DK148280C - Analogifremgangsmaade til fremstilling af thienothiazinderivater - Google Patents

Analogifremgangsmaade til fremstilling af thienothiazinderivater

Info

Publication number
DK148280C
DK148280C DK392778A DK392778A DK148280C DK 148280 C DK148280 C DK 148280C DK 392778 A DK392778 A DK 392778A DK 392778 A DK392778 A DK 392778A DK 148280 C DK148280 C DK 148280C
Authority
DK
Denmark
Prior art keywords
preparation
analogy procedure
thienothiazine derivatives
thienothiazine
derivatives
Prior art date
Application number
DK392778A
Other languages
Danish (da)
English (en)
Other versions
DK148280B (da
DK392778A (da
Inventor
Dieter Binder
Otto Hromatka
Rudolf Dr Pfister
Paul Dr Zeller
Original Assignee
Chemie Linz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemie Linz Ag filed Critical Chemie Linz Ag
Publication of DK392778A publication Critical patent/DK392778A/da
Publication of DK148280B publication Critical patent/DK148280B/da
Application granted granted Critical
Publication of DK148280C publication Critical patent/DK148280C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30Hetero atoms other than halogen
    • C07D333/34Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
DK392778A 1977-09-06 1978-09-05 Analogifremgangsmaade til fremstilling af thienothiazinderivater DK148280C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
LU78083 1977-09-06
LU78083 1977-09-06
CH790878 1978-07-21
CH790878 1978-07-21

Publications (3)

Publication Number Publication Date
DK392778A DK392778A (da) 1979-03-07
DK148280B DK148280B (da) 1985-05-28
DK148280C true DK148280C (da) 1985-11-18

Family

ID=25702440

Family Applications (1)

Application Number Title Priority Date Filing Date
DK392778A DK148280C (da) 1977-09-06 1978-09-05 Analogifremgangsmaade til fremstilling af thienothiazinderivater

Country Status (28)

Country Link
US (1) US4180662A (ja)
EP (1) EP0001113B1 (ja)
JP (1) JPS5448792A (ja)
AR (1) AR222472A1 (ja)
AT (1) AT364851B (ja)
AU (1) AU518216B2 (ja)
BR (1) BR7805845A (ja)
CA (1) CA1103246A (ja)
CS (1) CS202019B2 (ja)
DE (2) DE2861316D1 (ja)
DK (1) DK148280C (ja)
ES (1) ES473074A1 (ja)
FI (1) FI63587C (ja)
GB (1) GB2003877B (ja)
GR (1) GR73066B (ja)
HK (1) HK1085A (ja)
HU (1) HU176979B (ja)
IE (1) IE47261B1 (ja)
IL (1) IL55465A (ja)
IT (1) IT1099046B (ja)
LU (1) LU90207I2 (ja)
MC (1) MC1212A1 (ja)
NL (1) NL7809015A (ja)
NO (1) NO149174C (ja)
NZ (1) NZ188320A (ja)
PH (1) PH13949A (ja)
PT (1) PT68515A (ja)
SE (1) SE7809348L (ja)

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JPS58109492A (ja) * 1981-12-22 1983-06-29 Mitsui Toatsu Chem Inc チエノチアジン誘導体およびそれを含有する医薬組成物
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US4551452A (en) * 1983-12-21 1985-11-05 Pfizer Inc. Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
DE3346526C2 (de) * 1983-12-22 1986-12-11 A. Nattermann & Cie GmbH, 5000 Köln Pharmazeutisches Präparat zur therapeutischen Behandlung von rheumatischen Erkrankungen
JPS60184077A (ja) * 1984-02-23 1985-09-19 フアイザー・インコーポレーテツド 抗炎症性オキシム前駆薬
US4656265A (en) * 1984-06-21 1987-04-07 Pfizer Inc. Cyclic prodrugs of antiinflammatory oxicams
US4623486A (en) 1985-05-29 1986-11-18 Pfizer Inc. [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
US4610982A (en) * 1985-06-03 1986-09-09 Pfizer Inc. Anti-inflammatory benzo- and thieno-1,2-thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
US4914101A (en) * 1987-06-10 1990-04-03 Pfizer Inc. 3,4-Dihydro-2-alkyl-3-oxo-n-aryl-2H-(1)benzo-thieno(3,2-e)-1,2-thiazine-4-carboxamide-1,1-dioxides
NZ226477A (en) * 1987-10-29 1990-07-26 Cl Pharma Substituted thieno (2,3-e)-1,2 thiazine derivatives and pharmaceutical compositions
ATA39088A (de) 1988-02-18 1990-06-15 Binder Dieter Dr Basisch substituierte thienoisothiazol-3(2h)-on-1,1-dioxide und ihre pharmazeutisch vertraeglichen salze, verfahren zu ihrer herstellung und ihre verwendung
AT390060B (de) * 1988-05-02 1990-03-12 Cl Pharma Verfahren zur herstellung von 5-chlor-3chlorsulfonyl-2-thiophencarbonsaeureestern
JPH01316314A (ja) * 1988-06-16 1989-12-21 Taisho Pharmaceut Co Ltd 湿布剤
JPH01316315A (ja) * 1988-06-16 1989-12-21 Taisho Pharmaceut Co Ltd 硬膏剤
AT400568B (de) * 1994-05-18 1996-01-25 Chem Pharm Forsch Gmbh Neue n-heterocyclische thienothiazincarboxamide, verfahren zu ihrer herstellung und ihre verwendung
AT400437B (de) * 1993-12-14 1995-12-27 Chem Pharm Forsch Gmbh Neue n-heterocyclische thienothiazincarboxamide, verfahren zu ihrer herstellung und ihre verwendung
DE4141218A1 (de) * 1991-12-13 1993-06-17 Luitpold Werk Chem Pharm Thiadiazincarbonsaeureamidderivate, verfahren zu ihrer herstellung und arzneimittel
AT399880B (de) 1992-07-03 1995-08-25 Chem Pharm Forsch Gmbh Neue thienothiazinderivate, verfahren zu ihrer herstellung und ihre verwendung
AT400845B (de) * 1993-12-06 1996-03-25 Chem Pharm Forsch Gmbh Neue thienothiazinderivate, ein verfahren zu ihrer herstellung und ihre verwendung
EP0658559A1 (de) * 1993-12-14 1995-06-21 Chemisch Pharmazeutische Forschungsgesellschaft m.b.H. Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als 5-dipoxygenase und Cyclooxygenaseinhibitoren
DE19747625A1 (de) * 1997-10-29 1999-05-06 Bayer Ag Verfahren zur Herstellung von 3,5-Dimethylisoxazol-4-sulfochlorid
IT1308633B1 (it) 1999-03-02 2002-01-09 Nicox Sa Nitrossiderivati.
DE19933260A1 (de) 1999-07-15 2001-01-18 Bayer Ag Substituierte Thien-3-yl-sulfonylamino(thio)carbonyl-triazolin(thi)one
PL208713B1 (pl) * 2001-06-11 2011-05-31 Virochem Pharma Inc Związek stanowiący pochodną tiofenu, kompozycja farmaceutyczna zawierająca taki związek i jego zastosowanie
US8329924B2 (en) * 2001-06-11 2012-12-11 Vertex Pharmaceuticals (Canada) Incorporated Compounds and methods for the treatment or prevention of Flavivirus infections
CN1171892C (zh) * 2001-06-25 2004-10-20 李晶 具有抗炎镇痛活性的噻吩并噻嗪化合物及其制备方法和用途
PT1569929E (pt) 2002-12-10 2010-06-18 Virochem Pharma Inc Compostos e métodos para o tratamento ou prevenção de infecções por flavivírus
AT413944B (de) * 2003-05-27 2006-07-15 Binder Eva Dkfm Verwendung von oxicam-verbindungen
CN1266155C (zh) * 2003-08-01 2006-07-26 浙江震元制药有限公司 6-氯-4-羟基-2-甲基-2H-噻吩并(2,3-e)-1,2-噻嗪-1,1-二氧化物-3-羧酸酯的合成方法
DE102004010812A1 (de) * 2004-03-05 2005-09-22 Bayer Cropscience Ag Unkrautbekämpfungsverfahren
AU2005247943A1 (en) 2004-05-23 2005-12-08 Gerard M. Housey Theramutein modulators
EA016071B1 (ru) * 2005-05-13 2012-01-30 Вирокем Фарма Инк. Соединения и способы лечения или предотвращения флавивирусных инфекций
US8431110B2 (en) 2005-05-23 2013-04-30 Hmi Medical Innovations, Llc. Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators
US20090275070A1 (en) * 2005-11-23 2009-11-05 Housey Gerard M Compounds and Methods of Identifying, Synthesizing, Optimizing and Profiling Protein Modulators
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
EP2084165B1 (en) 2006-10-11 2013-06-12 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of oxicams and related compounds with very high skin penetration rate
RS52874B (en) 2006-11-15 2013-12-31 Vertex Pharmaceuticals Incorporated THYOPHEN ANALYSIS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS
PL2170826T3 (pl) 2007-06-04 2022-09-05 Techfields Inc Proleki nsaia o bardzo wysokim współczynniku przenikania przez skórę i błony oraz ich nowe zastosowania lecznicze
CN101314598B (zh) * 2008-07-14 2012-03-21 浙江工业大学 5-氯-2-羧酸甲酯-3-甲胺基磺酰噻吩的合成新工艺
BRPI0922263B1 (pt) 2008-12-04 2021-08-31 Chongxi Yu Composição de alta penetração de um fármaco principal, e seus usos
EP4356912A2 (en) 2012-05-16 2024-04-24 Techfields Pharma Co., Ltd. High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions
ITUB20152229A1 (it) * 2015-07-16 2017-01-16 Edmond Pharma Srl Processo per la preparazione di farmaci antiinfiammatori non steroidei della classe oxicam
CN108218895B (zh) * 2018-04-13 2019-06-18 北京金城泰尔制药有限公司沧州分公司 一锅法合成氯诺昔康中间体的方法
CN112125792B (zh) * 2020-09-24 2022-07-12 万华化学集团股份有限公司 一种联产羟基香茅醛和羟基香茅醇的方法
CN112661742A (zh) * 2020-12-25 2021-04-16 北京金城泰尔制药有限公司 氯诺昔康金属化活性中间体的合成方法
CN112645925A (zh) * 2020-12-25 2021-04-13 北京金城泰尔制药有限公司 氯诺昔康中间体5-氯-3-甲基磺酰胺噻吩-2-羧酸甲酯的合成方法
CN114213434A (zh) * 2021-12-29 2022-03-22 北京金城泰尔制药有限公司 氯诺昔康晶型及其制备方法

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US3787324A (en) 1971-03-01 1974-01-22 Warner Lambert Co 4-hydroxy-3-(3-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,dioxides and process for their production
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MC1135A1 (fr) * 1976-02-23 1977-11-18 Hoffmann La Roche Derives de thiazine

Also Published As

Publication number Publication date
NO149174C (no) 1984-02-29
NO783032L (no) 1979-03-07
MC1212A1 (fr) 1979-05-18
HK1085A (en) 1985-01-11
IE47261B1 (en) 1984-02-08
DE2861316D1 (en) 1982-01-14
BR7805845A (pt) 1979-04-24
FI782737A (fi) 1979-03-07
NZ188320A (en) 1981-01-23
EP0001113A1 (de) 1979-03-21
ATA642178A (de) 1981-04-15
CS202019B2 (en) 1980-12-31
NL7809015A (nl) 1979-03-08
GB2003877A (en) 1979-03-21
LU90207I2 (fr) 1998-04-29
AU518216B2 (en) 1981-09-17
FI63587B (fi) 1983-03-31
IE781788L (en) 1979-03-06
GB2003877B (en) 1982-03-17
JPS5448792A (en) 1979-04-17
DE2838851A1 (de) 1979-03-22
EP0001113B1 (de) 1981-11-11
US4180662A (en) 1979-12-25
NO149174B (no) 1983-11-21
DK148280B (da) 1985-05-28
PH13949A (en) 1980-11-04
AU3938978A (en) 1980-03-06
HU176979B (hu) 1981-06-28
IL55465A (en) 1982-02-28
FI63587C (fi) 1983-07-11
GR73066B (ja) 1984-01-30
DK392778A (da) 1979-03-07
IT7827396A0 (it) 1978-09-06
ES473074A1 (es) 1979-10-16
AR222472A1 (es) 1981-05-29
AT364851B (de) 1981-11-25
PT68515A (en) 1978-10-01
SE7809348L (sv) 1979-03-07
IT1099046B (it) 1985-09-18
CA1103246A (en) 1981-06-16
IL55465A0 (en) 1978-10-31
JPS6149318B2 (ja) 1986-10-29

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