FR1319M (en) |
| GB (1) | GB949719A (en) |
| NL (1) | NL112740C (en) |
-
1960
- 1960-06-11 DE DEM45602A patent/DE1157609B/en active Pending
-
1961
- 1961-04-28 CH CH498861A patent/CH388952A/en unknown
- 1961-05-30 BE BE604366A patent/BE604366A/en unknown
- 1961-05-30 NL NL265328A patent/NL112740C/xx active
- 1961-06-06 GB GB20433/61A patent/GB949719A/en not_active Expired
- 1961-06-09 FR FR864424A patent/FR1319M/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| FR1319M (en) | 1962-05-21 |
| NL112740C (en) | 1966-03-16 |
| BE604366A (en) | 1961-11-30 |
| DE1157609B (en) | 1963-11-21 |
| CH388952A (en) | 1965-03-15 |
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