FI942793A0 - Fuusioituneen bisyklisen renkaan sisältäviä yhdisteitä ja menetelmiä niiden valmistamiseksi - Google Patents
Fuusioituneen bisyklisen renkaan sisältäviä yhdisteitä ja menetelmiä niiden valmistamiseksiInfo
- Publication number
- FI942793A0 FI942793A0 FI942793A FI942793A FI942793A0 FI 942793 A0 FI942793 A0 FI 942793A0 FI 942793 A FI942793 A FI 942793A FI 942793 A FI942793 A FI 942793A FI 942793 A0 FI942793 A0 FI 942793A0
- Authority
- FI
- Finland
- Prior art keywords
- preparation
- methods
- compounds containing
- bicyclic ring
- fused bicyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C07C327/34—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups with amino groups bound to the same hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- Peptides Or Proteins (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Reduction Or Emphasis Of Bandwidth Of Signals (AREA)
- Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
- Dram (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7797893A | 1993-06-15 | 1993-06-15 | |
US7797893 | 1993-06-15 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI942793A0 true FI942793A0 (fi) | 1994-06-13 |
FI942793A FI942793A (fi) | 1994-12-16 |
FI106464B FI106464B (fi) | 2001-02-15 |
Family
ID=22141128
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI942793A FI106464B (fi) | 1993-06-15 | 1994-06-13 | Menetelmä uusien terapeuttisesti käyttökelpoisten pyridotiatsepiini-, pyrido-oksatsepiini-, pyridotiatsiini-, pyrrolo-oksatsepiini- ja pyrrolotiatsepiinijohdannaisten valmistamiseksi |
FI20000815A FI111950B (fi) | 1993-06-15 | 2000-04-06 | 5-okso-7H-pyrido[2,1-b][1,3]tiatsepiini-, 4-okso-2H,6H-pyrido[2,1-b][1,3]tiatsiini- ja 5-oksopyrrolo[2,1-b][1,3]tiatsepiinijohdannaisia |
FI20000814A FI111947B (fi) | 1993-06-15 | 2000-04-06 | Menetelmä uusien terapeuttisesti käyttökelpoisten 5-okso-[1,4]oksatsino[3,4-b][1,3]oksatsepiini- ja -tiatsepiini-7-karboksyylihappojohdannaisten valmistamiseksi |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI20000815A FI111950B (fi) | 1993-06-15 | 2000-04-06 | 5-okso-7H-pyrido[2,1-b][1,3]tiatsepiini-, 4-okso-2H,6H-pyrido[2,1-b][1,3]tiatsiini- ja 5-oksopyrrolo[2,1-b][1,3]tiatsepiinijohdannaisia |
FI20000814A FI111947B (fi) | 1993-06-15 | 2000-04-06 | Menetelmä uusien terapeuttisesti käyttökelpoisten 5-okso-[1,4]oksatsino[3,4-b][1,3]oksatsepiini- ja -tiatsepiini-7-karboksyylihappojohdannaisten valmistamiseksi |
Country Status (38)
Country | Link |
---|---|
US (5) | US5508272A (fi) |
EP (1) | EP0629627B1 (fi) |
JP (1) | JP3569550B2 (fi) |
KR (1) | KR100395604B1 (fi) |
CN (1) | CN1046525C (fi) |
AT (1) | ATE266032T1 (fi) |
AU (1) | AU672899B2 (fi) |
BG (1) | BG62139B1 (fi) |
BR (1) | BR1100970A (fi) |
CA (1) | CA2124375C (fi) |
CY (1) | CY2492B1 (fi) |
CZ (1) | CZ289488B6 (fi) |
DE (1) | DE69433752T2 (fi) |
DK (1) | DK0629627T3 (fi) |
EE (1) | EE03178B1 (fi) |
EG (1) | EG20537A (fi) |
ES (1) | ES2219644T3 (fi) |
FI (3) | FI106464B (fi) |
GE (1) | GEP19981301B (fi) |
HK (1) | HK1001814A1 (fi) |
HU (1) | HU216791B (fi) |
IL (2) | IL109924A (fi) |
LT (1) | LT3626B (fi) |
LV (1) | LV10622B (fi) |
MY (1) | MY123673A (fi) |
NO (1) | NO306405B1 (fi) |
NZ (1) | NZ260736A (fi) |
PH (1) | PH30830A (fi) |
PL (1) | PL178469B1 (fi) |
PT (1) | PT629627E (fi) |
RO (1) | RO112870B1 (fi) |
RU (1) | RU2125056C1 (fi) |
SG (1) | SG46510A1 (fi) |
SK (1) | SK282529B6 (fi) |
TW (1) | TW329423B (fi) |
UA (1) | UA39924C2 (fi) |
UY (1) | UY23787A1 (fi) |
ZA (1) | ZA944163B (fi) |
Families Citing this family (120)
Publication number | Priority date | Publication date | Assignee | Title |
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US5552397A (en) * | 1992-05-18 | 1996-09-03 | E. R. Squibb & Sons, Inc. | Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase |
US5504080A (en) * | 1992-10-28 | 1996-04-02 | Bristol-Myers Squibb Co. | Benzo-fused lactams |
US5654294A (en) * | 1993-05-13 | 1997-08-05 | Bristol-Myers Squibb | Spiro lactam dual action inhibitors |
CN1110865A (zh) * | 1993-06-11 | 1995-10-25 | 卫材株式会社 | 氨基酸衍生物 |
US5508272A (en) * | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
US5525723A (en) * | 1993-11-18 | 1996-06-11 | Bristol-Myers Squibb Co. | Compounds containing a fused multiple ring lactam |
US5587375A (en) * | 1995-02-17 | 1996-12-24 | Bristol-Myers Squibb Company | Azepinone compounds useful in the inhibition of ACE and NEP |
US5877313A (en) | 1995-05-17 | 1999-03-02 | Bristol-Myers Squibb | Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP |
US5635504A (en) * | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
US5650408A (en) * | 1995-06-07 | 1997-07-22 | Karanewsky; Donald S. | Thiazolo benzazepine containing dual action inhibitors |
US6777550B1 (en) | 1996-04-12 | 2004-08-17 | Bristol-Myers Squibb Company | N-formyl hydroxylamine containing compounds useful as ACE inhibitors and/or NEP inhibitors |
AU748824B2 (en) | 1997-03-14 | 2002-06-13 | Basf Aktiengesellschaft | Cycloalkylalkanecarboxamides and the production and use thereof |
US6133002A (en) | 1997-09-25 | 2000-10-17 | Dsm N.V. | Process for preparing optically active 2-amino-ω-oxoalkanoic acid derivatives |
US6340752B1 (en) | 1998-01-06 | 2002-01-22 | Bristol-Myers Squibb Co. | Deprotection and recrystallization processes |
IT1298268B1 (it) * | 1998-02-18 | 1999-12-20 | Zambon Spa | Procedimento per la preparazione dell'acido (s)-2-bromo-3-fenil- propionico |
IT1298267B1 (it) * | 1998-02-18 | 1999-12-20 | Zambon Spa | Procedimento per la preparazione dell'acido (s)-2-acetiltio-3-fenil- propionico e dei suoi sali |
WO1999065500A1 (en) | 1998-06-17 | 1999-12-23 | Bristol-Myers Squibb Company | Preventing cerebral infarction through administration of adp-receptor antiplatelet and antihypertensive drugs in combination |
DE69939190D1 (de) * | 1998-06-18 | 2008-09-04 | Hoffmann La Roche | Verfahren für Arylalkylsulfid |
US6174711B1 (en) | 1998-07-05 | 2001-01-16 | Mitsubishi Gas Chemical Company | Method for producing L-allysine acetal |
US6162913A (en) * | 1998-07-15 | 2000-12-19 | Bristol-Myers Squibb Co. | Preparation of [4S-(4α,7α,10aβ)]-4-amino-octahydro-5-oxo-7H-pyrido[2,1 -b] [1,3]thiazepine-7-carboxylic acid, methyl ester and salts thereof via novel disulfides |
EP1097236A4 (en) * | 1998-07-15 | 2006-10-04 | Bristol Myers Squibb Co | STEREOSELECTIVE REDUCING AMINATION OF KETONES |
US6468781B1 (en) | 1999-07-08 | 2002-10-22 | Bristol-Myers Squibb Company | Stereoselective reductive amination of ketones |
KR20010071895A (ko) * | 1998-07-15 | 2001-07-31 | 스티븐 비. 데이비스 | 신규 디옥솔란을 통한 (s)-2-아미노-6,6-디메톡시헥산산메틸 에스테르의 제조 방법 |
CA2342792A1 (en) | 1998-09-03 | 2000-03-16 | Bristol-Myers Squibb Company | Enzymatic oxidative deamination process |
ES2237970T3 (es) | 1998-11-11 | 2005-08-01 | Novartis Ag | Produccion de 2-amino-2-(2-(4-alquil c2-20-fenil)etil)propano-1,3-dioles. |
RU2245147C2 (ru) * | 1999-03-29 | 2005-01-27 | Бристол-Маерс Сквибб Компани | Применение ингибитора вазопептидазы для лечения стенокардии |
SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
DE60022525T2 (de) * | 1999-08-30 | 2006-06-14 | Sanofi Aventis Deutschland | Ramipril zur vorbeugung von kardiovaskulären vorfällen |
US6300503B1 (en) | 1999-12-17 | 2001-10-09 | Dixie Chemical Company | Hydantoin intermediates for the synthesis of omapatrilat and methods for producing and using the same |
NL1014353C2 (nl) * | 2000-02-11 | 2001-08-15 | Dsm Nv | Werkwijze voor de bereiding van (R) -2-broom-3-fenylpropaanzuur. |
NL1014354C2 (nl) * | 2000-02-11 | 2001-08-14 | Dsm Nv | Werkwijze voor de bereiding van (S) -2-acethylthio-3-fenylpropaanzuur. |
US6509330B2 (en) | 2000-02-17 | 2003-01-21 | Bristol-Myers Squibb Company | Hydroxamic acid containing compounds useful as ACE inhibitors and/or NEP inhibotors |
ATE275129T1 (de) | 2000-03-30 | 2004-09-15 | Ajinomoto Kk | Verfahren zur herstellung von aromatischen acylthiocarbonsäurederivaten |
US6620600B2 (en) * | 2000-09-15 | 2003-09-16 | Bristol-Myers Squibb Co. | Enzymatic resolution of aryl and thio-substituted acids |
US7388098B2 (en) | 2000-09-29 | 2008-06-17 | Bristol-Myers Squibb Company | Dynamic resolution of isomers and resolved isomers |
US8168616B1 (en) | 2000-11-17 | 2012-05-01 | Novartis Ag | Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension |
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US6828119B2 (en) * | 2001-01-04 | 2004-12-07 | Bristol Myers Squibb Company | Enzymatic deprotection of amines and hydroxides |
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ATE409466T1 (de) * | 2002-01-11 | 2008-10-15 | Novo Nordisk As | Verfahren und zusammensetzung zur behandlung von diabetes, hypertonie, chronischer herzinsuffizienz und mit flüssigkeitsretention einhergehenden zuständen |
EP1383042B1 (en) * | 2002-07-19 | 2007-03-28 | STMicroelectronics S.r.l. | A multiphase synchronous pipeline structure |
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US7459474B2 (en) | 2003-06-11 | 2008-12-02 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor and method |
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US7420059B2 (en) | 2003-11-20 | 2008-09-02 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
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TW200838501A (en) * | 2007-02-02 | 2008-10-01 | Theravance Inc | Dual-acting antihypertensive agents |
TWI448284B (zh) | 2007-04-24 | 2014-08-11 | Theravance Inc | 雙效抗高血壓劑 |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
EA020466B1 (ru) | 2007-06-04 | 2014-11-28 | Синерджи Фармасьютикалз Инк. | Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний |
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