FI119881B - Substituoituja 1-okso- ja 1,3-dioksoisoindoliineja ja niiden käyttö farmaseuttisissa koostumuksissa tulehdullisten sytokiinitasojen laskemiseksi - Google Patents

Substituoituja 1-okso- ja 1,3-dioksoisoindoliineja ja niiden käyttö farmaseuttisissa koostumuksissa tulehdullisten sytokiinitasojen laskemiseksi Download PDF

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Publication number
FI119881B
FI119881B FI20011839A FI20011839A FI119881B FI 119881 B FI119881 B FI 119881B FI 20011839 A FI20011839 A FI 20011839A FI 20011839 A FI20011839 A FI 20011839A FI 119881 B FI119881 B FI 119881B
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FI
Finland
Prior art keywords
compound
acid
amino
nitro
dioxoisoindolin
Prior art date
Application number
FI20011839A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI20011839A (fi
Inventor
David I Stirling
George W Muller
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Celgene Corp
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Publication of FI20011839A publication Critical patent/FI20011839A/fi
Application granted granted Critical
Publication of FI119881B publication Critical patent/FI119881B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
FI20011839A 1999-03-18 2001-09-18 Substituoituja 1-okso- ja 1,3-dioksoisoindoliineja ja niiden käyttö farmaseuttisissa koostumuksissa tulehdullisten sytokiinitasojen laskemiseksi FI119881B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12494299P 1999-03-18 1999-03-18
US12494299 1999-03-18
PCT/US2000/007029 WO2000055134A1 (fr) 1999-03-18 2000-03-17 1-oxo- et 1,3-dioxoisoindolines substituees et leur utilisation dans des compositions pharmaceutiques afin de reduire les taux de cytokines inflammatoires
US0007029 2000-03-17

Publications (2)

Publication Number Publication Date
FI20011839A FI20011839A (fi) 2001-09-18
FI119881B true FI119881B (fi) 2009-04-30

Family

ID=22417530

Family Applications (1)

Application Number Title Priority Date Filing Date
FI20011839A FI119881B (fi) 1999-03-18 2001-09-18 Substituoituja 1-okso- ja 1,3-dioksoisoindoliineja ja niiden käyttö farmaseuttisissa koostumuksissa tulehdullisten sytokiinitasojen laskemiseksi

Country Status (22)

Country Link
US (1) US6380239B1 (fr)
EP (1) EP1163219B1 (fr)
JP (1) JP4728487B2 (fr)
KR (1) KR100672892B1 (fr)
CN (1) CN1342146A (fr)
AT (1) ATE306469T1 (fr)
AU (1) AU771015B2 (fr)
BR (1) BR0010042A (fr)
CA (1) CA2361806C (fr)
CZ (1) CZ20013338A3 (fr)
DE (1) DE60023123T2 (fr)
DK (1) DK1163219T3 (fr)
ES (1) ES2250121T3 (fr)
FI (1) FI119881B (fr)
HK (1) HK1042494A1 (fr)
HU (1) HUP0200499A3 (fr)
NO (2) NO320028B1 (fr)
NZ (1) NZ513953A (fr)
RU (1) RU2001121987A (fr)
TR (1) TR200102688T2 (fr)
TW (1) TWI229074B (fr)
WO (1) WO2000055134A1 (fr)

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JP2002539197A (ja) 2002-11-19
HUP0200499A2 (en) 2002-06-29
AU771015B2 (en) 2004-03-11
NO20013982L (no) 2001-11-16
DE60023123D1 (de) 2006-02-23
CZ20013338A3 (cs) 2002-03-13
KR100672892B1 (ko) 2007-01-23
DE60023123T2 (de) 2006-06-22
NO20054581L (no) 2001-11-16
CA2361806A1 (fr) 2000-09-21
EP1163219B1 (fr) 2005-10-12
DK1163219T3 (da) 2006-02-27
RU2001121987A (ru) 2004-02-27
BR0010042A (pt) 2002-01-15
EP1163219A1 (fr) 2001-12-19
NO320028B1 (no) 2005-10-10
CA2361806C (fr) 2012-03-13
HUP0200499A3 (en) 2002-12-28
JP4728487B2 (ja) 2011-07-20
ES2250121T3 (es) 2006-04-16
NO20013982D0 (no) 2001-08-16
TR200102688T2 (tr) 2002-01-21
FI20011839A (fi) 2001-09-18
US6380239B1 (en) 2002-04-30
CN1342146A (zh) 2002-03-27
TWI229074B (en) 2005-03-11
WO2000055134A1 (fr) 2000-09-21
NZ513953A (en) 2001-09-28
ATE306469T1 (de) 2005-10-15
AU3755000A (en) 2000-10-04
HK1042494A1 (zh) 2002-08-16
KR20010109310A (ko) 2001-12-08

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