FI95201B - Förfarande för framställning av vätskeformiga farmaceutiska sammansättningar för dosering i näsan - Google Patents

Förfarande för framställning av vätskeformiga farmaceutiska sammansättningar för dosering i näsan Download PDF

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Publication number
FI95201B
FI95201B FI911722A FI911722A FI95201B FI 95201 B FI95201 B FI 95201B FI 911722 A FI911722 A FI 911722A FI 911722 A FI911722 A FI 911722A FI 95201 B FI95201 B FI 95201B
Authority
FI
Finland
Prior art keywords
calcitonin
pharmaceutical compositions
intranasal administration
compositions
process according
Prior art date
Application number
FI911722A
Other languages
English (en)
Finnish (fi)
Other versions
FI95201C (sv
FI911722A0 (sv
Inventor
Salvatore Mardente
Marilena Carazzone
Rodolfo Corneli
Original Assignee
Schiapparelli Salute Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26328146&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI95201(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from IT8822257A external-priority patent/IT1227174B/it
Priority claimed from IT8822548A external-priority patent/IT1227472B/it
Application filed by Schiapparelli Salute Spa filed Critical Schiapparelli Salute Spa
Publication of FI911722A0 publication Critical patent/FI911722A0/sv
Priority to FI920165A priority Critical patent/FI111339B/sv
Application granted granted Critical
Publication of FI95201B publication Critical patent/FI95201B/sv
Publication of FI95201C publication Critical patent/FI95201C/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1001—Piston pumps
    • B05B11/1016—Piston pumps the outlet valve having a valve seat located downstream a movable valve element controlled by a pressure actuated controlling element
    • B05B11/1018—Piston pumps the outlet valve having a valve seat located downstream a movable valve element controlled by a pressure actuated controlling element and the controlling element cooperating with means for opening or closing the inlet valve
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1042—Components or details
    • B05B11/1043—Sealing or attachment arrangements between pump and container
    • B05B11/1046—Sealing or attachment arrangements between pump and container the pump chamber being arranged substantially coaxially to the neck of the container
    • B05B11/1047—Sealing or attachment arrangements between pump and container the pump chamber being arranged substantially coaxially to the neck of the container the pump being preassembled as an independent unit before being mounted on the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/44—Valves specially adapted therefor; Regulating devices
    • B65D83/52—Valves specially adapted therefor; Regulating devices for metering
    • B65D83/54—Metering valves ; Metering valve assemblies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mechanical Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Claims (7)

1. Förfarande för framställning av vätskeformiga farmaceutiska sammansättningar for dosering i näsan, kännetecknat därav, att en terapeutiskt effektiv mängd av 5 calcitonin upplöstes i en natriumkloridlösning i rengjort vatten vars pH justerats tili 3,5-4,5.
2. Förfarande enligt patentkrav 1, kännetecknat därav, att calcitonin upplöses i en sädan mängd att en koncentration pä 100 tili 5000 I.U. per ml sammansättning 10 uppnäs.
3. Förfarande enligt patentkrav 1, kännetecknat därav, att calcitonin upplöses i en sädan mängd att en koncentration pä 250 tili 2000 I.U. per ml sammansättning uppnäs. 15
4. Förfarande enligt patentkraven 1-3, kännetecknat därav, att pH justeras till 3,5-4,5 genom tillsättning av saltsyra.
5. Förfarande enligt patentkraven 1-4, kännetecknat därav, att calcitoninet 20 som tillsätts är calcitonin (salcatonin) frän lax.
6. Förfarande enligt nägot av patentkraven 1-5, kännetecknat därav, att följande sammansättning framställs
25 Salcatonin U.I. 500 natriumklorid mg 9 IN klorvätesyra, tills pH 4,0 rengjort vatten, tills ml 1,0 30 95201
7. Förfarande enligt nägot av patentkraven 1-5, kännetecknat därav, att följande sammansättning framställs Salcatonin U.I. 1000 5 natriumklorid mg 9 IN klorvätesyra, tills pH 4,0 rengjort vatten, tills ml 1,0
FI911722A 1988-10-11 1991-04-10 Förfarande för framställning av vätskeformiga farmaceutiska sammansättningar för dosering i näsan FI95201C (sv)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI920165A FI111339B (sv) 1988-10-11 1992-01-14 Förfarande för framställning av en sprutningsenhet för administrering av calcitonin genom sprutning

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IT2225788 1988-10-11
IT8822257A IT1227174B (it) 1988-10-11 1988-10-11 Composizioni farmaceutiche a base di calcitonina, somministrabili per via intranasale.
IT8822548A IT1227472B (it) 1988-11-08 1988-11-08 Confezione spray per la somministrazione intranasale di calcitonina.
IT2254888 1988-11-08
PCT/EP1989/001186 WO1990003796A1 (en) 1988-10-11 1989-10-09 Pharmaceutical compositions comprising calcitonin for intranasal administration and a spray unit for the administration of the same
EP8901186 1989-10-09

Publications (3)

Publication Number Publication Date
FI911722A0 FI911722A0 (sv) 1991-04-10
FI95201B true FI95201B (sv) 1995-09-29
FI95201C FI95201C (sv) 1996-01-10

Family

ID=26328146

Family Applications (1)

Application Number Title Priority Date Filing Date
FI911722A FI95201C (sv) 1988-10-11 1991-04-10 Förfarande för framställning av vätskeformiga farmaceutiska sammansättningar för dosering i näsan

Country Status (19)

Country Link
EP (2) EP0363876B1 (sv)
JP (2) JPH0649658B2 (sv)
KR (1) KR0152065B1 (sv)
AU (1) AU632520B2 (sv)
BR (1) BR8907708A (sv)
CA (1) CA2000336C (sv)
DE (1) DE68912341T2 (sv)
DK (1) DK64291D0 (sv)
ES (1) ES2053905T3 (sv)
FI (1) FI95201C (sv)
GR (1) GR3007420T3 (sv)
HU (1) HU212495B (sv)
IE (1) IE62327B1 (sv)
IL (2) IL91856A0 (sv)
NO (1) NO301522B1 (sv)
NZ (1) NZ230965A (sv)
RO (1) RO113301B1 (sv)
RU (1) RU2097064C1 (sv)
WO (1) WO1990003796A1 (sv)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5026825A (en) * 1988-09-08 1991-06-25 Rhone-Poulenc Rorer Pharmaceuticals Inc. Intranasal calcitonin formulations
ES2067624T3 (es) * 1989-11-16 1995-04-01 Ph & T S R L Un procedimiento de preparacion de una composicion farmaceutica liquida para administracion nasal.
IT1242019B (it) * 1990-11-20 1994-02-02 Ripari Gero Ist Farm Biolog Composizioni farmaceutiche acquose a base di calcitonina, da somministrarsi per via nasale.
IT1282374B1 (it) * 1996-01-31 1998-03-20 Therapicon Srl Composizioni farmaceutiche parenterali a base di calcitonine sintetiche a ph controllato con basso indice di dolorosita'
DE19731472C2 (de) * 1997-07-22 2000-05-25 Gerhard Zellner Nasenspray-Flüssigkeit
IT1294191B1 (it) * 1997-09-05 1999-03-22 Alfa Wassermann Spa Composizioni farmaceutiche contenenti calcitonina in un dosatore spray per somministrazione intranasale.
SE9901658D0 (sv) * 1999-05-06 1999-05-06 Astra Ab New formulation
US6644305B2 (en) 2000-04-14 2003-11-11 Trudell Medical International Nasal inhaler
AU2002333785A1 (en) * 2002-09-03 2004-03-29 Pharmacure Health Care Ab Nasal sprays
US9050433B2 (en) * 2007-11-29 2015-06-09 Glaxo Group Limited Dispensing device
GB2464282A (en) * 2008-10-08 2010-04-14 Archimedes Dev Ltd A device for administering a dose of opioid analgesic
US9731869B2 (en) 2011-02-04 2017-08-15 Archimedes Development Limited Container
DE102011082420B4 (de) * 2011-09-09 2021-02-04 Aptar Radolfzell Gmbh Flüssigkeitsspender und Austragskopf für einen Flüssigkeitsspender

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA758010B (en) * 1975-11-14 1977-08-31 Syntex Inc Nasal spray adapter
CY1490A (en) * 1982-02-01 1990-02-16 Sandoz Ltd Improvements in or relating to nasal pharmaceutical compositions
JPS5989619A (ja) * 1982-10-05 1984-05-23 サンド・アクチエンゲゼルシヤフト カルシトニン組成物およびその用途
FR2561565B1 (fr) * 1984-03-23 1986-08-01 Norlac Plastiques Sa Couteau electrique destine notamment a l'ouverture des huitres
GB8407907D0 (en) * 1984-03-27 1984-05-02 Sandoz Ltd Organic compounds
JPS61118325A (ja) * 1984-11-12 1986-06-05 Yamanouchi Pharmaceut Co Ltd 塩基性および／または中性アミノ酸を含有するカルシトニン経鼻剤
JPS61126034A (ja) * 1984-11-26 1986-06-13 Yamanouchi Pharmaceut Co Ltd アルド−スを含有するカルシトニン経鼻剤
JPS61194034A (ja) * 1985-02-25 1986-08-28 Teijin Ltd 経鼻投与用粉末状組成物
JPS6310735A (ja) * 1986-07-02 1988-01-18 Yamanouchi Pharmaceut Co Ltd カルシトニン経鼻剤
JPS6339822A (ja) * 1986-08-04 1988-02-20 Yamanouchi Pharmaceut Co Ltd カルシトニン経鼻剤

Also Published As

Publication number Publication date
DK64291A (da) 1991-04-10
HUT63577A (en) 1993-09-28
IE893259L (en) 1990-04-11
ES2053905T3 (es) 1994-08-01
NZ230965A (en) 1992-04-28
FI95201C (sv) 1996-01-10
IL91931A0 (en) 1990-06-10
CA2000336C (en) 2000-10-03
JPH0649658B2 (ja) 1994-06-29
JPH03505213A (ja) 1991-11-14
GR3007420T3 (sv) 1993-07-30
EP0438531B1 (en) 1994-01-12
IE62327B1 (en) 1995-01-25
RU2097064C1 (ru) 1997-11-27
NO911395L (no) 1991-04-10
RO113301B1 (ro) 1998-06-30
IL91931A (en) 1995-03-15
KR0152065B1 (ko) 1998-10-15
NO301522B1 (no) 1997-11-10
FI911722A0 (sv) 1991-04-10
AU632520B2 (en) 1993-01-07
DE68912341T2 (de) 1994-05-05
DK64291D0 (da) 1991-04-10
JPH0796034A (ja) 1995-04-11
NO911395D0 (no) 1991-04-10
EP0438531A1 (en) 1991-07-31
KR900701306A (ko) 1990-12-01
AU4622589A (en) 1990-05-01
CA2000336A1 (en) 1990-04-11
BR8907708A (pt) 1991-07-30
DE68912341D1 (de) 1994-02-24
HU896876D0 (en) 1991-07-29
HU212495B (en) 1996-07-29
EP0363876B1 (en) 1992-12-23
WO1990003796A1 (en) 1990-04-19
EP0363876A1 (en) 1990-04-18
IL91856A0 (en) 1990-06-10

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BB Publication of examined application
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Owner name: ALFA WASSERMAN S.P.A.

MA Patent expired