FI96610B - Förfarande för framställning av fullständigt eller partiellt tvärbundna hyaluronsyraestrar - Google Patents

Förfarande för framställning av fullständigt eller partiellt tvärbundna hyaluronsyraestrar Download PDF

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Publication number
FI96610B
FI96610B FI874504A FI874504A FI96610B FI 96610 B FI96610 B FI 96610B FI 874504 A FI874504 A FI 874504A FI 874504 A FI874504 A FI 874504A FI 96610 B FI96610 B FI 96610B
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FI
Finland
Prior art keywords
added
hyaluronic acid
acetone
molar equivalents
groups
Prior art date
Application number
FI874504A
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English (en)
Finnish (fi)
Other versions
FI874504A (sv
FI874504A0 (sv
FI96610C (sv
Inventor
Valle Francesco Della
Aurelio Romeo
Original Assignee
Fidia Spa
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Publication of FI874504A0 publication Critical patent/FI874504A0/sv
Publication of FI874504A publication Critical patent/FI874504A/sv
Publication of FI96610B publication Critical patent/FI96610B/sv
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Publication of FI96610C publication Critical patent/FI96610C/sv

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Surgery (AREA)
  • Birds (AREA)
  • Transplantation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (8)

1. Förfarande för framställning av fullständigt eller par-tiellt tvärburtdna hyaluronsyraestrar, känneteck-n a t av att ett kvaternärt ammoniumsalt av hyaluronsyra omsätts i ett aprotiskt lösningsmedel med en dihalogenid med formeln Hal-R-Hal väri Hai betecknar en halogen ooh R betecknar en C2_16-alifatisk grupp eller en ClA-alkylen- f enyl - C2.14- alky lengrupp, och valbart med en halogenid med formeln Hal-R, väri Hai betecknar en halogen och R] betecknar en C2_lg-alkylengrupp, en CM-alk- oxikarbonyl -Cm -grupp, en f enyl-C, alkyl-eller -alkenylgrupp, en bensylgrupp eller en med en CM-alkyl eller med 1-3 metyl-• eller metoxigrupper eller med en halo- genatom substituerad bensyl eller en korti-kosteroidalkohol, och, ora sÄ_önskas, omvandlas en erhällen partiell ester till motsvarande salt av en alkalimetall eller en alka- lisk jordartsmetall.
2. Förfarande enligt krav 1, kännetecknat av att hyaluronsyrans kvaternära ammoniumsalt utgörs av tetrabutyl-ammoniumsalt.
3. Förfarande av krav 1, kännetecknat av att en il »:i liiti I I td 96610 dihalogenid med formeln Hal-R-Hal används, i vilken formel H betecknar en halogen och R en C2.14-alkylengrupp.
- 4. Forfarande enligt krav 1, kännetecknat av att R betecknar etylen, propylen, butylen, pentylen, hexylen, heptylen, oktylen, dekylen eller fenyletylen.
5. Forfarande enligt krav 3, kännetecknat av att R betecknar etylen, propylen, butylen, pentylen, hexylen, heptylen, oktylen eller dekylen.
6. Forfarande enligt nägot av kraven 1-3, kännetecknat av att R! betecknar etylen, propylen, isopro-pylen, n-butylen, isobutylen, t-butylen, pentylen, hexylen eller oktylen.
7. Forfarande enligt nägot av kraven 1-6, kännetecknat av att det aprotiska lösningsmedlet utgörs av dialkylsulfoxid, dialkylkarboxylamid eller en lägre alkyl-dialkylamid eller en lägre alifatisk syra.
8. Forfarande enligt krav 7, kännetecknat av att lösningsmedlet utgörs av dimetylsulfoxid, dimetyl- eller dietylformamid eller dimetyl- eller dietylacetamid.
FI874504A 1986-10-13 1987-10-13 Förfarande för framställning av fullständigt eller partiellt tvärbundna hyaluronsyraestrar FI96610C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT4854686 1986-10-13
IT48546/86A IT1198449B (it) 1986-10-13 1986-10-13 Esteri di alcoli polivalenti di acido ialuronico

Publications (4)

Publication Number Publication Date
FI874504A0 FI874504A0 (sv) 1987-10-13
FI874504A FI874504A (sv) 1988-04-14
FI96610B true FI96610B (sv) 1996-04-15
FI96610C FI96610C (sv) 1996-07-25

Family

ID=11267232

Family Applications (1)

Application Number Title Priority Date Filing Date
FI874504A FI96610C (sv) 1986-10-13 1987-10-13 Förfarande för framställning av fullständigt eller partiellt tvärbundna hyaluronsyraestrar

Country Status (23)

Country Link
US (1) US4957744A (sv)
EP (1) EP0265116B1 (sv)
JP (1) JP2648308B2 (sv)
KR (1) KR920002702B1 (sv)
CN (1) CN1025035C (sv)
AR (1) AR247406A1 (sv)
AT (1) ATE163942T1 (sv)
AU (1) AU610087B2 (sv)
CA (1) CA1317287C (sv)
DE (1) DE3752176T2 (sv)
DK (1) DK536087A (sv)
ES (1) ES2115583T3 (sv)
FI (1) FI96610C (sv)
HU (1) HU204858B (sv)
IE (1) IE872618L (sv)
IL (1) IL84032A (sv)
IN (1) IN170801B (sv)
IT (1) IT1198449B (sv)
NO (1) NO175374C (sv)
NZ (1) NZ221994A (sv)
PH (1) PH26025A (sv)
PT (1) PT85908B (sv)
ZA (1) ZA877559B (sv)

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US4957744A (en) 1990-09-18
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EP0265116A3 (en) 1989-02-08
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AU610087B2 (en) 1991-05-16
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