FI113272B - Parannettu proteiinien laskostamismenetelmä - Google Patents
Parannettu proteiinien laskostamismenetelmä Download PDFInfo
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- FI113272B FI113272B FI953705A FI953705A FI113272B FI 113272 B FI113272 B FI 113272B FI 953705 A FI953705 A FI 953705A FI 953705 A FI953705 A FI 953705A FI 113272 B FI113272 B FI 113272B
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6432—Coagulation factor Xa (3.4.21.6)
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- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21006—Coagulation factor Xa (3.4.21.6)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/124—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes based on group I or II introns
- C12N2310/1241—Tetrahymena
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- C—CHEMISTRY; METALLURGY
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/127—DNAzymes
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- Chemical & Material Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Endocrinology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK13093 | 1993-02-04 | ||
DK13093A DK13093D0 (da) | 1993-02-04 | 1993-02-04 | Processing of proteins |
DK13993 | 1993-02-05 | ||
DK13993A DK13993D0 (da) | 1993-02-05 | 1993-02-05 | Processing of proteins |
PCT/GB1993/002492 WO1994013804A1 (fr) | 1992-12-04 | 1993-12-03 | Proteines de liaison multivalentes et multispecifiques, leur fabrication et leur utilisation |
GB9302492 | 1993-12-03 | ||
PCT/DK1994/000054 WO1994018227A2 (fr) | 1993-02-04 | 1994-02-04 | Procede ameliore de repliement de proteines |
DK9400054 | 1994-02-04 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI953705A FI953705A (fi) | 1995-08-03 |
FI953705A0 FI953705A0 (fi) | 1995-08-03 |
FI113272B true FI113272B (fi) | 2004-03-31 |
Family
ID=26063372
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI953705A FI113272B (fi) | 1993-02-04 | 1995-08-03 | Parannettu proteiinien laskostamismenetelmä |
Country Status (14)
Country | Link |
---|---|
US (2) | US5739281A (fr) |
EP (1) | EP0686162B1 (fr) |
JP (1) | JP3695467B2 (fr) |
KR (1) | KR100310739B1 (fr) |
AT (1) | ATE241642T1 (fr) |
AU (1) | AU674568B2 (fr) |
CA (1) | CA2155335C (fr) |
DE (1) | DE69432744T2 (fr) |
DK (1) | DK0686162T3 (fr) |
ES (1) | ES2199959T3 (fr) |
FI (1) | FI113272B (fr) |
NO (1) | NO316274B1 (fr) |
NZ (1) | NZ261571A (fr) |
WO (1) | WO1994018227A2 (fr) |
Families Citing this family (47)
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ATE241642T1 (de) * | 1993-02-04 | 2003-06-15 | Denzyme Aps | Verbessertes verfahren zur rückfaltung der proteine |
AU6284896A (en) * | 1995-06-22 | 1997-01-22 | Eli Lilly And Company | Obesity protein intermediates and their preparation and use |
US7368111B2 (en) | 1995-10-06 | 2008-05-06 | Cambridge Antibody Technology Limited | Human antibodies specific for TGFβ2 |
WO1997017438A1 (fr) * | 1995-11-07 | 1997-05-15 | Toshio Tanaka | Procede de clonage par expression d'un gene codant une proteine liee a un ligand |
US6277618B1 (en) * | 1996-06-06 | 2001-08-21 | Roche Diagnostics Gmbh | Recombinant blood-coagulation proteases |
AU736707B2 (en) | 1997-06-11 | 2001-08-02 | Anaphore, Inc. | Trimerising module |
US20030207402A1 (en) * | 1997-08-22 | 2003-11-06 | Erhard Kopetzki | Autocatalytically activatable zymogenic precursors of proteases and their use |
US6492497B1 (en) | 1999-04-30 | 2002-12-10 | Cambridge Antibody Technology Limited | Specific binding members for TGFbeta1 |
CA2406236C (fr) * | 2000-04-17 | 2013-02-19 | Dyax Corp. | Nouvelles methodes de construction de bibliotheques de materiels genetiques representant les membres d'une famille diversifiee de peptides, de polypeptides ou de proteines |
US8288322B2 (en) | 2000-04-17 | 2012-10-16 | Dyax Corp. | Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries |
AU2001280436A1 (en) * | 2000-07-12 | 2002-01-21 | Eli Lilly And Company | Process to increase protein stability |
AU2001296303A1 (en) * | 2000-09-22 | 2002-04-02 | Ramot At Tel Aviv University Ltd. | A soluble beta 2 microglobulin (beta2m)/hfe monochain for biotechnological and therapeutic applications |
EP2343317A1 (fr) | 2000-11-10 | 2011-07-13 | F. Hoffmann-La Roche Ltd. | Constructions d'apolipoprotéines |
EP2284270A3 (fr) | 2000-12-13 | 2012-07-25 | Anaphore, Inc. | Procédé d'identification et d'isolation des polypeptides de liaison à partir des bibliothèques combinatoires de protéines dotées d'une structure d'échafaudage des domaines par exemple de la lectine de type C |
CA2430953A1 (fr) | 2000-12-13 | 2002-06-20 | Borean Pharma A/S | Echantillotheques combinatoires de proteines presentant la structure en echafaudage des domaines lectonoides de type c |
PT2316940E (pt) | 2000-12-18 | 2013-10-16 | Dyax Corp | Bibliotecas orientadas de pacotes genéticos |
US20060252917A1 (en) * | 2001-02-08 | 2006-11-09 | University Of Utah | Methods for refolding conformationally constrained peptides |
DE10105912A1 (de) * | 2001-02-09 | 2002-08-14 | Roche Diagnostics Gmbh | Rekombinante Proteinase K |
CA2491488A1 (fr) * | 2002-07-09 | 2004-01-15 | Genentech, Inc. | Compositions et methodes de diagnostic et de traitement de tumeurs |
EP1382614A1 (fr) * | 2002-07-15 | 2004-01-21 | Bayer HealthCare AG | Procédé de purification de l'interleukine-4 et ses muteines |
US20040067532A1 (en) | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
US20040072262A1 (en) * | 2002-10-11 | 2004-04-15 | Montero-Julian Felix A. | Methods and systems for detecting MHC class I binding peptides |
EP2311867A1 (fr) | 2002-10-29 | 2011-04-20 | Anaphore, Inc. | Protéines à liaison trimérique pour cytokines trimériques |
WO2004044166A2 (fr) * | 2002-11-12 | 2004-05-27 | Incyte Corporation | Proteines associees aux glucides |
AU2004232405B2 (en) | 2003-04-23 | 2008-06-19 | F. Hoffman - La Roche Ltd. | Cleavage of fusion proteins using granzyme B protease |
US20100028995A1 (en) * | 2004-02-23 | 2010-02-04 | Anaphore, Inc. | Tetranectin Trimerizing Polypeptides |
US7482148B2 (en) * | 2004-03-30 | 2009-01-27 | Sudershan Biotech Ltd. | Recombinant calf-chymosin and a process for producing the same |
AU2005310305A1 (en) * | 2004-10-22 | 2006-06-08 | Amgen Inc. | Methods for refolding polypeptides |
US8940871B2 (en) * | 2006-03-20 | 2015-01-27 | The Regents Of The University Of California | Engineered anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting |
EP1845103B1 (fr) * | 2006-04-10 | 2015-02-25 | Boehringer Ingelheim RCV GmbH & Co KG | Méthode pour replier une protéine |
JP6126773B2 (ja) | 2007-09-04 | 2017-05-10 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 癌のターゲッティングおよび検出のための高親和性抗前立腺幹細胞抗原(psca)抗体 |
US8877688B2 (en) * | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
US8691730B2 (en) | 2007-09-14 | 2014-04-08 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
US8324151B2 (en) * | 2007-11-20 | 2012-12-04 | The Feinstein Institute For Medical Research | Treatment of sepsis and septic shock using ghrelin and growth hormone |
WO2009114815A1 (fr) | 2008-03-13 | 2009-09-17 | Dyax Corp | Bibliothèques de boîtiers génétiques comprenant de nouvelles conceptions de hc cdr3 |
ES2528963T3 (es) | 2008-04-24 | 2015-02-13 | Dyax Corp. | Bibliotecas de paquetes genéticos que comprenden nuevos diseños de CDR1, CDR2, y CDR3 de HC y nuevos diseños de CDR1, CDR2, y CDR3 de LC |
EP2376105B1 (fr) * | 2008-12-18 | 2015-07-29 | Dana-Farber Cancer Institute, Inc. | Nkg2d-fc pour immunothérapie |
WO2011032181A2 (fr) * | 2009-09-14 | 2011-03-17 | Dyax Corp. | Bibliothèques d'ensembles génétiques comprenant de nouvelles conceptions de hc cdr3 |
EP2499255A4 (fr) * | 2009-11-09 | 2013-06-19 | Univ Colorado Regents | Production efficace de peptides |
CN105734678B (zh) | 2010-07-16 | 2019-11-05 | 阿迪马布有限责任公司 | 合成多核苷酸文库 |
EP2420253A1 (fr) | 2010-08-20 | 2012-02-22 | Leadartis, S.L. | Synthèse de molécules polyvalentes et multifonctionnelles avec un domaine de trimérisation de collagène XV |
US20150139991A1 (en) | 2010-10-15 | 2015-05-21 | Leadartis, S.L. | Generation of multifunctional and multivalent polypeptide complexes with collagen xviii trimerization domain |
EP2441776A1 (fr) | 2010-10-15 | 2012-04-18 | Leadartis, S.L. | Génération de complexes polyvalents et multifonctionnels avec un domaine de trimérisation XVIII du collagène |
JP2017520575A (ja) | 2014-07-01 | 2017-07-27 | ファイザー・インク | 二重特異的ヘテロ二量体ダイアボディおよびその使用 |
JP7037480B2 (ja) | 2015-11-13 | 2022-03-16 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | がんの免疫療法のためのnkg2d-ig融合タンパク質 |
EP3802601A1 (fr) | 2018-06-06 | 2021-04-14 | Leadartis, S.L. | Complexes polypeptidiques trimériques et leurs utilisations |
JP2024510947A (ja) | 2021-03-05 | 2024-03-12 | レアダルティス、ソシエダッド リミターダ | 三量体ポリペプチドおよびがん治療におけるその使用 |
Family Cites Families (14)
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CA1200773A (fr) * | 1980-02-29 | 1986-02-18 | William J. Rutter | Liens d'expression |
US4444878A (en) * | 1981-12-21 | 1984-04-24 | Boston Biomedical Research Institute, Inc. | Bispecific antibody determinants |
WO1984003711A1 (fr) * | 1983-03-25 | 1984-09-27 | Celltech Ltd | Procede de production d'une proteine |
GB8412517D0 (en) * | 1984-05-16 | 1984-06-20 | Nagai K | Recombinant fusion proteins |
GB8508340D0 (en) * | 1985-03-29 | 1985-05-09 | Creighton T E | Production of protein |
US4656255A (en) * | 1985-09-09 | 1987-04-07 | International Minerals & Chemical Corp. | Protein recovery |
CA1340522C (fr) * | 1987-03-10 | 1999-05-04 | Heinz Dobeli | Proteins hybrides renfermant des histidines voisines pour une purification amelioree |
US5074977A (en) * | 1987-05-05 | 1991-12-24 | The Washington Technology Center | Digital biosensors and method of using same |
US4999422A (en) * | 1988-04-15 | 1991-03-12 | Biogen, N.V. | Continuous method of refolding proteins |
US5231168A (en) * | 1988-09-16 | 1993-07-27 | Statens Seruminstitut | Malaria antigen |
DE3835350A1 (de) * | 1988-10-17 | 1990-04-19 | Boehringer Mannheim Gmbh | Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern |
DK0432419T3 (da) * | 1989-12-05 | 1994-11-14 | American Cyanamid Co | Fremgangsmåde til solubilisering og naturering af somatotropiner under anvendelse af lav urinstofkoncentration |
US5324436A (en) * | 1991-12-13 | 1994-06-28 | The Administrators Of The Tulane Educational Fund | Use of hydrate formation to control membrane mimetic systems |
ATE241642T1 (de) * | 1993-02-04 | 2003-06-15 | Denzyme Aps | Verbessertes verfahren zur rückfaltung der proteine |
-
1994
- 1994-02-04 AT AT94906891T patent/ATE241642T1/de active
- 1994-02-04 AU AU60380/94A patent/AU674568B2/en not_active Ceased
- 1994-02-04 WO PCT/DK1994/000054 patent/WO1994018227A2/fr active IP Right Grant
- 1994-02-04 KR KR1019950703244A patent/KR100310739B1/ko not_active IP Right Cessation
- 1994-02-04 ES ES94906891T patent/ES2199959T3/es not_active Expired - Lifetime
- 1994-02-04 CA CA002155335A patent/CA2155335C/fr not_active Expired - Fee Related
- 1994-02-04 NZ NZ261571A patent/NZ261571A/en not_active IP Right Cessation
- 1994-02-04 JP JP51754494A patent/JP3695467B2/ja not_active Expired - Fee Related
- 1994-02-04 EP EP94906891A patent/EP0686162B1/fr not_active Expired - Lifetime
- 1994-02-04 DE DE69432744T patent/DE69432744T2/de not_active Expired - Lifetime
- 1994-02-04 DK DK94906891T patent/DK0686162T3/da active
-
1995
- 1995-06-06 US US08/469,486 patent/US5739281A/en not_active Expired - Lifetime
- 1995-07-28 NO NO19952989A patent/NO316274B1/no not_active IP Right Cessation
- 1995-08-03 FI FI953705A patent/FI113272B/fi not_active IP Right Cessation
- 1995-09-18 US US08/469,658 patent/US5917018A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5739281A (en) | 1998-04-14 |
NO952989L (no) | 1995-10-03 |
CA2155335A1 (fr) | 1994-08-18 |
NZ261571A (en) | 1997-03-24 |
CA2155335C (fr) | 2001-06-05 |
EP0686162B1 (fr) | 2003-05-28 |
WO1994018227A3 (fr) | 1994-10-13 |
ES2199959T3 (es) | 2004-03-01 |
JP3695467B2 (ja) | 2005-09-14 |
DE69432744T2 (de) | 2004-03-25 |
ATE241642T1 (de) | 2003-06-15 |
FI953705A (fi) | 1995-08-03 |
US5917018A (en) | 1999-06-29 |
WO1994018227A2 (fr) | 1994-08-18 |
AU6038094A (en) | 1994-08-29 |
AU674568B2 (en) | 1997-01-02 |
NO952989D0 (no) | 1995-07-28 |
JPH08506243A (ja) | 1996-07-09 |
KR100310739B1 (ko) | 2002-05-30 |
FI953705A0 (fi) | 1995-08-03 |
DE69432744D1 (de) | 2003-07-03 |
EP0686162A1 (fr) | 1995-12-13 |
NO316274B1 (no) | 2004-01-05 |
KR960701083A (ko) | 1996-02-24 |
DK0686162T3 (da) | 2003-09-22 |
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