FI67552B - Foerfarande foer framstaellning av en ny som beta-laktamas-inhibitor anvaendbar 2beta-acetoxymetyl-2alfa-metyl-(5r)-penam-3alfa-karboxylsyra-1,1-dioxid - Google Patents
Foerfarande foer framstaellning av en ny som beta-laktamas-inhibitor anvaendbar 2beta-acetoxymetyl-2alfa-metyl-(5r)-penam-3alfa-karboxylsyra-1,1-dioxid Download PDFInfo
- Publication number
- FI67552B FI67552B FI803028A FI803028A FI67552B FI 67552 B FI67552 B FI 67552B FI 803028 A FI803028 A FI 803028A FI 803028 A FI803028 A FI 803028A FI 67552 B FI67552 B FI 67552B
- Authority
- FI
- Finland
- Prior art keywords
- compound
- formula
- penam
- acid
- acetoxymethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
- C07D499/32—Esters
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (3)
1. Förfarande för framställning av en ny, sorti β -laktamas-inhibitor användbar 2β-acetoxymetyl-2 oo-metyl-(5R)-penam-3oc-karboxylsyra-1., 1-dioxid med formeln I
0. O H \ ^ i| : St . CH--0-C-CH, Γ~Γ f, CH, J-ή-v (i) 0 'COOH eller farmaceutiskt godtagbara salter därav, känneteck-n a t därav, att man omsätter en förening med formeln III 0 H CH^-0-i:-CHo 3 3 -1 |''"ΌΗ L I (III) <y--N V//, o 0 '' COOR3 väri R3 är väte eller en sedvanlig penicillinkarboxiskyddsgrupp, med ett oxidationsmedel tillsoxidationen tili en förening med formeln II'
0. O f ch2-o4-ch3 )-N-L 3 (II·) 0 *' COOR 3 väri R betecknar sarana som ovan, är väsentligen total, och, ifali behövligt, avlägsnar karboxiskyddsgruppen, och, ifali önskvärt, bil-dar ett farmaceutiskt godtagbart sait av föreningen med formeln I genom reaktion med en bas.
2. Förfarande enligt patentkravet 1, känneteck-n a t därav, att föreningen med formeln III oxideras under användande av 2-5 molekvivalenter av en organisk peroxisyra i ett reaktionsinert lösningsmedel vid en temperatur i omrädet -20...50°C.
3. Förfarande enligt patentkravet 2, känneteck-n a t därav, att föreningen med formeln III oxideras med 3-klorperbensoesyra.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI840367A FI67854C (fi) | 1979-09-26 | 1984-01-30 | Som mellanprodukter vid framstaellningen av terapeutiskt anvaendbara 2beta-acetoximetyl-2alfa-metyl-(5r)-penam-3alfa-karboxylsyra-1,1-dioxidderivat anvaendbara 2beta-acetoximetyl-2alfa-metyl-(5r)-penam-3alfa-karboxylsyraderivat |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/079,127 US4256733A (en) | 1979-09-26 | 1979-09-26 | Acetoxymethyl penam compounds as β-lactamase inhibitors |
| US7912779 | 1979-09-26 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI803028A FI803028A (fi) | 1981-03-27 |
| FI67552B true FI67552B (fi) | 1984-12-31 |
| FI67552C FI67552C (fi) | 1985-04-10 |
Family
ID=22148609
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI803028A FI67552C (fi) | 1979-09-26 | 1980-09-25 | Foerfarande foer framstaellning av en ny som beta-laktamas-inhibitor anvaendbar 2beta-acetoxymetyl-2alfa-metyl-(5r)-penam-3alfa-karboxylsyra-1,1-dioxid |
| FI840367A FI67854C (fi) | 1979-09-26 | 1984-01-30 | Som mellanprodukter vid framstaellningen av terapeutiskt anvaendbara 2beta-acetoximetyl-2alfa-metyl-(5r)-penam-3alfa-karboxylsyra-1,1-dioxidderivat anvaendbara 2beta-acetoximetyl-2alfa-metyl-(5r)-penam-3alfa-karboxylsyraderivat |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI840367A FI67854C (fi) | 1979-09-26 | 1984-01-30 | Som mellanprodukter vid framstaellningen av terapeutiskt anvaendbara 2beta-acetoximetyl-2alfa-metyl-(5r)-penam-3alfa-karboxylsyra-1,1-dioxidderivat anvaendbara 2beta-acetoximetyl-2alfa-metyl-(5r)-penam-3alfa-karboxylsyraderivat |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US4256733A (sv) |
| JP (1) | JPS6016958B2 (sv) |
| KR (1) | KR840000796B1 (sv) |
| AR (1) | AR224547A1 (sv) |
| AT (1) | AT366384B (sv) |
| AU (1) | AU517074B2 (sv) |
| BE (1) | BE885389A (sv) |
| CA (1) | CA1150242A (sv) |
| CH (1) | CH645646A5 (sv) |
| CS (1) | CS212284B2 (sv) |
| DD (1) | DD153123A5 (sv) |
| DE (1) | DE3035995C2 (sv) |
| DK (1) | DK404980A (sv) |
| EG (1) | EG14888A (sv) |
| ES (1) | ES8106528A1 (sv) |
| FI (2) | FI67552C (sv) |
| FR (1) | FR2465736A1 (sv) |
| GB (2) | GB2059420B (sv) |
| GR (1) | GR70065B (sv) |
| HU (1) | HU183212B (sv) |
| IE (2) | IE50507B1 (sv) |
| IL (1) | IL61117A (sv) |
| IN (1) | IN154557B (sv) |
| IT (1) | IT1132754B (sv) |
| LU (1) | LU82795A1 (sv) |
| MX (1) | MX6580E (sv) |
| NL (1) | NL185923C (sv) |
| NO (2) | NO160370C (sv) |
| NZ (1) | NZ195058A (sv) |
| PH (1) | PH15697A (sv) |
| PL (1) | PL126949B1 (sv) |
| PT (1) | PT71837B (sv) |
| SE (2) | SE449865B (sv) |
| SU (1) | SU959628A3 (sv) |
| YU (1) | YU41733B (sv) |
| ZA (1) | ZA805132B (sv) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4364957A (en) * | 1979-09-26 | 1982-12-21 | Pfizer Inc. | Bis-esters of alkanediols as antibacterial agents |
| US4511512A (en) * | 1980-05-01 | 1985-04-16 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Produktionsaktiensel skab) | Substantially pure dicyclohexyl ammonium 6-β-bromo-penicillanate |
| US4361513A (en) * | 1980-12-11 | 1982-11-30 | Pfizer Inc. | Esters of penicillanic acid sulfone |
| US4474698A (en) * | 1980-12-11 | 1984-10-02 | Pfizer Inc. | Process for preparing esters of penicillanic acid sulfone |
| US4558042A (en) * | 1981-05-06 | 1985-12-10 | Farmitalia Carlo Erba S.P.A. | β-Lactam-containing antibacterial agents and β-lactamase inhibitors |
| ZA826687B (en) * | 1981-09-14 | 1983-07-27 | Pfizer | Beta-lactamase inhibiting 2-beta-substituted-2-alpha-methyl 5(r)penam-3-alpha-carboxylic acid 1,1-dioxides and intermediates therefor |
| JPS58185589A (ja) * | 1982-04-23 | 1983-10-29 | Taiho Yakuhin Kogyo Kk | ペニシリン誘導体 |
| JPS62198687A (ja) * | 1986-02-27 | 1987-09-02 | Taiho Yakuhin Kogyo Kk | ２β−置換チオメチルペニシリン誘導体 |
| US4861768A (en) * | 1986-02-27 | 1989-08-29 | Taiho Pharmaceutical Company, Limited | 2 β-substituted thiomethylpenicillin derivatives and their preparation and use |
| SK63894A3 (en) * | 1991-12-19 | 1995-03-08 | Novo Nordisk As | Method of preparation of beta-lactam antibiotic |
| CN115385934A (zh) * | 2022-10-26 | 2022-11-25 | 北京纳百生物科技有限公司 | 一种舒巴坦半抗原及其合成方法和应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN149747B (sv) * | 1977-06-07 | 1982-04-03 | Pfizer |
-
1979
- 1979-09-26 US US06/079,127 patent/US4256733A/en not_active Expired - Lifetime
-
1980
- 1980-08-13 SE SE8005714A patent/SE449865B/sv not_active IP Right Cessation
- 1980-08-20 ZA ZA00805132A patent/ZA805132B/xx unknown
- 1980-08-20 IN IN607/DEL/80A patent/IN154557B/en unknown
- 1980-09-19 SU SU802983144A patent/SU959628A3/ru active
- 1980-09-19 HU HU802310A patent/HU183212B/hu unknown
- 1980-09-22 PL PL1980226868A patent/PL126949B1/pl unknown
- 1980-09-22 CS CS806403A patent/CS212284B2/cs unknown
- 1980-09-23 AT AT0474680A patent/AT366384B/de not_active IP Right Cessation
- 1980-09-23 GB GB8030639A patent/GB2059420B/en not_active Expired
- 1980-09-23 EG EG584/80A patent/EG14888A/xx active
- 1980-09-23 GR GR62939A patent/GR70065B/el unknown
- 1980-09-23 CA CA000360886A patent/CA1150242A/en not_active Expired
- 1980-09-23 IL IL61117A patent/IL61117A/xx unknown
- 1980-09-24 PH PH24617A patent/PH15697A/en unknown
- 1980-09-24 LU LU82795A patent/LU82795A1/fr unknown
- 1980-09-24 DE DE3035995A patent/DE3035995C2/de not_active Expired
- 1980-09-24 KR KR1019800003721A patent/KR840000796B1/ko active
- 1980-09-24 AR AR282629A patent/AR224547A1/es active
- 1980-09-24 MX MX809044U patent/MX6580E/es unknown
- 1980-09-25 IT IT24920/80A patent/IT1132754B/it active
- 1980-09-25 FI FI803028A patent/FI67552C/fi not_active IP Right Cessation
- 1980-09-25 NO NO802836A patent/NO160370C/no unknown
- 1980-09-25 IE IE1095/85A patent/IE50507B1/en unknown
- 1980-09-25 NZ NZ195058A patent/NZ195058A/xx unknown
- 1980-09-25 PT PT71837A patent/PT71837B/pt unknown
- 1980-09-25 ES ES495354A patent/ES8106528A1/es not_active Expired
- 1980-09-25 FR FR8020618A patent/FR2465736A1/fr active Granted
- 1980-09-25 CH CH719980A patent/CH645646A5/fr not_active IP Right Cessation
- 1980-09-25 DD DD80224128A patent/DD153123A5/de unknown
- 1980-09-25 AU AU62713/80A patent/AU517074B2/en not_active Ceased
- 1980-09-25 BE BE0/202222A patent/BE885389A/fr not_active IP Right Cessation
- 1980-09-25 YU YU2449/80A patent/YU41733B/xx unknown
- 1980-09-25 IE IE1998/80A patent/IE50506B1/en not_active IP Right Cessation
- 1980-09-25 JP JP55133639A patent/JPS6016958B2/ja not_active Expired
- 1980-09-25 NL NLAANVRAGE8005344,A patent/NL185923C/xx not_active IP Right Cessation
- 1980-09-25 DK DK404980A patent/DK404980A/da not_active Application Discontinuation
-
1983
- 1983-03-25 NO NO83831082A patent/NO160299C/no unknown
- 1983-07-22 GB GB08319784A patent/GB2125037B/en not_active Expired
-
1984
- 1984-01-30 FI FI840367A patent/FI67854C/fi not_active IP Right Cessation
-
1985
- 1985-02-27 SE SE8500965A patent/SE461528B/sv not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: PFIZER INC. |