FI80274B - Foerfarande foer framstaellning av antibiotiskt aktivt kristallint monohydrat av cefalexinhydroklorid och ett alkanolsolvat som anvaends som utgaongsaemne i foerfarandet. - Google Patents

Foerfarande foer framstaellning av antibiotiskt aktivt kristallint monohydrat av cefalexinhydroklorid och ett alkanolsolvat som anvaends som utgaongsaemne i foerfarandet. Download PDF

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Publication number
FI80274B
FI80274B FI844631A FI844631A FI80274B FI 80274 B FI80274 B FI 80274B FI 844631 A FI844631 A FI 844631A FI 844631 A FI844631 A FI 844631A FI 80274 B FI80274 B FI 80274B
Authority
FI
Finland
Prior art keywords
cefalexin
som
solvate
monohydrate
hydrochloride
Prior art date
Application number
FI844631A
Other languages
English (en)
Finnish (fi)
Other versions
FI80274C (sv
FI844631A0 (fi
FI844631L (fi
Inventor
Joseph Michael Indelicato
Gary Lowell Engel
Harry Albert Rose
Lawrence Joseph Mcshane
Kuo Shang Yang
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI844631A0 publication Critical patent/FI844631A0/fi
Publication of FI844631L publication Critical patent/FI844631L/fi
Application granted granted Critical
Publication of FI80274B publication Critical patent/FI80274B/fi
Publication of FI80274C publication Critical patent/FI80274C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Claims (5)

1. Förfarande för framställning av antibiotiskt aktivt kristallint monohydrat av cefalexinhydroklorid, 5 kännetecknat därav, att man hydratiserar kristallint C^_^-alkanolsolvat av cefalexinhydroklorid genom att utsätta det för atmosfär med en relativ fuktighet av cirka 10 - 50 %.
2. Förfarande enligt patentkravet 1, kanne- 10 tecknat därav, att ett kristallint hydroklorid C^_2- alkanolsolvat av hydrokloriden hydratiseras.
3. Förfarande enligt patentkravet 2, kännetecknat därav, att solvatet är etanolsolvat.
4. Kristallint C^_^-alkanolsolvat av cefalexinhyd- 15 roklorid.
5. Alkanolsolvat enligt patentkravet 4, kännetecknat därav, att det är etanolsolvat av cefalexinhydroklorid .
FI844631A 1983-12-01 1984-11-26 Förfarande för framställning av antibiotiskt aktivt kristallint monohy drat av cefalexinhydroklorid och ett alkanolsolvat som används som ut gångsämne i förfarandet FI80274C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/556,887 US4600773A (en) 1983-12-01 1983-12-01 Crystalline cephalexin hydrochloride monohydrate
US55688783 1983-12-01

Publications (4)

Publication Number Publication Date
FI844631A0 FI844631A0 (fi) 1984-11-26
FI844631L FI844631L (fi) 1985-06-02
FI80274B true FI80274B (fi) 1990-01-31
FI80274C FI80274C (sv) 1990-05-10

Family

ID=24223233

Family Applications (1)

Application Number Title Priority Date Filing Date
FI844631A FI80274C (sv) 1983-12-01 1984-11-26 Förfarande för framställning av antibiotiskt aktivt kristallint monohy drat av cefalexinhydroklorid och ett alkanolsolvat som används som ut gångsämne i förfarandet

Country Status (46)

Country Link
US (1) US4600773A (sv)
EP (1) EP0143658B1 (sv)
JP (1) JPS60132990A (sv)
KR (1) KR870000527B1 (sv)
AT (1) AT390616B (sv)
AU (1) AU566080B2 (sv)
BE (1) BE901142A (sv)
BG (1) BG40966A3 (sv)
BR (1) BR8406037A (sv)
CH (1) CH661732A5 (sv)
CS (1) CS248725B2 (sv)
CY (1) CY1505A (sv)
DD (1) DD229410A5 (sv)
DE (1) DE3443065A1 (sv)
DK (1) DK158354C (sv)
ES (1) ES8602011A1 (sv)
FI (1) FI80274C (sv)
FR (1) FR2555990B1 (sv)
GB (1) GB2150566B (sv)
GR (1) GR81043B (sv)
GT (1) GT198400146A (sv)
HK (1) HK92089A (sv)
HU (1) HU192516B (sv)
IE (1) IE57886B1 (sv)
IL (1) IL73639A (sv)
IN (1) IN163078B (sv)
IT (1) IT1177329B (sv)
JO (1) JO1347B1 (sv)
LU (1) LU85650A1 (sv)
MA (1) MA20279A1 (sv)
MX (1) MX159670A (sv)
MY (1) MY102966A (sv)
NL (1) NL8403588A (sv)
NO (1) NO844711L (sv)
NZ (1) NZ210357A (sv)
OA (1) OA07876A (sv)
PH (1) PH20849A (sv)
PL (1) PL146014B1 (sv)
PT (1) PT79553B (sv)
SE (1) SE464026B (sv)
SG (1) SG59789G (sv)
SU (1) SU1251807A3 (sv)
YU (1) YU45680B (sv)
ZA (1) ZA849224B (sv)
ZM (1) ZM6384A1 (sv)
ZW (1) ZW19084A1 (sv)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2555989B1 (fr) * 1983-12-06 1987-02-20 Bristol Myers Sa Monohydrate de chlorocephadroxyle
JPS60142987A (ja) * 1983-12-29 1985-07-29 Mochida Pharmaceut Co Ltd セフアロスポリン誘導体
DE150507T1 (de) * 1983-12-29 1987-02-26 Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US4775751A (en) * 1985-06-03 1988-10-04 Eli Lilly & Company Process for cephalexin hydrochloride alcoholates
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
JPS63132893A (ja) * 1986-11-25 1988-06-04 Mochida Pharmaceut Co Ltd 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤
US5721229A (en) * 1995-12-26 1998-02-24 Veterinary Pharmacy Corporation Soluble forms of cephalosporins and treatment of animals
GB9717629D0 (en) 1997-08-21 1997-10-22 Johnson Matthey Plc Removal of residual organic solvents
AT413282B (de) * 2002-02-01 2006-01-15 Sandoz Ag Kristalline salze der 7-(((5-amino-1,2,4-thiadiazol-3-yl) (fluoromethoxy-imino)acetyl)amino)-3- ((imino-1-piperazinylmethyl)
US20040033262A1 (en) * 2002-08-19 2004-02-19 Orchid Health Care Sustained release pharmaceutical composition of a cephalosporin antibiotic

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507861A (en) * 1966-09-14 1970-04-21 Lilly Co Eli Certain 3-methyl-cephalosporin compounds
US3655656A (en) * 1970-06-04 1972-04-11 Lilly Co Eli Crystalline cephalexin monohydrate
DE2317179C2 (de) * 1973-04-05 1982-11-25 Bristol-Myers Co., 10154 New York, N.Y. Verfahren zur Herstellung der relativ wasserunlöslichen kristallinen Form von Cefalexinmonohydrat
US3985747A (en) * 1974-05-24 1976-10-12 Bristol-Myers Company Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
JPS50151890A (sv) * 1974-05-30 1975-12-06
CH642850A5 (it) * 1978-10-20 1984-05-15 Ausonia Farma Srl Composizioni farmaceutiche ad attivita antibatterica contro infezioni da germi gram-positivi e gram-negativi.
NZ206600A (en) * 1983-05-11 1987-01-23 Alza Corp Osmotic drug delivery device

Also Published As

Publication number Publication date
DD229410A5 (de) 1985-11-06
IT8423746A0 (it) 1984-11-27
BE901142A (fr) 1985-05-28
ZW19084A1 (en) 1985-06-12
DK561284A (da) 1985-06-02
JO1347B1 (en) 1986-11-30
ES538019A0 (es) 1985-11-01
US4600773A (en) 1986-07-15
AT390616B (de) 1990-06-11
SE8405954D0 (sv) 1984-11-26
PL250593A1 (en) 1985-07-30
CS248725B2 (en) 1987-02-12
MY102966A (en) 1993-03-31
NO844711L (no) 1985-06-03
IT8423746A1 (it) 1986-05-27
NL8403588A (nl) 1985-07-01
BG40966A3 (en) 1987-03-14
DK561284D0 (da) 1984-11-27
HUT35685A (en) 1985-07-29
MX159670A (es) 1989-08-02
JPH0548234B2 (sv) 1993-07-20
ZA849224B (en) 1986-07-30
DE3443065A1 (de) 1985-06-20
ES8602011A1 (es) 1985-11-01
DE3443065C2 (sv) 1989-03-23
GR81043B (en) 1985-03-27
EP0143658A3 (en) 1986-02-12
BR8406037A (pt) 1985-08-27
AU566080B2 (en) 1987-10-08
DK158354C (da) 1990-10-01
KR850004765A (ko) 1985-07-27
FR2555990B1 (fr) 1986-12-26
HK92089A (en) 1989-11-24
IE57886B1 (en) 1993-05-05
LU85650A1 (fr) 1985-07-17
GT198400146A (es) 1986-05-20
FI80274C (sv) 1990-05-10
IL73639A (en) 1988-06-30
IL73639A0 (en) 1985-02-28
GB2150566B (en) 1987-08-26
AU3589784A (en) 1985-06-06
OA07876A (fr) 1986-11-20
EP0143658A2 (en) 1985-06-05
IE843033L (en) 1985-06-01
SE464026B (sv) 1991-02-25
FI844631A0 (fi) 1984-11-26
ATA373284A (de) 1989-11-15
PT79553A (en) 1984-12-01
SE8405954L (sv) 1985-06-02
CH661732A5 (de) 1987-08-14
NZ210357A (en) 1988-05-30
YU45680B (sh) 1992-07-20
GB8430073D0 (en) 1985-01-09
SG59789G (en) 1989-12-29
IN163078B (sv) 1988-08-06
EP0143658B1 (en) 1989-03-22
PT79553B (en) 1986-12-15
IT1177329B (it) 1987-08-26
JPS60132990A (ja) 1985-07-16
PL146014B1 (en) 1988-12-31
SU1251807A3 (ru) 1986-08-15
GB2150566A (en) 1985-07-03
FR2555990A1 (fr) 1985-06-07
FI844631L (fi) 1985-06-02
HU192516B (en) 1987-06-29
YU199684A (en) 1987-02-28
KR870000527B1 (ko) 1987-03-14
PH20849A (en) 1987-05-08
MA20279A1 (fr) 1985-07-01
ZM6384A1 (en) 1985-07-22
DK158354B (da) 1990-05-07
CY1505A (en) 1990-08-03

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Owner name: ELI LILLY AND COMPANY