FI915779A - 3'-(2')-amino- eller tiolmodifierade nukleosider, nukleotider och oligonukleotider, till vilka kopplats ett fluorescerande faergaemne, foerfarande foer framstaellning av dessa samt anvaendning av dessa. - Google Patents

3'-(2')-amino- eller tiolmodifierade nukleosider, nukleotider och oligonukleotider, till vilka kopplats ett fluorescerande faergaemne, foerfarande foer framstaellning av dessa samt anvaendning av dessa. Download PDF

Info

Publication number
FI915779A
FI915779A FI915779A FI915779A FI915779A FI 915779 A FI915779 A FI 915779A FI 915779 A FI915779 A FI 915779A FI 915779 A FI915779 A FI 915779A FI 915779 A FI915779 A FI 915779A
Authority
FI
Finland
Prior art keywords
amino
thiolmodifierade
oligonucleotider
nucleotider
nucleosider
Prior art date
Application number
FI915779A
Other languages
English (en)
Finnish (fi)
Other versions
FI915779A0 (fi
Inventor
Joachim Engels
Mathias Herrlein
Renate Konrad
Matthias Mag
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI915779A0 publication Critical patent/FI915779A0/fi
Publication of FI915779A publication Critical patent/FI915779A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI915779A 1990-12-11 1991-12-09 3'-(2')-amino- eller tiolmodifierade nukleosider, nukleotider och oligonukleotider, till vilka kopplats ett fluorescerande faergaemne, foerfarande foer framstaellning av dessa samt anvaendning av dessa. FI915779A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4039488 1990-12-11

Publications (2)

Publication Number Publication Date
FI915779A0 FI915779A0 (fi) 1991-12-09
FI915779A true FI915779A (fi) 1992-06-12

Family

ID=6420050

Family Applications (1)

Application Number Title Priority Date Filing Date
FI915779A FI915779A (fi) 1990-12-11 1991-12-09 3'-(2')-amino- eller tiolmodifierade nukleosider, nukleotider och oligonukleotider, till vilka kopplats ett fluorescerande faergaemne, foerfarande foer framstaellning av dessa samt anvaendning av dessa.

Country Status (27)

Country Link
US (3) US5679785A (ko)
EP (1) EP0490281B1 (ko)
JP (1) JP3140127B2 (ko)
KR (1) KR920012107A (ko)
AT (1) ATE142222T1 (ko)
AU (1) AU643856B2 (ko)
BG (1) BG61484B1 (ko)
BR (1) BR9105335A (ko)
CA (1) CA2057475A1 (ko)
CS (1) CS374391A3 (ko)
DE (1) DE59108143D1 (ko)
DK (1) DK0490281T3 (ko)
ES (1) ES2093671T3 (ko)
FI (1) FI915779A (ko)
GR (1) GR3021041T3 (ko)
HU (1) HUT60505A (ko)
IE (1) IE75726B1 (ko)
IL (1) IL100298A (ko)
MX (1) MX9102468A (ko)
NO (1) NO914859L (ko)
NZ (1) NZ240900A (ko)
PL (1) PL168874B1 (ko)
PT (1) PT99747A (ko)
RO (1) RO111575B1 (ko)
RU (1) RU2073682C1 (ko)
TR (1) TR27715A (ko)
YU (1) YU187991A (ko)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476925A (en) * 1993-02-01 1995-12-19 Northwestern University Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups
HUT76094A (en) * 1994-03-18 1997-06-30 Lynx Therapeutics Oligonucleotide n3'-p5' phosphoramidates: synthesis and compounds; hybridization and nuclease resistance properties
US5599922A (en) 1994-03-18 1997-02-04 Lynx Therapeutics, Inc. Oligonucleotide N3'-P5' phosphoramidates: hybridization and nuclease resistance properties
US5726297A (en) * 1994-03-18 1998-03-10 Lynx Therapeutics, Inc. Oligodeoxyribonucleotide N3' P5' phosphoramidates
DE4418691A1 (de) * 1994-05-28 1996-02-22 Boehringer Mannheim Gmbh 3'-(4'-) nicht-radioaktiv markierte Nukleoside und Nukleotide mit Aminocarbonsäure-, Peptid- oder Carbonsäure-Spacer
US5962271A (en) * 1996-01-03 1999-10-05 Cloutech Laboratories, Inc. Methods and compositions for generating full-length cDNA having arbitrary nucleotide sequence at the 3'-end
US5684143A (en) * 1996-02-21 1997-11-04 Lynx Therapeutics, Inc. Oligo-2'-fluoronucleotide N3'->P5' phosphoramidates
US5859233A (en) * 1996-02-21 1999-01-12 Lynx Therapeutics, Inc. Synthons for synthesis of oligonucleotide N3-P5 phosphoramidates
US6017702A (en) * 1996-12-05 2000-01-25 The Perkin-Elmer Corporation Chain-termination type nucleic acid sequencing method including 2'-deoxyuridine-5'-triphosphate
DE19741084A1 (de) * 1997-09-18 1999-03-25 Knoell Hans Forschung Ev Hochaffine Nukleinsäuremoleküle mit funktionellen Gruppen zur spezifischen Erkennung von Zielmolekülen, ihre Herstellung und Verwendung
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
US6184347B1 (en) 1998-11-19 2001-02-06 Agilent Technologies Inc. Minimization of blooming in high-density arrays by using reactive wash reagents
US6761877B2 (en) * 2000-02-18 2004-07-13 Biocrystal, Ltd. Functionalized encapsulated fluorescent nanocrystals
WO2002026891A1 (en) 2000-09-29 2002-04-04 Molecular Probes, Inc. Modified carbocyanine dyes and their conjugates
US7563618B2 (en) * 2001-03-23 2009-07-21 Geron Corporation Oligonucleotide conjugates
KR100762261B1 (ko) * 2001-04-27 2007-10-04 (주)바이오니아 전장 상보 디옥시리보핵산 제조 방법과 이에 사용되는앵커와 프라이머
US7214428B2 (en) * 2001-09-17 2007-05-08 Invitrogen Corporation Highly luminescent functionalized semiconductor nanocrystals for biological and physical applications
US7205048B2 (en) * 2001-09-17 2007-04-17 Invitrogen Corporation Functionalized fluorescent nanocrystal compositions and methods of making
AU2002365124A1 (en) 2001-09-17 2003-07-09 Biocrystal, Ltd. Nanocrystals
AU2003297859A1 (en) * 2002-12-13 2004-07-09 The Trustees Of Columbia University In The City Of New York Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
JP4177123B2 (ja) * 2003-01-10 2008-11-05 富士通株式会社 配線図形検証方法、プログラム及び装置
ES2524048T3 (es) 2003-03-31 2014-12-03 F. Hoffmann-La Roche Ag Composiciones y métodos para la detección de ciertos flavivirus, incluidos los miembros del serogrupo del virus de la encefalitis japonesa
US20050131224A1 (en) * 2003-12-15 2005-06-16 Cti Pet Systems, Inc. Method for preparing radiolabeled thymidine
US7160537B2 (en) * 2003-12-15 2007-01-09 Siemens Medical Solutions Usa, Inc. Method for preparing radiolabeled thymidine having low chromophoric byproducts
US7939251B2 (en) 2004-05-06 2011-05-10 Roche Molecular Systems, Inc. SENP1 as a marker for cancer
US20060172133A1 (en) * 2004-08-17 2006-08-03 Imad Naasani Synthesis of highly luminescent colloidal particles
ATE556126T1 (de) 2004-10-29 2012-05-15 Life Technologies Corp Funktionalisierte fluoreszierende nanokristalle und verfahren zu deren herstellung und verwendung
EP1809765A2 (en) * 2004-11-04 2007-07-25 Roche Diagnostics GmbH Classification of acute myeloid leukemia
US7541144B2 (en) * 2005-01-31 2009-06-02 Agilent Technologies, Inc. RNA labeling method
US20080003571A1 (en) 2005-02-01 2008-01-03 Mckernan Kevin Reagents, methods, and libraries for bead-based sequencing
US7544471B2 (en) * 2005-07-30 2009-06-09 Agilent Technologies, Inc. Preparing RNA from a wax-embedded tissue specimen
US7700289B2 (en) * 2006-04-03 2010-04-20 Agilent Technologies, Inc. Method for labeling RNA
EP2007907A2 (en) * 2006-04-19 2008-12-31 Applera Corporation Reagents, methods, and libraries for gel-free bead-based sequencing
US7572585B2 (en) * 2006-07-31 2009-08-11 Agilent Technologies, Inc. Enzymatic labeling of RNA
MX2009005936A (es) * 2006-12-05 2010-01-15 Lasergen Inc Nucleotidos y nucleosidos marcados de foto-escision y nucleotidos y nucleosidos marcados y metodos para su uso en secunciacion de adn.
EP2185726B1 (en) 2007-08-06 2014-01-08 Orion Genomics, LLC Novel single nucleotide polymorphisms and combinations of novel and known polymorphisms for determining the allele-specific expression of the igf2 gene
JP2009077712A (ja) 2007-09-11 2009-04-16 F Hoffmann La Roche Ag Ｂ−Ｒａｆキナーゼ阻害剤に対する感受性についての診断試験
JP2010539982A (ja) * 2007-10-01 2010-12-24 アプライド バイオシステムズ， エルエルシー チェイスライゲーション配列決定法
US20100086914A1 (en) * 2008-10-03 2010-04-08 Roche Molecular Systems, Inc. High resolution, high throughput hla genotyping by clonal sequencing
JP5748672B2 (ja) 2009-02-11 2015-07-15 オリオン ゲノミクス エルエルシー Ｉｇｆ２の対立遺伝子特異的な発現を判定するための多型の組み合わせ
US8431416B2 (en) 2009-04-01 2013-04-30 Becton, Dickinson And Company Reactive heterocycle-substituted 7-hydroxycoumarins and their conjugates
US8309059B2 (en) * 2009-08-31 2012-11-13 Promega Corporation Reactive cyanine compounds
WO2011128096A1 (en) 2010-04-16 2011-10-20 Roche Diagnostics Gmbh Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
ES2647612T3 (es) 2010-06-04 2017-12-22 Chronix Biomedical Biomarcadores de ácidos nucleicos en circulación asociados al cáncer de próstata
US8623324B2 (en) 2010-07-21 2014-01-07 Aat Bioquest Inc. Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates
CA2852098C (en) 2011-10-21 2023-05-02 Chronix Biomedical Colorectal cancer associated circulating nucleic acid biomarkers
ES2413566B1 (es) 2011-12-14 2014-05-20 Fundación Pública Andaluza Progreso Y Salud Método de obtención de datos útiles para el diagnóstico y pronóstico de la hipoacusia neurosensorial.
CN104619894B (zh) 2012-06-18 2017-06-06 纽亘技术公司 用于非期望核酸序列的阴性选择的组合物和方法
PL2931922T3 (pl) 2012-12-14 2019-04-30 Chronix Biomedical Personalizowane biomarkery nowotworu
HUE041935T2 (hu) 2013-05-29 2019-06-28 Chronix Biomedical Donor sejtmentes DNS-ének detektálása és kvantifikálása a szervtranszplantátumot kapott recipiensek véráramában
ES2791328T3 (es) 2014-10-01 2020-11-03 Chronix Biomedical Métodos de cuantificación de ADN acelular
WO2017172608A1 (en) 2016-03-28 2017-10-05 Aat Bioquest, Inc. Polyfluoreno[4,5-cde]oxepine conjugates and their use in methods of analyte detection
US11220628B2 (en) 2019-02-20 2022-01-11 Aat Bioquest, Inc. Condensed polycyclic conjugated polymers and their use for biological detection
CN115280147A (zh) 2020-01-30 2022-11-01 阿特生物探索公司 可紫外激发的基于聚芴的缀合物及其在分析物检测方法中的用途
WO2023147355A2 (en) * 2022-01-25 2023-08-03 Oregon Health & Science University Methods and systems for increasing capture potential of a spatial array

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015733A (en) * 1983-12-20 1991-05-14 California Institute Of Technology Nucleosides possessing blocked aliphatic amino groups
US4849513A (en) * 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
EP0267996A1 (en) * 1986-11-20 1988-05-25 Tamir Biotechnology Ltd. New nucleotide derivatives
GB2236852B (en) * 1989-09-25 1994-04-06 Scotgen Ltd DNA probe based assays and intermediates useful in the synthesis of cleavable nucleic acids for use in such assays
US5227487A (en) * 1990-04-16 1993-07-13 Molecular Probes, Inc. Certain tricyclic and pentacyclic-hetero nitrogen rhodol dyes
US5541307A (en) * 1990-07-27 1996-07-30 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs and solid phase synthesis thereof

Also Published As

Publication number Publication date
TR27715A (tr) 1995-06-22
ES2093671T3 (es) 1997-01-01
RO111575B1 (ro) 1996-11-29
YU187991A (sh) 1994-09-09
PL168874B1 (pl) 1996-04-30
DK0490281T3 (ko) 1997-02-10
EP0490281A1 (de) 1992-06-17
PL292701A1 (en) 1992-09-21
NO914859L (no) 1992-06-12
GR3021041T3 (en) 1996-12-31
FI915779A0 (fi) 1991-12-09
BR9105335A (pt) 1992-08-25
IE914301A1 (en) 1992-06-17
HUT60505A (en) 1992-09-28
JP3140127B2 (ja) 2001-03-05
BG61484B1 (bg) 1997-09-30
RU2073682C1 (ru) 1997-02-20
ATE142222T1 (de) 1996-09-15
JPH04290896A (ja) 1992-10-15
IE75726B1 (en) 1997-09-24
KR920012107A (ko) 1992-07-25
NO914859D0 (no) 1991-12-10
US5668269A (en) 1997-09-16
US5659025A (en) 1997-08-19
US5679785A (en) 1997-10-21
MX9102468A (es) 1992-06-01
DE59108143D1 (de) 1996-10-10
EP0490281B1 (de) 1996-09-04
HU913885D0 (en) 1992-02-28
BG95575A (bg) 1993-12-24
PT99747A (pt) 1992-11-30
IL100298A (en) 1997-03-18
AU8892791A (en) 1992-06-18
IL100298A0 (en) 1992-09-06
AU643856B2 (en) 1993-11-25
NZ240900A (en) 1994-07-26
CS374391A3 (en) 1992-06-17
CA2057475A1 (en) 1992-06-12

Similar Documents

Publication Publication Date Title
FI915779A0 (fi) 3'-(2')-amino- eller tiolmodifierade nukleosider, nukleotider och oligonukleotider, till vilka kopplats ett fluorescerande faergaemne, foerfarande foer framstaellning av dessa samt anvaendning av dessa.
US6087095A (en) DNA sequencing method
US7973146B2 (en) Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing
AU687801B2 (en) DNA sequencing by mass spectrometry via exonuclease degradation
AU6180190A (en) Fast process for detecting and/or identifying a single base on a nucleic acid sequence and its applications
CN106604926A (zh) 修饰的核苷酸连接基
DE69627698D1 (de) Eine in kaskaden verlaufende vervielfältigungsreaktion von nukleinsäuren
JP2000513587A (ja) 不連続プライマー伸長による核酸の反復配列長の決定
ES2147180T3 (es) Procedimiento para la deteccion de acidos nucleicos semejantes.
CA2186340A1 (en) A dna meltometer and methods of use thereof
CN113748216B (zh) 一种基于自发光的单通道测序方法
CA2243637A1 (en) Nucleoside analogues
BR0000323A (pt) Processo para produzir um purina nucleotìdeo, dna, e, microorganismo
CA3118607A1 (en) Method for sequencing polynucleotides
JP2008048705A (ja) 塩基配列の分析方法及び塩基配列分析用プライマー
WO2000068422A3 (en) High density labeling of dna with modified or 'chromophore' carrying nucleotides and dna polymerases used
PT98963A (pt) Processo para a preparacao de compostos intermediarios para a sintese quimica de oligonucleotidos e para a preparacao de derivados de nucleosidos, de nucleotidos e de oligonucleotidos, utilizado esses intermediarios
JPS6491058A (en) Labeling method for non-radioactive nucleic acid and detection method using the same
Loechler Molecular modeling studies of O2-alkylthymines and O4-alkylthymines in DNA: Structures that may be pertinent to the incorporation of the corresponding dAlkTTP into DNA by DNA polymerases in vitro
FR2644163B2 (fr) Procede de marquage d'une sonde nucleique et trousse de reactifs pour la mise en oeuvre de ce procede