DK0432419T3 - Fremgangsmåde til solubilisering og naturering af somatotropiner under anvendelse af lav urinstofkoncentration - Google Patents

Fremgangsmåde til solubilisering og naturering af somatotropiner under anvendelse af lav urinstofkoncentration

Info

Publication number
DK0432419T3
DK0432419T3 DK90120309.1T DK90120309T DK0432419T3 DK 0432419 T3 DK0432419 T3 DK 0432419T3 DK 90120309 T DK90120309 T DK 90120309T DK 0432419 T3 DK0432419 T3 DK 0432419T3
Authority
DK
Denmark
Prior art keywords
somatotropins
solubilization
naturalization
urea concentration
low urea
Prior art date
Application number
DK90120309.1T
Other languages
English (en)
Inventor
Kevin Michael Mccoy
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of DK0432419T3 publication Critical patent/DK0432419T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/61Growth hormone [GH], i.e. somatotropin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Beans For Foods Or Fodder (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fertilizers (AREA)
  • Saccharide Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK90120309.1T 1989-12-05 1990-10-23 Fremgangsmåde til solubilisering og naturering af somatotropiner under anvendelse af lav urinstofkoncentration DK0432419T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44628089A 1989-12-05 1989-12-05

Publications (1)

Publication Number Publication Date
DK0432419T3 true DK0432419T3 (da) 1994-11-14

Family

ID=23772005

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90120309.1T DK0432419T3 (da) 1989-12-05 1990-10-23 Fremgangsmåde til solubilisering og naturering af somatotropiner under anvendelse af lav urinstofkoncentration

Country Status (16)

Country Link
EP (1) EP0432419B1 (da)
JP (1) JPH03181500A (da)
KR (1) KR0160975B1 (da)
AT (1) ATE113060T1 (da)
AU (1) AU628695B2 (da)
CA (1) CA2031369A1 (da)
DE (1) DE69013475T2 (da)
DK (1) DK0432419T3 (da)
ES (1) ES2062253T3 (da)
FI (1) FI97296C (da)
HU (1) HU214249B (da)
IE (1) IE66142B1 (da)
IL (1) IL96124A (da)
NZ (1) NZ236141A (da)
PT (1) PT96058B (da)
ZA (1) ZA909745B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ261571A (en) * 1993-02-04 1997-03-24 Denzyme Aps Producing correctly folded proteins using multiple denaturation and renaturation cycles
US5912327A (en) * 1996-09-30 1999-06-15 Human Genome Sciences, Inc. Method of purifying chemokines from inclusion bodies
US6632425B1 (en) 1997-03-20 2003-10-14 Human Genome Sciences, Inc. Chemokine compositions
AU739394B2 (en) * 1998-08-27 2001-10-11 Lg Chemical Limited Process for the preparation of active somatotropin from inclusion bodies
DE10044360A1 (de) 2000-09-08 2002-03-21 Merck Patent Gmbh Verfahren zur Aufreinigung von rekombinanten als unlösliche Aggregate exprimierte Proteinen
WO2002057296A1 (en) * 2001-01-16 2002-07-25 Københavns Universitet A method for refolding of proteins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1267615A (en) * 1984-08-27 1990-04-10 Dan Hadary Method for recovering purified growth hormones from genetically engineered microorganisms
AU612133B2 (en) * 1987-02-20 1991-07-04 Natinco Nv Production of proteins in active forms
JPH01257491A (ja) * 1988-04-08 1989-10-13 Tosoh Corp 不溶性融合異種蛋白質の処理方法

Also Published As

Publication number Publication date
HU214249B (hu) 1998-03-02
JPH03181500A (ja) 1991-08-07
ZA909745B (en) 1991-10-30
FI97296B (fi) 1996-08-15
DE69013475T2 (de) 1995-05-04
ES2062253T3 (es) 1994-12-16
AU628695B2 (en) 1992-09-17
CA2031369A1 (en) 1991-06-06
IE66142B1 (en) 1995-12-13
DE69013475D1 (de) 1994-11-24
AU6773690A (en) 1991-06-13
KR0160975B1 (ko) 1998-11-16
EP0432419A1 (en) 1991-06-19
ATE113060T1 (de) 1994-11-15
HUT58762A (en) 1992-03-30
KR910012235A (ko) 1991-08-07
FI97296C (fi) 1996-11-25
PT96058A (pt) 1991-09-30
FI905985A0 (fi) 1990-12-04
IE904204A1 (en) 1991-06-05
IL96124A (en) 1998-06-15
NZ236141A (en) 1993-01-27
IL96124A0 (en) 1991-07-18
EP0432419B1 (en) 1994-10-19
FI905985A (fi) 1991-06-06
HU908077D0 (en) 1991-06-28
PT96058B (pt) 1998-07-31

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