FI117556B - Rekombinant-DNA-förfarande för produktion av den glialderiverade neurotrofiska faktorn - Google Patents
Rekombinant-DNA-förfarande för produktion av den glialderiverade neurotrofiska faktorn Download PDFInfo
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- FI117556B FI117556B FI941285A FI941285A FI117556B FI 117556 B FI117556 B FI 117556B FI 941285 A FI941285 A FI 941285A FI 941285 A FI941285 A FI 941285A FI 117556 B FI117556 B FI 117556B
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
- Y10S530/809—Fused cells, e.g. hybridoma
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/839—Nerves; brain
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- Biomedical Technology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Claims (6)
1. Rekombinant DNA-förfarande för produktion av den glialderiverade neurotrofiskä faktorn (GDNF), kän-5 netecknat av att det omfattar stegen: (a) delkloning av en nukleinsyrasekvens, som kodar för den glialderiverade neurotrofiskä faktorn (GDNF), in i en expressionsvektor som innehäller de reglerande elemen-ten, vilka behövs för exprimering av den däri delklonade 10 nukleinsyrasekvensen, och väri nämnda nukleinsyrasekvens omfattar en nukleinsyrasekvens som har valts bland följan- ; de: i. en nukleinsyrasekvens, som kodar för en i figur 13 visad aminosyrasekvens (sekvens ID-nummer 3) av pre- 15. pro-rätt-GDNF; ii. en nukleinsyrasekvens, som kodar för en i fi- I gur 13 visad aminosyrasekvens (sekvens ID-nummer 4) av i fullvuxet rätt-GDNF; iii. en nukleinsyrasekvens, som kodar för en i fi- 20 gur 19 (sekvens ID-nummer 5) och 22 (sekvens ID-nummer 8) : visad aminosyrasekvens av human pre-pro-GDNF; • · · ’.'V iv. en nukleinsyrasekvens, som kodar för en i fi- • · · . rj \ *. gur 19 visad aminosyrasekvens (sekvens ID-nummer 6) av * * fullvuxet human GDNF; ·····' 25 v. en nukleinsyrasekvens, som kodar för en amino- • · * ·...* syrasekvens med en över 70-procentig homologigrad med • · · V * sekvenser visade med ID-nummer 4; vi. en nukleinsyrasekvens, som kodar för en amino- S Γ*ϊ syrasekvens med en över 70-procentig homologigrad med :***: 30 sekvenser visade med ID-nummer 6; * · · 1. vii. en nukleinsyrasekvens, som hybridiseras under • · · J stränga förhällanden med den komplementära sekvensen av . * · >' *·;·* den i punkt (i)-(vi) visade sekvensen *t**: (b) transformering av en värdcell med nämnda ex- ·*·.· 35 pressionsvektor; • · '4 ·. . I 117556 104 (c) odling av värdceller i förhällanden för förök- ning av vektorn och expression av den glialderiverade neu-rotrofiska faktorn (GDNF); och : (d) tillvaratagande av den glialderiverade neuro-5 trofiska faktorn (GDNF) frän värdcellodlingen.
2. Rekombinant-DNA-förfarande enligt patentkrav 1, kännetecknat av att det dessutom omfattar ett steg, där den tillvaratagna glialderiverade neurotrofiska fak- torn (GDNF) ätervikas och där den ätervikade GDNF har en 10 förmäga att främja upptagningen av dopamin i dopaminerga neuroner.
3. Rekombinant DNA-förfarande enligt patentkrav 1 eller 2, kännetecknat av att värdcellen är en animal cell. .,:,-
4. Rekombinant DNA-förfarande enligt patentkrav 3, kännetecknat av att värdcellen är en C0S-7-cell.
5. Rekombinant DNA-förfarande enligt patentkrav 1 eller 2, kännetecknat av att värdcellen är en bakte-riecell. ;
6. Rekombinant DNA-förfarande enligt patentkrav 5, kännetecknat av att värdcellen är coli. • · • · · • · · * · * · • « • · • · • · · • ·· • · · · · • * f # ··· • · · • * ® ' · · . .·. | • · · ? • · · • « · A • · • · ··· ··· • * * • * · • · • · • * • · · • · t Λ 1 *:»·; _ · '•f’it·
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76468591A | 1991-09-20 | 1991-09-20 | |
US76468591 | 1991-09-20 | ||
US77410991A | 1991-10-08 | 1991-10-08 | |
US77410991 | 1991-10-08 | ||
US78842391A | 1991-11-06 | 1991-11-06 | |
US78842391 | 1991-11-06 | ||
US85541392A | 1992-03-19 | 1992-03-19 | |
US85541392 | 1992-03-19 | ||
US9207888 | 1992-09-17 | ||
PCT/US1992/007888 WO1993006116A1 (en) | 1991-09-20 | 1992-09-17 | Glial derived neurotrophic factor |
Publications (3)
Publication Number | Publication Date |
---|---|
FI941285A FI941285A (sv) | 1994-03-18 |
FI941285A0 FI941285A0 (sv) | 1994-03-18 |
FI117556B true FI117556B (sv) | 2006-11-30 |
Family
ID=27505700
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI941285A FI117556B (sv) | 1991-09-20 | 1994-03-18 | Rekombinant-DNA-förfarande för produktion av den glialderiverade neurotrofiska faktorn |
Country Status (21)
Country | Link |
---|---|
US (7) | US7226758B1 (sv) |
EP (2) | EP0610254B1 (sv) |
KR (1) | KR100242093B1 (sv) |
AT (1) | ATE275197T1 (sv) |
AU (2) | AU679167B2 (sv) |
CA (1) | CA2119463C (sv) |
DE (1) | DE69233407T2 (sv) |
DK (1) | DK0610254T3 (sv) |
ES (1) | ES2225819T3 (sv) |
FI (1) | FI117556B (sv) |
GE (1) | GEP20002243B (sv) |
HK (2) | HK1017816A1 (sv) |
HU (2) | HU220795B1 (sv) |
IL (5) | IL103223A (sv) |
MX (1) | MX9205293A (sv) |
NO (1) | NO321382B1 (sv) |
NZ (1) | NZ244392A (sv) |
PT (1) | PT100879B (sv) |
SG (1) | SG48145A1 (sv) |
TW (1) | TW401422B (sv) |
WO (1) | WO1993006116A1 (sv) |
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