FI119880B - 2,2-dikloralkankarboxylsyror, en metod för deras framställning, läkemedel, vilka innehåller dessa och deras användning för behandling av insulinresistens - Google Patents
2,2-dikloralkankarboxylsyror, en metod för deras framställning, läkemedel, vilka innehåller dessa och deras användning för behandling av insulinresistens Download PDFInfo
- Publication number
- FI119880B FI119880B FI971951A FI971951A FI119880B FI 119880 B FI119880 B FI 119880B FI 971951 A FI971951 A FI 971951A FI 971951 A FI971951 A FI 971951A FI 119880 B FI119880 B FI 119880B
- Authority
- FI
- Finland
- Prior art keywords
- eller
- phenyl
- alkyl
- mmol
- group
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
- C07C17/2632—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving an organo-magnesium compound, e.g. Grignard synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
- C07C17/2635—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving a phosphorus compound, e.g. Wittig synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
- C07C17/266—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions of hydrocarbons and halogenated hydrocarbons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/19—Acids containing three or more carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/23—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
- C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/63—Halogen-containing esters of saturated acids
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4439947A DE4439947A1 (de) | 1994-11-09 | 1994-11-09 | 2,2-Dichloralkancarbonsäuren, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
DE4439947 | 1994-11-09 | ||
EP9504413 | 1995-11-09 | ||
PCT/EP1995/004413 WO1996015784A2 (de) | 1994-11-09 | 1995-11-09 | 2,2-dichloralkancarbonsäuren, verfahren zu ihrer herstellung diese enthaltende arzneimittel, und ihre verwendung zur behandlung der insulinresistenz |
Publications (3)
Publication Number | Publication Date |
---|---|
FI971951A0 FI971951A0 (sv) | 1997-05-07 |
FI971951A FI971951A (sv) | 1997-07-07 |
FI119880B true FI119880B (sv) | 2009-04-30 |
Family
ID=6532833
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI971951A FI119880B (sv) | 1994-11-09 | 1997-05-07 | 2,2-dikloralkankarboxylsyror, en metod för deras framställning, läkemedel, vilka innehåller dessa och deras användning för behandling av insulinresistens |
Country Status (23)
Country | Link |
---|---|
US (1) | US5968982A (sv) |
EP (1) | EP0790824B1 (sv) |
JP (1) | JP3012004B2 (sv) |
KR (1) | KR100273888B1 (sv) |
CN (1) | CN1105558C (sv) |
AT (1) | ATE212834T1 (sv) |
AU (1) | AU699480B2 (sv) |
CZ (1) | CZ294254B6 (sv) |
DE (2) | DE4439947A1 (sv) |
DK (1) | DK0790824T3 (sv) |
ES (1) | ES2170813T3 (sv) |
FI (1) | FI119880B (sv) |
HU (1) | HU224820B1 (sv) |
IL (1) | IL115920A (sv) |
NO (1) | NO316764B1 (sv) |
NZ (1) | NZ296524A (sv) |
PL (1) | PL181689B1 (sv) |
PT (1) | PT790824E (sv) |
RU (1) | RU2197960C2 (sv) |
SK (1) | SK284019B6 (sv) |
TW (1) | TW371656B (sv) |
WO (1) | WO1996015784A2 (sv) |
ZA (1) | ZA959451B (sv) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19605700A1 (de) * | 1996-02-16 | 1997-08-21 | Boehringer Mannheim Gmbh | 2,2-Difluoralkancarbonsäuren, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
WO1999029640A2 (en) * | 1997-12-05 | 1999-06-17 | Eisai Co., Ltd. | Compositions and methods for modulating the activity of fibroblast growth factor |
NZ513329A (en) * | 1999-02-05 | 2003-11-28 | Baylor University Medical Ct | Nutritional supplement or pharmaceutical preparation comprising triglycerides with seven-carbon fatty acid |
US20030162833A1 (en) | 2001-08-01 | 2003-08-28 | Roe Charles R. | Fatty acid treatment for cardiac patients |
US6740679B1 (en) * | 1999-02-05 | 2004-05-25 | Baylor University Medical Center | Nutritional supplement or pharmaceutical preparation comprising triglycerides with seven-carbon fatty acid |
CA2348799A1 (fr) * | 2001-05-22 | 2002-11-22 | Marcel Blais | Appareil d'essai de composants electroniques |
US20060051410A1 (en) * | 2002-01-16 | 2006-03-09 | Kobayashi Shin-Ichiro | Pharmaceutical composition containing 2,2-dichloro-12-(4-chlorophenyl)-dodecanoic acid |
SE0300988D0 (sv) * | 2003-04-03 | 2003-04-03 | Astrazeneca Ab | New use |
DE602004018634D1 (de) * | 2003-05-23 | 2009-02-05 | Kowa Co | Carbonsäureverbindung und arzneimittel welches diese enthält |
CN100368374C (zh) * | 2003-05-23 | 2008-02-13 | 兴和株式会社 | 羧酸化合物及含有该化合物的医药 |
US7109242B2 (en) * | 2003-05-23 | 2006-09-19 | Kowa Company, Ltd. | Carboxylic compound and medicine comprising the same |
GEP20084406B (en) | 2003-05-30 | 2008-06-25 | Ranbaxy Lab Ltd | Substituted pyrrole derivatives and their use as hmg-co inhibitors |
JPWO2005112944A1 (ja) * | 2004-05-21 | 2008-03-27 | 興和株式会社 | 糖尿病の予防または治療のための薬剤 |
WO2005117855A1 (ja) * | 2004-06-04 | 2005-12-15 | Kowa Company., Ltd. | 糖尿病の予防または治療のための薬剤 |
WO2006014353A2 (en) | 2004-07-02 | 2006-02-09 | Baylor Research Institute | Glycogen or polysaccharide storage disease treatment method |
US20060025478A1 (en) * | 2004-07-27 | 2006-02-02 | Keisuke Inoue | Medicine for prevention or treatment of diabetes |
EP1772149A1 (en) * | 2004-07-27 | 2007-04-11 | Kowa Company. Ltd. | Drug for prevention or treatment of diabetes |
WO2006118187A1 (ja) * | 2005-04-28 | 2006-11-09 | Ube Industries, Ltd. | 2,2-ジクロロ-12-(4-ハロフェニル)ドデカン酸塩及びその製造中間体の製法 |
AU2006313430B2 (en) | 2005-11-08 | 2012-09-06 | Ranbaxy Laboratories Limited | Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
MX2009002282A (es) | 2006-09-07 | 2009-03-20 | Nycomed Gmbh | Tratamiento de combinacion para diabetes mellitius. |
JP5298631B2 (ja) * | 2007-05-18 | 2013-09-25 | 住友化学株式会社 | 有機硫黄化合物及びその有害節足動物防除用途 |
JP2009001551A (ja) * | 2007-05-18 | 2009-01-08 | Sumitomo Chemical Co Ltd | 有機硫黄化合物及びその有害節足動物防除用途 |
CA2963857A1 (en) | 2007-06-04 | 2008-12-11 | Ben-Gurion University Of The Negev Research And Development Authority | Tri-aryl compounds and compositions comprising the same |
US8497382B2 (en) | 2008-12-01 | 2013-07-30 | Mitsubishi Tanabe Pharma Corporation | Carboxylic acid derivative containing thiazole ring and pharmaceutical use thereof |
JP6657101B2 (ja) | 2013-11-05 | 2020-03-04 | ベン グリオン ユニバーシティ オブ ザ ネガフ リサーチ アンド ディベロップメント オーソリティ | 糖尿病及びそれから生じる疾患合併症の治療のための化合物 |
KR101624040B1 (ko) * | 2014-09-05 | 2016-05-25 | 박종희 | 쓰레기 컨테이너 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3573332A (en) * | 1968-07-19 | 1971-03-30 | Union Oil Co | Preparation of aliphatic acids and esters |
IL64542A0 (en) * | 1981-12-15 | 1982-03-31 | Yissum Res Dev Co | Long-chain alpha,omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them |
DE3634356A1 (de) * | 1986-10-08 | 1988-04-21 | Epis Sa | Arzneimittel enthaltend alpha-halogenierte dicarbonsaeuren |
DE4224670A1 (de) * | 1992-07-25 | 1994-01-27 | Boehringer Mannheim Gmbh | Verwendung von â,w-Dicarbonsäuren als Fibrinogensenker |
-
1994
- 1994-11-09 DE DE4439947A patent/DE4439947A1/de not_active Withdrawn
-
1995
- 1995-11-08 IL IL11592095A patent/IL115920A/xx not_active IP Right Cessation
- 1995-11-08 TW TW084111846A patent/TW371656B/zh active
- 1995-11-08 ZA ZA959451A patent/ZA959451B/xx unknown
- 1995-11-09 EP EP95939248A patent/EP0790824B1/de not_active Expired - Lifetime
- 1995-11-09 HU HU9800381A patent/HU224820B1/hu not_active IP Right Cessation
- 1995-11-09 RU RU97109840/14A patent/RU2197960C2/ru not_active IP Right Cessation
- 1995-11-09 JP JP8516511A patent/JP3012004B2/ja not_active Expired - Fee Related
- 1995-11-09 NZ NZ296524A patent/NZ296524A/xx not_active IP Right Cessation
- 1995-11-09 DK DK95939248T patent/DK0790824T3/da active
- 1995-11-09 PT PT95939248T patent/PT790824E/pt unknown
- 1995-11-09 CN CN95197101A patent/CN1105558C/zh not_active Expired - Fee Related
- 1995-11-09 KR KR1019970703140A patent/KR100273888B1/ko not_active IP Right Cessation
- 1995-11-09 AT AT95939248T patent/ATE212834T1/de not_active IP Right Cessation
- 1995-11-09 SK SK568-97A patent/SK284019B6/sk not_active IP Right Cessation
- 1995-11-09 CZ CZ19971320A patent/CZ294254B6/cs not_active IP Right Cessation
- 1995-11-09 ES ES95939248T patent/ES2170813T3/es not_active Expired - Lifetime
- 1995-11-09 DE DE59510042T patent/DE59510042D1/de not_active Expired - Fee Related
- 1995-11-09 US US08/817,925 patent/US5968982A/en not_active Expired - Fee Related
- 1995-11-09 AU AU41153/96A patent/AU699480B2/en not_active Ceased
- 1995-11-09 WO PCT/EP1995/004413 patent/WO1996015784A2/de active IP Right Grant
- 1995-11-09 PL PL95320167A patent/PL181689B1/pl not_active IP Right Cessation
-
1997
- 1997-05-07 NO NO19972128A patent/NO316764B1/no not_active IP Right Cessation
- 1997-05-07 FI FI971951A patent/FI119880B/sv active IP Right Grant
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