FI75992C - Förfarande för utvinning av laxativa föreningar ur sennadrog - Google Patents
Förfarande för utvinning av laxativa föreningar ur sennadrog Download PDFInfo
- Publication number
- FI75992C FI75992C FI824454A FI824454A FI75992C FI 75992 C FI75992 C FI 75992C FI 824454 A FI824454 A FI 824454A FI 824454 A FI824454 A FI 824454A FI 75992 C FI75992 C FI 75992C
- Authority
- FI
- Finland
- Prior art keywords
- extraction
- methanol
- herb
- solvent
- extract
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
Claims (9)
1. Förfarande för tillvaratagning av laxativföreningar frän sennadrogen, kännetecknat därav, att a) sennadrogen extraheras med en metanol/vatten-blandning genom motströmsperkolering och extraktet indunstas vid en temperatur av ^ 50°C, tills metanolen fullständigt avgätt fran extraktet, b) det erhällna koncentratet renas genom kontinuerlig vätske-extraktion med ett organiskt lösningsmedel säsom butanol, rnetyletylketon eller metylisopropylketon, c) det erhällna raffinatet ledes tili en kristal.lisationsan-ordning och göres surt under omröring tili pH-värdet 1,5 - 2,0, ympning utföres med sennosidkristaller, utkristallisation i lösningen far ske under samtidig omröring och de erhällna kristallina räsennosiderna separeras, d) räsennosiderna omkristalliseras vid behov och eventuellt omvandlas med en farmaceutiskt lämplig bas tili ett farmaceu-tiskt lämpligt sait.
2. Förfarande enligt patentkrav 1, kännetecknat därav, att som extraktionslösning i skedet a) användes 70 procentig metanol.
3. Förfarande enligt patentkraven 1 och 2, kännetecknat därav, att extraktionen i skedet a) utföres vid nägot stegrade temperaturer, högst vid 35°C.
4. Förfarande enligt nägot av föregäende patentkrav, kännetecknat därav, att före perkoleringen fär sennaski-dorna svälla i efterperko.latet.
5. Förfarande enligt nägot av föregäende patentkrav, kännetecknat därav, att i det i skedet a) erhällna koncentratet tillsättes 5 procent butanol-2.
6. Förfarande enligt patentkrav 1, kännetecknat därav, att lösningsmedlet i skedet b) är med vatten mättad butano.l-2. I!
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3200131A DE3200131A1 (de) | 1982-01-05 | 1982-01-05 | "verfahren zur gewinnung von laxativen verbindungen aus sennadroge" |
| DE3200131 | 1982-01-05 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI824454A0 FI824454A0 (fi) | 1982-12-27 |
| FI824454L FI824454L (fi) | 1983-07-06 |
| FI75992B FI75992B (fi) | 1988-05-31 |
| FI75992C true FI75992C (sv) | 1988-09-09 |
Family
ID=6152636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI824454A FI75992C (sv) | 1982-01-05 | 1982-12-27 | Förfarande för utvinning av laxativa föreningar ur sennadrog |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS58131997A (sv) |
| KR (1) | KR880000018B1 (sv) |
| AR (1) | AR228690A1 (sv) |
| AT (1) | AT376368B (sv) |
| AU (1) | AU557773B2 (sv) |
| BE (1) | BE895536A (sv) |
| CA (1) | CA1203800A (sv) |
| CH (1) | CH653339A5 (sv) |
| DE (1) | DE3200131A1 (sv) |
| DK (1) | DK169075B1 (sv) |
| FI (1) | FI75992C (sv) |
| FR (1) | FR2519253B1 (sv) |
| GB (1) | GB2112640B (sv) |
| GR (1) | GR77138B (sv) |
| HK (1) | HK90585A (sv) |
| HU (1) | HU188241B (sv) |
| IE (1) | IE54425B1 (sv) |
| IL (1) | IL67147A (sv) |
| IT (1) | IT1191156B (sv) |
| LU (1) | LU84534A1 (sv) |
| MX (1) | MX7121E (sv) |
| NL (1) | NL188680C (sv) |
| PT (1) | PT75934B (sv) |
| SE (1) | SE8207515L (sv) |
| SG (1) | SG45385G (sv) |
| YU (1) | YU42829B (sv) |
| ZA (1) | ZA829570B (sv) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4120990C2 (de) * | 1991-06-25 | 1995-07-27 | Madaus Ag | Verfahren zur Herstellung von Diacetylrhein |
| DE4120989C2 (de) * | 1991-06-25 | 1995-07-27 | Madaus Ag | Verfahren zur Herstellung von Diacetylrhein |
| DE4120991A1 (de) * | 1991-06-25 | 1993-01-07 | Madaus Ag | Verfahren zur gewinnung der sennoside a, b und a1 |
| US5710260A (en) * | 1991-06-25 | 1998-01-20 | Madaus Ag | Method of extracting sennosides A, B and A1 |
| JP5449710B2 (ja) * | 2008-07-11 | 2014-03-19 | 株式会社ブルックスホールディングス | 機能性食品素材 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB744876A (en) * | 1953-10-27 | 1956-02-15 | Westminster Lab Ltd | Process for extracting the active principles from senna |
| DE1032888B (de) * | 1956-01-09 | 1958-06-26 | Byk Gulden Lomberg Chem Fab | Verfahren zur Gewinnung von die natuerlichen Sennosidsalze enthaltenden Wirkstoffen aus Sennesdrogen |
| GB804232A (en) * | 1956-01-09 | 1958-11-12 | Byk Gulden Lomberg Chem Fab | Improvements in or relating to the production of sennosides from folia sennae or folliculi sennae |
| GB832017A (en) * | 1957-10-02 | 1960-04-06 | Westminster Lab Ltd | Senna preparations |
| DE1158211B (de) * | 1961-09-02 | 1963-11-28 | Ludwig Heumann & Co Chemisch P | Verfahren zur Herstellung von Trockenpulvern mit Wirkstoffen der Sennesblaetter oder-schoten |
| US3364113A (en) * | 1962-04-23 | 1968-01-16 | Westminster Lab Ltd | Senna preparations and methods of making and using them |
| FR1490738A (fr) * | 1966-06-24 | 1967-08-04 | Ile De Rech Pharmaceutiqje Et | Procédé d'extraction de dérivés anthracéniques contenus dans certaines plantes |
| DE1617667B1 (de) * | 1966-09-08 | 1970-09-03 | Nattermann A & Cie | Verfahren zur Gewinnung eines sennosideichen Wirkstoffkonzentrates aus Sennesschoten |
| FR1536622A (fr) * | 1966-09-08 | 1968-08-16 | Nattermann & Compagnie A | Procédé pour la production d'un concentré de substance active riche en sennacidesavec des follicules de séné |
| JPS5936604B2 (ja) * | 1975-07-18 | 1984-09-05 | 大日本製薬株式会社 | センノサイド類のカルシウム塩の製造法 |
| FR2422678A1 (fr) * | 1978-04-14 | 1979-11-09 | Synthelabo | Extraction de sennosides |
-
1982
- 1982-01-05 DE DE3200131A patent/DE3200131A1/de active Granted
- 1982-10-20 AR AR291034A patent/AR228690A1/es active
- 1982-10-29 CA CA000414539A patent/CA1203800A/en not_active Expired
- 1982-11-01 IL IL67147A patent/IL67147A/xx unknown
- 1982-11-01 KR KR8204908A patent/KR880000018B1/ko active
- 1982-11-11 AU AU90375/82A patent/AU557773B2/en not_active Ceased
- 1982-11-22 NL NLAANVRAGE8204533,A patent/NL188680C/xx not_active IP Right Cessation
- 1982-11-24 GB GB08233475A patent/GB2112640B/en not_active Expired
- 1982-11-30 AT AT0435582A patent/AT376368B/de not_active IP Right Cessation
- 1982-12-03 PT PT75934A patent/PT75934B/pt not_active IP Right Cessation
- 1982-12-06 IE IE2884/82A patent/IE54425B1/en not_active IP Right Cessation
- 1982-12-15 LU LU84534A patent/LU84534A1/de unknown
- 1982-12-17 DK DK559682A patent/DK169075B1/da active
- 1982-12-27 FI FI824454A patent/FI75992C/sv not_active IP Right Cessation
- 1982-12-28 JP JP57227837A patent/JPS58131997A/ja active Granted
- 1982-12-28 IT IT25002/82A patent/IT1191156B/it active
- 1982-12-30 SE SE8207515A patent/SE8207515L/sv not_active Application Discontinuation
- 1982-12-30 ZA ZA829570A patent/ZA829570B/xx unknown
- 1982-12-31 YU YU2925/82A patent/YU42829B/xx unknown
- 1982-12-31 CH CH7650/82A patent/CH653339A5/de not_active IP Right Cessation
-
1983
- 1983-01-04 GR GR70202A patent/GR77138B/el unknown
- 1983-01-04 BE BE0/209848A patent/BE895536A/fr not_active IP Right Cessation
- 1983-01-04 HU HU8318A patent/HU188241B/hu not_active IP Right Cessation
- 1983-01-04 MX MX8310437U patent/MX7121E/es unknown
- 1983-01-05 FR FR8300110A patent/FR2519253B1/fr not_active Expired
-
1985
- 1985-06-15 SG SG45385A patent/SG45385G/en unknown
- 1985-11-14 HK HK905/85A patent/HK90585A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: OY EXTRACTA LTD Owner name: MADAUS AKTIENGESELLSCHAFT |