AR046921A1 - Metodo para la incorporacion de antigenos en vesiculas de membrana externa de bacterias y formulaciones resultantes - Google Patents
Metodo para la incorporacion de antigenos en vesiculas de membrana externa de bacterias y formulaciones resultantesInfo
- Publication number
- AR046921A1 AR046921A1 ARP040103962A ARP040103962A AR046921A1 AR 046921 A1 AR046921 A1 AR 046921A1 AR P040103962 A ARP040103962 A AR P040103962A AR P040103962 A ARP040103962 A AR P040103962A AR 046921 A1 AR046921 A1 AR 046921A1
- Authority
- AR
- Argentina
- Prior art keywords
- incorporation
- external membrane
- antigens
- bacteria
- vesicules
- Prior art date
Links
- 102000036639 antigens Human genes 0.000 title abstract 4
- 108091007433 antigens Proteins 0.000 title abstract 4
- 239000000427 antigen Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 241000894006 Bacteria Species 0.000 title abstract 2
- 238000010348 incorporation Methods 0.000 title abstract 2
- 239000012528 membrane Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 3
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 230000003308 immunostimulating effect Effects 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Método para la incorporacion de antígenos proteicos naturales, recombinantes o sintéticos en un preparado de vesículas de membrana externa de bacterias Gram negativas, sin producir ruptura de la estructura vesicular, manteniendo la inmunogenicidad y la capacidad inmunoestimuladora de las mismas, con la ventaja de que se genera contra el antígeno incorporado una respuesta inmune superior a la generada contra el antígeno administrado solo. Las composiciones vacunales resultantes son utiles para elevar el espectro protector de vacunas ya existentes y permiten extenderlo contra diferentes patogenos en enfermedades bacterianas, virales, cancerosas, o de otro origen. Las composiciones referidas son aplicables en la industria farmacéutica como vacunas para uso profiláctico y terapéutico en humano.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20030254A CU23377A1 (es) | 2003-11-04 | 2003-11-04 | Metodo para la incorporacion de antigenos en vesiculas de membrana externa de bacterias y formulaciones resultantes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR046921A1 true AR046921A1 (es) | 2006-01-04 |
Family
ID=34529418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040103962A AR046921A1 (es) | 2003-11-04 | 2004-10-29 | Metodo para la incorporacion de antigenos en vesiculas de membrana externa de bacterias y formulaciones resultantes |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20070166333A1 (es) |
| EP (1) | EP1688428A1 (es) |
| AR (1) | AR046921A1 (es) |
| AU (1) | AU2004284969A1 (es) |
| BR (1) | BRPI0416178A (es) |
| CA (1) | CA2543206A1 (es) |
| CU (1) | CU23377A1 (es) |
| NZ (1) | NZ547519A (es) |
| WO (1) | WO2005042571A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9387239B2 (en) * | 2008-05-30 | 2016-07-12 | U.S. Army Medical Research And Materiel Command | Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof |
| KR101430283B1 (ko) | 2009-09-01 | 2014-08-14 | 주식회사이언메딕스 | 장내 공생 세균유래 세포밖 소포체, 및 이를 이용한 질병모델, 백신, 후보 약물 탐색 방법, 및 진단 방법 |
| WO2011027956A2 (ko) | 2009-09-04 | 2011-03-10 | 주식회사이언메딕스 | 그람 양성 박테리아에서 유래한 세포밖 소포체 및 이를 이용한 질병 모델 |
| BR102020013216A2 (pt) * | 2020-06-26 | 2022-03-08 | Instituto Butantan | Processo de obtenção de vesículas apresentadoras de antígenos (vaa) que possibilita o acoplamento de um ou mais antígenos |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6558677B2 (en) * | 1996-10-15 | 2003-05-06 | Wendell D. Zollinger | Vaccine against gram negative bacteria |
| GB9823978D0 (en) * | 1998-11-02 | 1998-12-30 | Microbiological Res Authority | Multicomponent meningococcal vaccine |
| GB9918319D0 (en) * | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
| NO20002828D0 (no) * | 2000-06-02 | 2000-06-02 | Statens Inst For Folkehelse | Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav |
| GB0130123D0 (en) * | 2001-12-17 | 2002-02-06 | Microbiological Res Agency | Outer membrane vesicle vaccine and its preparation |
| GB0220194D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
-
2003
- 2003-11-04 CU CU20030254A patent/CU23377A1/es unknown
-
2004
- 2004-10-29 AR ARP040103962A patent/AR046921A1/es unknown
- 2004-11-03 CA CA002543206A patent/CA2543206A1/en not_active Abandoned
- 2004-11-03 AU AU2004284969A patent/AU2004284969A1/en not_active Abandoned
- 2004-11-03 EP EP04797391A patent/EP1688428A1/en not_active Withdrawn
- 2004-11-03 WO PCT/CU2004/000012 patent/WO2005042571A1/es active Application Filing
- 2004-11-03 US US10/577,000 patent/US20070166333A1/en not_active Abandoned
- 2004-11-03 NZ NZ547519A patent/NZ547519A/en unknown
- 2004-11-03 BR BRPI0416178-5A patent/BRPI0416178A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1688428A1 (en) | 2006-08-09 |
| AU2004284969A1 (en) | 2005-05-12 |
| CU23377A1 (es) | 2009-05-28 |
| NZ547519A (en) | 2009-01-31 |
| WO2005042571A1 (es) | 2005-05-12 |
| US20070166333A1 (en) | 2007-07-19 |
| CA2543206A1 (en) | 2005-05-12 |
| BRPI0416178A (pt) | 2007-01-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |