MC1212A1 - Derives de thiazine - Google Patents

Derives de thiazine

Info

Publication number
MC1212A1
MC1212A1 MC781322A MC1322A MC1212A1 MC 1212 A1 MC1212 A1 MC 1212A1 MC 781322 A MC781322 A MC 781322A MC 1322 A MC1322 A MC 1322A MC 1212 A1 MC1212 A1 MC 1212A1
Authority
MC
Monaco
Prior art keywords
thiazine derivatives
thiazine
derivatives
Prior art date
Application number
MC781322A
Other languages
English (en)
Inventor
O Hromatka
P Zeller
R Pfister
D Binder
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MC1212A1 publication Critical patent/MC1212A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
MC781322A 1977-09-06 1978-08-31 Derives de thiazine MC1212A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU78083 1977-09-06
CH790878 1978-07-21

Publications (1)

Publication Number Publication Date
MC1212A1 true MC1212A1 (fr) 1979-05-18

Family

ID=25702440

Family Applications (1)

Application Number Title Priority Date Filing Date
MC781322A MC1212A1 (fr) 1977-09-06 1978-08-31 Derives de thiazine

Country Status (28)

Country Link
US (1) US4180662A (fr)
EP (1) EP0001113B1 (fr)
JP (1) JPS5448792A (fr)
AR (1) AR222472A1 (fr)
AT (1) AT364851B (fr)
AU (1) AU518216B2 (fr)
BR (1) BR7805845A (fr)
CA (1) CA1103246A (fr)
CS (1) CS202019B2 (fr)
DE (2) DE2838851A1 (fr)
DK (1) DK148280C (fr)
ES (1) ES473074A1 (fr)
FI (1) FI63587C (fr)
GB (1) GB2003877B (fr)
GR (1) GR73066B (fr)
HK (1) HK1085A (fr)
HU (1) HU176979B (fr)
IE (1) IE47261B1 (fr)
IL (1) IL55465A (fr)
IT (1) IT1099046B (fr)
LU (1) LU90207I2 (fr)
MC (1) MC1212A1 (fr)
NL (1) NL7809015A (fr)
NO (1) NO149174C (fr)
NZ (1) NZ188320A (fr)
PH (1) PH13949A (fr)
PT (1) PT68515A (fr)
SE (1) SE7809348L (fr)

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AU5811280A (en) * 1979-06-13 1980-12-18 F. Hoffmann-La Roche Ag Thiazine derivatives
JPS58109492A (ja) * 1981-12-22 1983-06-29 Mitsui Toatsu Chem Inc チエノチアジン誘導体およびそれを含有する医薬組成物
EP0103142B1 (fr) * 1982-09-09 1987-04-22 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Dérivés de thiéno(2,3-e)-1,2-thiazine
GR80576B (en) * 1983-10-17 1984-11-29 Fujisawa Pharmaceutical Co Thiazine derivatives, process for preparation thereof and pharmaceutical composition comprising the same
US4551452A (en) * 1983-12-21 1985-11-05 Pfizer Inc. Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
DE3346526C2 (de) * 1983-12-22 1986-12-11 A. Nattermann & Cie GmbH, 5000 Köln Pharmazeutisches Präparat zur therapeutischen Behandlung von rheumatischen Erkrankungen
JPS60184077A (ja) * 1984-02-23 1985-09-19 フアイザー・インコーポレーテツド 抗炎症性オキシム前駆薬
US4656265A (en) * 1984-06-21 1987-04-07 Pfizer Inc. Cyclic prodrugs of antiinflammatory oxicams
US4623486A (en) * 1985-05-29 1986-11-18 Pfizer Inc. [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
US4610982A (en) * 1985-06-03 1986-09-09 Pfizer Inc. Anti-inflammatory benzo- and thieno-1,2-thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
MX174093B (es) * 1987-06-10 1994-04-21 Pfizer 1,1-DIOXIDOS DE 3,4-DIHIDRO-2-ALQUIL-3-OXO-N-ARIL-2H[1] BENZOTIENO[3,2-e]-1,2-TIAZINO-4-CARBOXIAMIDA
IL87951A (en) * 1987-10-29 1992-03-29 Chem Pharm Forsch Gmbh Carbonic acid esters of 6-chloro-4-(1-hydroxyethoxy)-2-methyl-n-(2-pyridyl)-2h-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide,their preparation and pharmaceutical compositions containing them
ATA39088A (de) 1988-02-18 1990-06-15 Binder Dieter Dr Basisch substituierte thienoisothiazol-3(2h)-on-1,1-dioxide und ihre pharmazeutisch vertraeglichen salze, verfahren zu ihrer herstellung und ihre verwendung
AT390060B (de) * 1988-05-02 1990-03-12 Cl Pharma Verfahren zur herstellung von 5-chlor-3chlorsulfonyl-2-thiophencarbonsaeureestern
JPH01316315A (ja) * 1988-06-16 1989-12-21 Taisho Pharmaceut Co Ltd 硬膏剤
JPH01316314A (ja) * 1988-06-16 1989-12-21 Taisho Pharmaceut Co Ltd 湿布剤
AT400437B (de) * 1993-12-14 1995-12-27 Chem Pharm Forsch Gmbh Neue n-heterocyclische thienothiazincarboxamide, verfahren zu ihrer herstellung und ihre verwendung
AT400568B (de) * 1994-05-18 1996-01-25 Chem Pharm Forsch Gmbh Neue n-heterocyclische thienothiazincarboxamide, verfahren zu ihrer herstellung und ihre verwendung
DE4141218A1 (de) * 1991-12-13 1993-06-17 Luitpold Werk Chem Pharm Thiadiazincarbonsaeureamidderivate, verfahren zu ihrer herstellung und arzneimittel
AT399880B (de) * 1992-07-03 1995-08-25 Chem Pharm Forsch Gmbh Neue thienothiazinderivate, verfahren zu ihrer herstellung und ihre verwendung
AT400845B (de) * 1993-12-06 1996-03-25 Chem Pharm Forsch Gmbh Neue thienothiazinderivate, ein verfahren zu ihrer herstellung und ihre verwendung
EP0658559A1 (fr) * 1993-12-14 1995-06-21 Chemisch Pharmazeutische Forschungsgesellschaft m.b.H. Dérivés thiénothianine, procédé pour leur préparation et leur application comme inhibiteurs de 5-dipoxygenase et cyclooxygenase
DE19747625A1 (de) * 1997-10-29 1999-05-06 Bayer Ag Verfahren zur Herstellung von 3,5-Dimethylisoxazol-4-sulfochlorid
IT1308633B1 (it) 1999-03-02 2002-01-09 Nicox Sa Nitrossiderivati.
DE19933260A1 (de) 1999-07-15 2001-01-18 Bayer Ag Substituierte Thien-3-yl-sulfonylamino(thio)carbonyl-triazolin(thi)one
CN101624391A (zh) * 2001-06-11 2010-01-13 病毒化学医药公司 用作黄病毒感染抗病毒剂的噻吩衍生物
US8329924B2 (en) * 2001-06-11 2012-12-11 Vertex Pharmaceuticals (Canada) Incorporated Compounds and methods for the treatment or prevention of Flavivirus infections
CN1171892C (zh) * 2001-06-25 2004-10-20 李晶 具有抗炎镇痛活性的噻吩并噻嗪化合物及其制备方法和用途
CN100413861C (zh) * 2002-12-10 2008-08-27 维勒凯姆制药股份有限公司 用于治疗或预防黄病毒感染的化合物
AT413944B (de) * 2003-05-27 2006-07-15 Binder Eva Dkfm Verwendung von oxicam-verbindungen
CN1266155C (zh) * 2003-08-01 2006-07-26 浙江震元制药有限公司 6－氯－4－羟基－2－甲基－2H－噻吩并（2，3－e）－1，2－噻嗪－1，1－二氧化物－3－羧酸酯的合成方法
DE102004010812A1 (de) * 2004-03-05 2005-09-22 Bayer Cropscience Ag Unkrautbekämpfungsverfahren
KR101347830B1 (ko) 2004-05-23 2014-01-07 에이치엠아이, 인코포레이티드 테라뮤틴 조절물질
JP5030947B2 (ja) 2005-05-13 2012-09-19 ヴァイロケム・ファーマ・インコーポレーテッド フラビウイルス感染の治療及び予防のための化合物及び方法
US8431110B2 (en) 2005-05-23 2013-04-30 Hmi Medical Innovations, Llc. Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators
JP2009523408A (ja) * 2005-11-23 2009-06-25 ジェラルド・エム・ハウシー タンパク質モジュレーターを同定、合成、最適化および解析する化合物群および方法群
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
WO2008044095A1 (fr) 2006-10-11 2008-04-17 Techfields Biochem Co. Ltd Pro-médicaments d'oxicams solubles dans l'eau et chargés positivement et composés apparentés avec une vitesse de pénétration de la peau très élevée
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
SG176488A1 (en) 2006-11-15 2011-12-29 Virochem Pharma Inc Thiophene analogues for the treatment or prevention of flavivirus infections
BRPI0721709B1 (pt) 2007-06-04 2024-03-12 Techfields Inc. PRÓ-FÁRMACOS DE NSAIAs, PROCESSO PARA PREPARAÇÃO DOS MESMOS, SEU USO, SISTEMAS TERAPÊUTICOS DE APLICAÇÃO TRANSDÉRMICA E COMPOSIÇÃO QUE OS COMPREENDE
CN101314598B (zh) * 2008-07-14 2012-03-21 浙江工业大学 5-氯-2-羧酸甲酯-3-甲胺基磺酰噻吩的合成新工艺
RU2630577C2 (ru) 2008-12-04 2017-09-11 Чунси ЮЙ Композиции интенсивного проникновения и их применение
MX2014013910A (es) 2012-05-16 2015-06-04 Techfields Pharma Co Ltd Composiciones de profarmacos de alta penetracion y composiciones farmaceuticas de los mismos para el tratamiento de afecciones pulmonares.
ITUB20152229A1 (it) * 2015-07-16 2017-01-16 Edmond Pharma Srl Processo per la preparazione di farmaci antiinfiammatori non steroidei della classe oxicam
CN108218895B (zh) * 2018-04-13 2019-06-18 北京金城泰尔制药有限公司沧州分公司 一锅法合成氯诺昔康中间体的方法
CN112125792B (zh) * 2020-09-24 2022-07-12 万华化学集团股份有限公司 一种联产羟基香茅醛和羟基香茅醇的方法
CN112661742A (zh) * 2020-12-25 2021-04-16 北京金城泰尔制药有限公司 氯诺昔康金属化活性中间体的合成方法
CN112645925A (zh) * 2020-12-25 2021-04-13 北京金城泰尔制药有限公司 氯诺昔康中间体5-氯-3-甲基磺酰胺噻吩-2-羧酸甲酯的合成方法
CN114213434A (zh) * 2021-12-29 2022-03-22 北京金城泰尔制药有限公司 氯诺昔康晶型及其制备方法

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GB1308533A (en) 1969-06-02 1973-02-21 Pfizer Benzothiazine dioxides as anti-thombotic agents
US3787324A (en) 1971-03-01 1974-01-22 Warner Lambert Co 4-hydroxy-3-(3-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,dioxides and process for their production
US3821211A (en) * 1972-03-10 1974-06-28 Warner Lambert Co Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolycarbamoyl)-2-methyl-2h-1,2-benzothiazine 1,1-dioxide
CA1010990A (en) 1973-06-06 1977-05-24 Leopold H. O'donnell Video tape recording animation system
IL47877A (en) 1974-08-26 1978-10-31 Sparamedica Ag Thienothiazine carboxamide derivatives,their manufacture and pharmaceutical compositions containing them
CA1066711A (fr) * 1974-08-26 1979-11-20 Hoffmann-La Roche Limited Derives de thiophene
MC1135A1 (fr) * 1976-02-23 1977-11-18 Hoffmann La Roche Derives de thiazine

Also Published As

Publication number Publication date
NL7809015A (nl) 1979-03-08
NZ188320A (en) 1981-01-23
BR7805845A (pt) 1979-04-24
FI63587B (fi) 1983-03-31
IT7827396A0 (it) 1978-09-06
HU176979B (hu) 1981-06-28
LU90207I2 (fr) 1998-04-29
DK392778A (da) 1979-03-07
HK1085A (en) 1985-01-11
FI782737A (fi) 1979-03-07
GB2003877A (en) 1979-03-21
AT364851B (de) 1981-11-25
ES473074A1 (es) 1979-10-16
DE2838851A1 (de) 1979-03-22
AR222472A1 (es) 1981-05-29
DE2861316D1 (en) 1982-01-14
IL55465A0 (en) 1978-10-31
FI63587C (fi) 1983-07-11
IE47261B1 (en) 1984-02-08
PT68515A (en) 1978-10-01
JPS5448792A (en) 1979-04-17
US4180662A (en) 1979-12-25
AU518216B2 (en) 1981-09-17
JPS6149318B2 (fr) 1986-10-29
AU3938978A (en) 1980-03-06
GB2003877B (en) 1982-03-17
EP0001113A1 (fr) 1979-03-21
SE7809348L (sv) 1979-03-07
NO783032L (no) 1979-03-07
DK148280B (da) 1985-05-28
IE781788L (en) 1979-03-06
IT1099046B (it) 1985-09-18
DK148280C (da) 1985-11-18
GR73066B (fr) 1984-01-30
CA1103246A (fr) 1981-06-16
CS202019B2 (en) 1980-12-31
EP0001113B1 (fr) 1981-11-11
NO149174B (no) 1983-11-21
IL55465A (en) 1982-02-28
ATA642178A (de) 1981-04-15
PH13949A (en) 1980-11-04
NO149174C (no) 1984-02-29

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