FI117556B - Rekombinant-DNA-förfarande för produktion av den glialderiverade neurotrofiska faktorn - Google Patents

Rekombinant-DNA-förfarande för produktion av den glialderiverade neurotrofiska faktorn Download PDF

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Publication number
FI117556B
FI117556B FI941285A FI941285A FI117556B FI 117556 B FI117556 B FI 117556B FI 941285 A FI941285 A FI 941285A FI 941285 A FI941285 A FI 941285A FI 117556 B FI117556 B FI 117556B
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gdnf
acid sequence
sequence
nucleic acid
cells
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FI941285A
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Finnish (fi)
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FI941285A (sv
FI941285A0 (sv
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Franklin D Collins
Daniel H Doherty
Leu-Fen H Lin
Jack Lile
Susan Bektesh
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Amgen Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Claims (6)

1. Rekombinant DNA-förfarande för produktion av den glialderiverade neurotrofiskä faktorn (GDNF), kän-5 netecknat av att det omfattar stegen: (a) delkloning av en nukleinsyrasekvens, som kodar för den glialderiverade neurotrofiskä faktorn (GDNF), in i en expressionsvektor som innehäller de reglerande elemen-ten, vilka behövs för exprimering av den däri delklonade 10 nukleinsyrasekvensen, och väri nämnda nukleinsyrasekvens omfattar en nukleinsyrasekvens som har valts bland följan- ; de: i. en nukleinsyrasekvens, som kodar för en i figur 13 visad aminosyrasekvens (sekvens ID-nummer 3) av pre- 15. pro-rätt-GDNF; ii. en nukleinsyrasekvens, som kodar för en i fi- I gur 13 visad aminosyrasekvens (sekvens ID-nummer 4) av i fullvuxet rätt-GDNF; iii. en nukleinsyrasekvens, som kodar för en i fi- 20 gur 19 (sekvens ID-nummer 5) och 22 (sekvens ID-nummer 8) : visad aminosyrasekvens av human pre-pro-GDNF; • · · ’.'V iv. en nukleinsyrasekvens, som kodar för en i fi- • · · . rj \ *. gur 19 visad aminosyrasekvens (sekvens ID-nummer 6) av * * fullvuxet human GDNF; ·····' 25 v. en nukleinsyrasekvens, som kodar för en amino- • · * ·...* syrasekvens med en över 70-procentig homologigrad med • · · V * sekvenser visade med ID-nummer 4; vi. en nukleinsyrasekvens, som kodar för en amino- S Γ*ϊ syrasekvens med en över 70-procentig homologigrad med :***: 30 sekvenser visade med ID-nummer 6; * · · 1. vii. en nukleinsyrasekvens, som hybridiseras under • · · J stränga förhällanden med den komplementära sekvensen av . * · >' *·;·* den i punkt (i)-(vi) visade sekvensen *t**: (b) transformering av en värdcell med nämnda ex- ·*·.· 35 pressionsvektor; • · '4 ·. . I 117556 104 (c) odling av värdceller i förhällanden för förök- ning av vektorn och expression av den glialderiverade neu-rotrofiska faktorn (GDNF); och : (d) tillvaratagande av den glialderiverade neuro-5 trofiska faktorn (GDNF) frän värdcellodlingen.
2. Rekombinant-DNA-förfarande enligt patentkrav 1, kännetecknat av att det dessutom omfattar ett steg, där den tillvaratagna glialderiverade neurotrofiska fak- torn (GDNF) ätervikas och där den ätervikade GDNF har en 10 förmäga att främja upptagningen av dopamin i dopaminerga neuroner.
3. Rekombinant DNA-förfarande enligt patentkrav 1 eller 2, kännetecknat av att värdcellen är en animal cell. .,:,-
4. Rekombinant DNA-förfarande enligt patentkrav 3, kännetecknat av att värdcellen är en C0S-7-cell.
5. Rekombinant DNA-förfarande enligt patentkrav 1 eller 2, kännetecknat av att värdcellen är en bakte-riecell. ;
6. Rekombinant DNA-förfarande enligt patentkrav 5, kännetecknat av att värdcellen är coli. • · • · · • · · * · * · • « • · • · • · · • ·· • · · · · • * f # ··· • · · • * ® ' · · . .·. | • · · ? • · · • « · A • · • · ··· ··· • * * • * · • · • · • * • · · • · t Λ 1 *:»·; _ · '•f’it·
FI941285A 1991-09-20 1994-03-18 Rekombinant-DNA-förfarande för produktion av den glialderiverade neurotrofiska faktorn FI117556B (sv)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US76468591A 1991-09-20 1991-09-20
US76468591 1991-09-20
US77410991A 1991-10-08 1991-10-08
US77410991 1991-10-08
US78842391A 1991-11-06 1991-11-06
US78842391 1991-11-06
US85541392A 1992-03-19 1992-03-19
US85541392 1992-03-19
US9207888 1992-09-17
PCT/US1992/007888 WO1993006116A1 (en) 1991-09-20 1992-09-17 Glial derived neurotrophic factor

Publications (3)

Publication Number Publication Date
FI941285A FI941285A (sv) 1994-03-18
FI941285A0 FI941285A0 (sv) 1994-03-18
FI117556B true FI117556B (sv) 2006-11-30

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FI941285A FI117556B (sv) 1991-09-20 1994-03-18 Rekombinant-DNA-förfarande för produktion av den glialderiverade neurotrofiska faktorn

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US (7) US7226758B1 (sv)
EP (2) EP1243652A3 (sv)
KR (1) KR100242093B1 (sv)
AT (1) ATE275197T1 (sv)
AU (2) AU679167B2 (sv)
CA (1) CA2119463C (sv)
DE (1) DE69233407T2 (sv)
DK (1) DK0610254T3 (sv)
ES (1) ES2225819T3 (sv)
FI (1) FI117556B (sv)
GE (1) GEP20002243B (sv)
HK (2) HK1017816A1 (sv)
HU (2) HU220795B1 (sv)
IL (5) IL103223A (sv)
MX (1) MX9205293A (sv)
NO (1) NO321382B1 (sv)
NZ (1) NZ244392A (sv)
PT (1) PT100879B (sv)
SG (1) SG48145A1 (sv)
TW (1) TW401422B (sv)
WO (1) WO1993006116A1 (sv)

Families Citing this family (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981165A (en) * 1991-07-08 1999-11-09 Neurospheres Holdings Ltd. In vitro induction of dopaminergic cells
WO1995006662A1 (en) * 1993-09-01 1995-03-09 Start Technology Partnership Neuron regulatory factor for promoting neuron survival
AU1443095A (en) * 1993-12-22 1995-07-10 University Of Medicine And Dentistry Of New Jersey Novel nucleic acid sequences isolated from glial cells
US6472585B1 (en) 1994-04-25 2002-10-29 Genentech, Inc. Cardiotrophin-1 defective mouse
US7258983B2 (en) 1994-04-25 2007-08-21 Genentech, Inc. Cardiotrophin-1 compositions and methods for the treatment of tumor
US5534615A (en) * 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
JP3906314B2 (ja) * 1994-04-25 2007-04-18 ジェネンテク・インコーポレイテッド カルジオトロフィンおよびその使用
US5853385A (en) * 1994-08-26 1998-12-29 Cytotherapeutics, Inc. Encapsulated PC12 cell transplants for treatment of Parkinson's disease
US5733875A (en) * 1994-11-15 1998-03-31 Amgen Inc. Methods of using GDNF as a neuroprotective agent
JP3093974B2 (ja) * 1995-06-27 2000-10-03 住友ベークライト株式会社 神経細胞用培養液、その製造方法及びこれを用いる神経細胞の培養方法
US6743628B1 (en) 1995-08-28 2004-06-01 Washington University Method of cell culture using neurturin
US5739307A (en) * 1995-08-28 1998-04-14 Washington University Polynucleotide encoding neurturin neurotrophic factor
US5731284A (en) * 1995-09-28 1998-03-24 Amgen Inc. Method for treating Alzheimer's disease using glial line-derived neurotrophic factor (GDNF) protein product
US6184200B1 (en) * 1995-09-28 2001-02-06 Amgen Inc. Truncated glial cell line-derived neurotrophic factor
US5641749A (en) * 1995-11-29 1997-06-24 Amgen Inc. Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product
US5641750A (en) * 1995-11-29 1997-06-24 Amgen Inc. Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product
AU1121997A (en) * 1995-11-29 1997-06-19 Amgen, Inc. Method for treating sensory neuropathy using glial cell line-derived neurotrophic factor (gdnf) protein product
US5905027A (en) * 1995-12-27 1999-05-18 Uab Research Foundation Method of diagnosing and treating gliomas
US5837681A (en) * 1996-02-23 1998-11-17 Amgen Inc. Method for treating sensorineural hearing loss using glial cell line-derived neurotrophic factor (GDNF) protein product
US5929041A (en) * 1996-02-23 1999-07-27 Amgen Inc. Method for preventing and treating sensorineural hearing loss and vestibular disorders using glial cell line-derived neurotrophic factor(GDNF) protein product
JP4301347B2 (ja) 1996-03-14 2009-07-22 ジェネンテク， インコーポレイテッド Ｇｄｎｆおよびｇｄｎｆ受容体の用途
US6222022B1 (en) 1996-03-14 2001-04-24 Washington University Persephin and related growth factors
US6716600B1 (en) 1996-03-14 2004-04-06 Washington University Persephin and related growth factors
ES2237793T3 (es) 1996-03-14 2005-08-01 Washington University Persefina y factores de crecimiento relacionados.
US5741778A (en) * 1996-03-19 1998-04-21 Amgen Inc. Method for treating Huntington's disease using glial cell line-derived neurotrophic factor (GDNF) protein product
US6299895B1 (en) 1997-03-24 2001-10-09 Neurotech S.A. Device and method for treating ophthalmic diseases
US6455277B1 (en) * 1996-04-22 2002-09-24 Amgen Inc. Polynucleotides encoding human glial cell line-derived neurotrophic factor receptor polypeptides
US7138251B1 (en) 1996-04-22 2006-11-21 Amgen Inc. Polynucleotides encoding a neurotrophic factor receptor
AU2677797A (en) * 1996-04-25 1997-11-12 Genetic Therapy, Inc. Viral vectors including polynucleotides encoding neurotrophic factors and uses therefor
EP0922101B1 (en) * 1996-07-29 2003-12-17 BIOPHARM Gesellschaft zur biotechnologischen Entwicklung und zum Vertrieb von Pharmaka mbH Egf-like factor from chromaffin granules and glia cell-derived neurotrophic factor with survival-promoting activity on daergic neurons
ES2308800T3 (es) 1997-01-08 2008-12-01 Invitrogen Corporation Metodos para la produccion de proteinas.
US6777196B2 (en) 1997-02-18 2004-08-17 Genentech, Inc. Neurturin receptor
US6025157A (en) 1997-02-18 2000-02-15 Genentech, Inc. Neurturin receptor
US6372453B1 (en) 1997-02-18 2002-04-16 Genetech, Inc. Neurturin receptor
US6042579A (en) * 1997-04-30 2000-03-28 Medtronic, Inc. Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain
US6043221A (en) * 1997-07-30 2000-03-28 Amgen Inc. Method for preventing and treating hearing loss using a neuturin protein product
EP1304119A3 (en) * 1997-07-30 2004-01-21 Amgen Inc. Method for preventing and treating hearing loss using a neurturin protein product
DE69837600T2 (de) * 1997-08-05 2007-12-27 F. Hoffmann-La Roche Ag Aus einer menschlichen glial zelllinie-abgeleiteter promotor eines neurotrophischen faktors, diesen enthaltende vektoren und methoden zum screenen von verbindungen damit
US7026138B1 (en) 1998-03-23 2006-04-11 Genentech, Inc. Polynucleotides encoding GFRα3
AU765070B2 (en) 1998-03-23 2003-09-11 Genentech Inc. GFRalpha3 and its uses
DE19816186A1 (de) * 1998-04-14 1999-10-21 Univ Muenchen L Maximilians GDNF-kodierende DNA, Teile davon und GDNF-Varianten
US6593133B1 (en) 1998-07-06 2003-07-15 Nsgene A/S Neurotrophic factors
US6284540B1 (en) * 1998-09-29 2001-09-04 Washington University Artemin, a novel neurotrophic factor
US7060676B2 (en) 1999-12-20 2006-06-13 Trustees Of Tufts College T. cruzi-derived neurotrophic agents and methods of use therefor
US20040014082A1 (en) * 2000-08-11 2004-01-22 Invitrogen Corporation Highly homogeneous molecular markers for electrophoresis
US6426065B1 (en) * 2000-11-07 2002-07-30 Clairol Incorporated Use of tris(hydroxymethyl)aminomethane in cold permanent waving processes
US7442370B2 (en) 2001-02-01 2008-10-28 Biogen Idec Ma Inc. Polymer conjugates of mutated neublastin
US7276580B2 (en) 2001-03-12 2007-10-02 Biogen Idec Ma Inc. Neurotrophic factors
AU2002250203B2 (en) 2001-03-28 2006-08-10 Biogen Ma Inc. Use of neublastin polypeptides for treating neuropathic pain
US20030050273A1 (en) * 2001-08-29 2003-03-13 Keiya Ozawa Compositions and methods for treating neurodegenerative diseases
US7613491B2 (en) * 2002-05-22 2009-11-03 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
US8364229B2 (en) * 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
JP2005526838A (ja) * 2002-04-25 2005-09-08 ウイスコンシン　アラムナイ　リサーチ　フオンデーシヨン パーキンソン病および他の神経変性疾患を治療するためのｇｄｎｆ分泌ヒト神経幹細胞の使用
US20060088899A1 (en) * 2002-05-31 2006-04-27 Alvarez Vernon L Combination chemotherapy with chlorotoxin
US7528112B2 (en) 2002-11-15 2009-05-05 Drexel University Small survival-promoting/immunomodulatory peptide for treatment of brain damage, neurodegenerative disorders, and inflammatory disorders
US7388079B2 (en) * 2002-11-27 2008-06-17 The Regents Of The University Of California Delivery of pharmaceutical agents via the human insulin receptor
US20050048041A1 (en) * 2003-01-13 2005-03-03 Rao Mahendra S. Persistent expression of candidate molecule in proliferating stem and progenitor cells for delivery of therapeutic products
KR20060002745A (ko) * 2003-01-13 2006-01-09 마헨드라 에스 라오 치료적 생성물의 전달을 위한 증식성 줄기세포 및전구세포에서의 후보 분자의 지속적 발현
US20040209810A1 (en) * 2003-02-24 2004-10-21 Gill Steven S. Method of treating Parkinson's disease in humans by intraputaminal infusion of glial cell-line derived neurotrophic factor
US8946151B2 (en) 2003-02-24 2015-02-03 Northern Bristol N.H.S. Trust Frenchay Hospital Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
CA2522364C (en) 2003-04-18 2014-12-09 Biogen Idec Ma Inc. Polymer-conjugated glycosylated neublastin
US7875293B2 (en) * 2003-05-21 2011-01-25 Dexcom, Inc. Biointerface membranes incorporating bioactive agents
WO2004108760A2 (en) 2003-06-10 2004-12-16 Nsgene A/S Improved secretion of neublastin
JP4708342B2 (ja) * 2003-07-25 2011-06-22 デックスコム・インコーポレーテッド 埋設可能な装置に用いる酸素増大膜システム
US9763609B2 (en) 2003-07-25 2017-09-19 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US9135402B2 (en) 2007-12-17 2015-09-15 Dexcom, Inc. Systems and methods for processing sensor data
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
EP1662879A4 (en) * 2003-08-29 2009-03-11 Univ New York INDIRECT ADMINISTRATION OF GROWTH FACTORS IN THE CENTRAL NERVOUS SYSTEM
US20060258576A1 (en) * 2003-09-05 2006-11-16 Licentia, Ltd Gdnf-related neuropeptides
US7598059B2 (en) 2003-10-02 2009-10-06 Biogen Idec Ma Inc. Neublastin expression constructs
US20060239966A1 (en) * 2003-10-20 2006-10-26 Tornoee Jens In vivo gene therapy of parkinson's disease
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US20050123526A1 (en) * 2003-12-01 2005-06-09 Medtronic Inc. Administration of growth factors for neurogenesis and gliagenesis
US8093205B2 (en) * 2003-12-01 2012-01-10 Medtronic, Inc. Method for treating a stroke by implanting a first therapy delivery element in the CNS and a second therapy delivery element in a damaged tissue of the CNS to promote neurogenesis
WO2005079257A2 (en) * 2004-02-12 2005-09-01 Dexcom, Inc. Biointerface with macro- and micro- architecture
WO2009048462A1 (en) 2007-10-09 2009-04-16 Dexcom, Inc. Integrated insulin delivery system with continuous glucose sensor
US20050208090A1 (en) * 2004-03-18 2005-09-22 Medtronic, Inc. Methods and systems for treatment of neurological diseases of the central nervous system
GB2414934A (en) * 2004-06-11 2005-12-14 Gill Steven Streatfield Treatment of Parkinson's disease with GDNF
CA2568150A1 (en) * 2004-06-21 2006-01-05 Medtronic, Inc. Medical systems and methods for delivering compositions to cells
US20060020192A1 (en) 2004-07-13 2006-01-26 Dexcom, Inc. Transcutaneous analyte sensor
CA2577690C (en) 2004-08-19 2013-08-06 Biogen Idec Ma Inc. Refolding transforming growth factor beta family proteins
SI1786454T1 (sl) 2004-08-19 2010-10-29 Biogen Idec Inc Variante neoblastina
US8133178B2 (en) 2006-02-22 2012-03-13 Dexcom, Inc. Analyte sensor
JP2009504689A (ja) * 2005-08-16 2009-02-05 ユニバーシティ オブ コペンハーゲン Ｇｄｎｆ由来ペプチド
US8124095B2 (en) * 2005-10-07 2012-02-28 Armagen Technologies, Inc. Fusion proteins for delivery of erythropoietin to the CNS
US8741260B2 (en) * 2005-10-07 2014-06-03 Armagen Technologies, Inc. Fusion proteins for delivery of GDNF to the CNS
US8053569B2 (en) * 2005-10-07 2011-11-08 Armagen Technologies, Inc. Nucleic acids encoding and methods of producing fusion proteins
EP1940471A1 (en) * 2005-10-28 2008-07-09 NsGene A/S IMPLANTABLE BIOCOMPATIBLE IMMtTNOISOLATORY VEHICLE FOR DELIVERY OF GDNF
PL1969003T3 (pl) * 2005-12-14 2011-05-31 Herantis Pharma Plc Zastosowanie białka czynnika neurotroficznego
TWI501774B (zh) 2006-02-27 2015-10-01 Biogen Idec Inc 神經性病症之治療
WO2007120381A2 (en) * 2006-04-14 2007-10-25 Dexcom, Inc. Analyte sensor
DK2019683T4 (da) 2006-04-25 2022-08-29 Univ California Indgivelse af vækstfaktorer til behandling af CNS-lidelser
JP2009535360A (ja) * 2006-04-26 2009-10-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 高分子量神経治療薬の対流増加送達のための組成物および方法
EP1872790A1 (en) 2006-06-26 2008-01-02 DeveloGen Aktiengesellschaft New formulation for increasing bioavailability of neurturin
US8759297B2 (en) * 2006-08-18 2014-06-24 Armagen Technologies, Inc. Genetically encoded multifunctional compositions bidirectionally transported between peripheral blood and the cns
KR100770440B1 (ko) * 2006-08-29 2007-10-26 삼성전기주식회사 질화물 반도체 발광소자
US8637459B2 (en) * 2006-11-08 2014-01-28 Emory University Enhancing a population of insulin releasing cells using GFR-A1 agonists
CA2685686A1 (en) 2007-05-01 2008-11-13 Biogen Idec Ma Inc. Neublastin polypeptides for use increasing vascularization in a tissue
US20090011040A1 (en) * 2007-05-02 2009-01-08 Naash Muna I Use of compacted nucleic acid nanoparticles in non-viral treatments of ocular diseases
US20200037875A1 (en) 2007-05-18 2020-02-06 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
WO2008157308A2 (en) * 2007-06-13 2008-12-24 Wayne State University Board Of Governors A zwitterion solution for low-volume therapeutic delivery
EP2167071B1 (en) 2007-06-13 2020-03-18 Wayne State University Board Of Governors A baclofen solution for low-volume therapeutic delivery
EP2182980A4 (en) 2007-07-27 2012-04-18 Armagen Technologies Inc METHOD AND COMPOSITIONS FOR INCREASED ALPHA IDURONIDASE ACTIVITY IN THE CNS
FI20070808A0 (sv) 2007-10-25 2007-10-25 Mart Saarma Splitsvarienter av GDNF och användningar därav
US8417312B2 (en) 2007-10-25 2013-04-09 Dexcom, Inc. Systems and methods for processing sensor data
US9839395B2 (en) 2007-12-17 2017-12-12 Dexcom, Inc. Systems and methods for processing sensor data
GB0803352D0 (en) * 2008-02-22 2008-04-02 Ntnu Technology Transfer As Oligopeptidic compounds and uses thereof
US20090247856A1 (en) 2008-03-28 2009-10-01 Dexcom, Inc. Polymer membranes for continuous analyte sensors
FI20080326A0 (sv) 2008-04-30 2008-04-30 Licentia Oy Neurotrofisk faktor MANF och dess användningar
BRPI0912683A2 (pt) 2008-05-15 2016-01-26 Transmolecular Inc tratamento de tumores metastáticos
JP6066035B2 (ja) 2009-02-12 2017-01-25 クルナ・インコーポレーテッド グリア細胞由来神経栄養因子（ｇｄｎｆ）関連疾病の、ｇｄｎｆに対する天然アンチセンス転写物の抑制による治療
EP2408474B1 (en) 2009-03-18 2019-06-26 Armagen, Inc. Compositions and methods for blood-brain barrier delivery of igg-decoy receptor fusion proteins
WO2010144696A1 (en) 2009-06-11 2010-12-16 Burnham Institute For Medical Research Directed differentiation of stem cells
EP3533467B1 (en) 2009-10-09 2023-07-26 Armagen, Inc. Methods and compositions for increasing iduronate 2-sulfatase activity in the cns
WO2011064437A2 (es) 2009-11-26 2011-06-03 Proyecto De Biomedicina Cima, S.L. Vectores virales y procedimientos útiles en la preparación de gdnf
EP2531206B1 (en) 2010-02-04 2017-05-31 Morphotek, Inc. Chlorotoxin polypeptides and conjugates and uses thereof
CN106957356B (zh) 2010-05-11 2021-05-25 弗雷德哈钦森癌症研究中心 氯毒素变体、缀合物及其使用方法
CN103502464B (zh) 2010-12-02 2016-03-23 神经技术美国有限公司 分泌抗血管生成抗体支架和可溶性受体的细胞系及其用途
UA112981C2 (uk) 2011-04-11 2016-11-25 Елі Ліллі Енд Компані Варіант людського gdnf
US9549692B2 (en) 2011-08-26 2017-01-24 Dexcom, Inc. Polymer membranes for continuous analyte sensors
AU2012346448B2 (en) 2011-12-02 2017-09-14 Armagen, Inc. Methods and compositions for increasing arylsulfatase A activity in the CNS
US9788765B2 (en) 2012-09-28 2017-10-17 Dexcom, Inc. Zwitterion surface modifications for continuous sensors
RU2015126650A (ru) 2012-12-10 2017-01-12 Фред Хатчинсон Кэнсер Рисёрч Сентер Партнеры липокалина по слиянию
WO2014152511A1 (en) 2013-03-15 2014-09-25 The Jackson Laboratory Methods for promoting wound healing and hair growth
US11559580B1 (en) 2013-09-17 2023-01-24 Blaze Bioscience, Inc. Tissue-homing peptide conjugates and methods of use thereof
US10369329B2 (en) 2014-01-30 2019-08-06 Renishaw Plc Neurosurgical apparatus and method
EP3140429B1 (en) 2014-05-05 2020-02-19 Medtronic Inc. Methods for scd, crt, crt-d, or sca therapy identification and/or selection
US10538589B2 (en) 2015-01-14 2020-01-21 Armagen Inc. Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU
GB201506052D0 (en) 2015-04-09 2015-05-27 Renishaw Plc Movement disorder
CA2986769A1 (en) 2015-05-27 2016-12-01 Neurotech Usa, Inc. Use of encapsulated cell therapy for treatment of ophthalmic disorders
US20170188923A1 (en) 2015-12-30 2017-07-06 Dexcom, Inc. Diffusion resistance layer for analyte sensors
JP2019535267A (ja) 2016-11-10 2019-12-12 ケロス セラピューティクス インコーポレイテッドＫｅｒｏｓ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Ｇｄｎｆ融合ポリペプチド及びその使用方法
AU2022238919A1 (en) 2021-03-19 2023-10-19 Dexcom, Inc. Drug releasing membrane for analyte sensor
WO2023043908A1 (en) 2021-09-15 2023-03-23 Dexcom, Inc. Bioactive releasing membrane for analyte sensor
CA3228457A1 (en) 2022-02-02 2023-08-10 Dexcom, Inc. Sensing systems and methods for diagnosing, staging, treating, and assessing risks of liver disease using monitored analyte data
WO2023164584A1 (en) 2022-02-23 2023-08-31 Dexcom, Inc. Sensing systems and methods for providing decision support around kidney health and/or diabetes
CA3238100A1 (en) 2022-06-01 2023-12-07 Dexcom, Inc. Sensing systems and methods for diagnosing kidney disease
WO2024050126A2 (en) 2022-09-02 2024-03-07 Dexcom, Inc. Continuous analyte sensor devices and methods

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518526A (en) * 1982-12-22 1985-05-21 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
EP0154434B1 (en) 1984-02-17 1993-01-27 Genentech, Inc. Human transforming growth factor and precursor or fragment thereof, cells, dna, vectors and methods for their production, compositions and products containing them, and related antibodies and diagnostic methods
US4886747A (en) 1985-03-22 1989-12-12 Genentech, Inc. Nucleic acid encoding TGF-β and its uses
US5284763A (en) 1985-03-22 1994-02-08 Genentech, Inc. Nucleic acid encoding TGF-β and its uses
US5374548A (en) 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
US5089396A (en) 1985-10-03 1992-02-18 Genentech, Inc. Nucleic acid encoding β chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid
US5427780A (en) 1985-10-30 1995-06-27 Biogen, Inc. Composition comprising Mullerian inhibiting substance-like polypeptides
EP0233838A3 (en) 1986-02-04 1990-01-31 Incyte Pharmaceuticals, Inc. Neurite-promoting factor and process for the manufacture thereof
US5187076A (en) * 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US5106627A (en) 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
US5283187A (en) 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US4892538A (en) 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5158881A (en) 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US5324819A (en) 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
US5250414A (en) 1988-11-04 1993-10-05 Erziehungsdirektion Of The Canton Zurich Diagnostic methods using neurite growth regulatory factors
WO1990005191A1 (en) * 1988-11-04 1990-05-17 Erziehungsdirektion Of The Canton Zurich Neurite growth regulatory factors
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US5017735A (en) 1989-07-24 1991-05-21 Catalytica, Inc. Selective sorption of 2,6-diisopropylnaphthalene
AU6174490A (en) 1989-08-04 1991-03-11 Board Of Regents, The University Of Texas System Methods and compositions; purified preparation of neural progenitor regulatory factor
US5215969A (en) 1989-08-11 1993-06-01 Hahnemann University Dopaminergic neurotrophic factor for treatment of Parkinson's disease
EP0486584A4 (en) * 1989-08-11 1993-02-03 Hahnemann University Dopaminergic neurotrophic factor for treatment of parkinson's disease
WO1991010470A1 (en) 1990-01-08 1991-07-25 Brown University Research Foundation Devices and methods for enhanced delivery of active factors
US5270181A (en) 1991-02-06 1993-12-14 Genetics Institute, Inc. Peptide and protein fusions to thioredoxin and thioredoxin-like molecules

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