FI20070808A0 - Splitsvarienter av GDNF och användningar därav - Google Patents
Splitsvarienter av GDNF och användningar däravInfo
- Publication number
- FI20070808A0 FI20070808A0 FI20070808A FI20070808A FI20070808A0 FI 20070808 A0 FI20070808 A0 FI 20070808A0 FI 20070808 A FI20070808 A FI 20070808A FI 20070808 A FI20070808 A FI 20070808A FI 20070808 A0 FI20070808 A0 FI 20070808A0
- Authority
- FI
- Finland
- Prior art keywords
- gdnf
- variants
- split
- split variants
- Prior art date
Links
- 102000024452 GDNF Human genes 0.000 title 1
- 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10041—Use of virus, viral particle or viral elements as a vector
- C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10071—Demonstrated in vivo effect
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI20070808A FI20070808A0 (sv) | 2007-10-25 | 2007-10-25 | Splitsvarienter av GDNF och användningar därav |
US12/739,715 US9579362B2 (en) | 2007-10-25 | 2008-10-24 | Splice variants of GDNF and uses thereof |
EP08842264A EP2257570A4 (en) | 2007-10-25 | 2008-10-24 | SPONGE VARIANTS OF GDNF AND APPLICATIONS THEREOF |
AU2008316398A AU2008316398A1 (en) | 2007-10-25 | 2008-10-24 | Splice variants of GDNF and uses thereof |
PCT/FI2008/050599 WO2009053536A2 (en) | 2007-10-25 | 2008-10-24 | Splice variants of gdnf and uses thereof |
CN2008801228304A CN102282165A (zh) | 2007-10-25 | 2008-10-24 | Gdnf剪接变体及其用途 |
JP2010530499A JP2011500075A (ja) | 2007-10-25 | 2008-10-24 | Gdnfのスプライスバリアントおよびその用途 |
CA2703614A CA2703614A1 (en) | 2007-10-25 | 2008-10-24 | Splice variants of gdnf and uses thereof |
EP12189585.8A EP2551281B1 (en) | 2007-10-25 | 2008-10-24 | Splice variants of GDNF and uses thereof |
US15/424,505 US10017553B2 (en) | 2007-10-25 | 2017-02-03 | Splice variants of GDNF and uses thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI20070808A FI20070808A0 (sv) | 2007-10-25 | 2007-10-25 | Splitsvarienter av GDNF och användningar därav |
Publications (1)
Publication Number | Publication Date |
---|---|
FI20070808A0 true FI20070808A0 (sv) | 2007-10-25 |
Family
ID=38656817
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI20070808A FI20070808A0 (sv) | 2007-10-25 | 2007-10-25 | Splitsvarienter av GDNF och användningar därav |
Country Status (8)
Country | Link |
---|---|
US (2) | US9579362B2 (sv) |
EP (2) | EP2257570A4 (sv) |
JP (1) | JP2011500075A (sv) |
CN (1) | CN102282165A (sv) |
AU (1) | AU2008316398A1 (sv) |
CA (1) | CA2703614A1 (sv) |
FI (1) | FI20070808A0 (sv) |
WO (1) | WO2009053536A2 (sv) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2719582A1 (en) * | 2008-03-25 | 2009-10-01 | Amarantus Therapeutics, Inc. | Methods and compositions for treating parkinson's disease with manf |
RU2013103763A (ru) | 2010-07-02 | 2014-08-10 | Ангиохем Инк. | Короткие и содержащие d-аминокислоты полипептиды для терапевтических конъюгатов и их применения |
UA112981C2 (uk) * | 2011-04-11 | 2016-11-25 | Елі Ліллі Енд Компані | Варіант людського gdnf |
RU2527169C2 (ru) * | 2012-10-15 | 2014-08-27 | Федеральное государственное бюджетное учреждение науки Институт биологии гена Российской академии наук (ИБГ РАН) | ГЕНЕТИЧЕСКАЯ КОНСТРУКЦИЯ, СОДЕРЖАЩАЯ hGDNF ПОД КОНТРОЛЕМ ТЕМПЕРАТУРОЧУВСТВИТЕЛЬНОГО ПРОМОТОРА ДЛЯ РЕГУЛИРУЕМОЙ ЭКСПРЕССИИ НЕЙРОТРОФИЧЕСКОГО ФАКТОРА КАК В КЛЕТКАХ, ТАК И НЕПОСРЕДСТВЕННО В ОРГАНИЗМЕ МЛЕКОПИТАЮЩИХ |
CN103173489B (zh) * | 2013-02-25 | 2015-09-09 | 潍坊易思特生物科技有限公司 | 用哺乳动物细胞生产高纯度糖基化的重组人胶质细胞源性神经营养因子的方法 |
US10376562B2 (en) | 2013-03-15 | 2019-08-13 | The Jackson Laboratory | Methods for promoting wound healing and hair growth comprising GDNF administration |
JP6608357B2 (ja) | 2013-06-28 | 2019-11-20 | メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー | 細胞において神経毒ポリペプチドの生物活性を決定する手段及び方法 |
CN103614481B (zh) * | 2013-12-04 | 2015-12-30 | 徐州医学院 | 用于检测gdnf剪接变异体2、4的实时荧光定量pcr专用引物 |
TWI704156B (zh) * | 2015-03-04 | 2020-09-11 | 德商曼茲法瑪股份有限公司 | 用於增進肉毒桿菌神經毒素進入細胞之特定攝取的方法 |
BR112018073300A2 (pt) | 2016-05-13 | 2019-03-26 | Instituto De Medicina Molecular | métodos para tratamento de doenças associadas com as células ilc3 |
AU2017351914B2 (en) * | 2016-10-31 | 2020-09-10 | Kolon Life Science, Inc. | Composition for alleviating or treating pain |
IL309027A (en) | 2021-06-03 | 2024-02-01 | Fundac?O D Anna De Sommer Champalimaud E Dr Carlos Montez Champalimaud | Neuro-messenger units that control ILC2 and obesity in brain fat cell circuit findings |
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US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
US4892538A (en) | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
US5158881A (en) | 1987-11-17 | 1992-10-27 | Brown University Research Foundation | Method and system for encapsulating cells in a tubular extrudate in separate cell compartments |
US5106627A (en) | 1987-11-17 | 1992-04-21 | Brown University Research Foundation | Neurological therapy devices |
US5716826A (en) | 1988-03-21 | 1998-02-10 | Chiron Viagene, Inc. | Recombinant retroviruses |
US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
WO1991010470A1 (en) | 1990-01-08 | 1991-07-25 | Brown University Research Foundation | Devices and methods for enhanced delivery of active factors |
US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
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US5328688A (en) | 1990-09-10 | 1994-07-12 | Arch Development Corporation | Recombinant herpes simplex viruses vaccines and methods |
US5849571A (en) | 1990-10-10 | 1998-12-15 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Latency active herpes virus promoters and their use |
US6071889A (en) | 1991-07-08 | 2000-06-06 | Neurospheres Holdings Ltd. | In vivo genetic modification of growth factor-responsive neural precursor cells |
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US5661033A (en) | 1992-11-25 | 1997-08-26 | The Board Of Trustees Of The Leland Stanford Junior University | Gene transfer using herpes virus vectors as a tool for neuroprotection |
US5631237A (en) | 1992-12-22 | 1997-05-20 | Dzau; Victor J. | Method for producing in vivo delivery of therapeutic agents via liposomes |
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WO1995017203A1 (en) * | 1993-12-22 | 1995-06-29 | The University Of Medicine And Dentistry Of New Jersey | Novel nucleic acid sequences isolated from glial cells |
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US5686278A (en) | 1994-03-25 | 1997-11-11 | Indiana University Foundation | Methods for enhanced retrovirus-mediated gene transfer |
US6204059B1 (en) | 1994-06-30 | 2001-03-20 | University Of Pittsburgh | AAV capsid vehicles for molecular transfer |
US5856152A (en) | 1994-10-28 | 1999-01-05 | The Trustees Of The University Of Pennsylvania | Hybrid adenovirus-AAV vector and methods of use therefor |
US5792453A (en) | 1995-02-28 | 1998-08-11 | The Regents Of The University Of California | Gene transfer-mediated angiogenesis therapy |
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US5773289A (en) | 1995-06-06 | 1998-06-30 | University Of Pittsburgh | AAV directed targeted integration |
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DE19816186A1 (de) | 1998-04-14 | 1999-10-21 | Univ Muenchen L Maximilians | GDNF-kodierende DNA, Teile davon und GDNF-Varianten |
ATE316576T1 (de) | 1998-05-27 | 2006-02-15 | Avigen Inc | Konvektion-erhöhte verabreichung aadc-kodierende aav vektoren |
US6610836B1 (en) | 1999-01-29 | 2003-08-26 | Genome Therapeutics Corporation | Nucleic acid amino acid sequences relating to Klebsiella pneumoniae for diagnostics and therapeutics |
CN1202129C (zh) * | 2000-09-20 | 2005-05-18 | 中国人民解放军军事医学科学院基础医学研究所 | Gdnf突变体及其治疗应用 |
AU2002359786A1 (en) | 2001-12-19 | 2003-07-09 | Hiroaki Mizukami | Adeno-associated virus-mediated delivery of gdnf to skeletal muscles |
EP1660659A2 (en) | 2003-09-05 | 2006-05-31 | Licentia, Ltd. | Gdnf-related neuropeptides |
CA2627543A1 (en) | 2005-10-28 | 2007-05-03 | Ns Gene A/S | Implantable biocompatible immttnoisolatory vehicle for delivery of gdnf |
EP1993590B1 (en) | 2006-03-01 | 2013-12-25 | Biogen Idec MA Inc. | Compostions and methods for administering gdnf ligand family proteins |
-
2007
- 2007-10-25 FI FI20070808A patent/FI20070808A0/sv not_active Application Discontinuation
-
2008
- 2008-10-24 CA CA2703614A patent/CA2703614A1/en not_active Abandoned
- 2008-10-24 JP JP2010530499A patent/JP2011500075A/ja not_active Withdrawn
- 2008-10-24 CN CN2008801228304A patent/CN102282165A/zh active Pending
- 2008-10-24 AU AU2008316398A patent/AU2008316398A1/en not_active Abandoned
- 2008-10-24 EP EP08842264A patent/EP2257570A4/en not_active Withdrawn
- 2008-10-24 US US12/739,715 patent/US9579362B2/en active Active
- 2008-10-24 EP EP12189585.8A patent/EP2551281B1/en active Active
- 2008-10-24 WO PCT/FI2008/050599 patent/WO2009053536A2/en active Application Filing
-
2017
- 2017-02-03 US US15/424,505 patent/US10017553B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP2257570A2 (en) | 2010-12-08 |
JP2011500075A (ja) | 2011-01-06 |
WO2009053536A8 (en) | 2011-09-15 |
WO2009053536A2 (en) | 2009-04-30 |
EP2551281A1 (en) | 2013-01-30 |
AU2008316398A1 (en) | 2009-04-30 |
US10017553B2 (en) | 2018-07-10 |
CA2703614A1 (en) | 2009-04-30 |
US20170145066A1 (en) | 2017-05-25 |
CN102282165A (zh) | 2011-12-14 |
US20100311653A1 (en) | 2010-12-09 |
EP2551281B1 (en) | 2015-10-14 |
US9579362B2 (en) | 2017-02-28 |
WO2009053536A3 (en) | 2009-06-18 |
EP2257570A4 (en) | 2011-10-12 |
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