KR100772980B1 - 메트포르민의 경구투여용 서방성 제제 - Google Patents
메트포르민의 경구투여용 서방성 제제 Download PDFInfo
- Publication number
- KR100772980B1 KR100772980B1 KR1020040022527A KR20040022527A KR100772980B1 KR 100772980 B1 KR100772980 B1 KR 100772980B1 KR 1020040022527 A KR1020040022527 A KR 1020040022527A KR 20040022527 A KR20040022527 A KR 20040022527A KR 100772980 B1 KR100772980 B1 KR 100772980B1
- Authority
- KR
- South Korea
- Prior art keywords
- metformin
- sustained
- release
- sustained release
- oral administration
- Prior art date
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- E—FIXED CONSTRUCTIONS
- E04—BUILDING
- E04H—BUILDINGS OR LIKE STRUCTURES FOR PARTICULAR PURPOSES; SWIMMING OR SPLASH BATHS OR POOLS; MASTS; FENCING; TENTS OR CANOPIES, IN GENERAL
- E04H13/00—Monuments; Tombs; Burial vaults; Columbaria
- E04H13/003—Funeral monuments, grave sites curbing or markers not making part of vaults
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B44—DECORATIVE ARTS
- B44C—PRODUCING DECORATIVE EFFECTS; MOSAICS; TARSIA WORK; PAPERHANGING
- B44C1/00—Processes, not specifically provided for elsewhere, for producing decorative surface effects
- B44C1/16—Processes, not specifically provided for elsewhere, for producing decorative surface effects for applying transfer pictures or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
Abstract
Description
Claims (5)
- 약리학적 활성성분으로서 메트포르민(metformin) 또는 이의 약학적으로 허용가능한 염; 서방화 담체로서 폴리에틸렌옥사이드 및 천연 검; 및 약학적으로 허용가능한 첨가제를 포함하는 메트포르민의 경구투여용 서방성 제제로서, 상기 서방화 담체를 메트포르민 1 중량부에 대해 0.01 내지 1 중량부 미만으로 포함하는, 메트포르민의 경구투여용 서방성 제제.
- 제1항에 있어서,메트포르민의 약학적으로 허용가능한 염이 메트포르민 염산염, 메트포르민 숙시네이트 또는 메트포르민 푸마레이트인 것을 특징으로 하는 서방성 제제.
- 제1항에 있어서,폴리에틸렌옥사이드의 평균 분자량이 100,000 내지 7,000,000 인 것을 특징으로 하는 서방성 제제.
- 제1항에 있어서,천연 검이 크산탄 검, 로커스트 빈 검, 구아 검 및 이들의 혼합물로부터 이루어진 군으로부터 선택되는 것을 특징으로 하는 서방성 제제.
- 삭제
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020040022527A KR100772980B1 (ko) | 2004-04-01 | 2004-04-01 | 메트포르민의 경구투여용 서방성 제제 |
ES05733390.8T ES2547722T3 (es) | 2004-04-01 | 2005-03-31 | Formulación de liberación controlada para la administración oral de metformina |
US10/599,500 US20070185218A1 (en) | 2004-04-01 | 2005-03-31 | Controlled release formulation for oral administration of metformin |
PCT/KR2005/000936 WO2005094794A1 (en) | 2004-04-01 | 2005-03-31 | Controlled release formulation for oral administration of metformin |
JP2007506084A JP5300262B2 (ja) | 2004-04-01 | 2005-03-31 | メトホルミンの経口投与用徐放性製剤 |
EP05733390.8A EP1755568B1 (en) | 2004-04-01 | 2005-03-31 | Controlled release formulation for oral administration of metformin |
CNB2005800101321A CN100553630C (zh) | 2004-04-01 | 2005-03-31 | 用于口服二甲双胍的控释制剂 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020040022527A KR100772980B1 (ko) | 2004-04-01 | 2004-04-01 | 메트포르민의 경구투여용 서방성 제제 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020070011523A Division KR20070022134A (ko) | 2007-02-05 | 2007-02-05 | 메트포르민의 경구투여용 서방성 제제 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20050097269A KR20050097269A (ko) | 2005-10-07 |
KR100772980B1 true KR100772980B1 (ko) | 2007-11-02 |
Family
ID=35063488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020040022527A KR100772980B1 (ko) | 2004-04-01 | 2004-04-01 | 메트포르민의 경구투여용 서방성 제제 |
Country Status (7)
Country | Link |
---|---|
US (1) | US20070185218A1 (ko) |
EP (1) | EP1755568B1 (ko) |
JP (1) | JP5300262B2 (ko) |
KR (1) | KR100772980B1 (ko) |
CN (1) | CN100553630C (ko) |
ES (1) | ES2547722T3 (ko) |
WO (1) | WO2005094794A1 (ko) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015012633A1 (ko) | 2013-07-25 | 2015-01-29 | 씨제이헬스케어 주식회사 | 서방형 메트포르민과 속방형 HMG-CoA 환원효소 억제제를 포함하는 복합제제 |
KR20150068730A (ko) | 2013-12-12 | 2015-06-22 | 한미약품 주식회사 | 메트포르민 및 로자탄을 포함하는 이층정 복합 제제 |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1515701B1 (en) | 2002-06-17 | 2014-09-17 | Inventia Healthcare Private Limited | Process for the manufacture of multilayer tablet compositions comprising thiazolidinedione and biguanide |
US8858993B2 (en) * | 2005-07-25 | 2014-10-14 | Metrics, Inc. | Coated tablet with zero-order or near zero-order release kinetics |
EP1968559A4 (en) * | 2005-12-09 | 2013-08-07 | Metaproteomics Llc | INFLAMMATORY BOTANICAL PRODUCTS FOR THE TREATMENT OF METABOLIC SYNDROME AND DIABETES |
CN102133204B (zh) * | 2011-03-17 | 2012-12-12 | 山东新华制药股份有限公司 | 一种二甲双胍渗透泵控释片的制备方法 |
CN105878204B (zh) * | 2014-12-16 | 2019-04-09 | 合肥立方制药股份有限公司 | 一种盐酸二甲双胍渗透泵控释片及其制备方法 |
CN106176623A (zh) * | 2016-08-30 | 2016-12-07 | 上海交通大学 | 盐酸二甲双胍plga微球及其制备方法和应用 |
KR20220047073A (ko) | 2020-10-08 | 2022-04-15 | 한미약품 주식회사 | 유전독성 안정성이 개선된 메트포르민 또는 약학적으로 허용 가능한 그의 염을 포함하는 약학적 조성물 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6340475B2 (en) | 1997-06-06 | 2002-01-22 | Depomed, Inc. | Extending the duration of drug release within the stomach during the fed mode |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4432757A1 (de) * | 1994-09-14 | 1996-03-21 | Boehringer Mannheim Gmbh | Pharmazeutische Zubereitung enthaltend Metformin und Verfahren zu deren Herstellung |
EA002482B1 (ru) * | 1997-07-01 | 2002-06-27 | Пфайзер Инк. | Соли сертралина и лекарственные формы с длительным высвобождением сертралина |
ATE340563T1 (de) * | 2000-02-04 | 2006-10-15 | Depomed Inc | DOSIERUNGSFORM DES TYPS ßHÜLLE UND KERNß MIT EINER WIRKSTOFFFREISETZUNG, DIE SICH DER NULLTEN ORDNUNG ANNÄHERT |
US20030021841A1 (en) * | 2001-07-02 | 2003-01-30 | Matharu Amol Singh | Pharmaceutical composition |
MXPA04002702A (es) * | 2001-09-28 | 2004-07-05 | Sun Pharmaceutical Ind Ltd | Forma de dosificacion para el tratamiento de diabetes mellitus. |
AU2003241537A1 (en) * | 2002-05-23 | 2003-12-12 | Andrx Corporation | Biguanide formulations |
EP1549296A4 (en) * | 2002-08-02 | 2006-08-09 | Penwest Pharmaceuticals Co | METFORMIN FORMULATIONS WITH DELAYED RELEASE |
US20050042289A1 (en) * | 2003-04-29 | 2005-02-24 | Yamanouchi Pharma Technologies, Inc. | Tablets and methods for modified release of hydrophylic and other active agents |
EP1646374A1 (en) * | 2003-06-16 | 2006-04-19 | Ranbaxy Laboratories, Ltd. | Extended-release tablets of metformin |
WO2005060942A1 (en) * | 2003-12-19 | 2005-07-07 | Aurobindo Pharma Ltd | Extended release pharmaceutical composition of metformin |
-
2004
- 2004-04-01 KR KR1020040022527A patent/KR100772980B1/ko active IP Right Grant
-
2005
- 2005-03-31 JP JP2007506084A patent/JP5300262B2/ja not_active Expired - Fee Related
- 2005-03-31 WO PCT/KR2005/000936 patent/WO2005094794A1/en active Application Filing
- 2005-03-31 US US10/599,500 patent/US20070185218A1/en not_active Abandoned
- 2005-03-31 CN CNB2005800101321A patent/CN100553630C/zh active Active
- 2005-03-31 EP EP05733390.8A patent/EP1755568B1/en not_active Expired - Fee Related
- 2005-03-31 ES ES05733390.8T patent/ES2547722T3/es active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6340475B2 (en) | 1997-06-06 | 2002-01-22 | Depomed, Inc. | Extending the duration of drug release within the stomach during the fed mode |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015012633A1 (ko) | 2013-07-25 | 2015-01-29 | 씨제이헬스케어 주식회사 | 서방형 메트포르민과 속방형 HMG-CoA 환원효소 억제제를 포함하는 복합제제 |
KR20150068730A (ko) | 2013-12-12 | 2015-06-22 | 한미약품 주식회사 | 메트포르민 및 로자탄을 포함하는 이층정 복합 제제 |
Also Published As
Publication number | Publication date |
---|---|
CN1938007A (zh) | 2007-03-28 |
US20070185218A1 (en) | 2007-08-09 |
WO2005094794A1 (en) | 2005-10-13 |
ES2547722T3 (es) | 2015-10-08 |
CN100553630C (zh) | 2009-10-28 |
EP1755568A4 (en) | 2010-03-03 |
EP1755568A1 (en) | 2007-02-28 |
JP2007530670A (ja) | 2007-11-01 |
KR20050097269A (ko) | 2005-10-07 |
EP1755568B1 (en) | 2015-08-12 |
JP5300262B2 (ja) | 2013-09-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR100760430B1 (ko) | 당뇨병 치료제의 경구 투여용 서방성 복합 제제 및 이의제조 방법 | |
US8747898B2 (en) | Controlled release oral dosage form | |
US6589553B2 (en) | Controlled release oral dosage form | |
IL163205A (en) | Method for the manufacture of a pharmaceutical tablet delivering both immediate release and sustained release drugs | |
IE862468L (en) | Slow-release pharmaceutical agent | |
NZ542303A (en) | A process for preparing sustained release tablets | |
KR100791844B1 (ko) | 메트포르민 또는 그의 염을 함유하는 서방성 제제 및 그의제조방법 | |
EP1755568B1 (en) | Controlled release formulation for oral administration of metformin | |
US20120003307A1 (en) | Levetiracetam controlled release composition | |
US20030035840A1 (en) | Controlled release oral dosage form | |
JP2885858B2 (ja) | 有効物質の制御放出システムおよびその製造方法 | |
KR20070022134A (ko) | 메트포르민의 경구투여용 서방성 제제 | |
CA2685214C (en) | Improved controlled release oral dosage form | |
JPH04360826A (ja) | 放出制御製剤 | |
KR20060130006A (ko) | 경구 서방성 정제 | |
EP0974343B1 (en) | Process for manufacturing a solid metoprolol composition | |
WO2010112221A1 (en) | Pharmaceutical compositions comprising memantine | |
JP2005510449A (ja) | 改良型制御放出経口剤形 | |
AU2002253907A1 (en) | Improved controlled release oral dosage form | |
KR20110090142A (ko) | 지속적인 방출을 갖는 신규 약제학적 조성물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
AMND | Amendment | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application | ||
J201 | Request for trial against refusal decision | ||
A107 | Divisional application of patent | ||
AMND | Amendment | ||
E902 | Notification of reason for refusal | ||
B701 | Decision to grant | ||
GRNT | Written decision to grant | ||
G170 | Publication of correction | ||
FPAY | Annual fee payment |
Payment date: 20120820 Year of fee payment: 6 |
|
FPAY | Annual fee payment |
Payment date: 20130924 Year of fee payment: 7 |
|
FPAY | Annual fee payment |
Payment date: 20140917 Year of fee payment: 8 |
|
FPAY | Annual fee payment |
Payment date: 20150915 Year of fee payment: 9 |
|
FPAY | Annual fee payment |
Payment date: 20160912 Year of fee payment: 10 |
|
FPAY | Annual fee payment |
Payment date: 20181004 Year of fee payment: 12 |
|
FPAY | Annual fee payment |
Payment date: 20191001 Year of fee payment: 13 |