FI59408C - Foerfarande foer framstaellning av farmakologiskt vaerdefulla bensimidazoler - Google Patents

Foerfarande foer framstaellning av farmakologiskt vaerdefulla bensimidazoler Download PDF

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Publication number
FI59408C
FI59408C FI751700A FI751700A FI59408C FI 59408 C FI59408 C FI 59408C FI 751700 A FI751700 A FI 751700A FI 751700 A FI751700 A FI 751700A FI 59408 C FI59408 C FI 59408C
Authority
FI
Finland
Prior art keywords
oxo
phenyl
benzimidazole
dihydro
pyridazinyl
Prior art date
Application number
FI751700A
Other languages
English (en)
Finnish (fi)
Other versions
FI59408B (fi
FI751700A (ru
Inventor
Volkard Austel
Eberhard Kutter
Joachim Heider
Wolfgang Eberlein
Rudolf Kadatz
Willi Diederen
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19742427943 external-priority patent/DE2427943C2/de
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of FI751700A publication Critical patent/FI751700A/fi
Application granted granted Critical
Publication of FI59408B publication Critical patent/FI59408B/fi
Publication of FI59408C publication Critical patent/FI59408C/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI751700A 1974-06-10 1975-06-09 Foerfarande foer framstaellning av farmakologiskt vaerdefulla bensimidazoler FI59408C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE2427943 1974-06-10
DE19742427943 DE2427943C2 (de) 1974-06-10 1974-06-10 Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE2516040A DE2516040C2 (de) 1974-06-10 1975-04-12 Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE2516040 1975-04-12

Publications (3)

Publication Number Publication Date
FI751700A FI751700A (ru) 1975-12-11
FI59408B FI59408B (fi) 1981-04-30
FI59408C true FI59408C (fi) 1981-08-10

Family

ID=25767253

Family Applications (1)

Application Number Title Priority Date Filing Date
FI751700A FI59408C (fi) 1974-06-10 1975-06-09 Foerfarande foer framstaellning av farmakologiskt vaerdefulla bensimidazoler

Country Status (23)

Country Link
US (1) US4026891A (ru)
JP (1) JPS6015632B2 (ru)
AT (1) AT342610B (ru)
BE (1) BE830030A (ru)
BG (2) BG23216A3 (ru)
CA (1) CA1041095A (ru)
CH (1) CH620438A5 (ru)
CS (1) CS195292B2 (ru)
DD (1) DD120440A5 (ru)
DE (1) DE2516040C2 (ru)
DK (1) DK258975A (ru)
ES (2) ES437296A1 (ru)
FI (1) FI59408C (ru)
FR (1) FR2273545A1 (ru)
GB (1) GB1466547A (ru)
HU (1) HU171059B (ru)
IE (1) IE41257B1 (ru)
IL (1) IL47445A (ru)
NL (1) NL178969C (ru)
NO (1) NO142402C (ru)
PH (1) PH14298A (ru)
RO (1) RO68750A (ru)
SE (1) SE420836B (ru)

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JPS53117215A (en) * 1977-03-24 1978-10-13 Hideyoshi Morita Earthquakeeproof steel beam
ES482789A0 (es) * 1978-08-25 1980-12-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona
US4258185A (en) * 1978-10-17 1981-03-24 Yoshitomi Pharmaceutical Industries, Ltd. Pyridazinone compounds
DE2935359A1 (de) * 1979-09-01 1981-03-26 Basf Ag, 67063 Ludwigshafen 6-imidazolyl-3-hydrazino-pyridazine
DE3006671A1 (de) * 1980-02-22 1981-08-27 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzoxazole, deren herstellung und deren verwendung als arzneumittel
US4699909A (en) * 1981-07-25 1987-10-13 Dr. Karl Thomae Gmbh Benzotriazolyl-4,5-dihydro-3(2H)-pyridazinones
DE3129447A1 (de) * 1981-07-25 1983-02-10 Dr. Karl Thomae Gmbh, 7950 Biberach "neue benztriazole, ihre herstellung und ihre verwendung als arzneimittel"
ZA859091B (en) * 1984-12-24 1987-07-29 Warner Lambert Co Novel 6-substituted-2 (1h)-quinolinones and related compounds having use as cardiotonic,anti-hypertensive,and anti-thrombotic agents
US4840955A (en) * 1984-12-24 1989-06-20 Warner-Lambert Company 6-substituted-2(1H)-quinolinones and related compounds having use as cardiotonic, antihypertensive, and antithrombotic agents
US4868300A (en) * 1985-11-22 1989-09-19 Rorer Pharmaceutical Corporation Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses
US4906630A (en) * 1985-11-22 1990-03-06 Rorer Pharmaceutical Corporation Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds
US4725686A (en) * 1985-11-22 1988-02-16 William H. Rorer, Inc. Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses
US4785101A (en) * 1985-11-22 1988-11-15 Rorer Pharmaceutical Corporation Benzodiazinone-hydroxypyrazolyl compounds, cardiotonic compositions including the same and their uses
JPS62249019A (ja) * 1986-04-21 1987-10-30 Anritsu Corp 組合せ計量装置
JPS62249018A (ja) * 1986-04-21 1987-10-30 Anritsu Corp 組合せ計量装置
US5002944A (en) * 1986-10-29 1991-03-26 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having cardiotonic activity
US4859672A (en) * 1986-10-29 1989-08-22 Rorer Pharmaceutical Corporation Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone
JPS63181827U (ru) * 1987-05-13 1988-11-24
DE4237656A1 (de) * 1992-06-13 1993-12-16 Merck Patent Gmbh Benzimidazolderivate
US6465484B1 (en) 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
US6162804A (en) * 1997-09-26 2000-12-19 Merck & Co., Inc. Tyrosine kinase inhibitors
ES2215327T3 (es) * 1998-10-23 2004-10-01 Toray Industries, Inc. Composicion de medicamento inmunomodulador.
US20050119251A1 (en) * 2001-12-21 2005-06-02 Jian-Min Fu Nicotinamide derivatives and their use as therapeutic agents
US20030236259A1 (en) * 2002-02-05 2003-12-25 Rolf Hohlweg Novel aryl- and heteroarylpiperazines
US7547698B2 (en) * 2004-09-20 2009-06-16 Xenon Pharmaceuticals Inc. Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-coadesaturase (SCD)
EP2289510A1 (en) 2004-09-20 2011-03-02 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
EP1807085B1 (en) 2004-09-20 2013-08-21 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
JP5094398B2 (ja) 2004-09-20 2012-12-12 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環式誘導体およびステアロイル−CoAデサチュラーゼのメディエータとしてのそれらの使用
CN101084207A (zh) * 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途
MX2007003321A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como agentes terapeuticos.
US7829712B2 (en) 2004-09-20 2010-11-09 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase
AU2005329423A1 (en) * 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
JP4714921B2 (ja) * 2005-02-14 2011-07-06 トーアエイヨー株式会社 ピモベンダンの製造法及びその中間体
CN101208089A (zh) * 2005-06-03 2008-06-25 泽农医药公司 氨基噻唑衍生物作为人硬酯酰-CoA去饱和酶抑制剂
ATE536344T1 (de) * 2005-07-04 2011-12-15 High Point Pharmaceuticals Llc Histamine h3 receptor antagonisten
MX2008002166A (es) * 2005-08-15 2008-04-22 Irm Llc Compuestos y composiciones como mimeticos de trombopoietina (tpo).
PL2079732T3 (pl) * 2006-05-29 2012-05-31 High Point Pharmaceuticals Llc 3-(1,3-benzodioksol-5-ylo)-6-(4-cyklopropylopiperazyn-1-ylo)-pirydazyna, jej sole i solwaty oraz jej zastosowanie jako antagonisty receptora histaminowego h3
EP2014656A3 (en) * 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
EP2408766A1 (en) * 2009-03-18 2012-01-25 Schering Corporation Bicyclic compounds as inhibitors of diacylglycerol acyltransferase
MY174339A (en) 2012-08-13 2020-04-09 Novartis Ag 1,4-disubstituted pyridazine analogs and methods for treating smn-deficiency-related conditions
MX2020011652A (es) * 2013-07-31 2022-09-27 Novartis Ag Derivados de piridazina 1,4-disustituida, y su uso para el tratamiento de afecciones relacionadas con la deficiencia de smn.
WO2018086703A1 (en) * 2016-11-11 2018-05-17 Bayer Pharma Aktiengesellschaft Dihydropyridazinones substituted with phenylureas

Family Cites Families (4)

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Publication number Priority date Publication date Assignee Title
IL23847A (en) * 1964-08-07 1969-02-27 Merck & Co Inc Benzimidazoles useful as antifungals
US3705157A (en) * 1970-10-19 1972-12-05 American Cyanamid Co Azolylpyridazine compounds and quaternary salts thereof
US3935209A (en) * 1973-03-12 1976-01-27 Syntex (U.S.A.) Inc. 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity
US3969526A (en) * 1973-05-29 1976-07-13 Smithkline Corporation Anthelmintic 5-heterocycliothio and oxy-2-carbalkoxyaminobenzimidazles

Also Published As

Publication number Publication date
NO142402B (no) 1980-05-05
ES437296A1 (es) 1977-01-01
FR2273545B1 (ru) 1979-08-10
ES441340A1 (es) 1977-03-16
SE420836B (sv) 1981-11-02
FR2273545A1 (fr) 1976-01-02
SE7506583L (sv) 1975-12-11
US4026891A (en) 1977-05-31
DE2516040A1 (de) 1976-11-04
GB1466547A (en) 1977-03-09
FI59408B (fi) 1981-04-30
CA1041095A (en) 1978-10-24
PH14298A (en) 1981-05-19
FI751700A (ru) 1975-12-11
NL178969C (nl) 1986-06-16
RO68750A (ro) 1980-03-15
BG24052A3 (en) 1977-12-15
DE2516040C2 (de) 1984-12-20
ATA344575A (de) 1977-08-15
DK258975A (da) 1975-12-11
IE41257L (en) 1975-12-10
CS195292B2 (en) 1980-01-31
CH620438A5 (ru) 1980-11-28
BG23216A3 (ru) 1977-07-12
IL47445A (en) 1978-07-31
JPS516980A (ru) 1976-01-20
NL7506806A (nl) 1975-12-12
HU171059B (hu) 1977-10-28
JPS6015632B2 (ja) 1985-04-20
AU8192675A (en) 1976-12-16
AT342610B (de) 1978-04-10
NO752022L (ru) 1975-12-11
NO142402C (no) 1980-08-13
DD120440A5 (ru) 1976-06-12
IL47445A0 (en) 1975-08-31
IE41257B1 (en) 1979-11-21
BE830030A (fr) 1975-12-09

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Owner name: DR. KARL THOMAE GESELLSCHAFT MIT