SE446724B - Ornitin- och argininsalter av ketoanaloger av grenkedjiga essentiella aminosyror samt farmaceutiska kompositioner innehallande nemnda salter - Google Patents

Ornitin- och argininsalter av ketoanaloger av grenkedjiga essentiella aminosyror samt farmaceutiska kompositioner innehallande nemnda salter

Info

Publication number
SE446724B
SE446724B SE7902401A SE7902401A SE446724B SE 446724 B SE446724 B SE 446724B SE 7902401 A SE7902401 A SE 7902401A SE 7902401 A SE7902401 A SE 7902401A SE 446724 B SE446724 B SE 446724B
Authority
SE
Sweden
Prior art keywords
ornithine
salts
acid
arginine
branched chain
Prior art date
Application number
SE7902401A
Other languages
English (en)
Swedish (sv)
Other versions
SE7902401L (sv
Inventor
M Walser
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Publication of SE7902401L publication Critical patent/SE7902401L/
Publication of SE446724B publication Critical patent/SE446724B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SE7902401A 1978-03-17 1979-03-16 Ornitin- och argininsalter av ketoanaloger av grenkedjiga essentiella aminosyror samt farmaceutiska kompositioner innehallande nemnda salter SE446724B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/887,570 US4228099A (en) 1978-03-17 1978-03-17 Ornithine and arginine salts of branched chain keto acids and uses in treatment of hepatic and renal disorders

Publications (2)

Publication Number Publication Date
SE7902401L SE7902401L (sv) 1979-10-16
SE446724B true SE446724B (sv) 1986-10-06

Family

ID=25391422

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7902401A SE446724B (sv) 1978-03-17 1979-03-16 Ornitin- och argininsalter av ketoanaloger av grenkedjiga essentiella aminosyror samt farmaceutiska kompositioner innehallande nemnda salter

Country Status (17)

Country Link
US (1) US4228099A (OSRAM)
JP (1) JPS5838421B2 (OSRAM)
AU (1) AU517505B2 (OSRAM)
BE (1) BE874900A (OSRAM)
CA (1) CA1115729A (OSRAM)
DE (1) DE2910221A1 (OSRAM)
DK (1) DK153542C (OSRAM)
ES (1) ES478710A1 (OSRAM)
FI (1) FI72118C (OSRAM)
FR (1) FR2419723A1 (OSRAM)
GB (1) GB2017094B (OSRAM)
IE (1) IE48336B1 (OSRAM)
IT (1) IT1202904B (OSRAM)
LU (1) LU81057A1 (OSRAM)
NL (1) NL7902136A (OSRAM)
NO (1) NO151119C (OSRAM)
SE (1) SE446724B (OSRAM)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4296127A (en) * 1979-04-18 1981-10-20 The Johns Hopkins University Mixed salts of essential or semi-essential amino acids and nitrogen-free analogs thereof
DE3438455A1 (de) * 1984-10-19 1986-06-26 Institut Dr. Ziegler, Bettingen L-lysin- und l-histidinpyruvat
US4677121A (en) * 1985-01-22 1987-06-30 The Johns Hopkins University Method of inhibiting muscle protein degradation
US4752619A (en) * 1985-12-23 1988-06-21 The Johns Hopkins University Nutritional supplement for treatment of uremia
US4744990A (en) * 1986-09-25 1988-05-17 W. R. Grace & Co. Hydantoins as animal food supplements
US4871552A (en) * 1986-09-25 1989-10-03 W. R. Grace & Co.-Conn. Hydantoins as animal food supplements
US5639731A (en) * 1987-05-22 1997-06-17 Pripps Bryggerier Ab Amino acids for the preparation of a beverage
FR2615734B1 (fr) * 1987-05-27 1989-12-01 Synthelabo Compositions pharmaceutiques contenant un melange de sels de cetoacides et d'amino-acides utiles pour le traitement de l'uremie
FR2618331B1 (fr) * 1987-07-23 1991-10-04 Synthelabo Compositions pharmaceutiques utiles pour le traitement de l'uremie
AT393079B (de) * 1989-03-06 1991-08-12 Lubec Gert Pharmazeutische verwendung von agmatin
AT393080B (de) * 1988-11-25 1991-08-12 Lubec Gert Pharmazeutische verwendung von arginin (salzen)
SE462463B (sv) * 1988-12-02 1990-07-02 Decken Alexandra V D Livs- och fodermedel innehaallande ketosyror
JP2522034B2 (ja) * 1988-12-27 1996-08-07 味の素株式会社 α−ケト酸・アミノ酸塩化合物及びその製造方法
US5210098A (en) * 1990-09-21 1993-05-11 Regents Of The University Of Minnesota Use of pyruvate to treat acute renal failure
US5234696A (en) * 1991-12-27 1993-08-10 Abbott Laboratories Method of producing tablets, tablets produced thereby, and method of treatment using same
US6287620B1 (en) 1994-10-07 2001-09-11 Firmenich Sa Flavor enhancing methods
US5591736A (en) * 1995-07-03 1997-01-07 The Johns Hopkins University Method of retarding the progression of chronic renal failure
JP2004527529A (ja) * 2001-04-04 2004-09-09 クリティカル セラピューティックス インコーポレイテッド 急性腎不全を予防するための方法
JP4778913B2 (ja) * 2004-11-15 2011-09-21 協和発酵バイオ株式会社 Ｌ−オルニチン結晶およびその製造方法
GB0426141D0 (en) * 2004-11-26 2004-12-29 Ucl Biomedica Plc Treatment
PT2319581E (pt) 2004-11-26 2015-06-30 Ucl Business Plc Composições compreendendo ornitina e fenilacetato ou fenilbutirato para tratamento de encefalopatia hepática
DK3263100T3 (da) 2009-04-03 2020-05-11 Ocera Therapeutics Inc L-ornithinphenylacetat og fremgangsmåder til fremstilling deraf
AU2010258888B2 (en) 2009-06-08 2014-08-07 Ocera Therapeutics, Inc. Treatment of portal hypertension and restoration of liver function using L-ornithine phenylacetate
MX360062B (es) 2010-10-06 2018-10-22 Ocera Therapeutics Inc Metodos de elaboracion de fenilacetato de l-ornitina.
CN107206021B (zh) 2014-11-24 2021-09-03 Ucl商业有限公司 使用降氨疗法治疗与肝星状细胞激活相关的疾病
EP3337473A4 (en) 2015-08-18 2019-04-17 Ocera Therapeutics, Inc. TREATMENT AND PREVENTION OF MUSCLE WOUND BY L-ORNITHIN IN COMBINATION WITH AT LEAST ONE PHENYL ACETATE AND PHENYL BUTYRATE
CN106674057A (zh) * 2015-11-09 2017-05-17 江西乐维生物药业有限公司 L-精氨酸a-酮基异己酸盐的制备方法
US11219611B2 (en) 2015-11-13 2022-01-11 Ocera Therapeutics, Inc. Formulations of L-ornithine phenylacetate
WO2017090007A1 (en) * 2015-11-29 2017-06-01 Rao M Surya Compositions and methods for the treatment of urea cycle disorders and hepatic diseases
CN110740988A (zh) 2017-05-11 2020-01-31 欧塞拉治疗有限公司 制备l-鸟氨酸苯乙酸盐的方法
US11484579B2 (en) 2017-11-29 2022-11-01 Edgar L Hull Vitamins and alpha keto acid compositions for use in a treatment program for chronic kidney disease patients
US12109254B2 (en) 2017-11-29 2024-10-08 Edgar Hull Vitamins and alpha keto acid compositions for use in a treatment program for chronic kidney disease patients
WO2019108809A2 (en) 2017-11-29 2019-06-06 Hull Edgar L Jr Alpha keto acid compositions for treating hypo-albuminemia

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA814483A (en) * 1969-06-03 Abe Kyuji L-ornithine-l-aspartate
GB1034358A (en) 1963-05-01 1966-06-29 Chugai Pharmaceutical Co Ltd Body-protein-biosynthesis promoting composition
FR1432756A (fr) 1965-02-11 1966-03-25 D Opochimiotherapie Lab Pyruvates d'amino-acides et leur procédé de préparation
US3441650A (en) * 1965-07-23 1969-04-29 Lab Jacques Logeais Sa Therapy of ammonical intoxications by di-l-ornithine alpha-ketoglutarate
DE2335215B2 (de) * 1972-07-13 1979-04-05 The Johns Hopkins University, Baltimore, Md. (V.St.A.) Verwendung einer Mischung bei der Bekämpfung von zur Urämie führenden Nierenerkrankungen
US4100161A (en) * 1974-04-15 1978-07-11 The Johns Hopkins University Promotion of protein synthesis and suppression of urea formation in the body by keto analogs of essential amino acids
US3950529A (en) * 1975-02-03 1976-04-13 Massachusetts General Hospital Amino acid formulations for patients with liver disease and method of using same

Also Published As

Publication number Publication date
CA1115729A (en) 1982-01-05
FR2419723A1 (fr) 1979-10-12
IT1202904B (it) 1989-02-15
NO151119C (no) 1985-02-13
BE874900A (fr) 1979-07-16
JPS5838421B2 (ja) 1983-08-23
LU81057A1 (fr) 1979-09-07
SE7902401L (sv) 1979-10-16
GB2017094B (en) 1982-07-07
DK153542C (da) 1988-12-05
IT7921071A0 (it) 1979-03-16
DE2910221C2 (OSRAM) 1988-04-28
FI72118B (fi) 1986-12-31
US4228099A (en) 1980-10-14
FR2419723B1 (OSRAM) 1982-10-29
AU517505B2 (en) 1981-08-06
NO151119B (no) 1984-11-05
DK153542B (da) 1988-07-25
DE2910221A1 (de) 1979-09-20
GB2017094A (en) 1979-10-03
DK110879A (da) 1979-09-18
NL7902136A (nl) 1979-09-19
FI790901A7 (fi) 1979-09-18
IE48336B1 (en) 1984-12-12
NO790903L (no) 1979-09-18
AU4515479A (en) 1979-09-20
FI72118C (fi) 1987-04-13
IE790993L (en) 1979-09-17
JPS54163518A (en) 1979-12-26
ES478710A1 (es) 1980-01-16

Similar Documents

Publication Publication Date Title
SE446724B (sv) Ornitin- och argininsalter av ketoanaloger av grenkedjiga essentiella aminosyror samt farmaceutiska kompositioner innehallande nemnda salter
US4320146A (en) Treatment of hepatic and renal disorders with ornithine and arginine salts of branched chain keto acids
KR101522066B1 (ko) 혈당 제어용 신규한 메트포르민 글리시네이트 염
US4393236A (en) Production of nonhygroscopic salts of 4-hydroxybutyric acid
TWI279230B (en) Pregabalin composition
DE3015076A1 (de) Mischsalze aus essentiellen oder halbessentiellen aminosaeuren und deren stickstoff-freien analoga, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4898729A (en) Treatment of hypertension, compounds and compositions for antihypertension and diuresis
JPS62120317A (ja) 痴呆症状改善・治療剤
FR2584405A1 (fr) Sels de furosemide, composition pharmaceutique les contenant et leur procede de preparation
US6399658B1 (en) Composition containing ascorbic acid
SK287547B6 (sk) Farmaceutické činidlo, ktoré obsahuje ako aktívnu zložku derivát benzamidu
US7456216B2 (en) Methods for the preparation and formulation of l-carnitine valproate salts
US4973553A (en) Salt or organogermanium compound and medicine containing the same
JPH06509817A (ja) グルタチオンアルキルエステルと非アミノ酸類との塩類
US3299124A (en) Tetracycline cyclohexyl sulphamate and process for preparation
JPS5865214A (ja) Ｎ−アシル−ｌ−アスパルチルタウリンを含有する医薬
US3501577A (en) Method of treating hypertension with alkali metal salts of zinc diethylenetriaminepentaacetate
US3255190A (en) Amine salts of pyrrolidone carboxylic acid
JPH04352720A (ja) 癌患者用アミノ酸製剤
WO2025132868A1 (en) L-carnitine and valproic acid drug-drug co-crystal
FR2512015A1 (fr) Sels de l'acide 2-oxo-1,5-pentane dioique, leur procede de fabrication et medicaments renfermant ces sels
SU535293A1 (ru) Аренсульфогидразиды оксалогидроксамовой кислоты,про вл ющие сахароснижающую активность
AU2024229006A1 (en) Crystal form of 8-chloro-3-pentyl-3,7-dihydro-1h-purin-2,6-dione compound and preparation method therefor
CA2256712C (en) Stable, non-hygroscopic salts of l(-)carnitine and alkanoyl l(-)carnitines, a process for their preparation and solid, orally administrable compositions containing such salts
HK1161224A (en) A new metformin glycinate salt for blood glucose control

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 7902401-4

Format of ref document f/p: F

NUG Patent has lapsed

Ref document number: 7902401-4

Format of ref document f/p: F