IL96124A - Method for solubilization and naturation of somatotropins utilizing low urea concentration - Google Patents
Method for solubilization and naturation of somatotropins utilizing low urea concentrationInfo
- Publication number
- IL96124A IL96124A IL96124A IL9612490A IL96124A IL 96124 A IL96124 A IL 96124A IL 96124 A IL96124 A IL 96124A IL 9612490 A IL9612490 A IL 9612490A IL 96124 A IL96124 A IL 96124A
- Authority
- IL
- Israel
- Prior art keywords
- naturation
- somatotropins
- solubilization
- urea concentration
- utilizing low
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title abstract 2
- 239000004202 carbamide Substances 0.000 title abstract 2
- 230000007928 solubilization Effects 0.000 title abstract 2
- 238000005063 solubilization Methods 0.000 title abstract 2
- 239000012670 alkaline solution Substances 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Beans For Foods Or Fodder (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Fertilizers (AREA)
- Saccharide Compounds (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44628089A | 1989-12-05 | 1989-12-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL96124A0 IL96124A0 (en) | 1991-07-18 |
| IL96124A true IL96124A (en) | 1998-06-15 |
Family
ID=23772005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL96124A IL96124A (en) | 1989-12-05 | 1990-10-25 | Method for solubilization and naturation of somatotropins utilizing low urea concentration |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0432419B1 (da) |
| JP (1) | JPH03181500A (da) |
| KR (1) | KR0160975B1 (da) |
| AT (1) | ATE113060T1 (da) |
| AU (1) | AU628695B2 (da) |
| CA (1) | CA2031369A1 (da) |
| DE (1) | DE69013475T2 (da) |
| DK (1) | DK0432419T3 (da) |
| ES (1) | ES2062253T3 (da) |
| FI (1) | FI97296C (da) |
| HU (1) | HU214249B (da) |
| IE (1) | IE66142B1 (da) |
| IL (1) | IL96124A (da) |
| NZ (1) | NZ236141A (da) |
| PT (1) | PT96058B (da) |
| ZA (1) | ZA909745B (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ261571A (en) * | 1993-02-04 | 1997-03-24 | Denzyme Aps | Producing correctly folded proteins using multiple denaturation and renaturation cycles |
| US5912327A (en) * | 1996-09-30 | 1999-06-15 | Human Genome Sciences, Inc. | Method of purifying chemokines from inclusion bodies |
| US6632425B1 (en) | 1997-03-20 | 2003-10-14 | Human Genome Sciences, Inc. | Chemokine compositions |
| AU739394B2 (en) * | 1998-08-27 | 2001-10-11 | Lg Chemical Limited | Process for the preparation of active somatotropin from inclusion bodies |
| DE10044360A1 (de) | 2000-09-08 | 2002-03-21 | Merck Patent Gmbh | Verfahren zur Aufreinigung von rekombinanten als unlösliche Aggregate exprimierte Proteinen |
| WO2002057296A1 (en) * | 2001-01-16 | 2002-07-25 | Københavns Universitet | A method for refolding of proteins |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1267615A (en) * | 1984-08-27 | 1990-04-10 | Dan Hadary | Method for recovering purified growth hormones from genetically engineered microorganisms |
| AU612133B2 (en) * | 1987-02-20 | 1991-07-04 | Natinco Nv | Production of proteins in active forms |
| JPH01257491A (ja) * | 1988-04-08 | 1989-10-13 | Tosoh Corp | 不溶性融合異種蛋白質の処理方法 |
-
1990
- 1990-10-23 AT AT90120309T patent/ATE113060T1/de not_active IP Right Cessation
- 1990-10-23 DK DK90120309.1T patent/DK0432419T3/da active
- 1990-10-23 EP EP90120309A patent/EP0432419B1/en not_active Expired - Lifetime
- 1990-10-23 ES ES90120309T patent/ES2062253T3/es not_active Expired - Lifetime
- 1990-10-23 DE DE69013475T patent/DE69013475T2/de not_active Expired - Fee Related
- 1990-10-25 IL IL96124A patent/IL96124A/xx active IP Right Grant
- 1990-11-20 NZ NZ236141A patent/NZ236141A/xx unknown
- 1990-11-21 IE IE420490A patent/IE66142B1/en not_active IP Right Cessation
- 1990-11-27 KR KR1019900019285A patent/KR0160975B1/ko not_active IP Right Cessation
- 1990-11-30 JP JP2331005A patent/JPH03181500A/ja active Pending
- 1990-12-03 CA CA002031369A patent/CA2031369A1/en not_active Abandoned
- 1990-12-03 PT PT96058A patent/PT96058B/pt not_active IP Right Cessation
- 1990-12-04 FI FI905985A patent/FI97296C/fi not_active IP Right Cessation
- 1990-12-04 AU AU67736/90A patent/AU628695B2/en not_active Ceased
- 1990-12-04 ZA ZA909745A patent/ZA909745B/xx unknown
- 1990-12-05 HU HU908077A patent/HU214249B/hu not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK0432419T3 (da) | 1994-11-14 |
| HU214249B (hu) | 1998-03-02 |
| JPH03181500A (ja) | 1991-08-07 |
| ZA909745B (en) | 1991-10-30 |
| FI97296B (fi) | 1996-08-15 |
| DE69013475T2 (de) | 1995-05-04 |
| ES2062253T3 (es) | 1994-12-16 |
| AU628695B2 (en) | 1992-09-17 |
| CA2031369A1 (en) | 1991-06-06 |
| IE66142B1 (en) | 1995-12-13 |
| DE69013475D1 (de) | 1994-11-24 |
| AU6773690A (en) | 1991-06-13 |
| KR0160975B1 (ko) | 1998-11-16 |
| EP0432419A1 (en) | 1991-06-19 |
| ATE113060T1 (de) | 1994-11-15 |
| HUT58762A (en) | 1992-03-30 |
| KR910012235A (ko) | 1991-08-07 |
| FI97296C (fi) | 1996-11-25 |
| PT96058A (pt) | 1991-09-30 |
| FI905985A0 (fi) | 1990-12-04 |
| IE904204A1 (en) | 1991-06-05 |
| NZ236141A (en) | 1993-01-27 |
| IL96124A0 (en) | 1991-07-18 |
| EP0432419B1 (en) | 1994-10-19 |
| FI905985A (fi) | 1991-06-06 |
| HU908077D0 (en) | 1991-06-28 |
| PT96058B (pt) | 1998-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted |