DK110879A - Ornithin-og argininsalte af forgrenede keto-syrer fremgangsmaade til fremstilling deraf samt deres anvendelse - Google Patents
Ornithin-og argininsalte af forgrenede keto-syrer fremgangsmaade til fremstilling deraf samt deres anvendelseInfo
- Publication number
- DK110879A DK110879A DK110879A DK110879A DK110879A DK 110879 A DK110879 A DK 110879A DK 110879 A DK110879 A DK 110879A DK 110879 A DK110879 A DK 110879A DK 110879 A DK110879 A DK 110879A
- Authority
- DK
- Denmark
- Prior art keywords
- ornithin
- acides
- procedures
- preparation
- arginine salts
- Prior art date
Links
- KJDGFQJCHFJTRH-YONAWACDSA-N 16-Ketoestradiol Chemical class OC1=CC=C2[C@H]3CC[C@](C)([C@H](C(=O)C4)O)[C@@H]4[C@@H]3CCC2=C1 KJDGFQJCHFJTRH-YONAWACDSA-N 0.000 title 1
- 229930194542 Keto Natural products 0.000 title 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 title 1
- 150000001483 arginine derivatives Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/887,570 US4228099A (en) | 1978-03-17 | 1978-03-17 | Ornithine and arginine salts of branched chain keto acids and uses in treatment of hepatic and renal disorders |
| US88757078 | 1978-03-17 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK110879A true DK110879A (da) | 1979-09-18 |
| DK153542B DK153542B (da) | 1988-07-25 |
| DK153542C DK153542C (da) | 1988-12-05 |
Family
ID=25391422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK110879A DK153542C (da) | 1978-03-17 | 1979-03-16 | Analogifremgangsmaade til fremstilling af ornithin- eller argininsalte af forgrenede alfa-keto-syrer |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4228099A (da) |
| JP (1) | JPS5838421B2 (da) |
| AU (1) | AU517505B2 (da) |
| BE (1) | BE874900A (da) |
| CA (1) | CA1115729A (da) |
| DE (1) | DE2910221A1 (da) |
| DK (1) | DK153542C (da) |
| ES (1) | ES478710A1 (da) |
| FI (1) | FI72118C (da) |
| FR (1) | FR2419723A1 (da) |
| GB (1) | GB2017094B (da) |
| IE (1) | IE48336B1 (da) |
| IT (1) | IT1202904B (da) |
| LU (1) | LU81057A1 (da) |
| NL (1) | NL7902136A (da) |
| NO (1) | NO151119C (da) |
| SE (1) | SE446724B (da) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4296127A (en) * | 1979-04-18 | 1981-10-20 | The Johns Hopkins University | Mixed salts of essential or semi-essential amino acids and nitrogen-free analogs thereof |
| DE3438455A1 (de) * | 1984-10-19 | 1986-06-26 | Institut Dr. Ziegler, Bettingen | L-lysin- und l-histidinpyruvat |
| US4677121A (en) * | 1985-01-22 | 1987-06-30 | The Johns Hopkins University | Method of inhibiting muscle protein degradation |
| US4752619A (en) * | 1985-12-23 | 1988-06-21 | The Johns Hopkins University | Nutritional supplement for treatment of uremia |
| US4871552A (en) * | 1986-09-25 | 1989-10-03 | W. R. Grace & Co.-Conn. | Hydantoins as animal food supplements |
| US4744990A (en) * | 1986-09-25 | 1988-05-17 | W. R. Grace & Co. | Hydantoins as animal food supplements |
| US5639731A (en) * | 1987-05-22 | 1997-06-17 | Pripps Bryggerier Ab | Amino acids for the preparation of a beverage |
| FR2615734B1 (fr) * | 1987-05-27 | 1989-12-01 | Synthelabo | Compositions pharmaceutiques contenant un melange de sels de cetoacides et d'amino-acides utiles pour le traitement de l'uremie |
| FR2618331B1 (fr) * | 1987-07-23 | 1991-10-04 | Synthelabo | Compositions pharmaceutiques utiles pour le traitement de l'uremie |
| AT393080B (de) * | 1988-11-25 | 1991-08-12 | Lubec Gert | Pharmazeutische verwendung von arginin (salzen) |
| AT393079B (de) * | 1989-03-06 | 1991-08-12 | Lubec Gert | Pharmazeutische verwendung von agmatin |
| SE462463B (sv) * | 1988-12-02 | 1990-07-02 | Decken Alexandra V D | Livs- och fodermedel innehaallande ketosyror |
| JP2522034B2 (ja) * | 1988-12-27 | 1996-08-07 | 味の素株式会社 | α−ケト酸・アミノ酸塩化合物及びその製造方法 |
| US5210098A (en) * | 1990-09-21 | 1993-05-11 | Regents Of The University Of Minnesota | Use of pyruvate to treat acute renal failure |
| US5234696A (en) * | 1991-12-27 | 1993-08-10 | Abbott Laboratories | Method of producing tablets, tablets produced thereby, and method of treatment using same |
| DE69530067T2 (de) | 1994-10-07 | 2004-01-29 | Firmenich & Cie | Aromazusammensetzungen und aromatisierungsverfahren |
| US5591736A (en) * | 1995-07-03 | 1997-01-07 | The Johns Hopkins University | Method of retarding the progression of chronic renal failure |
| WO2002081020A2 (en) * | 2001-04-04 | 2002-10-17 | Critical Therapeutics, Inc. | Method for preventing acute renal failure |
| JP4778913B2 (ja) * | 2004-11-15 | 2011-09-21 | 協和発酵バイオ株式会社 | Ｌ−オルニチン結晶およびその製造方法 |
| GB0426141D0 (en) * | 2004-11-26 | 2004-12-29 | Ucl Biomedica Plc | Treatment |
| PL1824563T3 (pl) * | 2004-11-26 | 2010-07-30 | Ucl Business Plc | Kompozycje zawierające ornitynę i fenylooctan lub fenylomaślan do leczenia encefalopatii wątrobowej |
| SG174982A1 (en) | 2009-04-03 | 2011-11-28 | Ocera Therapeutics Inc | L-ornithine phenyl acetate and methods of making thereof |
| JP5749255B2 (ja) | 2009-06-08 | 2015-07-15 | ユーシーエル ビジネス ピーエルシー | Ｌ−オルニチンフェニル酢酸塩を用いる門脈圧亢進の治療及び肝機能の修復 |
| JP6087284B2 (ja) | 2010-10-06 | 2017-03-01 | オセラ セラピューティクス， インコーポレイテッド | Ｌ−オルニチンフェニルアセテートを製造するための方法 |
| IL281349B (en) | 2014-11-24 | 2022-09-01 | Ucl Business Ltd | Treatment of diseases related to hepatic stellate cell activity using ammonia-lowering treatments |
| US10835506B2 (en) | 2015-08-18 | 2020-11-17 | Ocera Therapeutics, Inc. | Treatment and prevention of muscle loss using L-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
| CN106674057A (zh) * | 2015-11-09 | 2017-05-17 | 江西乐维生物药业有限公司 | L-精氨酸a-酮基异己酸盐的制备方法 |
| US11219611B2 (en) | 2015-11-13 | 2022-01-11 | Ocera Therapeutics, Inc. | Formulations of L-ornithine phenylacetate |
| WO2017090007A1 (en) * | 2015-11-29 | 2017-06-01 | Rao M Surya | Compositions and methods for the treatment of urea cycle disorders and hepatic diseases |
| CA3063134A1 (en) | 2017-05-11 | 2018-11-15 | Ocera Therapeutics, Inc. | Processes of making l-ornithine phenylacetate |
| US12109254B2 (en) | 2017-11-29 | 2024-10-08 | Edgar Hull | Vitamins and alpha keto acid compositions for use in a treatment program for chronic kidney disease patients |
| US11484579B2 (en) | 2017-11-29 | 2022-11-01 | Edgar L Hull | Vitamins and alpha keto acid compositions for use in a treatment program for chronic kidney disease patients |
| EP3716966A4 (en) | 2017-11-29 | 2021-08-18 | Hull, Edgar, L., Jr. | ALPHA-KETO ACID COMPOSITIONS FOR THE TREATMENT OF HYPOALBUMINEMIA |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA814483A (en) * | 1969-06-03 | Abe Kyuji | L-ornithine-l-aspartate | |
| GB1034358A (en) | 1963-05-01 | 1966-06-29 | Chugai Pharmaceutical Co Ltd | Body-protein-biosynthesis promoting composition |
| FR1432756A (fr) | 1965-02-11 | 1966-03-25 | D Opochimiotherapie Lab | Pyruvates d'amino-acides et leur procédé de préparation |
| US3441650A (en) * | 1965-07-23 | 1969-04-29 | Lab Jacques Logeais Sa | Therapy of ammonical intoxications by di-l-ornithine alpha-ketoglutarate |
| DE2335215B2 (de) | 1972-07-13 | 1979-04-05 | The Johns Hopkins University, Baltimore, Md. (V.St.A.) | Verwendung einer Mischung bei der Bekämpfung von zur Urämie führenden Nierenerkrankungen |
| US4100161A (en) * | 1974-04-15 | 1978-07-11 | The Johns Hopkins University | Promotion of protein synthesis and suppression of urea formation in the body by keto analogs of essential amino acids |
| US3950529A (en) * | 1975-02-03 | 1976-04-13 | Massachusetts General Hospital | Amino acid formulations for patients with liver disease and method of using same |
-
1978
- 1978-03-17 US US05/887,570 patent/US4228099A/en not_active Expired - Lifetime
-
1979
- 1979-03-14 FR FR7906533A patent/FR2419723A1/fr active Granted
- 1979-03-15 DE DE19792910221 patent/DE2910221A1/de active Granted
- 1979-03-15 AU AU45154/79A patent/AU517505B2/en not_active Expired
- 1979-03-16 SE SE7902401A patent/SE446724B/sv not_active IP Right Cessation
- 1979-03-16 NO NO790903A patent/NO151119C/no unknown
- 1979-03-16 JP JP54030069A patent/JPS5838421B2/ja not_active Expired
- 1979-03-16 LU LU81057A patent/LU81057A1/xx unknown
- 1979-03-16 IT IT21071/79A patent/IT1202904B/it active
- 1979-03-16 ES ES478710A patent/ES478710A1/es not_active Expired
- 1979-03-16 BE BE0/194065A patent/BE874900A/xx not_active IP Right Cessation
- 1979-03-16 DK DK110879A patent/DK153542C/da not_active IP Right Cessation
- 1979-03-16 CA CA323,574A patent/CA1115729A/en not_active Expired
- 1979-03-16 FI FI790901A patent/FI72118C/fi not_active IP Right Cessation
- 1979-03-16 GB GB7909350A patent/GB2017094B/en not_active Expired
- 1979-03-19 NL NL7902136A patent/NL7902136A/xx not_active Application Discontinuation
- 1979-08-08 IE IE993/79A patent/IE48336B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IE790993L (en) | 1979-09-17 |
| FI72118B (fi) | 1986-12-31 |
| GB2017094B (en) | 1982-07-07 |
| GB2017094A (en) | 1979-10-03 |
| DE2910221C2 (da) | 1988-04-28 |
| ES478710A1 (es) | 1980-01-16 |
| JPS5838421B2 (ja) | 1983-08-23 |
| AU517505B2 (en) | 1981-08-06 |
| FI790901A7 (fi) | 1979-09-18 |
| LU81057A1 (fr) | 1979-09-07 |
| NL7902136A (nl) | 1979-09-19 |
| US4228099A (en) | 1980-10-14 |
| IT1202904B (it) | 1989-02-15 |
| AU4515479A (en) | 1979-09-20 |
| IT7921071A0 (it) | 1979-03-16 |
| JPS54163518A (en) | 1979-12-26 |
| FR2419723B1 (da) | 1982-10-29 |
| FI72118C (fi) | 1987-04-13 |
| DK153542B (da) | 1988-07-25 |
| BE874900A (fr) | 1979-07-16 |
| FR2419723A1 (fr) | 1979-10-12 |
| SE7902401L (sv) | 1979-10-16 |
| NO151119B (no) | 1984-11-05 |
| DE2910221A1 (de) | 1979-09-20 |
| CA1115729A (en) | 1982-01-05 |
| NO790903L (no) | 1979-09-18 |
| NO151119C (no) | 1985-02-13 |
| SE446724B (sv) | 1986-10-06 |
| IE48336B1 (en) | 1984-12-12 |
| DK153542C (da) | 1988-12-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |