PT68515A - Process for preparing thiazine derivatives. - Google Patents

Process for preparing thiazine derivatives.

Info

Publication number
PT68515A
PT68515A PT68515A PT6851578A PT68515A PT 68515 A PT68515 A PT 68515A PT 68515 A PT68515 A PT 68515A PT 6851578 A PT6851578 A PT 6851578A PT 68515 A PT68515 A PT 68515A
Authority
PT
Portugal
Prior art keywords
preparing
thiazine derivatives
thiazine
derivatives
preparing thiazine
Prior art date
Application number
PT68515A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PT68515A publication Critical patent/PT68515A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
PT68515A 1977-09-06 1978-09-05 Process for preparing thiazine derivatives. PT68515A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU78083 1977-09-06
CH790878 1978-07-21

Publications (1)

Publication Number Publication Date
PT68515A true PT68515A (en) 1978-10-01

Family

ID=25702440

Family Applications (1)

Application Number Title Priority Date Filing Date
PT68515A PT68515A (en) 1977-09-06 1978-09-05 Process for preparing thiazine derivatives.

Country Status (28)

Country Link
US (1) US4180662A (pt)
EP (1) EP0001113B1 (pt)
JP (1) JPS5448792A (pt)
AR (1) AR222472A1 (pt)
AT (1) AT364851B (pt)
AU (1) AU518216B2 (pt)
BR (1) BR7805845A (pt)
CA (1) CA1103246A (pt)
CS (1) CS202019B2 (pt)
DE (2) DE2838851A1 (pt)
DK (1) DK148280C (pt)
ES (1) ES473074A1 (pt)
FI (1) FI63587C (pt)
GB (1) GB2003877B (pt)
GR (1) GR73066B (pt)
HK (1) HK1085A (pt)
HU (1) HU176979B (pt)
IE (1) IE47261B1 (pt)
IL (1) IL55465A (pt)
IT (1) IT1099046B (pt)
LU (1) LU90207I2 (pt)
MC (1) MC1212A1 (pt)
NL (1) NL7809015A (pt)
NO (1) NO149174C (pt)
NZ (1) NZ188320A (pt)
PH (1) PH13949A (pt)
PT (1) PT68515A (pt)
SE (1) SE7809348L (pt)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2838377A1 (de) * 1978-09-02 1980-03-20 Thomae Gmbh Dr K Neue 4-hydroxy-2h eckige klammer auf 1 eckige klammer zu benzothieno eckige klammer auf 2,3-e eckige klammer zu -1,2- thiazin-3-carboxamid-1,1-dioxide sowie deren salze, deren verwendung und verfahren zu ihrer herstellung
AU5811280A (en) * 1979-06-13 1980-12-18 F. Hoffmann-La Roche Ag Thiazine derivatives
JPS58109492A (ja) * 1981-12-22 1983-06-29 Mitsui Toatsu Chem Inc チエノチアジン誘導体およびそれを含有する医薬組成物
ATE26720T1 (de) * 1982-09-09 1987-05-15 Hoffmann La Roche Thieno(2,3-e)-1,2-thiazin-derivate.
GR80576B (en) * 1983-10-17 1984-11-29 Fujisawa Pharmaceutical Co Thiazine derivatives, process for preparation thereof and pharmaceutical composition comprising the same
US4551452A (en) * 1983-12-21 1985-11-05 Pfizer Inc. Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
DE3346526C2 (de) * 1983-12-22 1986-12-11 A. Nattermann & Cie GmbH, 5000 Köln Pharmazeutisches Präparat zur therapeutischen Behandlung von rheumatischen Erkrankungen
JPS60184077A (ja) * 1984-02-23 1985-09-19 フアイザー・インコーポレーテツド 抗炎症性オキシム前駆薬
US4656265A (en) * 1984-06-21 1987-04-07 Pfizer Inc. Cyclic prodrugs of antiinflammatory oxicams
US4623486A (en) 1985-05-29 1986-11-18 Pfizer Inc. [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
US4610982A (en) * 1985-06-03 1986-09-09 Pfizer Inc. Anti-inflammatory benzo- and thieno-1,2-thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
WO1988009793A1 (en) * 1987-06-10 1988-12-15 Pfizer Inc. 3,4-DIHYDRO-2-ALKYL-3-OXO-N-ARYL-2H-[1]BENZOTHIENO[3,2-e]-1,2-THIAZINE-4-CARBOXAMIDE-1,1-DIOXIDES
NZ226477A (en) * 1987-10-29 1990-07-26 Cl Pharma Substituted thieno (2,3-e)-1,2 thiazine derivatives and pharmaceutical compositions
ATA39088A (de) 1988-02-18 1990-06-15 Binder Dieter Dr Basisch substituierte thienoisothiazol-3(2h)-on-1,1-dioxide und ihre pharmazeutisch vertraeglichen salze, verfahren zu ihrer herstellung und ihre verwendung
AT390060B (de) * 1988-05-02 1990-03-12 Cl Pharma Verfahren zur herstellung von 5-chlor-3chlorsulfonyl-2-thiophencarbonsaeureestern
JPH01316315A (ja) * 1988-06-16 1989-12-21 Taisho Pharmaceut Co Ltd 硬膏剤
JPH01316314A (ja) * 1988-06-16 1989-12-21 Taisho Pharmaceut Co Ltd 湿布剤
AT400568B (de) * 1994-05-18 1996-01-25 Chem Pharm Forsch Gmbh Neue n-heterocyclische thienothiazincarboxamide, verfahren zu ihrer herstellung und ihre verwendung
AT400437B (de) * 1993-12-14 1995-12-27 Chem Pharm Forsch Gmbh Neue n-heterocyclische thienothiazincarboxamide, verfahren zu ihrer herstellung und ihre verwendung
DE4141218A1 (de) * 1991-12-13 1993-06-17 Luitpold Werk Chem Pharm Thiadiazincarbonsaeureamidderivate, verfahren zu ihrer herstellung und arzneimittel
AT399880B (de) * 1992-07-03 1995-08-25 Chem Pharm Forsch Gmbh Neue thienothiazinderivate, verfahren zu ihrer herstellung und ihre verwendung
AT400845B (de) * 1993-12-06 1996-03-25 Chem Pharm Forsch Gmbh Neue thienothiazinderivate, ein verfahren zu ihrer herstellung und ihre verwendung
EP0658559A1 (de) * 1993-12-14 1995-06-21 Chemisch Pharmazeutische Forschungsgesellschaft m.b.H. Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als 5-dipoxygenase und Cyclooxygenaseinhibitoren
DE19747625A1 (de) * 1997-10-29 1999-05-06 Bayer Ag Verfahren zur Herstellung von 3,5-Dimethylisoxazol-4-sulfochlorid
IT1308633B1 (it) 1999-03-02 2002-01-09 Nicox Sa Nitrossiderivati.
DE19933260A1 (de) * 1999-07-15 2001-01-18 Bayer Ag Substituierte Thien-3-yl-sulfonylamino(thio)carbonyl-triazolin(thi)one
US8329924B2 (en) * 2001-06-11 2012-12-11 Vertex Pharmaceuticals (Canada) Incorporated Compounds and methods for the treatment or prevention of Flavivirus infections
SK288015B6 (sk) * 2001-06-11 2012-11-05 Virochem Pharma Inc. Thiophene derivatives as antiviral agents for flavivirus infection
CN1171892C (zh) * 2001-06-25 2004-10-20 李晶 具有抗炎镇痛活性的噻吩并噻嗪化合物及其制备方法和用途
PT1569929E (pt) 2002-12-10 2010-06-18 Virochem Pharma Inc Compostos e métodos para o tratamento ou prevenção de infecções por flavivírus
AT413944B (de) * 2003-05-27 2006-07-15 Binder Eva Dkfm Verwendung von oxicam-verbindungen
CN1266155C (zh) * 2003-08-01 2006-07-26 浙江震元制药有限公司 6－氯－4－羟基－2－甲基－2H－噻吩并（2，3－e）－1，2－噻嗪－1，1－二氧化物－3－羧酸酯的合成方法
DE102004010812A1 (de) * 2004-03-05 2005-09-22 Bayer Cropscience Ag Unkrautbekämpfungsverfahren
KR101347830B1 (ko) * 2004-05-23 2014-01-07 에이치엠아이, 인코포레이티드 테라뮤틴 조절물질
US7569600B2 (en) 2005-05-13 2009-08-04 Virochem Pharma Inc. Compounds and methods for the treatment of prevention of Flavivirus infections
US8431110B2 (en) 2005-05-23 2013-04-30 Hmi Medical Innovations, Llc. Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators
CN103789389B (zh) * 2005-11-23 2017-01-04 杰勒德·M·豪斯 鉴定、合成、优化和表征蛋白调节剂的化合物和方法
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
CN101522692A (zh) 2006-10-11 2009-09-02 于崇曦 具有快速皮肤穿透速度的带正电荷的水溶性的昔康及其相关化合物的前药
SG176488A1 (en) 2006-11-15 2011-12-29 Virochem Pharma Inc Thiophene analogues for the treatment or prevention of flavivirus infections
RU2509076C2 (ru) * 2007-06-04 2014-03-10 Текфилдз Инк Пролекарства нестероидных противовоспалительных средств (nsaia) c очень высокой скоростью проникновения через кожу и мембраны и новые медицинские применения указанных пролекарств
CN101314598B (zh) * 2008-07-14 2012-03-21 浙江工业大学 5-氯-2-羧酸甲酯-3-甲胺基磺酰噻吩的合成新工艺
KR101753296B1 (ko) 2008-12-04 2017-07-03 충시 위 고투과력을 가진 조성물 및 이의 적용
BR112014028643A2 (pt) 2012-05-16 2021-08-03 Techfields Pharma Co., Ltd. profármaco de alta penetração, seu uso e composição farmacêutica para o tratamento de condições pulmonares
ITUB20152229A1 (it) * 2015-07-16 2017-01-16 Edmond Pharma Srl Processo per la preparazione di farmaci antiinfiammatori non steroidei della classe oxicam
CN108218895B (zh) * 2018-04-13 2019-06-18 北京金城泰尔制药有限公司沧州分公司 一锅法合成氯诺昔康中间体的方法
CN112125792B (zh) * 2020-09-24 2022-07-12 万华化学集团股份有限公司 一种联产羟基香茅醛和羟基香茅醇的方法
CN112661742A (zh) * 2020-12-25 2021-04-16 北京金城泰尔制药有限公司 氯诺昔康金属化活性中间体的合成方法
CN112645925A (zh) * 2020-12-25 2021-04-13 北京金城泰尔制药有限公司 氯诺昔康中间体5-氯-3-甲基磺酰胺噻吩-2-羧酸甲酯的合成方法
CN114213434A (zh) * 2021-12-29 2022-03-22 北京金城泰尔制药有限公司 氯诺昔康晶型及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1308533A (en) 1969-06-02 1973-02-21 Pfizer Benzothiazine dioxides as anti-thombotic agents
US3787324A (en) 1971-03-01 1974-01-22 Warner Lambert Co 4-hydroxy-3-(3-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,dioxides and process for their production
US3821211A (en) * 1972-03-10 1974-06-28 Warner Lambert Co Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolycarbamoyl)-2-methyl-2h-1,2-benzothiazine 1,1-dioxide
CA1010990A (en) 1973-06-06 1977-05-24 Leopold H. O'donnell Video tape recording animation system
CA1066711A (en) * 1974-08-26 1979-11-20 Hoffmann-La Roche Limited Thiophene derivatives
IL47877A (en) * 1974-08-26 1978-10-31 Sparamedica Ag Thienothiazine carboxamide derivatives,their manufacture and pharmaceutical compositions containing them
MC1135A1 (fr) * 1976-02-23 1977-11-18 Hoffmann La Roche Derives de thiazine

Also Published As

Publication number Publication date
IT7827396A0 (it) 1978-09-06
GB2003877B (en) 1982-03-17
SE7809348L (sv) 1979-03-07
IL55465A (en) 1982-02-28
CS202019B2 (en) 1980-12-31
IE47261B1 (en) 1984-02-08
NO149174C (no) 1984-02-29
GR73066B (pt) 1984-01-30
EP0001113B1 (de) 1981-11-11
EP0001113A1 (de) 1979-03-21
LU90207I2 (fr) 1998-04-29
AT364851B (de) 1981-11-25
NO783032L (no) 1979-03-07
HU176979B (hu) 1981-06-28
DK148280B (da) 1985-05-28
DE2838851A1 (de) 1979-03-22
JPS6149318B2 (pt) 1986-10-29
IL55465A0 (en) 1978-10-31
AU3938978A (en) 1980-03-06
ES473074A1 (es) 1979-10-16
DK148280C (da) 1985-11-18
FI782737A (fi) 1979-03-07
HK1085A (en) 1985-01-11
FI63587C (fi) 1983-07-11
DK392778A (da) 1979-03-07
FI63587B (fi) 1983-03-31
AU518216B2 (en) 1981-09-17
DE2861316D1 (en) 1982-01-14
CA1103246A (en) 1981-06-16
AR222472A1 (es) 1981-05-29
IT1099046B (it) 1985-09-18
PH13949A (en) 1980-11-04
NL7809015A (nl) 1979-03-08
US4180662A (en) 1979-12-25
JPS5448792A (en) 1979-04-17
BR7805845A (pt) 1979-04-24
NO149174B (no) 1983-11-21
GB2003877A (en) 1979-03-21
ATA642178A (de) 1981-04-15
IE781788L (en) 1979-03-06
MC1212A1 (fr) 1979-05-18
NZ188320A (en) 1981-01-23

Similar Documents

Publication Publication Date Title
PT68515A (en) Process for preparing thiazine derivatives.
YU199478A (en) Process for preparing triphenylalkene derivatives
YU41121B (en) Process for obtaining 1-phenyl-2-azolyl-4,4-dmethyl-1-pentene-3-ole
PT67865A (en) Process for preparing imidazodiazepine derivatives.
HU178992B (en) Process for preparing 3-indoly-tert. butylamino-propanol derivatives
YU41015B (en) Process for obtainig 2-formqequinoxaline -1,4-dioxyde cyanoacetylhydrazone
PT67980A (en) Process for preparing benzimidazole derivatives.
HU177722B (en) Process for preparing 14-amino-morfine derivatives
PT67615A (en) Process for preparing oxadiazolopyrimidine derivatives
PT67614A (en) Process for preparing oxadiazolopyrimidine derivatives
GB1537867A (en) Process for preparing 4-acylamino-piperidine derivatives
HU178247B (en) Process for preparing benzolsulphonyl-carbamide derivatives
HU178804B (en) Process for preparing 1-hidroxy-aporphine derivatives
PT67635A (en) Process for preparing everninomicin derivatives
HU179711B (en) Process for preparing steroid-spiro-oxazolidinone derivatives
PT67998A (en) Process for preparing novel phenylglycine derivatives.
PT67927A (en) Process for preparing d-homosteroids.
YU57478A (en) Process for obtaining 1,2,3-thiadiazoline-2-ide derivatives
YU40958B (en) Process for preparing new 1-phenyl-2-amino-1,3-propandiol-n-alkyl derivatives
PT68019A (en) Process for preparing semi-syntetic 4-sulfonylamino- oleandomycin derivatives.
PT71381B (en) Process for preparing thiazine derivatives
YU40418B (en) Process for obtainining halo-oxazoline derivatives
HU179661B (en) Process for preparing anthracene-bis carbonyl-hydrazone derivatives
HU179294B (en) Process for preparing pregn-4-en-3-oxime derivatives
HU177898B (en) Process for preparing amidine-phosphonate derivatives

Legal Events

Date Code Title Description
PC3A Transfer or assignment

Free format text: 930510 HAFSLUND NYCOMED PHARMA AKTIENGESELLSCHAFT AT