FR17C0008I2 - Derives de (thio) carbamoyl-cyclohexane utilises en tant qu'antagonistes des recepteurs d3/d2 - Google Patents
Derives de (thio) carbamoyl-cyclohexane utilises en tant qu'antagonistes des recepteurs d3/d2Info
- Publication number
- FR17C0008I2 FR17C0008I2 FR17C0008C FR17C0008C FR17C0008I2 FR 17C0008 I2 FR17C0008 I2 FR 17C0008I2 FR 17C0008 C FR17C0008 C FR 17C0008C FR 17C0008 C FR17C0008 C FR 17C0008C FR 17C0008 I2 FR17C0008 I2 FR 17C0008I2
- Authority
- FR
- France
- Prior art keywords
- carbamoyl
- thio
- receptor antagonists
- derivatives used
- cyclohexane derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0302451A HU227534B1 (en) | 2003-08-04 | 2003-08-04 | (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them |
| PCT/HU2004/000056 WO2005012266A1 (en) | 2003-08-04 | 2004-05-21 | (thio) carbamoyl-cyclohexane derivatives as d3/d2 receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR17C0008I1 FR17C0008I1 (fr) | 2018-12-07 |
| FR17C0008I2 true FR17C0008I2 (fr) | 2018-12-07 |
Family
ID=89981557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR17C0008C Active FR17C0008I2 (fr) | 2003-08-04 | 2017-10-10 | Derives de (thio) carbamoyl-cyclohexane utilises en tant qu'antagonistes des recepteurs d3/d2 |
Country Status (36)
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007106746A (ja) * | 2005-09-13 | 2007-04-26 | Tosoh Corp | 新規アリールホモピペラジン類、またはその塩と製造方法 |
| EP1870405A1 (en) * | 2006-06-22 | 2007-12-26 | Bioprojet | Carbonylated (Aza)cyclohexanes as dopamine D3 receptor ligands |
| KR101114651B1 (ko) | 2006-10-31 | 2012-06-12 | 에프. 호프만-라 로슈 아게 | 5-ｈｔ2ａ 및 ｄ3 수용체 이중 조절자 에터 유도체 |
| HUP0700269A2 (en) * | 2007-04-11 | 2009-04-28 | Richter Gedeon Nyrt | Pyrimidinyl-piperazines useful as d3/d2 receptor ligands, pharmaceutical compositions containing them and their use |
| MY148643A (en) * | 2007-05-11 | 2013-05-15 | Richter Gedeon Nyrt | Solvate and crystalline forms of carbamoyl-cyclohexane derivatives |
| HU230748B1 (hu) * | 2007-05-11 | 2018-02-28 | Richter Gedeon Nyrt | Új piperazin só és előállítási eljárása |
| HUP0700353A2 (en) * | 2007-05-18 | 2008-12-29 | Richter Gedeon Nyrt | Metabolites of (thio)carbamoyl-cyclohexane derivatives |
| HUP0700370A2 (en) * | 2007-05-24 | 2009-04-28 | Richter Gedeon Nyrt | Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment of acute mania |
| HUP0700369A2 (en) * | 2007-05-24 | 2009-04-28 | Richter Gedeon Nyrt | Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment in the manufacture of a medicament for the treatment of schizophrenia |
| ES2653852T3 (es) * | 2007-08-03 | 2018-02-09 | Richter Gedeon Nyrt. | Composiciones farmacéuticas que contienen ligandos del receptor de dopamina y procedimientos de tratamiento usando ligandos del receptor de dopamina |
| US7875610B2 (en) | 2007-12-03 | 2011-01-25 | Richter Gedeon Nyrt. | Pyrimidinyl-piperazines useful as D3/D2 receptor ligands |
| CA2715760C (en) | 2008-02-21 | 2017-06-13 | Mitsubishi Tanabe Pharma Corporation | Solid preparation for oral administration of cariprazine hydrochloride |
| US20090275597A1 (en) * | 2008-05-02 | 2009-11-05 | Forest Laboratories Holdings Limited | Methods of treating cns disorders |
| AU2009270823B2 (en) * | 2008-07-16 | 2014-07-17 | Richter Gedeon Nyrt. | Pharmaceutical formulations containing dopamine receptor ligands |
| HU230067B1 (hu) * | 2008-12-17 | 2015-06-29 | Richter Gedeon Nyrt | Új piperazin só és eljárás előállítására |
| HUP0800766A2 (en) * | 2008-12-18 | 2010-11-29 | Richter Gedeon Vegyeszet | Process for the preparation of piperazine derivatives |
| HUP0800765A2 (en) | 2008-12-18 | 2010-11-29 | Richter Gedeon Nyrt | A new process for the preparation of piperazine derivatives and their hydrochloric salts |
| WO2010126527A1 (en) * | 2009-05-01 | 2010-11-04 | Forest Laboratories Holdings Limited | Methods of treating cns disorders |
| US20110117214A1 (en) * | 2009-11-16 | 2011-05-19 | Auspex Pharmaceuticals, Inc. | Cyclohexyl urea modulators of d2 receptors and/or d3 receptors |
| HUP0900790A2 (en) | 2009-12-17 | 2011-09-28 | Richter Gedeon Nyrt | A new process for the preparation of piperazine and their hydrochloric salts |
| CN103130737B (zh) * | 2011-12-05 | 2015-12-02 | 江苏恒谊药业有限公司 | 环己烷胺类化合物及其作为抗精神分裂症药物的应用 |
| US8912197B2 (en) | 2012-08-20 | 2014-12-16 | Forest Laboratories Holdings Ltd. | Crystalline form of carbamoyl-cyclohexane derivatives |
| DK2906221T3 (da) * | 2012-10-11 | 2019-07-22 | Southern Res Inst | Urinstof og amidderivater af aminoalkylpiperaziner og anvendelse deraf |
| HU231227B1 (hu) | 2012-11-29 | 2022-03-28 | Richter Gedeon Nyrt. | Transz-4-{2-[4-(2,3-diklórfenil)-piperazin-1-il]-etil}N,N-dimetilkarbamoil-ciklohexilamin skizofrénia negatív tüneteinek kezelésére |
| ITMI20131693A1 (it) * | 2013-10-14 | 2015-04-15 | Chemo Res S L | Derivati della 1,4-cicloesilammina e loro preparazione |
| CN105085345B (zh) * | 2015-08-14 | 2016-09-14 | 天津小新医药科技有限公司 | 含硝基的l-薄荷醇类p2y12受体拮抗剂及其用途 |
| CN105085346B (zh) * | 2015-08-14 | 2017-03-29 | 天津小新医药科技有限公司 | 含胺基的l-薄荷醇类p2y12受体拮抗剂及其用途 |
| CN105218484B (zh) * | 2015-09-14 | 2018-02-23 | 安徽省逸欣铭医药科技有限公司 | 酒石酸卡利拉嗪及其制备方法和医药用途 |
| CN106518841B (zh) * | 2015-09-15 | 2019-03-05 | 浙江京新药业股份有限公司 | 环己烷衍生物或其立体异构体或盐及其制备与应用 |
| CN106543039A (zh) * | 2015-09-22 | 2017-03-29 | 江苏恩华药业股份有限公司 | 一种用于制备卡利拉嗪的化合物及其制备方法 |
| CN106560179B (zh) * | 2015-09-30 | 2020-02-21 | 石药集团中奇制药技术（石家庄）有限公司 | 盐酸卡利拉嗪药物组合物及其制备方法 |
| CN105330616B (zh) * | 2015-12-09 | 2017-09-26 | 苏州明锐医药科技有限公司 | 卡利拉嗪的制备方法 |
| EP3231418A1 (en) | 2016-04-14 | 2017-10-18 | Richter Gedeon Nyrt. | Granule formulation for oral administration |
| HU231173B1 (hu) * | 2016-07-08 | 2021-06-28 | Richter Gedeon Nyrt. | Ipari eljárás cariprazine előállítására |
| US11274087B2 (en) | 2016-07-08 | 2022-03-15 | Richter Gedeon Nyrt. | Industrial process for the preparation of cariprazine |
| EP3495363B1 (en) | 2016-07-28 | 2023-08-23 | Shionogi & Co., Ltd | Nitrogen-containing condensed ring compounds having dopamine d3 receptor antagonistic effect |
| CN107793350B (zh) * | 2016-09-05 | 2021-06-04 | 上海医药工业研究院 | 芳乙基哌啶基衍生物及其治疗精神分裂症的应用 |
| HUP1700253A1 (hu) | 2017-06-13 | 2019-01-28 | Richter Gedeon Nyrt | Szilárd orális gyógyszerkészítmények |
| WO2018229794A1 (en) | 2017-06-13 | 2018-12-20 | Cipla Limited | Amorphous form of cariprazine |
| US11447484B2 (en) | 2018-01-26 | 2022-09-20 | Shionogi & Co., Ltd. | Cyclic compound having dopamine D3 receptor antagonistic effect |
| CA3089498A1 (en) | 2018-01-26 | 2019-08-01 | Shionogi & Co., Ltd. | Condensed ring compounds having dopamine d3 receptor antagonistic effect |
| CN108586389B (zh) * | 2018-06-29 | 2020-06-12 | 成都福柯斯医药技术有限公司 | 一种合成卡利拉嗪的方法 |
| CN110872262A (zh) | 2018-08-29 | 2020-03-10 | 上海科胜药物研发有限公司 | 一种卡利拉嗪的合成方法 |
| CN110872269B (zh) * | 2018-08-30 | 2024-06-07 | 浙江京新药业股份有限公司 | 一种环己烷衍生物的盐 |
| CN110872270A (zh) * | 2018-08-30 | 2020-03-10 | 浙江京新药业股份有限公司 | 一种环己烷衍生物的盐 |
| CN111320594A (zh) * | 2018-12-13 | 2020-06-23 | 江苏恩华药业股份有限公司 | 一种卡利拉嗪杂质及其制备工艺和用途 |
| HU231500B1 (hu) * | 2019-04-10 | 2024-04-28 | Richter Gedeon Nyrt | Karbamoil-ciklohexán származékok autizmus spektrum betegség kezelésére |
| US11547707B2 (en) | 2019-04-10 | 2023-01-10 | Richter Gedeon Nyrt. | Carbamoyl cyclohexane derivatives for treating autism spectrum disorder |
| CN112239433B (zh) * | 2019-07-17 | 2024-05-14 | 北京盈科瑞创新药物研究有限公司 | 一种环己烷衍生物、制备方法及其应用 |
| CN110372557B (zh) * | 2019-08-06 | 2021-05-18 | 上海勋和医药科技有限公司 | 环己烷胺类d3/d2受体部分激动剂 |
| US12617759B2 (en) * | 2019-10-29 | 2026-05-05 | Shanghai Hansoh Biomedical Co., Ltd. | Modifier of four-membered ring derivative, preparation method and application thereof |
| KR102947882B1 (ko) * | 2019-11-05 | 2026-04-03 | 상하이 한서 바이오메디컬 컴퍼니 리미티드 | 벤조티오펜 유도체 조절제, 그의 제조 방법 및 그의 용도 |
| US20230355612A1 (en) | 2020-08-26 | 2023-11-09 | Shanghai Bocimed Pharmaceutical Co., Ltd. | Pharmaceutically acceptable salt of cariprazine and crystal form thereof, and preparation method therefor and use thereof |
| HUP2100108A1 (hu) | 2021-03-12 | 2022-09-28 | Richter Gedeon Nyrt | Eljárás és berendezés gyógyászatilag alkalmazható piperazin származékok folyamatos áramú, áramlásos konszekutív redukálással történõ elõállítására |
| TW202302576A (zh) | 2021-04-28 | 2023-01-16 | 大陸商上海翰森生物醫藥科技有限公司 | 含哌嗪多環類衍生物的鹽及晶型及其製備方法和應用 |
| HUP2100259A1 (hu) | 2021-07-07 | 2023-01-28 | Richter Gedeon Nyrt | Cariprazine tartalmú szabályozott hatóanyag-leadású injekciós készítmények |
| US20250122542A1 (en) | 2021-09-15 | 2025-04-17 | Richter Gedeon Nyrt. | Process to produce (1r,4r)-4-substituted cyclohexane-1-amines |
| HU231682B1 (hu) | 2022-08-05 | 2025-10-28 | Richter Gedeon Nyrt. | Kariprazin tartalmú szájban diszpergálódó tabletta |
| WO2024072930A1 (en) * | 2022-09-30 | 2024-04-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Dopamine d3/d2 receptor partial agonists for the treatment of neuropsychiatric disorders |
| KR102921799B1 (ko) * | 2023-01-11 | 2026-02-04 | 리히터 게데온 닐트. | 도파민 d3/d2 수용체 조절 화합물 |
| CN118388432B (zh) * | 2024-03-25 | 2025-07-18 | 成都奥邦药业有限公司 | 采用液相色谱法分离盐酸卡利拉嗪及其顺式异构体杂质的方法 |
| EP4635946A1 (en) | 2024-04-17 | 2025-10-22 | F.I.S. Fabbrica Italiana Sintetici S.p.A. | Improved process for the preparation of cariprazine |
| EP4755452A1 (en) | 2024-12-05 | 2026-06-10 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Improved process for the preparation of cariprazine |
| WO2026153547A1 (zh) * | 2025-01-20 | 2026-07-23 | 上海则正医药科技股份有限公司 | D3/d2受体部分激动剂及制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5977110A (en) | 1995-09-22 | 1999-11-02 | Warner-Lambert Company | Substituted cyclohexylamines as central nervous systems agents |
| US6528529B1 (en) | 1998-03-31 | 2003-03-04 | Acadia Pharmaceuticals Inc. | Compounds with activity on muscarinic receptors |
| KR100672186B1 (ko) | 1998-03-31 | 2007-01-19 | 아카디아 파마슈티칼스 인코포레이티드 | 무스카린 수용체에 대해 활성을 갖는 화합물 |
| SE9802208D0 (sv) | 1998-06-22 | 1998-06-22 | Astra Pharma Inc | Novel compounds |
| HU227543B1 (en) * | 2001-09-28 | 2011-08-29 | Richter Gedeon Nyrt | N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them |
-
2003
- 2003-08-04 HU HU0302451A patent/HU227534B1/hu unknown
-
2004
- 2004-05-21 WO PCT/HU2004/000056 patent/WO2005012266A1/en not_active Ceased
- 2004-05-21 ES ES04734301T patent/ES2389840T3/es not_active Expired - Lifetime
- 2004-05-21 DK DK04734301.7T patent/DK1663996T3/da active
- 2004-05-21 PT PT04734301T patent/PT1663996E/pt unknown
- 2004-05-21 ME MEP-849/08A patent/ME00564A/xx unknown
- 2004-05-21 EA EA200600364A patent/EA009022B1/ru active Protection Beyond IP Right Term
- 2004-05-21 KR KR1020067002364A patent/KR100870284B1/ko not_active Expired - Lifetime
- 2004-05-21 NZ NZ544999A patent/NZ544999A/en not_active IP Right Cessation
- 2004-05-21 SI SI200431919T patent/SI1663996T1/sl unknown
- 2004-05-21 JP JP2006522421A patent/JP3999806B2/ja not_active Expired - Lifetime
- 2004-05-21 CA CA002532818A patent/CA2532818C/en not_active Expired - Fee Related
- 2004-05-21 PL PL04734301T patent/PL1663996T3/pl unknown
- 2004-05-21 CN CN2004800219507A patent/CN1829703B/zh not_active Expired - Lifetime
- 2004-05-21 AU AU2004261490A patent/AU2004261490B2/en active Active
- 2004-05-21 UA UAA200600942A patent/UA84022C2/ru unknown
- 2004-05-21 MX MXPA06001033A patent/MXPA06001033A/es active IP Right Grant
- 2004-05-21 RS RS20060041A patent/RS52771B/sr unknown
- 2004-05-21 HR HRP20120715TT patent/HRP20120715T1/hr unknown
- 2004-05-21 EP EP04734301A patent/EP1663996B1/en not_active Expired - Lifetime
- 2004-05-21 BR BRPI0413283-1A patent/BRPI0413283B1/pt not_active IP Right Cessation
- 2004-06-01 TW TW093115688A patent/TWI327141B/zh not_active IP Right Cessation
- 2004-06-07 MY MYPI20042187A patent/MY142760A/en unknown
-
2005
- 2005-12-21 IL IL172746A patent/IL172746A/en active Protection Beyond IP Right Term
- 2005-12-22 IS IS8199A patent/IS2905B/is unknown
- 2005-12-23 TN TNP2005000328A patent/TNSN05328A1/en unknown
-
2006
- 2006-01-20 US US11/337,275 patent/US7737142B2/en active Active
- 2006-02-03 ZA ZA200601026A patent/ZA200601026B/en unknown
- 2006-03-03 MA MA28855A patent/MA28024A1/fr unknown
- 2006-03-06 NO NO20061076A patent/NO334973B1/no active Protection Beyond IP Right Term
-
2010
- 2010-05-12 US US12/779,014 patent/US20100240640A1/en not_active Abandoned
-
2012
- 2012-09-10 CY CY20121100815T patent/CY1113099T1/el unknown
-
2017
- 2017-08-24 LT LTPA2017027C patent/LTC1663996I2/lt unknown
- 2017-10-09 NO NO2017051C patent/NO2017051I2/no unknown
- 2017-10-10 FR FR17C0008C patent/FR17C0008I2/fr active Active
- 2017-10-10 LU LU00039C patent/LUC00039I2/en unknown
- 2017-10-18 CY CY2017032C patent/CY2017032I1/el unknown
- 2017-11-02 HU HUS1700044C patent/HUS1700044I1/hu unknown
- 2017-11-14 BE BE2017C045C patent/BE2017C045I2/fr unknown
- 2017-11-17 NL NL300913C patent/NL300913I2/nl unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FR17C0008I1 (fr) | Derives de (thio) carbamoyl-cyclohexane utilises en tant qu'antagonistes des recepteurs d3/d2 | |
| FR20C1039I2 (fr) | Derives de l'uk-2a | |
| MA27680A1 (fr) | Derives de 4-phenyl-pyridine en tant qu'antagonistes du recepteur de la neurokinine-1 | |
| EP1320366A4 (en) | SUBSTITUTED PIPERIDINES AS MELANOCORTIN RECEPTOR AGONISTS | |
| FR18C1024I1 (fr) | Derives d'heterocyclocarboxamide | |
| EP1268449A4 (en) | SUBSTITUTED PIPERIDINE AS MELANOCORTIN RECEPTOR AGONISTS | |
| EP1966183A4 (en) | HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A-DELTA-9-DESATURASE | |
| MA27679A1 (fr) | Derives d'acides carboxyliques en tant qu'antagonistes ip | |
| ATE354570T1 (de) | 5,6-diaryl-pyrazineamidderivate als cb1 antagonisten | |
| IL161074A0 (en) | Lactam derivatives as antagonists for human 11cby receptors | |
| EP1482895A4 (en) | AMINO ALKYL PHOSPHONATES AND RELATED COMPOUNDS AS EDG RECEPTOR AGONISTS | |
| EP1587535A4 (en) | N-cyclohexylaminocarbonyl-benzenesulfonamide derivatives | |
| PT1349839E (pt) | Derivados de feniletenilo ou feniletinilo como antagonistas do receptor de glutamato | |
| DZ3443A1 (fr) | Derives de 3-aroylindole et leur utilisation en tant qu'agonistes des recepteurs cb2 | |
| EP1951731A4 (en) | AZACYCLOHEXANDERIVATES AS INHIBITORS OF STEAROYL-COENZYME-A-DELTA-9-DESATURASE | |
| MA26933A1 (fr) | Derives de 4-phenyl-pyridine en tant qu'antagonistes de recepteur de la neurokinine 1. | |
| AU2003235696A8 (en) | Substituted 4-aminopyridine derivatives used as pest control agents | |
| DK1440059T3 (da) | 3-azabicyclo(3.1.0)hexanderivater som opioidreceptorantagonister | |
| NO20032142D0 (no) | Substituerte 2-fenylaminoimidazolin-fenylketon-derivater som IP-antagonister | |
| FR2813756B1 (fr) | Dilueur pour la conservation de spermatozoides de porcins | |
| MA28479B1 (fr) | Derives d'heteroarylaminopyrazole utilises pour traiter le diabete | |
| MA27046A1 (fr) | Nouveaux derives d'oxazolidinones en tant qu'agents antibacteriens. | |
| MA28819B1 (fr) | Derives amides d'acide kynurenique utilises en tant qu'antagonistes de recepteurs de nr2b | |
| EP1565190A4 (en) | ARYLCYCLOPROPYLCARBOXYLIC ACID AMIDE AS A KALIUM CHANNEL OPENER | |
| DE60207399D1 (de) | Alkoxycarbonylaminobenzoesäure- oder alkoxycarbonylaminotetrazolylphenylderivate als ip-antagonisten |