FI61485C - Foerfarande foer framstaellning av tetrahydroisokinoliniumderivat med muskel-nervblockerande inverkan - Google Patents

Foerfarande foer framstaellning av tetrahydroisokinoliniumderivat med muskel-nervblockerande inverkan Download PDF

Info

Publication number
FI61485C
FI61485C FI763543A FI763543A FI61485C FI 61485 C FI61485 C FI 61485C FI 763543 A FI763543 A FI 763543A FI 763543 A FI763543 A FI 763543A FI 61485 C FI61485 C FI 61485C
Authority
FI
Finland
Prior art keywords
formula
dioxa
bis
group
compound
Prior art date
Application number
FI763543A
Other languages
English (en)
Finnish (fi)
Other versions
FI61485B (fi
FI763543A (it
Inventor
John Bedford Stenlake
Roger David Waigh
George Henry Dewar
John Urwin
Nirmal Chandra Dhar
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26265501&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI61485(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB4502876A external-priority patent/GB1579822A/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of FI763543A publication Critical patent/FI763543A/fi
Publication of FI61485B publication Critical patent/FI61485B/fi
Application granted granted Critical
Publication of FI61485C publication Critical patent/FI61485C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI763543A 1975-12-10 1976-12-09 Foerfarande foer framstaellning av tetrahydroisokinoliniumderivat med muskel-nervblockerande inverkan FI61485C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB5058975 1975-12-10
GB5058975 1975-12-10
GB4502876A GB1579822A (en) 1976-10-29 1976-10-29 Tetrahydroisoquinolinium muscle relaxants
GB4502876 1976-10-29

Publications (3)

Publication Number Publication Date
FI763543A FI763543A (it) 1977-06-11
FI61485B FI61485B (fi) 1982-04-30
FI61485C true FI61485C (fi) 1982-08-10

Family

ID=26265501

Family Applications (1)

Application Number Title Priority Date Filing Date
FI763543A FI61485C (fi) 1975-12-10 1976-12-09 Foerfarande foer framstaellning av tetrahydroisokinoliniumderivat med muskel-nervblockerande inverkan

Country Status (24)

Country Link
US (1) US4179507A (it)
JP (1) JPS6043342B2 (it)
AT (1) AT365579B (it)
AU (1) AU506657B2 (it)
CA (1) CA1075241A (it)
CH (1) CH625223A5 (it)
CY (1) CY1217A (it)
DD (1) DD128320A5 (it)
DE (1) DE2655883A1 (it)
DK (1) DK149751C (it)
FI (1) FI61485C (it)
FR (1) FR2334359A1 (it)
HK (1) HK35084A (it)
IE (1) IE44569B1 (it)
IL (1) IL51074A (it)
IT (1) IT1188908B (it)
KE (1) KE3361A (it)
LU (1) LU76355A1 (it)
MC (1) MC1119A1 (it)
MY (1) MY8500287A (it)
NL (1) NL178688C (it)
NZ (1) NZ182847A (it)
SE (1) SE434154B (it)
SU (1) SU718008A3 (it)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1125287A (en) * 1978-07-21 1982-06-08 John J. Savarese Bis isoquinolinium compositions and methods of use
US4235906A (en) 1978-07-21 1980-11-25 Massachusetts General Hospital Bis-isoquinolinium compounds, compositions and methods of use
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
US4315935A (en) * 1980-04-14 1982-02-16 Smithkline Corporation N,N'-Bis[substituted-1,2,3,4-tetrahydroisoquinolinolyl]disulfonylimides and antiallergic compositions and method of use
US4317826A (en) * 1980-05-27 1982-03-02 Smithkline Corporation N,N'-Bis[substituted-1,2,3,4 tetrahydroisoquinolyl]disulfonylimides and antiallergic compositions and method of use
US4701460A (en) * 1980-12-17 1987-10-20 Burroughs Wellcome Co. Long duration neuromuscular blocking agents
GB8418303D0 (en) * 1984-07-18 1984-08-22 Wellcome Found Compounds
GB9015473D0 (en) 1990-07-13 1990-08-29 Wellcome Found Neuromuscular blocking agents
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
US5510355A (en) * 1994-09-06 1996-04-23 Bencherif; Merouane Depolarizing skeletal muscle relaxants
IT1277700B1 (it) * 1995-12-22 1997-11-11 Poli Ind Chimica Spa Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura
US5684154A (en) * 1996-02-16 1997-11-04 Abbott Laboratories Process for the preparation and isolation of atracurium besylate
DE69840816D1 (de) * 1997-03-25 2009-06-18 Avera Pharmaceuticals Inc Isochinoline und deren Herstellung
GB0204087D0 (en) * 2002-02-21 2002-04-10 Legislator 1563 Ltd Di-ester derivatives as short acting neuromuscular blockers
JP5213137B2 (ja) * 2006-12-06 2013-06-19 コーネル リサーチ ファウンデーション， インコーポレイテッド 中程度の持続時間の神経筋遮断剤およびそのアンタゴニスト
US8461338B2 (en) * 2007-03-08 2013-06-11 Chemagis Ltd. (1R, 1′R)-atracurium salts separation process
EP2125743A1 (en) * 2007-03-26 2009-12-02 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
BRPI0809892A2 (pt) * 2007-05-01 2014-09-30 Chemagis Ltd Composto de isoquinolínio, forma cristalina, composto cristalino (vii) e método para preparar cis-atracúrio
EP2155684B1 (en) * 2007-05-01 2014-04-09 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
US8357805B2 (en) * 2007-06-18 2013-01-22 Chemagis Ltd. (1R,1′R)-atracurium salts separation process
CN101337936B (zh) * 2007-07-06 2011-03-23 江苏恒瑞医药股份有限公司 一种用柱色谱法纯化苯磺酸阿曲库铵的方法
CN101337935B (zh) * 2007-07-06 2011-01-12 江苏恒瑞医药股份有限公司 一种用两相萃取法纯化苯磺酸阿曲库铵的方法
BRPI0812625A2 (pt) * 2007-07-09 2019-02-19 Chemagis Ltd processo para preparar um sal de cis-atracúrio
US8354537B2 (en) * 2007-10-29 2013-01-15 Chemagis Ltd. R,R1-atracurium salts
US20110185796A1 (en) * 2008-05-01 2011-08-04 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
US8592451B2 (en) 2009-03-17 2013-11-26 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
BRPI1013562B1 (pt) * 2009-04-14 2021-08-03 Glaxo Group Limited Processo para a preparação do composto, e, composto
CN102573794B (zh) 2009-08-19 2017-03-15 康奈尔大学 供生理注射用的半胱氨酸
EP2514754B1 (en) 2011-04-08 2013-08-21 King Saud University 6,7-dihydro-[1,3,4]thiadiazolo-[3,2-a][1,3]diazepin derivatives and pharmaceutical composition containing the same as neuromuscular blocker or skeletal muscle relaxant, and method for the preparation
CN102249998B (zh) * 2011-06-20 2013-09-25 浙江仙琚制药股份有限公司 一种制备顺苯磺酸阿曲库铵的方法
CN102898370A (zh) * 2012-11-11 2013-01-30 苏州二叶制药有限公司 注射用顺苯磺阿曲库铵
WO2018193463A1 (en) * 2017-04-21 2018-10-25 Neon Laboratories Limited An improved process for the preparation of tetrahydroisoquinoline compounds
CN114181147A (zh) * 2021-12-27 2022-03-15 上海药坦药物研究开发有限公司 一种苯磺阿曲库铵的处理方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3004031A (en) * 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
GB1125619A (en) * 1965-11-15 1968-08-28 Wellcome Found Derivatives of bis-isoquinolines

Also Published As

Publication number Publication date
IT8048000A0 (it) 1980-02-25
IE44569L (en) 1977-06-10
IL51074A0 (en) 1977-02-28
CH625223A5 (it) 1981-09-15
DK149751B (da) 1986-09-22
IT8048000A1 (it) 1981-08-25
AU2037576A (en) 1978-06-15
KE3361A (en) 1984-02-17
DE2655883C2 (it) 1990-02-01
AT365579B (de) 1982-01-25
NZ182847A (en) 1979-06-08
DK149751C (da) 1987-03-23
AU506657B2 (en) 1980-01-17
SE434154B (sv) 1984-07-09
FI61485B (fi) 1982-04-30
MC1119A1 (fr) 1977-08-12
SU718008A3 (ru) 1980-02-25
LU76355A1 (it) 1977-06-24
CY1217A (en) 1984-04-06
JPS5277069A (en) 1977-06-29
HK35084A (en) 1984-04-27
FR2334359A1 (fr) 1977-07-08
US4179507A (en) 1979-12-18
MY8500287A (en) 1985-12-31
IL51074A (en) 1980-05-30
NL178688C (nl) 1986-05-01
DE2655883A1 (de) 1977-06-23
NL178688B (nl) 1985-12-02
FI763543A (it) 1977-06-11
SE7613824L (sv) 1977-06-11
DK553676A (da) 1977-06-11
ATA908476A (de) 1981-06-15
FR2334359B1 (it) 1981-10-16
DD128320A5 (de) 1977-11-09
JPS6043342B2 (ja) 1985-09-27
NL7613695A (nl) 1977-06-14
CA1075241A (en) 1980-04-08
IT1188908B (it) 1988-01-28
IE44569B1 (en) 1982-01-13

Similar Documents

Publication Publication Date Title
FI61485C (fi) Foerfarande foer framstaellning av tetrahydroisokinoliniumderivat med muskel-nervblockerande inverkan
FI78479B (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara aryloxi-hydroxipropylenpiperazinylacetanilider.
RU2095357C1 (ru) Производные бензофурана, бензотиофена, индола или индолизина, способы их получения, композиция, обладающая антиаритмическим действием
FI59990C (fi) Foerfarande foer framstaellning av pao centralnervsystemet verkande racemiska eller optiskt aktiva arylpiperaziner samt deras syraadditionssalter
FI85019B (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara (e)-4-oktendioylbis (oxitrimetylen) bis (1,2,3,4-tetrahydro-6,7-dimetoxi-2-metyl-1-(3,4,5-trimetoxibensyl) isokinolinium) foereningar.
US4169152A (en) Isohexide and tetrahydrofuran ethers and their carbamates in method of bringing about relaxation of skeletal musculature
EA002224B1 (ru) Замещенные изохинолины в качестве нервно-мышечных блокаторов ультракраткосрочного действия
US20110185796A1 (en) Cisatracurium derivatives, preparation and uses thereof
FI62079C (fi) Foerfarande foer framstaellning av pao centralnervsystemet verkande n-(metoximetylfurylmetyl)-6,7-benzomorfaner och deras syraadditionssalter
CN103145617A (zh) 菲啶类衍生物及其药物组合物和其制备方法与应用
US4491665A (en) Method of preparing isomers of bis isoquinolinium compounds
CS197300B2 (en) Method of producing new 1-/isoquinoline-1-one-2-yl and 1,2,3,4-tetrahydrobenzazepine-1-one-2-ylalkyl/ phenyl-et
US5240939A (en) Nitrogen bridge tetrahydroisoquinolines
Aoyama et al. Synthesis and structure-activity study of protease inhibitors. IV. Amidinonaphthols and related acyl derivatives
CS195653B2 (en) Method of producing new aminoalkoxyphenylderivatives
Omodei-Sale et al. A new class of nonhormonal pregnancy-terminating agents. Synthesis and contragestational activity of 3, 5-diaryl-s-triazoles
DK165786B (da) Fremgangsmaade til fremstilling af 1-(2-chlorethyl)-1-nitrosourinstoffer
US6300368B1 (en) Anilide derivatives and antiarrhythmic agents containing the same
US4340595A (en) Aminopropanol derivatives of 6-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one and pharmaceutical formulations containing the said compounds
GB1579822A (en) Tetrahydroisoquinolinium muscle relaxants
USRE38460E1 (en) Huperzine A derivatives, their preparation and their use
FI67537C (fi) Foerfarande foer framstaellning av farmakologiskt vaerdefulla nya 1,2-bis-dialkylaminoetoxi-3-fenoxipropaner
US4952602A (en) Phenyl benzothiophene hypolipidemic derivatives
UA46790C2 (uk) 1-ар(алк)ілімідазолін-2-они, які містять дизаміщений аміновий радикал в 4 положенні, спосіб їх одержання, фармацевтичний препарат і спосіб лікування епілепсії (варіанти)
McCarthy et al. New bicyclic antidepressant agent. Synthesis and activity of napactadine and related compounds

Legal Events

Date Code Title Description
MA Patent expired
MA Patent expired

Owner name: THE WELLCOME FOUNDATION LIMITED