FR13C0046I2 - Vesicules de membrane externe bacterienne ameliorees - Google Patents

Vesicules de membrane externe bacterienne ameliorees

Info

Publication number
FR13C0046I2
FR13C0046I2 FR13C0046C FR13C0046C FR13C0046I2 FR 13C0046 I2 FR13C0046 I2 FR 13C0046I2 FR 13C0046 C FR13C0046 C FR 13C0046C FR 13C0046 C FR13C0046 C FR 13C0046C FR 13C0046 I2 FR13C0046 I2 FR 13C0046I2
Authority
FR
France
Prior art keywords
pellet
outer membrane
membrane vesicles
collecting
detergent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR13C0046C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9943238&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR13C0046(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of FR13C0046I1 publication Critical patent/FR13C0046I1/fr
Application granted granted Critical
Publication of FR13C0046I2 publication Critical patent/FR13C0046I2/fr
Active legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06—Lysis of microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
FR13C0046C 2002-08-30 2013-07-31 Vesicules de membrane externe bacterienne ameliorees Active FR13C0046I2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0220194.5A GB0220194D0 (en) 2002-08-30 2002-08-30 Improved vesicles
EP07012893.9A EP1864679B1 (fr) 2002-08-30 2003-09-01 Vésicules de membrane externe bactérienne améliorées
EP03791150A EP1534326B1 (fr) 2002-08-30 2003-09-01 Ameliorations apportees a des vesicules de membrane externe bacteriennes

Publications (2)

Publication Number Publication Date
FR13C0046I1 FR13C0046I1 (fr) 2013-09-06
FR13C0046I2 true FR13C0046I2 (fr) 2014-05-16

Family

ID=9943238

Family Applications (1)

Application Number Title Priority Date Filing Date
FR13C0046C Active FR13C0046I2 (fr) 2002-08-30 2013-07-31 Vesicules de membrane externe bacterienne ameliorees

Country Status (21)

Country Link
US (2) US20060166344A1 (fr)
EP (5) EP2258388B1 (fr)
JP (3) JP2006503822A (fr)
CN (2) CN1688334A (fr)
AT (1) ATE366117T1 (fr)
AU (1) AU2003263534B2 (fr)
BR (1) BRPI0314094A8 (fr)
CA (1) CA2497165C (fr)
CY (3) CY1107737T1 (fr)
DE (1) DE60314756T2 (fr)
DK (3) DK1864679T3 (fr)
ES (4) ES2289351T3 (fr)
FR (1) FR13C0046I2 (fr)
GB (1) GB0220194D0 (fr)
LU (1) LU92239I2 (fr)
MX (1) MXPA05002316A (fr)
NZ (1) NZ538673A (fr)
PT (3) PT1534326E (fr)
RU (1) RU2325184C2 (fr)
SI (2) SI1864679T1 (fr)
WO (1) WO2004019977A2 (fr)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1047784T4 (en) * 1998-01-14 2015-06-15 Novartis Vaccines & Diagnostic NEISSERA meningitidis ANTIGENS
NZ508771A (en) 1998-05-29 2003-08-29 Chiron Corp Neisseria meningitidis vaccine comprising NmC oligosaccharides, NmB outer membrane proteins, and a carrier
EP2270172B1 (fr) 1999-05-19 2016-01-13 GlaxoSmithKline Biologicals SA Compositions à base de combinaisons de Neisseria
GB9928196D0 (en) 1999-11-29 2000-01-26 Chiron Spa Combinations of B, C and other antigens
MXPA02006962A (es) 2000-01-17 2002-12-13 Chiron Spa Vacuna de vesicula de membrana exterior que comprende proteinas de membrana exterior de neisseria meningitidis serogrupo b.
JP5511117B2 (ja) 2000-07-27 2014-06-04 チルドレンズ ホスピタル アンド リサーチ センター アット オークランド 髄膜炎菌に起因する疾患に対する広域防御のためのワクチン
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
GB0316560D0 (en) 2003-07-15 2003-08-20 Chiron Srl Vesicle filtration
GB0323103D0 (en) 2003-10-02 2003-11-05 Chiron Srl De-acetylated saccharides
CU23377A1 (es) * 2003-11-04 2009-05-28 Ct De Ingenieria Genetica Y Biotecnologia Metodo para la incorporacion de antigenos en vesiculas de membrana externa de bacterias y formulaciones resultantes
GB0416120D0 (en) 2004-07-19 2004-08-18 Health Prot Agency Stable compositions containing OMV's
US8029777B2 (en) * 2004-08-13 2011-10-04 Marshall Barry J Helicobacter system and uses thereof
CN102078622A (zh) 2004-08-13 2011-06-01 巴里.J.马沙尔 细菌递送系统
GB0419627D0 (en) * 2004-09-03 2004-10-06 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
GB0424092D0 (en) 2004-10-29 2004-12-01 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
CA2590974C (fr) * 2005-01-27 2017-10-03 Children's Hospital & Research Center At Oakland Vaccins vesiculaires a base de gna1870 conferant une protection a large spectre contre les maladies provoquees par neisseria meningitidis
WO2006091517A2 (fr) * 2005-02-18 2006-08-31 Novartis Vaccines And Diagnostics Inc. Immunogenes d'escherichia coli uropathogene
US20090074712A1 (en) * 2005-05-19 2009-03-19 Compton Methods for Treatment and Prevention of Infection
SI1896065T2 (sl) 2005-06-27 2014-12-31 Glaxosmithkline Biologicals S.A. Postopek za pripravo cepiv
GB0524066D0 (en) 2005-11-25 2006-01-04 Chiron Srl 741 ii
AU2016204760A1 (en) * 2006-04-26 2016-07-28 Wyeth Llc Novel formulations which stabilize and inhibit precipitation of immunogenic compositions
AU2014268186C1 (en) * 2006-04-26 2017-12-07 Wyeth Llc Novel formulations which stabilize and inhibit precipitation of immunogenic compositions
AR064642A1 (es) 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
US20100285069A1 (en) 2007-10-19 2010-11-11 Mario Contorni Meningococcal vaccine formulations
EP2245048B1 (fr) 2008-02-21 2014-12-31 Novartis AG Polypeptides fhbp à méningocoques
GB0819633D0 (en) * 2008-10-25 2008-12-03 Isis Innovation Composition
GB0822634D0 (en) 2008-12-11 2009-01-21 Novartis Ag Meningitis vaccines
AU2009329193A1 (en) 2008-12-17 2011-07-14 Novartis Ag Meningococcal vaccines including hemoglobin receptor
BRPI1009828A2 (pt) 2009-03-24 2019-03-12 Novartis Ag adjuvante de proteína de ligação de fator h meningocócica
AU2010242905B2 (en) * 2009-04-30 2014-10-23 Children's Hospital & Research Center At Oakland Chimeric factor H binding proteins (fHbp) and methods of use
EP2440245B1 (fr) 2009-06-10 2017-12-06 GlaxoSmithKline Biologicals SA Vaccins contenant benzonaphtyridines
US20110045564A1 (en) * 2009-08-20 2011-02-24 Srisuda Dhamwichukorn Method of enhanced sustainable production of algal bio-products, comprising use of symbiotic diazotroph-attenuated stress co-cultivation
CN102596240B (zh) 2009-08-27 2015-02-04 诺华股份有限公司 包括脑膜炎球菌fHBP序列的杂交多肽
BR112012004276A2 (pt) 2009-08-27 2017-10-24 Novartis Ag adjuvante compreendendo alumínio, oligonucleotídeo e policátion
KR101430283B1 (ko) 2009-09-01 2014-08-14 주식회사이언메딕스 장내 공생 세균유래 세포밖 소포체, 및 이를 이용한 질병모델, 백신, 후보 약물 탐색 방법, 및 진단 방법
WO2011027956A2 (fr) 2009-09-04 2011-03-10 주식회사이언메딕스 Vésicules extracellulaires issues de bactéries à gram positif, et modèle de maladie utilisant celles-ci
DK2459216T3 (da) 2009-09-02 2013-12-09 Novartis Ag Immunogene sammensætninger omfattende tlr-aktivitetsmodulatorer
TWI445708B (zh) 2009-09-02 2014-07-21 Irm Llc 作為ｔｌｒ活性調節劑之化合物及組合物
GB0917003D0 (en) 2009-09-28 2009-11-11 Novartis Vaccines Inst For Global Health Srl Purification of bacterial vesicles
WO2011039631A2 (fr) 2009-09-30 2011-04-07 Novartis Ag Expression de polypeptides fhbp méningococciques
MX2012004850A (es) 2009-10-27 2012-05-22 Novartis Ag Polipeptidos fhbp meningococicos modificados.
WO2011057148A1 (fr) 2009-11-05 2011-05-12 Irm Llc Composés et compositions permettant de moduler l'activité des tlr-7
JP5814933B2 (ja) 2009-12-15 2015-11-17 ノバルティス アーゲー 免疫増強化合物の均質な懸濁物およびその使用
EP2547357A1 (fr) 2010-03-18 2013-01-23 Novartis AG Vaccins adjuvantés contre le méningocoque de sérogroupe b
EA023725B1 (ru) 2010-03-23 2016-07-29 Новартис Аг Соединения (липопептиды на основе цистеина) и композиции в качестве агонистов tlr2, применяемые для лечения инфекционных, воспалительных, респираторных и других заболеваний
US9066971B2 (en) 2010-07-01 2015-06-30 Postech Academy-Industry Foundation Method for treating and diagnosing cancer by using cell-derived microvesicles
HUE052850T2 (hu) 2010-08-23 2021-05-28 Wyeth Llc Neisseria meningitidis RLP2086 antigéneket tartalmazó stabil készítmények
AU2011300418B2 (en) 2010-09-10 2016-05-12 Glaxosmithkline Biologicals Sa Meningococcus overexpressing NadA and/or NHBA and outer membrane vesicles derived therefrom
ES2585328T5 (es) 2010-09-10 2022-12-14 Wyeth Llc Variantes no lipidadas de antígenos ORF2086 de Neisseria meningitidis
EP2707009A1 (fr) 2011-05-12 2014-03-19 Novartis AG Antipyrétiques pour améliorer la tolérabilité de vaccins à base de vésicules
DK2729167T3 (en) * 2011-07-07 2018-04-30 De Staat Der Nederlanden Vert Door De Mini Van Vws PROCEDURE FOR DETERGENT-FREE PREPARATION OF Outer Membrane Vesicles by a Gram-Negative Bacteria
CN104114706A (zh) 2012-02-02 2014-10-22 诺华股份有限公司 用于脑膜炎球菌中增加的蛋白表达的启动子
WO2013132040A2 (fr) 2012-03-08 2013-09-12 Novartis Ag Dosage de puissance in vitro pour des vaccins méningococciques à base de protéine
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
MY167723A (en) 2012-03-09 2018-09-21 Pfizer Neisseria meningitidis compositions and methods thereof
EP2833911A4 (fr) 2012-04-06 2016-07-13 Univ Cornell Plateforme de délivrance de vaccins sous-unité pour réponses immunitaires humorales et cellulaires robustes
BR112014031386A2 (pt) 2012-06-14 2017-08-01 Pasteur Institut vacinas para meningococos do sorogrupo x
US10000545B2 (en) 2012-07-27 2018-06-19 Institut National De La Sante Et De La Recherche Medicale CD147 as receptor for pilus-mediated adhesion of Meningococci to vascular endothelia
CN104602705A (zh) 2012-09-06 2015-05-06 诺华股份有限公司 血清组b脑膜炎球菌和d/t/p的联合疫苗
EP2897635A1 (fr) 2012-09-18 2015-07-29 Novartis AG Vésicules de membrane externe
CN105163724A (zh) 2013-02-07 2015-12-16 葛兰素史密丝克莱恩生物有限公司 包含囊泡的药物组合物
JP6446377B2 (ja) 2013-03-08 2018-12-26 ファイザー・インク 免疫原性融合ポリペプチド
CA2923129C (fr) 2013-09-08 2020-06-09 Pfizer Inc. Compositions utilisables contre neisseria meningitidis et procedes associes
MX2016011176A (es) 2014-02-28 2017-02-23 Glaxosmithkline Biologicals Sa Polipeptidos fhbp meningococicos modificados.
BR112017017460A2 (pt) 2015-02-19 2018-04-10 Pfizer Inc. composições de neisseria meningitidis e métodos das mesmas
EP3298031B1 (fr) 2015-05-18 2020-10-21 BiOMVis Srl Compositions immunogènes comprenant des vesicules de membrane externe bacteriennes et leur utilisation
CA3004924A1 (fr) * 2015-11-10 2017-05-18 Ohio State Innovation Foundation Methodes et compositions associees a une affinite humorale acceleree
WO2018042015A1 (fr) 2016-09-02 2018-03-08 Glaxosmithkline Biologicals Sa Vaccins contre neisseria gonorrhoeae
AU2017347870A1 (en) * 2016-10-28 2019-05-02 Vedanta Biosciences, Inc. Methods and compositions for preserving bacteria
US10183070B2 (en) 2017-01-31 2019-01-22 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
WO2018179003A2 (fr) * 2017-03-31 2018-10-04 Indian Council Of Medical Research Vaccin à base de vésicules de membrane externe bivalentes (bomv) contre les salmonelles typhiques
US10793865B2 (en) 2018-06-05 2020-10-06 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Transferrable mechanism of generating inducible, BAR domain protein-mediated bacterial outer membrane extensions
EP3607967A1 (fr) 2018-08-09 2020-02-12 GlaxoSmithKline Biologicals S.A. Polypeptides modifiés du méningocoque fhbp
US20230201325A1 (en) 2018-11-06 2023-06-29 Glaxosmithkline Biologicals Sa Immunogenic compositions
WO2020172492A2 (fr) * 2019-02-22 2020-08-27 Evelo Biosciences, Inc. Préparations de membrane bactérienne
US20220378902A1 (en) * 2019-08-22 2022-12-01 Sichuan University Bacterial membrane vesicles, and separation and preparation system and method therefor
CN110563829B (zh) * 2019-09-17 2021-03-26 中国人民解放军国防科技大学 用于调控脂质体囊泡行为、功能的反光蛋白体系及其应用
EP3799884A1 (fr) 2019-10-01 2021-04-07 GlaxoSmithKline Biologicals S.A. Compositions immunogènes
KR20230066041A (ko) 2020-09-11 2023-05-12 글락소스미스클라인 바이오로지칼즈 에스.에이. 외막 소포
GB202115077D0 (en) 2021-10-21 2021-12-08 Glaxosmithkline Biologicals Sa Assay
WO2023097652A1 (fr) * 2021-12-03 2023-06-08 National Center For Nanoscience And Technology Cellule modifiée et son application
GB202211033D0 (en) 2022-07-28 2022-09-14 Glaxosmithkline Biologicals Sa Purification process

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2848965A1 (de) 1978-11-11 1980-05-22 Behringwerke Ag Verfahren zur herstellung von membranproteinen aus neisseria meningitidis und diese enthaltende vaccine
US4707543A (en) * 1985-09-17 1987-11-17 The United States Of America As Represented By The Secretary Of The Army Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines
JPH01125328A (ja) 1987-07-30 1989-05-17 Centro Natl De Biopreparados 髄膜炎菌ワクチン
DE3841091A1 (de) 1988-12-07 1990-06-13 Behringwerke Ag Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung
AU640118B2 (en) 1988-12-19 1993-08-19 De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezonheid En Cultuur Meningococcal class 1 outer-membrane protein vaccine
ES2055785T3 (es) 1989-01-17 1994-09-01 Eniricerche Spa Peptidos sinteticos y su uso como vehiculos universales para la preparacion de conjugados inmunogenos aptos para el desarrollo de vacunas sinteticas.
HU212924B (en) 1989-05-25 1996-12-30 Chiron Corp Adjuvant formulation comprising a submicron oil droplet emulsion
AU651949B2 (en) 1989-07-14 1994-08-11 American Cyanamid Company Cytokine and hormone carriers for conjugate vaccines
IT1237764B (it) 1989-11-10 1993-06-17 Eniricerche Spa Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici.
DE69113564T2 (de) 1990-08-13 1996-05-30 American Cyanamid Co Faser-Hemagglutinin von Bordetella pertussis als Träger für konjugierten Impfstoff.
US5993826A (en) 1993-03-02 1999-11-30 Board Of Regents, The University Of Texas Methods and compositions relating to useful antigens of moraxella catarrhalis
US5552146A (en) 1991-08-15 1996-09-03 Board Of Regents, The University Of Texas System Methods and compositions relating to useful antigens of Moraxella catarrhalis
WO1993018150A1 (fr) 1992-03-02 1993-09-16 Biocine S.P.A. Proteines d'helicobacter pylori utiles pour des vaccins et des diagnostics
IT1262896B (it) 1992-03-06 1996-07-22 Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini.
FR2692592B1 (fr) * 1992-06-19 1995-03-31 Pasteur Merieux Serums Vacc Fragments d'ADN codant pour les sous-unités du récepteur de la transferrine de Neisseria meningitidis et procédés les exprimant.
SG49909A1 (en) 1992-06-25 1998-06-15 Smithkline Beecham Biolog Vaccine composition containing adjuvants
IL102687A (en) 1992-07-30 1997-06-10 Yeda Res & Dev Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them
NL9201716A (nl) 1992-10-02 1994-05-02 Nederlanden Staat Buitenmembraanvesikel dat voorzien is van een groep polypeptiden welke ten minste de immuunwerking van aan membraan gebonden buitenmembraaneiwitten (OMP's) hebben, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk buitenmembraanvesikel omvat.
PT624376E (pt) * 1993-05-13 2000-07-31 American Cyanamid Co Preparacao e utilizacoes de proteinas de membranas externas deficitarias em los de cocos gram-negativos
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
EP0710118B1 (fr) * 1994-04-20 1998-11-25 U.S. Department Of The Army Vaccin contre les infections par des bacteries gram-negatives
EP0769018B1 (fr) 1994-07-01 2002-12-18 Chiron Corporation Proteines d'helicobacter et vaccins
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
PT772619E (pt) 1994-07-15 2006-10-31 Univ Iowa Res Found Oligonucleotidos imunomoduladores
IL117483A (en) 1995-03-17 2008-03-20 Bernard Brodeur MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K.
US6180111B1 (en) 1995-05-18 2001-01-30 University Of Maryland Vaccine delivery system
GB9513261D0 (en) 1995-06-29 1995-09-06 Smithkline Beecham Biolog Vaccines
EP0841944A2 (fr) 1995-08-04 1998-05-20 University Of Guelph Nouveaux vaccins et nouvelles compositions pharmaceutiques utilisant des vesicules de membrane de micro-organismes et leurs procedes d'elaboration
EP0909323B1 (fr) 1996-01-04 2007-02-28 Novartis Vaccines and Diagnostics, Inc. Bacterioferritine de helicobacter pilori
DE19630390A1 (de) 1996-07-26 1998-01-29 Chiron Behring Gmbh & Co Proteine, insbesondere Membranproteine von Helicobacter pylori, ihre Herstellung und Verwendung
CA2268825C (fr) 1996-10-11 2006-04-18 The Regents Of The University Of California Conjugues polynucleotide immunostimulateur/molecule immunomodulatrice
NZ337054A (en) 1997-01-30 2001-03-30 Chiron Corp Microparticles PLA and PLG with adsorbed viral antigen to stimulate immune responses particularly for intracellular viruses such as HSV-1 or HSV-2, varicella zoster virus. epstein-barr virus or cytomegalovirus (CMV)
JP2001513776A (ja) 1997-02-28 2001-09-04 ユニバーシティ オブ アイオワ リサーチ ファウンデーション ＬＰＳ関連障害の処置における非メチル化ＣｐＧジヌクレオチドを含む核酸の使用
DK1005368T3 (da) 1997-03-10 2010-01-04 Ottawa Hospital Res Inst Anvendelse af nukleinsyrer, der indeholder ikke-metyleret CpG dinukleotid i kombination med alun som hjælpestoffer
AU7690898A (en) 1997-05-20 1998-12-11 Ottawa Civic Hospital Loeb Research Institute Vectors and methods for immunization or therapeutic protocols
JP4101888B2 (ja) 1997-06-06 2008-06-18 ダイナバックス テクノロジーズ コーポレイション 免疫刺激オリゴヌクレオチド、その組成物およびその使用方法
GB9711964D0 (en) 1997-06-09 1997-08-06 Medical Res Council Live attenuated vaccines
GB9712347D0 (en) 1997-06-14 1997-08-13 Smithkline Beecham Biolog Vaccine
GB9713156D0 (en) 1997-06-20 1997-08-27 Microbiological Res Authority Vaccines
CA2297072A1 (fr) * 1997-07-17 1999-01-28 North American Vaccine, Inc. Conjugues immunogenes renfermant une porine meningococcique du groupe b et un polysaccharide h. influenzae
CA2300854C (fr) 1997-08-21 2011-04-05 Peter Andre Van Der Ley Nouveaux mutants de bacteries des muqueuses gram negatives et leur application dans des vaccins
EP1279401B1 (fr) 1997-09-05 2008-01-09 GlaxoSmithKline Biologicals S.A. Emulsions du type huile-dans-l'eau contenant des saponines
DE69841807D1 (de) 1997-11-06 2010-09-16 Novartis Vaccines & Diagnostic Neisseriale antigene
WO1999027105A2 (fr) 1997-11-21 1999-06-03 Genset Sequence genomique et polypeptides de chlamydia pneumoniae, leurs fragments et leurs utilisations, en particulier pour le diagnostic, la prevention ou le traitement d'une infection
CN1280619A (zh) 1997-11-28 2001-01-17 根瑟特公司 沙眼衣原体的基因组序列和多肽,其片段以及其用途,特别是用于诊断、预防和治疗感染
GB9725084D0 (en) 1997-11-28 1998-01-28 Medeva Europ Ltd Vaccine compositions
DK1047784T4 (en) 1998-01-14 2015-06-15 Novartis Vaccines & Diagnostic NEISSERA meningitidis ANTIGENS
GB9806456D0 (en) * 1998-03-25 1998-05-27 Smithkline Beecham Biolog Vaccine composition
AU746163B2 (en) 1998-04-09 2002-04-18 Smithkline Beecham Biologicals (Sa) Adjuvant compositions
EP2261351A3 (fr) 1998-05-01 2012-01-11 Novartis Vaccines and Diagnostics, Inc. Antigènes de Neisseria meningitidis et compositions
GB9817052D0 (en) 1998-08-05 1998-09-30 Smithkline Beecham Biolog Vaccine
AU1202200A (en) * 1998-10-09 2000-05-01 Chiron Corporation Neisseria genomic sequences and methods of their use
TR200101055T2 (tr) 1998-10-16 2001-09-21 Smithkline Beecham Biologicals S.A. Adjuvan sistemler ve aşılar
GB9823978D0 (en) 1998-11-02 1998-12-30 Microbiological Res Authority Multicomponent meningococcal vaccine
CA2350775A1 (fr) 1998-11-12 2000-05-18 The Regents Of The University Of California Sequence genomique de chlamydia pneumoniae
GB9828000D0 (en) 1998-12-18 1999-02-10 Chiron Spa Antigens
WO2000045841A2 (fr) * 1999-02-05 2000-08-10 Merck & Co., Inc. Formulations vaccinales contre le virus du papillome humain
US7081244B2 (en) * 1999-02-22 2006-07-25 Health Protection Agency Neisserial vaccine compositions and methods
WO2000050074A2 (fr) 1999-02-22 2000-08-31 Microbiological Research Authority Compositions de vaccin a neisseria et procedes correspondants
ES2350306T3 (es) 1999-02-26 2011-01-20 Novartis Vaccines And Diagnostics, Inc. Uso de bioadhesivos y adyuvantes para la administración de antígenos por vía mucosa.
SI1162999T1 (sl) 1999-03-19 2007-04-30 Glaxosmithkline Biolog Sa Vakcina proti Streptococcus pneumoniae
US6245568B1 (en) * 1999-03-26 2001-06-12 Merck & Co., Inc. Human papilloma virus vaccine with disassembled and reassembled virus-like particles
JP2002541808A (ja) 1999-04-09 2002-12-10 テクラブ， インコーポレイテッド ポリサッカリド結合体ワクチンのための組換えトキシンａタンパク質キャリア
ES2228497T3 (es) 1999-04-19 2005-04-16 Glaxosmithkline Biologicals S.A. Composicion adyuvante que comprende saponina y un oligonucleotido inmunoestimulante.
AUPQ005499A0 (en) * 1999-04-30 1999-05-27 Townsend, Roy Leslie Printing process
ES2477194T3 (es) 1999-04-30 2014-07-16 Novartis Vaccines And Diagnostics S.R.L. Ant�genos neisseriales conservados
EP2270172B1 (fr) 1999-05-19 2016-01-13 GlaxoSmithKline Biologicals SA Compositions à base de combinaisons de Neisseria
GB9918319D0 (en) * 1999-08-03 1999-10-06 Smithkline Beecham Biolog Vaccine composition
AR025749A1 (es) 1999-09-24 2002-12-11 Smithkline Beecham Biolog Vacunas
MXPA02003067A (es) 1999-09-24 2002-09-30 Smithkline Beecham Biolog Uso de combinacion de ester sorbitano de polioxietileno y octoxinol como adjuvante y su uso en vacunas.
WO2001034642A2 (fr) 1999-11-12 2001-05-17 University Of Iowa Research Foundation Commande de la synthese de membrane de neisseria
MXPA02006962A (es) 2000-01-17 2002-12-13 Chiron Spa Vacuna de vesicula de membrana exterior que comprende proteinas de membrana exterior de neisseria meningitidis serogrupo b.
GB0007433D0 (en) * 2000-03-27 2000-05-17 Microbiological Res Authority Recombinant transferrin binding proteins
GB0007432D0 (en) 2000-03-27 2000-05-17 Microbiological Res Authority Proteins for use as carriers in conjugate vaccines
NO20002828D0 (no) 2000-06-02 2000-06-02 Statens Inst For Folkehelse Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav
ATE440861T1 (de) 2000-07-03 2009-09-15 Novartis Vaccines & Diagnostic Immunisierung gegen chlamydia pneumoniae
GB0017149D0 (en) 2000-07-12 2000-08-30 Chiron Spa Helicobacter pylori mutants
JP5511117B2 (ja) * 2000-07-27 2014-06-04 チルドレンズ ホスピタル アンド リサーチ センター アット オークランド 髄膜炎菌に起因する疾患に対する広域防御のためのワクチン
GB0103170D0 (en) 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
CA2420621C (fr) 2000-09-28 2011-05-24 Chiron Corporation Compositions de microparticules et procede de fabrication desdites compositions
AU2002214127B2 (en) 2000-10-27 2007-06-07 J. Craig Venter Institute, Inc. Nucleic acids and proteins from streptococcus groups A and B
GB0103171D0 (en) * 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
GB0103424D0 (en) 2001-02-12 2001-03-28 Chiron Spa Gonococcus proteins
GB0115176D0 (en) 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
WO2003009869A1 (fr) 2001-07-26 2003-02-06 Chiron Srl. Vaccins comprenant des adjuvants aluminium et histidine
GB0118249D0 (en) * 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
GB0121591D0 (en) 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
GB0130123D0 (en) * 2001-12-17 2002-02-06 Microbiological Res Agency Outer membrane vesicle vaccine and its preparation
ES2537737T3 (es) * 2002-08-02 2015-06-11 Glaxosmithkline Biologicals S.A. Composiciones de vacuna que comprenden lipooligosacáridos de inmunotipo L2 y/o L3 de Neisseria meningitidis de IgtB

Also Published As

Publication number Publication date
ES2520392T3 (es) 2014-11-11
EP1864679B1 (fr) 2014-06-18
GB0220194D0 (en) 2002-10-09
CN1688334A (zh) 2005-10-26
RU2005108994A (ru) 2006-02-10
DK2258389T3 (da) 2013-08-26
RU2325184C2 (ru) 2008-05-27
PT1864679E (pt) 2014-09-25
LU92239I2 (fr) 2013-09-04
EP1534326B1 (fr) 2007-07-04
EP2258388B1 (fr) 2014-08-13
CA2497165C (fr) 2015-10-20
DE60314756T2 (de) 2008-03-06
JP2006503822A (ja) 2006-02-02
ES2289351T3 (es) 2008-02-01
EP1534326A2 (fr) 2005-06-01
JP2010150287A (ja) 2010-07-08
BR0314094A (pt) 2005-11-16
CA2497165A1 (fr) 2004-03-11
ATE366117T1 (de) 2007-07-15
NZ538673A (en) 2008-04-30
EP2258389B1 (fr) 2013-06-05
EP2258388A1 (fr) 2010-12-08
EP2258389A1 (fr) 2010-12-08
ES2423019T3 (es) 2013-09-17
CY1115777T1 (el) 2017-01-25
PT2258389E (pt) 2013-08-22
DK1534326T3 (da) 2007-10-22
CY1114570T1 (el) 2017-01-25
SI2258389T1 (sl) 2013-07-31
EP1864679A2 (fr) 2007-12-12
EP1864679A3 (fr) 2008-04-02
WO2004019977A2 (fr) 2004-03-11
ES2483592T3 (es) 2014-08-06
DE60314756D1 (de) 2007-08-16
WO2004019977A3 (fr) 2004-07-15
US20150258188A1 (en) 2015-09-17
JP5808358B2 (ja) 2015-11-10
JP2013139471A (ja) 2013-07-18
CY1107737T1 (el) 2013-04-18
SI1864679T1 (sl) 2014-10-30
CN102188700A (zh) 2011-09-21
AU2003263534B2 (en) 2010-08-05
MXPA05002316A (es) 2005-06-08
EP2258390A1 (fr) 2010-12-08
US20060166344A1 (en) 2006-07-27
BRPI0314094A8 (pt) 2018-04-03
FR13C0046I1 (fr) 2013-09-06
DK1864679T3 (da) 2014-08-25
PT1534326E (pt) 2007-10-17
AU2003263534A1 (en) 2004-03-19

Similar Documents

Publication Publication Date Title
FR13C0046I2 (fr) Vesicules de membrane externe bacterienne ameliorees
JP2006503822A5 (fr)
NO963508L (no) Urease-basert vaksine og behandling av Helicobacter-infeksjon
AU2003244855A1 (en) Method to enhance an immune response of nucleic acid vaccination
DE69831594D1 (de) Intakte oder zerstörte insektenzellen als antigenadjuvant
AU1463097A (en) Helicobacter pylori bacterioferritin
WO2003105784A8 (fr) Compositions et procedes pour adoucir, fluidifier et enlever le tissu hyperkeratosique
WO2005112994A8 (fr) Composition d'immunisation comportant des vlp de type nodavirus
EP1583502A4 (fr) Procedes et reactifs pour l'amelioration de la transduction virale dans l'epithelium de la vessie
DE60041157D1 (de) Verfahren zur verbesserung der gentransfer-effizienz in pflanzenzellen
CA2514332A1 (fr) Procede d'inactivation/elimination d'agents pathogenes presents sur un tissu
ATE404547T1 (de) Verfahren zur herstellung von propylenoxid
EP1546357A4 (fr) Polypeptides immunogenes de mycoplasma hyopneumoniae
RU2008148606A (ru) Способ экстракции компонентов из культуры дрожжевых клеток
ES2074968B1 (es) Nuevas cepas de pseudomonas aeruginosa atenuadas.
RU2008111708A (ru) Способ получения эмбриональных фибробластоподобных клеток из пупочного канатика новорожденного
CN114395525A (zh) 一种脱细胞去抗原的异种肌腱制备方法
IT1317849B1 (it) Mezzi e metodi per l'espressione di proteine omologhe ed eterologhe inceppi di rhodococcus.
AR029547A1 (es) Composiciones y metodos para la terapia y el diagnostico de cancer de pulmon
GB0407828D0 (en) Therapeutic composition for autoimmune conditions
RU2002132049A (ru) Способ получения липополисахаридов
WO2006020824A3 (fr) Diagnostic et traitement de la maladie de kawasaki et d'une infection a coronavirus
BR0311463A (pt) Composições compreendendo uma bactéria do gênero dietzia que são úteis para o tratamento de paratuberculose em ruminantes e método para a cultura da bactéria
ATE496745T1 (de) Holzbehandlungsmethode
RU2003134680A (ru) Способ получения эндонуклеазы рестрикции spm i