EA199900964A1 - Соли сертралина и лекарственные формы с длительным высвобождением сертралина - Google Patents

Соли сертралина и лекарственные формы с длительным высвобождением сертралина

Info

Publication number
EA199900964A1
EA199900964A1 EA199900964A EA199900964A EA199900964A1 EA 199900964 A1 EA199900964 A1 EA 199900964A1 EA 199900964 A EA199900964 A EA 199900964A EA 199900964 A EA199900964 A EA 199900964A EA 199900964 A1 EA199900964 A1 EA 199900964A1
Authority
EA
Eurasian Patent Office
Prior art keywords
sertraline
salts
serturaline
liberation
term
Prior art date
Application number
EA199900964A
Other languages
English (en)
Other versions
EA002482B1 (ru
Inventor
Мэри Таня Ам Энд
Уильям Джон Кьюратоло
Хайлар Льюис Фридман
Рави Майсор Шенкер
Скотт Макс Хербиг
Дуэйн Томас Фризен
Джеймс Блэр Вест
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA199900964A1 publication Critical patent/EA199900964A1/ru
Publication of EA002482B1 publication Critical patent/EA002482B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Лекарственные формы с длительным высвобождением сертралина, которые высвобождают сертралин со скоростью, находящейся в пределах от 1 до 40 мгА/ч. Лекарственные формы могут проявлять начальный период замедления, в течение которого сертралин высвобождается со скоростью менее чем 1 мгА/ч. Настоящее изобретение также относится к соли ацетату, соли L-лактату и соли L-аспартату сертралина, их фармацевтическим композициям и способам использования этой соли для лечения различных состояний и расстройств. Настоящее изобретение также относится к получению ацетата сертралина, L-лактата сертралина и L-аспартата сертралина.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900964A 1997-07-01 1998-06-15 Соли сертралина и лекарственные формы с длительным высвобождением сертралина EA002482B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5141497P 1997-07-01 1997-07-01
US5142097P 1997-07-01 1997-07-01
US5149897P 1997-07-01 1997-07-01
US5140297P 1997-07-01 1997-07-01
PCT/IB1998/000934 WO1999001121A1 (en) 1997-07-01 1998-06-15 Sertraline salts and sustained-release dosage forms of sertraline

Publications (2)

Publication Number Publication Date
EA199900964A1 true EA199900964A1 (ru) 2000-08-28
EA002482B1 EA002482B1 (ru) 2002-06-27

Family

ID=27489408

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900964A EA002482B1 (ru) 1997-07-01 1998-06-15 Соли сертралина и лекарственные формы с длительным высвобождением сертралина

Country Status (33)

Country Link
US (1) US6517866B1 (ru)
EP (1) EP0999830A1 (ru)
JP (1) JP2000514101A (ru)
KR (2) KR100446366B1 (ru)
CN (1) CN1256085C (ru)
AP (1) AP1526A (ru)
AR (2) AR015919A1 (ru)
AU (1) AU739261B2 (ru)
BG (1) BG103915A (ru)
BR (1) BR9810403A (ru)
CA (1) CA2290966C (ru)
CO (1) CO4940402A1 (ru)
DZ (1) DZ2546A1 (ru)
EA (1) EA002482B1 (ru)
HK (1) HK1026630A1 (ru)
HR (1) HRP980379B1 (ru)
HU (1) HUP0002296A3 (ru)
ID (1) ID23503A (ru)
IL (2) IL152330A0 (ru)
IS (1) IS5265A (ru)
MY (1) MY129175A (ru)
NO (1) NO996518L (ru)
NZ (2) NZ501251A (ru)
OA (1) OA11245A (ru)
PA (1) PA8454401A1 (ru)
PE (1) PE88699A1 (ru)
PL (1) PL337806A1 (ru)
SK (1) SK180499A3 (ru)
TN (1) TNSN98125A1 (ru)
TR (1) TR199903280T2 (ru)
TW (1) TWI241188B (ru)
UY (1) UY25067A1 (ru)
WO (1) WO1999001121A1 (ru)

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KR100412327B1 (ko) 2003-12-31
HUP0002296A3 (en) 2001-11-28
AR015919A1 (es) 2001-05-30
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PE88699A1 (es) 1999-09-20
EA002482B1 (ru) 2002-06-27
US6517866B1 (en) 2003-02-11
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UY25067A1 (es) 2000-12-29
NO996518D0 (no) 1999-12-28
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IL133080A0 (en) 2001-03-19
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