FI63587C - Foerfarande foer framstaellning av anti-inflammatoriska halogenerade 4-hydroxi-2-alkyl-3-karbamoyl-2h-tieno-1,2-tiazin-1,1-dioxidderivat - Google Patents

Foerfarande foer framstaellning av anti-inflammatoriska halogenerade 4-hydroxi-2-alkyl-3-karbamoyl-2h-tieno-1,2-tiazin-1,1-dioxidderivat Download PDF

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Publication number
FI63587C
FI63587C FI782737A FI782737A FI63587C FI 63587 C FI63587 C FI 63587C FI 782737 A FI782737 A FI 782737A FI 782737 A FI782737 A FI 782737A FI 63587 C FI63587 C FI 63587C
Authority
FI
Finland
Prior art keywords
methyl
pyridyl
formula
thiazine
hydroxy
Prior art date
Application number
FI782737A
Other languages
English (en)
Finnish (fi)
Other versions
FI782737A (fi
FI63587B (fi
Inventor
Dieter Binder
Otto Hromatka
Rudolf Dr Pfister
Paul Dr Zeller
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI782737A publication Critical patent/FI782737A/fi
Publication of FI63587B publication Critical patent/FI63587B/fi
Application granted granted Critical
Publication of FI63587C publication Critical patent/FI63587C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
FI782737A 1977-09-06 1978-09-06 Foerfarande foer framstaellning av anti-inflammatoriska halogenerade 4-hydroxi-2-alkyl-3-karbamoyl-2h-tieno-1,2-tiazin-1,1-dioxidderivat FI63587C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
LU78083 1977-09-06
LU78083 1977-09-06
CH790878 1978-07-21
CH790878 1978-07-21

Publications (3)

Publication Number Publication Date
FI782737A FI782737A (fi) 1979-03-07
FI63587B FI63587B (fi) 1983-03-31
FI63587C true FI63587C (fi) 1983-07-11

Family

ID=25702440

Family Applications (1)

Application Number Title Priority Date Filing Date
FI782737A FI63587C (fi) 1977-09-06 1978-09-06 Foerfarande foer framstaellning av anti-inflammatoriska halogenerade 4-hydroxi-2-alkyl-3-karbamoyl-2h-tieno-1,2-tiazin-1,1-dioxidderivat

Country Status (28)

Country Link
US (1) US4180662A (ja)
EP (1) EP0001113B1 (ja)
JP (1) JPS5448792A (ja)
AR (1) AR222472A1 (ja)
AT (1) AT364851B (ja)
AU (1) AU518216B2 (ja)
BR (1) BR7805845A (ja)
CA (1) CA1103246A (ja)
CS (1) CS202019B2 (ja)
DE (2) DE2861316D1 (ja)
DK (1) DK148280C (ja)
ES (1) ES473074A1 (ja)
FI (1) FI63587C (ja)
GB (1) GB2003877B (ja)
GR (1) GR73066B (ja)
HK (1) HK1085A (ja)
HU (1) HU176979B (ja)
IE (1) IE47261B1 (ja)
IL (1) IL55465A (ja)
IT (1) IT1099046B (ja)
LU (1) LU90207I2 (ja)
MC (1) MC1212A1 (ja)
NL (1) NL7809015A (ja)
NO (1) NO149174C (ja)
NZ (1) NZ188320A (ja)
PH (1) PH13949A (ja)
PT (1) PT68515A (ja)
SE (1) SE7809348L (ja)

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AT399880B (de) 1992-07-03 1995-08-25 Chem Pharm Forsch Gmbh Neue thienothiazinderivate, verfahren zu ihrer herstellung und ihre verwendung
AT400845B (de) * 1993-12-06 1996-03-25 Chem Pharm Forsch Gmbh Neue thienothiazinderivate, ein verfahren zu ihrer herstellung und ihre verwendung
EP0658559A1 (de) * 1993-12-14 1995-06-21 Chemisch Pharmazeutische Forschungsgesellschaft m.b.H. Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als 5-dipoxygenase und Cyclooxygenaseinhibitoren
DE19747625A1 (de) * 1997-10-29 1999-05-06 Bayer Ag Verfahren zur Herstellung von 3,5-Dimethylisoxazol-4-sulfochlorid
IT1308633B1 (it) 1999-03-02 2002-01-09 Nicox Sa Nitrossiderivati.
DE19933260A1 (de) 1999-07-15 2001-01-18 Bayer Ag Substituierte Thien-3-yl-sulfonylamino(thio)carbonyl-triazolin(thi)one
PL208713B1 (pl) * 2001-06-11 2011-05-31 Virochem Pharma Inc Związek stanowiący pochodną tiofenu, kompozycja farmaceutyczna zawierająca taki związek i jego zastosowanie
US8329924B2 (en) * 2001-06-11 2012-12-11 Vertex Pharmaceuticals (Canada) Incorporated Compounds and methods for the treatment or prevention of Flavivirus infections
CN1171892C (zh) * 2001-06-25 2004-10-20 李晶 具有抗炎镇痛活性的噻吩并噻嗪化合物及其制备方法和用途
PT1569929E (pt) 2002-12-10 2010-06-18 Virochem Pharma Inc Compostos e métodos para o tratamento ou prevenção de infecções por flavivírus
AT413944B (de) * 2003-05-27 2006-07-15 Binder Eva Dkfm Verwendung von oxicam-verbindungen
CN1266155C (zh) * 2003-08-01 2006-07-26 浙江震元制药有限公司 6－氯－4－羟基－2－甲基－2H－噻吩并（2，3－e）－1，2－噻嗪－1，1－二氧化物－3－羧酸酯的合成方法
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EA016071B1 (ru) * 2005-05-13 2012-01-30 Вирокем Фарма Инк. Соединения и способы лечения или предотвращения флавивирусных инфекций
US8431110B2 (en) 2005-05-23 2013-04-30 Hmi Medical Innovations, Llc. Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators
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US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
EP2084165B1 (en) 2006-10-11 2013-06-12 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of oxicams and related compounds with very high skin penetration rate
RS52874B (en) 2006-11-15 2013-12-31 Vertex Pharmaceuticals Incorporated THYOPHEN ANALYSIS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS
PL2170826T3 (pl) 2007-06-04 2022-09-05 Techfields Inc Proleki nsaia o bardzo wysokim współczynniku przenikania przez skórę i błony oraz ich nowe zastosowania lecznicze
CN101314598B (zh) * 2008-07-14 2012-03-21 浙江工业大学 5-氯-2-羧酸甲酯-3-甲胺基磺酰噻吩的合成新工艺
BRPI0922263B1 (pt) 2008-12-04 2021-08-31 Chongxi Yu Composição de alta penetração de um fármaco principal, e seus usos
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CN108218895B (zh) * 2018-04-13 2019-06-18 北京金城泰尔制药有限公司沧州分公司 一锅法合成氯诺昔康中间体的方法
CN112125792B (zh) * 2020-09-24 2022-07-12 万华化学集团股份有限公司 一种联产羟基香茅醛和羟基香茅醇的方法
CN112661742A (zh) * 2020-12-25 2021-04-16 北京金城泰尔制药有限公司 氯诺昔康金属化活性中间体的合成方法
CN112645925A (zh) * 2020-12-25 2021-04-13 北京金城泰尔制药有限公司 氯诺昔康中间体5-氯-3-甲基磺酰胺噻吩-2-羧酸甲酯的合成方法
CN114213434A (zh) * 2021-12-29 2022-03-22 北京金城泰尔制药有限公司 氯诺昔康晶型及其制备方法

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Also Published As

Publication number Publication date
NO149174C (no) 1984-02-29
NO783032L (no) 1979-03-07
MC1212A1 (fr) 1979-05-18
HK1085A (en) 1985-01-11
IE47261B1 (en) 1984-02-08
DE2861316D1 (en) 1982-01-14
BR7805845A (pt) 1979-04-24
DK148280C (da) 1985-11-18
FI782737A (fi) 1979-03-07
NZ188320A (en) 1981-01-23
EP0001113A1 (de) 1979-03-21
ATA642178A (de) 1981-04-15
CS202019B2 (en) 1980-12-31
NL7809015A (nl) 1979-03-08
GB2003877A (en) 1979-03-21
LU90207I2 (fr) 1998-04-29
AU518216B2 (en) 1981-09-17
FI63587B (fi) 1983-03-31
IE781788L (en) 1979-03-06
GB2003877B (en) 1982-03-17
JPS5448792A (en) 1979-04-17
DE2838851A1 (de) 1979-03-22
EP0001113B1 (de) 1981-11-11
US4180662A (en) 1979-12-25
NO149174B (no) 1983-11-21
DK148280B (da) 1985-05-28
PH13949A (en) 1980-11-04
AU3938978A (en) 1980-03-06
HU176979B (hu) 1981-06-28
IL55465A (en) 1982-02-28
GR73066B (ja) 1984-01-30
DK392778A (da) 1979-03-07
IT7827396A0 (it) 1978-09-06
ES473074A1 (es) 1979-10-16
AR222472A1 (es) 1981-05-29
AT364851B (de) 1981-11-25
PT68515A (en) 1978-10-01
SE7809348L (sv) 1979-03-07
IT1099046B (it) 1985-09-18
CA1103246A (en) 1981-06-16
IL55465A0 (en) 1978-10-31
JPS6149318B2 (ja) 1986-10-29

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