FI113694B - Förfarande och förpackningskonstruktion för kylförvaring och lagring av odlade vävnadsekvivalenter - Google Patents
Förfarande och förpackningskonstruktion för kylförvaring och lagring av odlade vävnadsekvivalenter Download PDFInfo
- Publication number
- FI113694B FI113694B FI972563A FI972563A FI113694B FI 113694 B FI113694 B FI 113694B FI 972563 A FI972563 A FI 972563A FI 972563 A FI972563 A FI 972563A FI 113694 B FI113694 B FI 113694B
- Authority
- FI
- Finland
- Prior art keywords
- tissue
- cold
- cultured
- skin
- temperature
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0278—Physical preservation processes
- A01N1/0284—Temperature processes, i.e. using a designated change in temperature over time
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D55/00—Accessories for container closures not otherwise provided for
- B65D55/02—Locking devices; Means for discouraging or indicating unauthorised opening or removal of closure
- B65D55/06—Deformable or tearable wires, strings, or strips; Use of seals, e.g. destructible locking pins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
- B65D77/04—Articles or materials enclosed in two or more containers disposed one within another
- B65D77/048—Articles or materials enclosed in two or more containers disposed one within another the inner and outer containers being rigid and the outer container being of curved cross-section, e.g. cylindrical
- B65D77/0486—Articles or materials enclosed in two or more containers disposed one within another the inner and outer containers being rigid and the outer container being of curved cross-section, e.g. cylindrical the inner container being coaxially disposed within the outer container
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
- B65D85/50—Containers, packaging elements or packages, specially adapted for particular articles or materials for living organisms, articles or materials sensitive to changes of environment or atmospheric conditions, e.g. land animals, birds, fish, water plants, non-aquatic plants, flower bulbs, cut flowers or foliage
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Mechanical Engineering (AREA)
- Hematology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Packages (AREA)
- Packging For Living Organisms, Food Or Medicinal Products That Are Sensitive To Environmental Conditiond (AREA)
- Catching Or Destruction (AREA)
- Materials For Medical Uses (AREA)
Claims (11)
1. Förfarande för kallförvaring av harveste-rad däggdjurs vävnad eller odlad vävnadsekvivalent, kännetecknat därav, att: 5 (a) vävnaden sänks i en kryoskyddslösning, kryoskyddsiösningen och den sänkta vävnaden blandas för att ästadkomma att kryoskyddsiösningen effektivt tränger in i vävnaden och för att ästadkomma en perfuse rad vävnad; 10 (b) extracellulärt is ympas i kryoskyddsiös ningen och i perfuserade vävnaden; (c) perfuserade vävnaden frän steg (b) avkyls tili ett kallförvaringsläge genom att nedfrysa vävnaden med en lag nedfrysningshastighet tili en tempera- 15 tur av minst ca. -70°C eller lägre för producerande av en kallförvarad vävnad, och (d) den kallförvarade vävnaden lagras vid en temperatur av minst ca. -70°C eller lägre.
2. Förfarande enligt patentkrav 1, k ä n - 20 netecknat därav, att nedsänkningen i steg (a) utförs vid en utgängstemperatur av ca. 20°C och däref-ter avkyles, under perfusion, med hastigheten ca. -, 10°C/min tili en temperatur av ca. -6°C.
: ,·, 3. Förfarande enligt patentkrav 1, k ä n n e - * · a ! 25 t e c k n a t därav, att i steg (c) sker nedfrysningen • 1 · .1 ’ med hastigheten -l°C/min tili en temperatur av ca. - • · _’1 8°C och behälls där en tillräckligt läng tid för att • 1 · '·’ ‘ nä en fysiologisk och biologisk jämvikt av kryoskydds iösningen i vävnaden. • ’,1 30
4. Förfarande enligt patentkrav 1, k ä n - : : netecknat därav, att i steg (c) hälls tempera- turen konstant en tillräckligt läng tid för att tiliä- • i » .'I! ta att en fysiologisk och biologisk jämvikt av kryo- ·;·’ skyddslösningen i vävnaden näs. 35
5. Förfarande enligt patentkrav 3, k ä n - ·;"1 netecknat därav, att avkylning fortsätts med 43 113694 hastigheten ca. -0,3 - -0,02°C/min till en temperatur av ca. -70°C eller lägre.
6. Förfarande enligt patentkrav 1, k ä n - netecknat därav, att harvesterad däggdjurs väv- 5 nad är harvesterad däggdjurs hud.
7. Förfarande enligt patentkrav l, k anne t e c k n a t därav, att den odlade vävnadsekviva- lenten väljs ur en grupp, som innehaller en odlad överhudekvivalent, en odlad hudekvivalent och en odlad 10 hornhinna-ekvivalent.
8. Förfarande enligt patentkrav 1, k ä n - netecknat därav, att temperaturen av kallförva-ringstillständet är -120°C eller lägre - -196°C eller lägre. 15
9. Förfarande enligt patentkrav 1, kin - netecknat därav, att kryoskyddslösningen är 1,5 - 2,5M glycerol i DMEM-bas (Dulbecco's Modified Eagle 's Medium).
10. Förfarande enligt patentkrav 1, vilket 20 innefattar ytterligare smältning av den förglasade vävnaden, kännetecknat därav, att vävnaden :*·’; smälts inom ca. 1-2 minuter.
. 11. Anläggning för kallförvaring av harveste- : ,·, rad däggdjurs vävnad eller odlad vävnadsekvivalent en- • * * [!' ! 25 ligt patentkrav 1, kännetecknad därav, att ,) * den innef attar·. • “ en skäl (40), vilken innefattar en bottenyta ’·’ * (41) som är enhetlig med sidoväggen (42) och flänsen (43), vilken sidovägg innefattar inät sträckande stöd-30 delar som sträcker sig frän och är enhetliga med sido-.· väggen (44) ; en bärbas (30) , vilken innehäller en jämn ge-,!! nomtränglig hinna (32) fäst tili ena ändan av den i ;·’ huvudsakligen rörformiga stöddelen (33) och en kant '-'l *. 35 (31) i den rörformiga stöddelens motsatta ända, väri skälens inät sträckande stöddelar stöder kanten (31) ; 44 113694 ett lock (10), vilket innefattar en pian bot-tenyta (13) som är enhetlig med sidoväggen (12) och flänsen (11) , väri flänsen (11) är i tät kontakt med skälens fläns; och 5 en tätning (20) mellan skälen och locket. * » I * * * * · < • t i t • » I · • ! » * f » « >
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38009995 | 1995-01-30 | ||
US08/380,099 US5891617A (en) | 1993-09-15 | 1995-01-30 | Cryopreservation of harvested skin and cultured skin or cornea equivalents by slow freezing |
US9601217 | 1996-01-30 | ||
PCT/US1996/001217 WO1996024018A1 (en) | 1995-01-30 | 1996-01-30 | Method and package design for cryopreservation and storage of cultured tisse equivalents |
Publications (3)
Publication Number | Publication Date |
---|---|
FI972563A0 FI972563A0 (sv) | 1997-06-16 |
FI972563A FI972563A (sv) | 1997-09-29 |
FI113694B true FI113694B (sv) | 2004-05-31 |
Family
ID=23499896
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI972563A FI113694B (sv) | 1995-01-30 | 1997-06-16 | Förfarande och förpackningskonstruktion för kylförvaring och lagring av odlade vävnadsekvivalenter |
Country Status (21)
Country | Link |
---|---|
US (1) | US5891617A (sv) |
EP (2) | EP0807234B1 (sv) |
JP (4) | JPH11501298A (sv) |
KR (1) | KR100328742B1 (sv) |
CN (2) | CN1119599C (sv) |
AT (2) | ATE282805T1 (sv) |
AU (1) | AU716869B2 (sv) |
BR (1) | BR9606864A (sv) |
CZ (1) | CZ294950B6 (sv) |
DE (2) | DE69637301T2 (sv) |
ES (1) | ES2231804T3 (sv) |
FI (1) | FI113694B (sv) |
HU (1) | HU223789B1 (sv) |
NO (1) | NO310491B1 (sv) |
NZ (1) | NZ302913A (sv) |
PL (1) | PL181762B1 (sv) |
PT (1) | PT807234E (sv) |
RU (1) | RU2178865C2 (sv) |
SG (1) | SG106553A1 (sv) |
SK (1) | SK284801B6 (sv) |
WO (1) | WO1996024018A1 (sv) |
Families Citing this family (91)
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1995
- 1995-01-30 US US08/380,099 patent/US5891617A/en not_active Expired - Lifetime
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1996
- 1996-01-30 NZ NZ302913A patent/NZ302913A/en unknown
- 1996-01-30 DE DE69637301T patent/DE69637301T2/de not_active Expired - Lifetime
- 1996-01-30 CN CN96191673A patent/CN1119599C/zh not_active Expired - Fee Related
- 1996-01-30 EP EP96905275A patent/EP0807234B1/en not_active Expired - Lifetime
- 1996-01-30 AU AU49082/96A patent/AU716869B2/en not_active Ceased
- 1996-01-30 WO PCT/US1996/001217 patent/WO1996024018A1/en active IP Right Grant
- 1996-01-30 CZ CZ19972413A patent/CZ294950B6/cs not_active IP Right Cessation
- 1996-01-30 PL PL96321089A patent/PL181762B1/pl not_active IP Right Cessation
- 1996-01-30 KR KR1019970705324A patent/KR100328742B1/ko not_active IP Right Cessation
- 1996-01-30 AT AT96905275T patent/ATE282805T1/de not_active IP Right Cessation
- 1996-01-30 JP JP8523665A patent/JPH11501298A/ja not_active Withdrawn
- 1996-01-30 PT PT96905275T patent/PT807234E/pt unknown
- 1996-01-30 EP EP04077072A patent/EP1516532B1/en not_active Expired - Lifetime
- 1996-01-30 RU RU97116150/13A patent/RU2178865C2/ru not_active IP Right Cessation
- 1996-01-30 BR BR9606864A patent/BR9606864A/pt not_active IP Right Cessation
- 1996-01-30 SK SK1033-97A patent/SK284801B6/sk unknown
- 1996-01-30 DE DE69633854T patent/DE69633854T2/de not_active Expired - Lifetime
- 1996-01-30 ES ES96905275T patent/ES2231804T3/es not_active Expired - Lifetime
- 1996-01-30 SG SG9802806A patent/SG106553A1/en unknown
- 1996-01-30 HU HU9800411A patent/HU223789B1/hu not_active IP Right Cessation
- 1996-01-30 CN CNB031457983A patent/CN1292651C/zh not_active Expired - Fee Related
- 1996-01-30 AT AT04077072T patent/ATE376356T1/de not_active IP Right Cessation
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1997
- 1997-06-16 FI FI972563A patent/FI113694B/sv active
- 1997-07-28 NO NO19973463A patent/NO310491B1/no unknown
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2007
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