CU23377A1 - Metodo para la incorporacion de antigenos en vesiculas de membrana externa de bacterias y formulaciones resultantes - Google Patents

Metodo para la incorporacion de antigenos en vesiculas de membrana externa de bacterias y formulaciones resultantes

Info

Publication number
CU23377A1
CU23377A1 CU20030254A CU20030254A CU23377A1 CU 23377 A1 CU23377 A1 CU 23377A1 CU 20030254 A CU20030254 A CU 20030254A CU 20030254 A CU20030254 A CU 20030254A CU 23377 A1 CU23377 A1 CU 23377A1
Authority
CU
Cuba
Prior art keywords
incorporation
antigens
bacteria
vesicules
external membrane
Prior art date
Application number
CU20030254A
Other languages
English (en)
Inventor
Espina Maitu Delgado
Perez Olivia Niebla
Dunn Alejandro Miguel Martyn
Feyt Rolando Pajon
Perez Hilda Elisa Garay
Blanco Sonia Gonzalez
Nieto Gerardo Enrique Guillen
Original Assignee
Ct De Ingenieria Genetica Y Biotecnologia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct De Ingenieria Genetica Y Biotecnologia filed Critical Ct De Ingenieria Genetica Y Biotecnologia
Priority to CU20030254A priority Critical patent/CU23377A1/es
Priority to ARP040103962A priority patent/AR046921A1/es
Priority to US10/577,000 priority patent/US20070166333A1/en
Priority to PCT/CU2004/000012 priority patent/WO2005042571A1/es
Priority to NZ547519A priority patent/NZ547519A/en
Priority to BRPI0416178-5A priority patent/BRPI0416178A/pt
Priority to CA002543206A priority patent/CA2543206A1/en
Priority to EP04797391A priority patent/EP1688428A1/en
Priority to AU2004284969A priority patent/AU2004284969A1/en
Publication of CU23377A1 publication Critical patent/CU23377A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Abstract

Metodo para la incorporacion de antigenos proteicos naturales, recombinantes o sinteticos en un preparado de vesiculas de membrana externa de bacterias Gram negativas, sin producir ruptura de la estructura vesicular, manteniendo la inmunoestimuladora de las mismas, con la ventaje de que se genera contra el antigeno incorporado una respuesta inmune superior a la generada contra el antigeno administrado solo. Las composiciones vacunales resultantes son utiles para elevar el espectro protector de vacunas ya existentes y permiten extenderlo contra diferentes patogenos en enfermedades bacterianas, virales, cancerosas, o de otro origen. Las composiciones referidas son aplicables en la industria farmaceutica como vacunas para uso profilactico y terapeutico de humano.
CU20030254A 2003-11-04 2003-11-04 Metodo para la incorporacion de antigenos en vesiculas de membrana externa de bacterias y formulaciones resultantes CU23377A1 (es)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CU20030254A CU23377A1 (es) 2003-11-04 2003-11-04 Metodo para la incorporacion de antigenos en vesiculas de membrana externa de bacterias y formulaciones resultantes
ARP040103962A AR046921A1 (es) 2003-11-04 2004-10-29 Metodo para la incorporacion de antigenos en vesiculas de membrana externa de bacterias y formulaciones resultantes
US10/577,000 US20070166333A1 (en) 2003-11-04 2004-11-03 Method of antigen incorporation into neisseria bacterial outer membrane vesicles and resulting vaccine formulations
PCT/CU2004/000012 WO2005042571A1 (es) 2003-11-04 2004-11-03 Método para la incorporación de antígenos en vesiculas de membrana externa de bacterias y formulaciones resultantes
NZ547519A NZ547519A (en) 2003-11-04 2004-11-03 Method of antigen incorporation into neisseria bacterial outer membrane vesicles and resulting vaccine formulations
BRPI0416178-5A BRPI0416178A (pt) 2003-11-04 2004-11-03 método de incorporação de antìgeno em vesìculas de membrana externa de bactérias neisseria e formulações de vacina resultantes
CA002543206A CA2543206A1 (en) 2003-11-04 2004-11-03 Method of antigen incorporation into neisseria bacterial outer membrane vesicles and resulting vaccine formulations
EP04797391A EP1688428A1 (en) 2003-11-04 2004-11-03 Method of antigen incorporation into neisseria bacterial outer membrane vesicles and resulting vaccine formulations
AU2004284969A AU2004284969A1 (en) 2003-11-04 2004-11-03 Method of antigen incorporation into Neisseria bacterial outer membrane vesicles and resulting vaccine formulations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20030254A CU23377A1 (es) 2003-11-04 2003-11-04 Metodo para la incorporacion de antigenos en vesiculas de membrana externa de bacterias y formulaciones resultantes

Publications (1)

Publication Number Publication Date
CU23377A1 true CU23377A1 (es) 2009-05-28

Family

ID=34529418

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20030254A CU23377A1 (es) 2003-11-04 2003-11-04 Metodo para la incorporacion de antigenos en vesiculas de membrana externa de bacterias y formulaciones resultantes

Country Status (9)

Country Link
US (1) US20070166333A1 (es)
EP (1) EP1688428A1 (es)
AR (1) AR046921A1 (es)
AU (1) AU2004284969A1 (es)
BR (1) BRPI0416178A (es)
CA (1) CA2543206A1 (es)
CU (1) CU23377A1 (es)
NZ (1) NZ547519A (es)
WO (1) WO2005042571A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009158142A1 (en) 2008-05-30 2009-12-30 The U.S.A., As Represented By The Secretary Of The Army, On Behalf Of Walter Reed Army Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof
WO2011027956A2 (ko) 2009-09-04 2011-03-10 주식회사이언메딕스 그람 양성 박테리아에서 유래한 세포밖 소포체 및 이를 이용한 질병 모델
KR101430283B1 (ko) 2009-09-01 2014-08-14 주식회사이언메딕스 장내 공생 세균유래 세포밖 소포체, 및 이를 이용한 질병모델, 백신, 후보 약물 탐색 방법, 및 진단 방법
BR102020013216A2 (pt) * 2020-06-26 2022-03-08 Instituto Butantan Processo de obtenção de vesículas apresentadoras de antígenos (vaa) que possibilita o acoplamento de um ou mais antígenos

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6558677B2 (en) * 1996-10-15 2003-05-06 Wendell D. Zollinger Vaccine against gram negative bacteria
GB9823978D0 (en) * 1998-11-02 1998-12-30 Microbiological Res Authority Multicomponent meningococcal vaccine
GB9918319D0 (en) * 1999-08-03 1999-10-06 Smithkline Beecham Biolog Vaccine composition
NO20002828D0 (no) * 2000-06-02 2000-06-02 Statens Inst For Folkehelse Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav
GB0130123D0 (en) * 2001-12-17 2002-02-06 Microbiological Res Agency Outer membrane vesicle vaccine and its preparation
GB0220194D0 (en) * 2002-08-30 2002-10-09 Chiron Spa Improved vesicles

Also Published As

Publication number Publication date
BRPI0416178A (pt) 2007-01-09
CA2543206A1 (en) 2005-05-12
EP1688428A1 (en) 2006-08-09
WO2005042571A1 (es) 2005-05-12
AR046921A1 (es) 2006-01-04
US20070166333A1 (en) 2007-07-19
NZ547519A (en) 2009-01-31
AU2004284969A1 (en) 2005-05-12

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