FI964520A - Azabicykloföreningar - Google Patents

Azabicykloföreningar Download PDF

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Publication number
FI964520A
FI964520A FI964520A FI964520A FI964520A FI 964520 A FI964520 A FI 964520A FI 964520 A FI964520 A FI 964520A FI 964520 A FI964520 A FI 964520A FI 964520 A FI964520 A FI 964520A
Authority
FI
Finland
Prior art keywords
azabicyclo
exchangeable
formulae
intermediates
symbols
Prior art date
Application number
FI964520A
Other languages
English (en)
Finnish (fi)
Other versions
FI103879B (sv
FI103879B1 (sv
FI964520A0 (sv
Inventor
Katherine Elizabeth Brighty
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI964520A publication Critical patent/FI964520A/sv
Publication of FI964520A0 publication Critical patent/FI964520A0/sv
Application granted granted Critical
Publication of FI103879B publication Critical patent/FI103879B/sv
Publication of FI103879B1 publication Critical patent/FI103879B1/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI964520A 1989-08-16 1996-11-11 Azabicykloföreningar FI103879B1 (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8903489 1989-08-16
PCT/US1989/003489 WO1991002526A1 (en) 1989-08-16 1989-08-16 Azabicyclo quinolone carboxylic acids
FI920632 1992-02-14
FI920632A FI108228B (sv) 1989-08-16 1992-02-14 Förfarande för framställning av terapeutiskt användbara azabicyklokinolonkarboxylsyror

Publications (4)

Publication Number Publication Date
FI964520A true FI964520A (sv) 1996-11-11
FI964520A0 FI964520A0 (sv) 1996-11-11
FI103879B FI103879B (sv) 1999-10-15
FI103879B1 FI103879B1 (sv) 1999-10-15

Family

ID=22215165

Family Applications (2)

Application Number Title Priority Date Filing Date
FI920632A FI108228B (sv) 1989-08-16 1992-02-14 Förfarande för framställning av terapeutiskt användbara azabicyklokinolonkarboxylsyror
FI964520A FI103879B1 (sv) 1989-08-16 1996-11-11 Azabicykloföreningar

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI920632A FI108228B (sv) 1989-08-16 1992-02-14 Förfarande för framställning av terapeutiskt användbara azabicyklokinolonkarboxylsyror

Country Status (30)

Country Link
EP (1) EP0413455B1 (sv)
JP (2) JPH072734B2 (sv)
KR (1) KR930004844B1 (sv)
CN (1) CN1025192C (sv)
AT (1) ATE124040T1 (sv)
AU (1) AU623801B2 (sv)
BA (1) BA98299A (sv)
CA (2) CA2127561C (sv)
CY (2) CY1969A (sv)
CZ (1) CZ281127B6 (sv)
DD (1) DD298399A5 (sv)
DE (3) DE19875050I2 (sv)
DK (1) DK0413455T3 (sv)
EG (1) EG19251A (sv)
ES (1) ES2074131T4 (sv)
FI (2) FI108228B (sv)
GR (1) GR3017072T3 (sv)
HK (1) HK1000207A1 (sv)
HU (2) HU219403B (sv)
IE (1) IE66202B1 (sv)
IL (1) IL95331A (sv)
LU (2) LU90311I2 (sv)
NL (2) NL980032I2 (sv)
NO (1) NO300214B1 (sv)
NZ (1) NZ234920A (sv)
PL (1) PL166381B1 (sv)
PT (1) PT94998B (sv)
RU (1) RU2049777C1 (sv)
WO (1) WO1991002526A1 (sv)
ZA (1) ZA906450B (sv)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
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EP0449445A3 (en) * 1990-03-27 1993-08-25 Pfizer Inc. Preparation of beta-ketoesters useful in preparing quinolone antibiotics
FR2675144B1 (fr) * 1991-04-10 1995-06-16 Bouchara Sa Nouvelles quinolones difluorees - leur procede de preparation et les compositions pharmaceutiques en renfermant.
WO1992022550A1 (en) * 1991-06-19 1992-12-23 Pfizer Inc. Azaspiro quinolone antibacterial agents
US5256791A (en) * 1992-03-02 1993-10-26 Pfizer Inc. Preparation of intermediates in the synthesis of quinoline antibiotics
EG20543A (en) * 1992-10-30 1999-07-31 Procter & Gamble Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones
US5527910A (en) * 1992-12-30 1996-06-18 Cheil Foods & Chemicals, Inc. Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
US5591766A (en) * 1993-12-03 1997-01-07 Cheil Foods & Chemicals, Inc. Solid oral formulations of pyridone carboxylic acids
ES2173175T3 (es) * 1994-02-04 2002-10-16 Dainippon Pharmaceutical Co Derivado de acido piridonacarboxilico sustituido con un grupo amino biciclico, ester del mismo, sal del mismo, y amina biciclica como intermedio para su preparacion.
JPH08213881A (ja) * 1995-02-02 1996-08-20 Fujitsu Ltd 周波数制御回路
US5849757A (en) * 1995-02-02 1998-12-15 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivatives substituted by a bicyclic amino group as antibacterials
EP0816355B1 (en) * 1995-02-07 2003-05-14 Daiichi Pharmaceutical Co., Ltd. Heterocyclic spiro derivatives
CA2223404C (en) * 1995-06-06 2001-01-16 Thomas A. Morris Novel crystal form of anhydrous 7-(¬1.alpha., 5.alpha., 6.alpha.|-6-amino-3-azabicyclo¬3.1.0|hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt
DK0833837T3 (da) * 1995-06-15 2002-09-02 Pfizer Fremgangsmåde til fremstilling af derivater af azabicyclonaphthydridincarboxylsyre omfattende et dipeptid
CN100395244C (zh) * 1996-02-09 2008-06-18 富山化学工业株式会社 喹诺酮羧酸衍生物或它们的盐类
AP788A (en) * 1996-08-26 1999-12-03 Pfizer Novel crystal form of anhydrous 7-(1a, 5a, 6a)-6-Amino-3-Azabicyclo(3.1.0) hex-3-YI)-6-Fluoro-1-(2,4- Difluorophenyl)-1,4-Dihydro-4-Oxo-1, 8-Naphthyridine-3-Carboxylic Acid, Methanesulfonic acid salt.
TW519542B (en) * 1996-09-27 2003-02-01 Daiichi Seiyaku Co Bicyclic amine derivative
DK0947513T3 (da) * 1996-10-25 2004-08-30 Daiichi Seiyaku Co Tricykliske aminderivater
US20020032216A1 (en) 1997-03-21 2002-03-14 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
MA24500A1 (fr) 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
DE19733439A1 (de) * 1997-08-02 1999-02-04 Bayer Ag Neue 6-endo-Amino-3-azabicyclo(3.1.0)hexande, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung von Chinolon- und Naphthyridincarbonsäure-Derviaten mit verbesserten Eigenschaften
TR200001435T2 (tr) 1997-09-15 2000-08-21 The Procter & Gamble Company Antimikrobiyal kuinolonlar, bunların bileşimleri ve kullanımları
US6184380B1 (en) * 1999-01-25 2001-02-06 Pfizer Inc. Process for preparing naphthyridones and intermediates
US7019142B2 (en) 1998-01-16 2006-03-28 Pfizer Inc. Process for preparing naphthyridones and intermediates
PA8464701A1 (es) * 1998-01-16 2000-09-29 Pfizer Prod Inc Procedimiento e intermedios para preparar naftiridonas
GB9820405D0 (en) * 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
CN1343128B (zh) 1999-03-17 2010-04-21 第一制药株式会社 药物组合物
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
JP2004515548A (ja) 2000-12-14 2004-05-27 ザ プロクター アンド ギャンブル カンパニー 抗微生物キノロン
AU2002230893B2 (en) 2000-12-14 2005-06-09 The Procter & Gamble Company Antimicrobial 2-pyridones, their compositions and uses
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
EP1546099B1 (en) 2002-07-08 2008-12-31 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo 3.1.0 hexane derivatives useful as muscarinic receptor antagonists
EP1534675B1 (en) 2002-08-23 2009-02-25 Ranbaxy Laboratories, Ltd. Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo¬3.1.0 hexane derivatives as muscarinic receptor antagonists
EP1618091A1 (en) 2003-04-09 2006-01-25 Ranbaxy Laboratories, Ltd. Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
US7592359B2 (en) 2003-04-10 2009-09-22 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
NZ542952A (en) 2003-04-11 2008-11-28 Ranbaxy Lab Ltd Azabicyclo derivatives as muscarinic receptor antagonists
WO2005026121A1 (en) * 2003-09-18 2005-03-24 Ranbaxy Laboratories Limited PROCESS FOR THE PREPARATION OF (1α, 5α, 6α)-6-AMINOMETHYL-3-BENZYL-3-AZABICYCLO[3.1.0]HEXANE
JP5097967B2 (ja) 2006-03-28 2012-12-12 タイゲン バイオテクノロジー カンパニー，リミテッド リンゴ酸塩類、及び（３ｓ，５ｓ）−７−［３−アミノ−５−メチルーピペリジニル］−１−シクロプロピル−１，４−ジヒドロ−８−メトキシ−４−オキソ−３−キノリンカルボン酸の多形体類
KR20110082635A (ko) 2006-03-28 2011-07-19 워너 칠콧 컴퍼니 엘엘씨 퀴놀론 중간체를 제조하기 위한 커플링 방법
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
EP2621902B1 (en) 2010-09-28 2017-04-12 Panacea Biotec Ltd 3-azabicyclo[3.1.0]hexane compounds useful for the treatment of cns disorders
WO2020073031A1 (en) * 2018-10-05 2020-04-09 New York University Fused bicyclic heterocycles as thereapeutic agents
CN112442084B (zh) * 2020-12-03 2022-09-09 国药集团致君（深圳）制药有限公司 一种抗菌药中间体的制备方法
CN113307768B (zh) * 2021-04-29 2023-12-12 中国农业科学院兰州畜牧与兽药研究所 喹诺酮类衍生物及其制备方法和用途

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JPH0676400B2 (ja) * 1987-08-25 1994-09-28 大日本製薬株式会社 新規ピリドンカルボン酸誘導体、そのエステルおよびその塩
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
US4973091A (en) * 1989-09-20 1990-11-27 Truth Incorporated Sliding patio door dual point latch and lock

Also Published As

Publication number Publication date
ZA906450B (en) 1992-03-25
FI103879B (sv) 1999-10-15
DE19875050I2 (de) 2009-05-28
RU2049777C1 (ru) 1995-12-10
FI108228B (sv) 2001-12-14
CN1025192C (zh) 1994-06-29
IE902950A1 (en) 1991-02-27
JPH0819099B2 (ja) 1996-02-28
FI103879B1 (sv) 1999-10-15
HU211681A9 (en) 1995-12-28
WO1991002526A1 (en) 1991-03-07
JPH072734B2 (ja) 1995-01-18
LU90310I2 (fr) 1999-01-25
CA2127561C (en) 1998-07-28
CA2127561A1 (en) 1991-02-17
KR910004572A (ko) 1991-03-28
DD298399A5 (de) 1992-02-20
JPH07149758A (ja) 1995-06-13
CA2023217A1 (en) 1991-02-17
HK1000207A1 (en) 1998-02-06
ES2074131T4 (es) 1996-05-01
NO920599D0 (no) 1992-02-14
CN1049501A (zh) 1991-02-27
IE66202B1 (en) 1995-12-13
CY99010I2 (en) 2010-07-28
PT94998B (pt) 1997-05-28
ES2074131T3 (es) 1995-09-01
NL980032I1 (nl) 1999-02-01
NZ234920A (en) 1992-06-25
FI964520A0 (sv) 1996-11-11
EP0413455A3 (en) 1991-10-09
GR3017072T3 (en) 1995-11-30
KR930004844B1 (ko) 1993-06-09
NO920599L (no) 1992-04-14
EG19251A (en) 1994-09-29
NL980032I2 (nl) 1999-05-03
PL166381B1 (pl) 1995-05-31
HU219403B (hu) 2001-04-28
LU90311I2 (fr) 1999-01-25
IL95331A (en) 1995-07-31
NL980033I2 (nl) 1999-05-03
EP0413455B1 (en) 1995-06-21
EP0413455A2 (en) 1991-02-20
AU623801B2 (en) 1992-05-21
JPH0386875A (ja) 1991-04-11
CZ402790A3 (en) 1996-04-17
BA98299A (bs) 2001-09-14
NO300214B1 (no) 1997-04-28
AU6104290A (en) 1991-02-21
CA2023217C (en) 1996-12-10
CZ281127B6 (cs) 1996-06-12
PL286484A1 (en) 1991-05-20
NL980033I1 (nl) 1999-02-01
IL95331A0 (en) 1991-06-30
CY1969A (en) 1997-09-05
DE19875052I2 (de) 2009-05-28
PT94998A (pt) 1991-04-18
ATE124040T1 (de) 1995-07-15
DE69020262D1 (de) 1995-07-27
DK0413455T3 (da) 1995-08-14
DE69020262T2 (de) 1995-10-26
FI920632A0 (fi) 1992-02-14

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