FI890652A - Förfarande för framställning av terapeutiskt aktiva substituerade indolylpyrrolderivat - Google Patents

Förfarande för framställning av terapeutiskt aktiva substituerade indolylpyrrolderivat Download PDF

Info

Publication number
FI890652A
FI890652A FI890652A FI890652A FI890652A FI 890652 A FI890652 A FI 890652A FI 890652 A FI890652 A FI 890652A FI 890652 A FI890652 A FI 890652A FI 890652 A FI890652 A FI 890652A
Authority
FI
Finland
Prior art keywords
indolylpyrrole
derivatives
preparation
therapeutically active
active substituted
Prior art date
Application number
FI890652A
Other languages
English (en)
Finnish (fi)
Other versions
FI96861C (sv
FI890652A0 (sv
FI96861B (sv
Inventor
Peter David Davis
Christopher Huw Hill
Geoffrey Lawton
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888803048A external-priority patent/GB8803048D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI890652A0 publication Critical patent/FI890652A0/sv
Publication of FI890652A publication Critical patent/FI890652A/sv
Application granted granted Critical
Publication of FI96861B publication Critical patent/FI96861B/sv
Publication of FI96861C publication Critical patent/FI96861C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrrole Compounds (AREA)
FI890652A 1988-02-10 1989-02-10 Förfarande för framställning av terapeutiskt aktiva substituerade indolylpyrrolderivat FI96861C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8803048 1988-02-10
GB888803048A GB8803048D0 (en) 1988-02-10 1988-02-10 Substituted pyrroles
GB888827565A GB8827565D0 (en) 1988-02-10 1988-11-25 Substituted pyrroles
GB8827565 1988-11-25

Publications (4)

Publication Number Publication Date
FI890652A0 FI890652A0 (sv) 1989-02-10
FI890652A true FI890652A (sv) 1989-08-11
FI96861B FI96861B (sv) 1996-05-31
FI96861C FI96861C (sv) 1996-09-10

Family

ID=26293462

Family Applications (1)

Application Number Title Priority Date Filing Date
FI890652A FI96861C (sv) 1988-02-10 1989-02-10 Förfarande för framställning av terapeutiskt aktiva substituerade indolylpyrrolderivat

Country Status (22)

Country Link
US (1) US5057614A (sv)
EP (1) EP0328026B1 (sv)
JP (1) JPH0730071B2 (sv)
AU (1) AU623630B2 (sv)
CA (1) CA1320194C (sv)
CZ (1) CZ280738B6 (sv)
DE (1) DE58904168D1 (sv)
DK (1) DK171891B1 (sv)
DZ (1) DZ1323A1 (sv)
ES (1) ES2054890T3 (sv)
FI (1) FI96861C (sv)
HU (1) HU201054B (sv)
IE (1) IE63489B1 (sv)
IL (1) IL89167A (sv)
IS (1) IS1941B (sv)
MC (1) MC2010A1 (sv)
NO (1) NO172540C (sv)
NZ (1) NZ227850A (sv)
PH (1) PH25185A (sv)
PT (1) PT89661B (sv)
SK (1) SK75289A3 (sv)
YU (1) YU47101B (sv)

Families Citing this family (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8904161D0 (en) * 1989-02-23 1989-04-05 Hoffmann La Roche Substituted pyrroles
MC2096A1 (fr) * 1989-02-23 1991-02-15 Hoffmann La Roche Pyrroles substitues
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
IL94274A0 (en) * 1989-05-05 1991-03-10 Goedecke Ag Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
DE3914764A1 (de) * 1989-05-05 1990-11-08 Goedecke Ag Maleinimid-derivate und deren verwendung als arzneimittel
DE4005970A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
DE4005969A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
US5292747A (en) * 1990-08-07 1994-03-08 Hoffman-La Roche Inc. Substituted pyrroles
CA2046801C (en) * 1990-08-07 2002-02-26 Peter D. Davis Substituted pyrroles
GB9123396D0 (en) * 1991-11-04 1991-12-18 Hoffmann La Roche A process for the manufacture of substituted maleimides
EP0630241A1 (en) * 1992-03-20 1994-12-28 The Wellcome Foundation Limited Indole derivatives with antiviral activity
US5290777A (en) * 1993-02-24 1994-03-01 Regents Of The Univ. Of California Use for topsentin compounds and pharmaceutical compositions containing same
AU678435B2 (en) * 1993-05-10 1997-05-29 F. Hoffmann-La Roche Ag Substituted pyrroles
US5721230A (en) * 1993-05-10 1998-02-24 Hoffmann-La Roche Inc. Substituted pyrroles
US5405864A (en) * 1993-10-15 1995-04-11 Syntex (U.S.A.) Inc. Chemotherapeutic maleimides
TW270114B (sv) * 1993-10-22 1996-02-11 Hoffmann La Roche
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
HU219709B (hu) * 1993-12-07 2001-06-28 Eli Lilly And Co. Proteinkináz C gátló hatású kondenzált indolszármazékok, eljárás előállításukra, és az ezeket tartalmazó gyógyászati készítmények
ES2134910T3 (es) * 1993-12-07 1999-10-16 Lilly Co Eli Sintesis de bisindolilmaleimidas.
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
US5545636A (en) * 1993-12-23 1996-08-13 Eli Lilly And Company Protein kinase C inhibitors
PT817627E (pt) 1993-12-23 2005-07-29 Lilly Co Eli Inibidores da proteina cinase c
AU2771395A (en) * 1994-06-14 1996-01-05 Sloan-Kettering Institute For Cancer Research Ceramide-activated protein kinase and methods of use of effectors
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
US5491242A (en) * 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
DE69505470T2 (de) * 1994-08-04 1999-05-12 F. Hoffmann-La Roche Ag, Basel Pyrrolocarbazol
US5475110A (en) * 1994-10-14 1995-12-12 Cephalon, Inc. Fused Pyrrolocarbazoles
US5591855A (en) * 1994-10-14 1997-01-07 Cephalon, Inc. Fused pyrrolocarbazoles
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
US5594009A (en) * 1994-10-14 1997-01-14 Cephalon, Inc. Fused pyrrolocarbazoles
US5559228A (en) * 1995-03-30 1996-09-24 Eli Lilly And Company Synthesis of bisindolylmaleimides
WO1997009339A1 (fr) * 1995-09-05 1997-03-13 Banyu Pharmaceutical Co., Ltd. Derives antitumoraux d'indolopyrrolocarbazole
HU226821B1 (en) * 1995-11-20 2009-11-30 Lilly Co Eli The mesylate salt of a macrocyclic bis-indolyl-maleimide derivative, process for its preparation, use thereof and pharmaceutical compositions containing the same
US5616724A (en) * 1996-02-21 1997-04-01 Cephalon, Inc. Fused pyrrolo[2,3-c]carbazole-6-ones
AU2217797A (en) * 1996-03-20 1997-10-10 Eli Lilly And Company Synthesis of indolylmaleimides
UA54427C2 (uk) * 1996-05-01 2003-03-17 Елі Ліллі Енд Компані Спосіб лікування очних захворювань, які пов'язані з фактором васкулярного ендотеліального росту
US6232299B1 (en) 1996-05-01 2001-05-15 Eli Lilly And Company Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy
EA001779B1 (ru) 1996-05-01 2001-08-27 Эли Лилли Энд Компани Способ лечения заболеваний, связанных с фактором роста сосудистого эндотелия
PE91698A1 (es) * 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
PE91498A1 (es) * 1996-07-29 1998-12-22 Hoffmann La Roche Pirroles sustituidos
PE91598A1 (es) 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
US6093709A (en) * 1996-08-22 2000-07-25 Eli Lilly And Company Therapeutic treatment for sexual dysfunctions
IL128376A0 (en) * 1996-08-23 2000-01-31 Lilly Co Eli Synthesis of bisindolylmalimides
US5962446A (en) * 1996-08-30 1999-10-05 Eli Lilly And Company Therapetutic treatment for human T cell lymphotrophic virus type 1 infection
US6107327A (en) * 1996-08-30 2000-08-22 Eli Lilly And Company Therapeutic treatment for HIV infection
SE9603284D0 (sv) * 1996-09-10 1996-09-10 Astra Ab New compounds
SE9603283D0 (sv) * 1996-09-10 1996-09-10 Astra Ab New compounds
TW472045B (en) * 1996-09-25 2002-01-11 Astra Ab Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation
ATE258050T1 (de) * 1996-10-31 2004-02-15 Harbor Branch Oceanographic Verwendung neurogen-entzuendungshemmender verbindungen und zusammensetzungen
US5859261A (en) * 1997-03-20 1999-01-12 Eli Lilly And Company Synthesis of indolylmaleimides
US6093740A (en) * 1997-04-30 2000-07-25 Eli Lilly And Company Therapeutic treatment for skin disorders
US6133452A (en) * 1997-08-22 2000-10-17 Eli Lilly And Company Synthesis of bisindolylmalimides
AR017200A1 (es) 1997-12-23 2001-08-22 Astrazeneca Ab Compuestos inhibidores de la proteina cinasa c, sales farmaceuticamente aceptables de los mismos, formulaciones farmaceuitcas que los comprenden, usode las mismas y proceso para la sintesis de dichos compuestos
EP1057484A4 (en) * 1998-02-23 2002-11-20 Sagami Chem Res INHIBITORS OF CELL DEATH
US6291446B1 (en) 1998-03-05 2001-09-18 Eli Lilly And Company Therapeutic treatment for cytomegalovirus infection
US6225301B1 (en) 1998-03-05 2001-05-01 Eli Lilly And Company Therapeutic treatment for renal dysfunction
US6103712A (en) * 1998-03-05 2000-08-15 Eli Lilly And Company Therapeutic treatment for asthma
US6103713A (en) * 1998-03-05 2000-08-15 Eli Lilly And Company Therapeutic treatment for autoimmune diseases
SE9800835D0 (sv) 1998-03-13 1998-03-13 Astra Ab New Compounds
BR9908882A (pt) * 1998-03-17 2000-11-21 Hoffmann La Roche Bisindolimaleimidas substituìdas para a inibição de proliferação de célula
SE9802538D0 (sv) * 1998-07-13 1998-07-13 Astra Ab New pharmaceutically active compounds
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
WO2000021927A2 (en) * 1998-10-08 2000-04-20 Smithkline Beecham Plc Pyrrole-2,5-diones as gsk-3 inhibitors
US6719520B2 (en) 1998-10-08 2004-04-13 Smithkline Beecham Corporation Method and compounds
GB9828640D0 (en) * 1998-12-23 1999-02-17 Smithkline Beecham Plc Novel method and compounds
AU773504B2 (en) * 1999-03-31 2004-05-27 Verona Pharma Plc Derivatives of pyrimido(6,1-a)isoquinolin-4-one
US6492406B1 (en) 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds
US6284783B1 (en) 1999-06-09 2001-09-04 The Uab Research Foundation Use of bisindolylmaleimide compounds to induce Fas-mediated apoptosis
US6346625B1 (en) 1999-06-23 2002-02-12 Astrazeneca Ab Protein kinase inhibitors
EP1224932A4 (en) * 1999-08-20 2002-10-16 Sagami Chem Res DRUGS INHIBITING CELL DEATH
US6559164B1 (en) 1999-10-12 2003-05-06 Hoffmann-La Roche Inc. Substituted pyrroles suitable for continuous infusion
US6313143B1 (en) * 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
US6281356B1 (en) 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
GB0008264D0 (en) * 2000-04-04 2000-05-24 Smithkline Beecham Plc Novel method and compounds
US6326501B1 (en) * 2000-04-19 2001-12-04 Hoffmann-La Roche Inc. Methylation of indole compounds using dimethyl carbonate
US7129250B2 (en) * 2000-05-19 2006-10-31 Aegera Therapeutics Inc. Neuroprotective and anti-proliferative compounds
CA2308994A1 (en) * 2000-05-19 2001-11-19 Aegera Therapeutics Inc. Neuroprotective compounds
US6353007B1 (en) * 2000-07-13 2002-03-05 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenyl)indoles and their use as anti-inflammatory agents
PL366701A1 (en) 2000-07-27 2005-02-07 F.Hoffmann-La Roche Ag 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta
US6469179B1 (en) * 2000-10-03 2002-10-22 Hoffmann-La Roche Inc. Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
US6482847B2 (en) * 2000-10-03 2002-11-19 Hoffmann-La Roche Inc. Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
MXPA03004037A (es) * 2000-11-07 2003-08-19 Novartis Ag Derivados de indolilmaleimida como inhibidores de proteina de cinasa c.
US6645970B2 (en) * 2000-11-07 2003-11-11 Novartis Ag Indolylmaleimide derivatives
MXPA03005140A (es) * 2000-12-08 2004-10-15 Johnson & Johnson Compuestos de pirrolina sustituidos con indazolilo como inhibidores de cinasa.
US6548531B2 (en) 2001-02-09 2003-04-15 Hoffmann-La Roche Inc. Method for cancer therapy
DE10109280A1 (de) * 2001-02-26 2002-09-05 Peter Mayser Indolderivate mit inhibitorischer Wirkung auf Proteinkinasen
WO2002102373A1 (en) * 2001-06-15 2002-12-27 F. Hoffmann-La Roche Ag Method for administration of cancer therapeutic
TWI335221B (en) 2001-09-27 2011-01-01 Alcon Inc Inhibtors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma
KR20050040832A (ko) * 2001-10-29 2005-05-03 넥타르 테라퓨틱스 에이엘, 코포레이션 단백질 키나아제 ｃ 억제제의 중합체 공액
US20030139373A1 (en) * 2001-11-20 2003-07-24 Breimer Lars Holger Method for cancer therapy
DE60309848T2 (de) 2002-03-05 2007-05-16 Eli Lilly And Co., Indianapolis Purinderivate als kinaseinhibitoren
IL163777A0 (en) * 2002-03-08 2005-12-18 Lilly Co Eli Kinase inhibitors
PE20040079A1 (es) 2002-04-03 2004-04-19 Novartis Ag Derivados de indolilmaleimida
EP1900738A3 (en) * 2002-05-08 2008-04-09 Janssen Pharmaceutica, N.V. Substituted pyrroline kinase inhibitors
WO2003095452A1 (en) * 2002-05-08 2003-11-20 Janssen Pharmaceutica N.V. Substituted pyrroline kinase inhibitors
MXPA04012188A (es) 2002-06-05 2005-07-25 Johnson & Johnson Derivados de bisindolil-maleimida como inhibidores de cinasa.
US7232906B2 (en) * 2002-06-05 2007-06-19 Janssen Pharmaceutica N.V. Substituted pyrrolines as kinase inhibitors
CA2393720C (en) * 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
US6800655B2 (en) * 2002-08-20 2004-10-05 Sri International Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
GB0303319D0 (en) 2003-02-13 2003-03-19 Novartis Ag Organic compounds
JP2006521386A (ja) * 2003-03-27 2006-09-21 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ キナーゼ阻害剤である置換ピロリン
CN1832940A (zh) * 2003-06-13 2006-09-13 詹森药业有限公司 用作激酶抑制剂的取代的吲唑基(吲哚基)马来酰亚胺衍生物
CA2533861A1 (en) 2003-08-08 2005-02-17 Novartis Ag Combinations comprising staurosporines
ES2402298T3 (es) * 2004-01-19 2013-04-30 Novartis Ag Derivados de indolilmaleimida como inhibidores del tratamiento de rechazo del injerto o enfermedades autoinmunes
EP1734952A1 (en) * 2004-04-08 2006-12-27 Novartis AG Protein kinase c inhibitors for the treatment of autoimmune diseases and of transplant rejection
EP2277595A3 (en) 2004-06-24 2011-09-28 Novartis Vaccines and Diagnostics, Inc. Compounds for immunopotentiation
AU2005313485B2 (en) * 2004-12-08 2011-02-03 Johannes Gutenberg-Universitat Mainz 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors
US7563772B2 (en) * 2005-01-04 2009-07-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of increasing cerebral blood flow
EP1846406B9 (en) * 2005-02-09 2012-01-11 ArQule, Inc. Maleimide derivatives, pharmaceutical compositions and methods for treatment of cancer
KR20080023732A (ko) * 2005-07-11 2008-03-14 노파르티스 아게 인돌릴말레이미드 유도체
US20070066526A1 (en) * 2005-09-02 2007-03-22 Daria Mochly-Rosen Method for reducing risk of and extent of injury due to stroke in hypertensive subjects
US20070112053A1 (en) 2005-09-16 2007-05-17 Pickett Cecil B Pharmaceutical compositions and methods using temozolomide and a protein kinase inhibitor
WO2008077138A1 (en) * 2006-12-19 2008-06-26 The Board Of Trustees Of The University Of Illinois 3-benzofuranyl-4-indolyl maleimides as potent gsk3 inhibitors for neurogenerative disorders
JP2010530885A (ja) * 2007-06-22 2010-09-16 アークル インコーポレイテッド キナゾリノン化合物およびその使用方法
CN101801969B (zh) * 2007-06-22 2014-10-29 艾科尔公司 治疗癌症的吲哚基吡咯烷
EP2170870B1 (en) * 2007-06-22 2014-03-05 ArQule, Inc. Pyrrolidinone, pyrrolidine-2, 5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
FR2927075A1 (fr) * 2008-02-04 2009-08-07 Centre Nat Rech Scient Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes
US8304421B2 (en) * 2008-09-30 2012-11-06 Vanderbilt University Indole compounds and their use as radiation sensitizing agents and chemotherapeutic agents
EP2343291A1 (en) * 2009-12-18 2011-07-13 Johannes Gutenberg-Universität Mainz 3-(Indolyl)- or 3-(Azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
EP2338486A1 (en) 2009-12-18 2011-06-29 Johannes Gutenberg-Universität Mainz 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives for use in the treatment of colon and gastric adenocarcinoma
EP2474541A1 (en) 2010-12-23 2012-07-11 Johannes- Gutenberg-Universität Mainz Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
GB201111427D0 (en) * 2011-07-05 2011-08-17 Amakem Nv Novel bisindolylmaleimides, pan-pkc inhibitors
JP2016508962A (ja) * 2012-12-10 2016-03-24 セントジーン アーゲー ガンを予防および治療するためのマレイミド誘導体の使用
EP2928466B1 (en) * 2012-12-10 2020-10-28 Centogene GmbH Use of maleimide derivatives for preventing and treating leukemia
CN103382199A (zh) * 2013-06-28 2013-11-06 北京理工大学 一种n-烷基-双吲哚马来酰亚胺的制备方法
JP2017524739A (ja) 2014-07-17 2017-08-31 アンセルムＩｎｓｅｒｍ 神経筋接合部関連疾患の処置方法
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
EP3187495A1 (en) 2015-12-30 2017-07-05 Johannes Gutenberg-Universität Mainz 3-(5-fluoroindolyl)-4-arylmaleimide compounds and their use in tumor treatment
CN109535158B (zh) * 2016-04-26 2021-04-23 浙江工业大学 一种双芳基马来酰亚胺类化合物及其药学上可接受的盐及其制备方法和应用
US20230203017A1 (en) * 2021-12-28 2023-06-29 Kamal D. Mehta Protein Kinase C Beta Inhibitors and Uses Thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5373501A (en) * 1976-12-11 1978-06-30 Kitasato Inst Novel antibiotics amm2282 and process for preparing same
JPS62220196A (ja) * 1986-03-20 1987-09-28 Kyowa Hakko Kogyo Co Ltd 新規物質ｕｃｎ―０１
IL86632A0 (en) * 1987-06-15 1988-11-30 Ciba Geigy Ag Derivatives substituted at methyl-amino nitrogen
AU605304B2 (en) * 1987-06-22 1991-01-10 Nihon Tokushu Nayaku Seizo K.K. Benzo-fused cyclic compounds
IL94274A0 (en) * 1989-05-05 1991-03-10 Goedecke Ag Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
YU47101B (sh) 1994-12-28
YU28489A (en) 1991-06-30
HUT49348A (en) 1989-09-28
JPH01233281A (ja) 1989-09-19
NO172540C (no) 1993-08-04
SK278989B6 (sk) 1998-05-06
FI96861C (sv) 1996-09-10
FI890652A0 (sv) 1989-02-10
CZ280738B6 (cs) 1996-04-17
AU623630B2 (en) 1992-05-21
IE63489B1 (en) 1995-05-03
NO890568D0 (no) 1989-02-09
DZ1323A1 (fr) 2004-09-13
IL89167A0 (en) 1989-09-10
IE890416L (en) 1989-08-10
DE58904168D1 (de) 1993-06-03
IS1941B (is) 2004-07-30
JPH0730071B2 (ja) 1995-04-05
CZ75289A3 (en) 1995-12-13
DK55889A (da) 1989-08-11
NO890568L (no) 1989-08-11
PH25185A (en) 1991-03-27
FI96861B (sv) 1996-05-31
PT89661A (pt) 1989-10-04
NO172540B (no) 1993-04-26
AU2965889A (en) 1989-08-10
PT89661B (pt) 1994-02-28
CA1320194C (en) 1993-07-13
DK171891B1 (da) 1997-08-04
DK55889D0 (da) 1989-02-07
HU201054B (en) 1990-09-28
MC2010A1 (fr) 1990-02-16
NZ227850A (en) 1991-11-26
ES2054890T3 (es) 1994-08-16
IL89167A (en) 1994-02-27
SK75289A3 (en) 1998-05-06
US5057614A (en) 1991-10-15
IS3433A7 (is) 1989-08-11
EP0328026B1 (de) 1993-04-28
EP0328026A1 (de) 1989-08-16

Similar Documents

Publication Publication Date Title
FI96861C (sv) Förfarande för framställning av terapeutiskt aktiva substituerade indolylpyrrolderivat
FI890282A0 (sv) Förfarande för framställning av terapeutiskt användbara 23,24-didehydro-25-hydroxikalciferolderivat
NO179584C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-acylaminotiazoler
FI91152B (sv) Förfarande för framställning av terapeutiskt aktiva bensimidazolderivat
NO178619C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive di-t-butylfenoler
NO175978C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive bis-aza-bicykliske forbindelser
FI881223A0 (sv) Förfarande för framställning av terapeutiskt aktiva 9-aminotetrahydroakridiner och därmed närbesläktade föreningar
NO174467C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive kromanderivater
NO176275C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive pyridazinonderivater
FI890072A (sv) Förfarande för framställning av farmaceutiskt användbara isokinolinderivat
FI930723A0 (sv) Förfarande för framställning av terapeutiskt aktiva tiazolidinderivat
FI96601C (sv) Förfarande för framställning av terapeutiskt aktiva tetrazolderivat
NO903941D0 (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive diazepinon-derivater.
NO173334C (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive alkylaminoalkylenderivater 2H-1-benzopyraner
FI93444B (sv) Förfarande för framställning av terapeutiskt aktiva dihydropyridinföreningar
NO174959C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive N-aminobutyl-N-fenyl-arylamidderivater
FI883672A (sv) Förfarande för framställning av terapeutiskt användbara aminoalkoxifenylderivat
NO173784C (no) Anaslogifremgangsmaate for fremstilling av terapeutisk aktive tieno-tri-azolo-diazepinderivater
NO174391C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive kromanderivater
NO174422C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive kromanderivater
FI903077A0 (sv) Förfarande för framställning av terapeutiskt aktiva R(-)-3-kinuklidinolderivat
NO174203C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive
NO173606C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive tieno- triazolo-diazepin-derivater
NO174463C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive pyrrolidinderivater
FI884473A (sv) Förfarande för framställning av terapeutiskt användbara fenoxialkylpyrokatekolderivat

Legal Events

Date Code Title Description
BB Publication of examined application
FG Patent granted

Owner name: F. HOFFMANN-LA ROCHE AG

MA Patent expired