FI953705A0 - Parannettu proteiinien laskostamismenetelmä - Google Patents

Parannettu proteiinien laskostamismenetelmä

Info

Publication number
FI953705A0
FI953705A0 FI953705A FI953705A FI953705A0 FI 953705 A0 FI953705 A0 FI 953705A0 FI 953705 A FI953705 A FI 953705A FI 953705 A FI953705 A FI 953705A FI 953705 A0 FI953705 A0 FI 953705A0
Authority
FI
Finland
Prior art keywords
proteins
factor
recognition sites
novel
correctly folded
Prior art date
Application number
FI953705A
Other languages
English (en)
Swedish (sv)
Other versions
FI953705A (fi
FI113272B (fi
Inventor
Hans Christian Thoegersen
Thor Las Holtet
Michael Etzerodt
Original Assignee
Denzyme Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK13093A external-priority patent/DK13093D0/da
Priority claimed from DK13993A external-priority patent/DK13993D0/da
Priority claimed from PCT/GB1993/002492 external-priority patent/WO1994013804A1/en
Application filed by Denzyme Aps filed Critical Denzyme Aps
Publication of FI953705A publication Critical patent/FI953705A/fi
Publication of FI953705A0 publication Critical patent/FI953705A0/fi
Application granted granted Critical
Publication of FI113272B publication Critical patent/FI113272B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/124—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes based on group I or II introns
    • C12N2310/1241—Tetrahymena
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/127—DNAzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
FI953705A 1993-02-04 1995-08-03 Parannettu proteiinien laskostamismenetelmä FI113272B (fi)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DK13093 1993-02-04
DK13093A DK13093D0 (da) 1993-02-04 1993-02-04 Processing of proteins
DK13993 1993-02-05
DK13993A DK13993D0 (da) 1993-02-05 1993-02-05 Processing of proteins
PCT/GB1993/002492 WO1994013804A1 (en) 1992-12-04 1993-12-03 Multivalent and multispecific binding proteins, their manufacture and use
GB9302492 1993-12-03
PCT/DK1994/000054 WO1994018227A2 (en) 1993-02-04 1994-02-04 Improved method for the refolding of proteins
DK9400054 1994-02-04

Publications (3)

Publication Number Publication Date
FI953705A FI953705A (fi) 1995-08-03
FI953705A0 true FI953705A0 (fi) 1995-08-03
FI113272B FI113272B (fi) 2004-03-31

Family

ID=26063372

Family Applications (1)

Application Number Title Priority Date Filing Date
FI953705A FI113272B (fi) 1993-02-04 1995-08-03 Parannettu proteiinien laskostamismenetelmä

Country Status (14)

Country Link
US (2) US5739281A (fi)
EP (1) EP0686162B1 (fi)
JP (1) JP3695467B2 (fi)
KR (1) KR100310739B1 (fi)
AT (1) ATE241642T1 (fi)
AU (1) AU674568B2 (fi)
CA (1) CA2155335C (fi)
DE (1) DE69432744T2 (fi)
DK (1) DK0686162T3 (fi)
ES (1) ES2199959T3 (fi)
FI (1) FI113272B (fi)
NO (1) NO316274B1 (fi)
NZ (1) NZ261571A (fi)
WO (1) WO1994018227A2 (fi)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE241642T1 (de) * 1993-02-04 2003-06-15 Denzyme Aps Verbessertes verfahren zur rückfaltung der proteine
AU6284896A (en) * 1995-06-22 1997-01-22 Eli Lilly And Company Obesity protein intermediates and their preparation and use
US7368111B2 (en) 1995-10-06 2008-05-06 Cambridge Antibody Technology Limited Human antibodies specific for TGFβ2
WO1997017438A1 (fr) * 1995-11-07 1997-05-15 Toshio Tanaka Procede de clonage par expression d'un gene codant une proteine liee a un ligand
US6277618B1 (en) * 1996-06-06 2001-08-21 Roche Diagnostics Gmbh Recombinant blood-coagulation proteases
AU736707B2 (en) 1997-06-11 2001-08-02 Anaphore, Inc. Trimerising module
US20030207402A1 (en) * 1997-08-22 2003-11-06 Erhard Kopetzki Autocatalytically activatable zymogenic precursors of proteases and their use
US6492497B1 (en) 1999-04-30 2002-12-10 Cambridge Antibody Technology Limited Specific binding members for TGFbeta1
CA2406236C (en) * 2000-04-17 2013-02-19 Dyax Corp. Novel methods of constructing libraries of genetic packages that collectively display the members of a diverse family of peptides, polypeptides or proteins
US8288322B2 (en) 2000-04-17 2012-10-16 Dyax Corp. Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
AU2001280436A1 (en) * 2000-07-12 2002-01-21 Eli Lilly And Company Process to increase protein stability
AU2001296303A1 (en) * 2000-09-22 2002-04-02 Ramot At Tel Aviv University Ltd. A soluble beta 2 microglobulin (beta2m)/hfe monochain for biotechnological and therapeutic applications
EP2343317A1 (en) 2000-11-10 2011-07-13 F. Hoffmann-La Roche Ltd. Apolipoprotein analogues
EP2284270A3 (en) 2000-12-13 2012-07-25 Anaphore, Inc. Method for the identification and isolation of binding polypeptides from combinatorial libraries of proteins having the scaffold structure of C-type lectin-like domains
CA2430953A1 (en) 2000-12-13 2002-06-20 Borean Pharma A/S Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains
PT2316940E (pt) 2000-12-18 2013-10-16 Dyax Corp Bibliotecas orientadas de pacotes genéticos
US20060252917A1 (en) * 2001-02-08 2006-11-09 University Of Utah Methods for refolding conformationally constrained peptides
DE10105912A1 (de) * 2001-02-09 2002-08-14 Roche Diagnostics Gmbh Rekombinante Proteinase K
CA2491488A1 (en) * 2002-07-09 2004-01-15 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
EP1382614A1 (en) * 2002-07-15 2004-01-21 Bayer HealthCare AG Process for the purification of interleukin-4 and its muteins
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
US20040072262A1 (en) * 2002-10-11 2004-04-15 Montero-Julian Felix A. Methods and systems for detecting MHC class I binding peptides
EP2311867A1 (en) 2002-10-29 2011-04-20 Anaphore, Inc. Trimeric binding proteins for trimeric cytokines
WO2004044166A2 (en) * 2002-11-12 2004-05-27 Incyte Corporation Carbohydrate-associated proteins
AU2004232405B2 (en) 2003-04-23 2008-06-19 F. Hoffman - La Roche Ltd. Cleavage of fusion proteins using granzyme B protease
US20100028995A1 (en) * 2004-02-23 2010-02-04 Anaphore, Inc. Tetranectin Trimerizing Polypeptides
US7482148B2 (en) * 2004-03-30 2009-01-27 Sudershan Biotech Ltd. Recombinant calf-chymosin and a process for producing the same
AU2005310305A1 (en) * 2004-10-22 2006-06-08 Amgen Inc. Methods for refolding polypeptides
US8940871B2 (en) * 2006-03-20 2015-01-27 The Regents Of The University Of California Engineered anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting
EP1845103B1 (en) * 2006-04-10 2015-02-25 Boehringer Ingelheim RCV GmbH & Co KG Method for refolding a protein
JP6126773B2 (ja) 2007-09-04 2017-05-10 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 癌のターゲッティングおよび検出のための高親和性抗前立腺幹細胞抗原（ｐｓｃａ）抗体
US8877688B2 (en) * 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US8691730B2 (en) 2007-09-14 2014-04-08 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US8324151B2 (en) * 2007-11-20 2012-12-04 The Feinstein Institute For Medical Research Treatment of sepsis and septic shock using ghrelin and growth hormone
WO2009114815A1 (en) 2008-03-13 2009-09-17 Dyax Corp Libraries of genetic packages comprising novel hc cdr3 designs
ES2528963T3 (es) 2008-04-24 2015-02-13 Dyax Corp. Bibliotecas de paquetes genéticos que comprenden nuevos diseños de CDR1, CDR2, y CDR3 de HC y nuevos diseños de CDR1, CDR2, y CDR3 de LC
EP2376105B1 (en) * 2008-12-18 2015-07-29 Dana-Farber Cancer Institute, Inc. Nkg2d-fc for immunotherapy
WO2011032181A2 (en) * 2009-09-14 2011-03-17 Dyax Corp. Libraries of genetic packages comprising novel hc cdr3 designs
EP2499255A4 (en) * 2009-11-09 2013-06-19 Univ Colorado Regents EFFECTIVE PRODUCTION OF PEPTIDES
CN105734678B (zh) 2010-07-16 2019-11-05 阿迪马布有限责任公司 合成多核苷酸文库
EP2420253A1 (en) 2010-08-20 2012-02-22 Leadartis, S.L. Engineering multifunctional and multivalent molecules with collagen XV trimerization domain
US20150139991A1 (en) 2010-10-15 2015-05-21 Leadartis, S.L. Generation of multifunctional and multivalent polypeptide complexes with collagen xviii trimerization domain
EP2441776A1 (en) 2010-10-15 2012-04-18 Leadartis, S.L. Generation of multifunctional and multivalent polypeptide complexes with collagen XVIII trimerization domain
JP2017520575A (ja) 2014-07-01 2017-07-27 ファイザー・インク 二重特異的ヘテロ二量体ダイアボディおよびその使用
JP7037480B2 (ja) 2015-11-13 2022-03-16 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド がんの免疫療法のためのｎｋｇ２ｄ－ｉｇ融合タンパク質
EP3802601A1 (en) 2018-06-06 2021-04-14 Leadartis, S.L. Trimeric polypeptide complexes and uses thereof
JP2024510947A (ja) 2021-03-05 2024-03-12 レアダルティス、ソシエダッド リミターダ 三量体ポリペプチドおよびがん治療におけるその使用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1200773A (en) * 1980-02-29 1986-02-18 William J. Rutter Expression linkers
US4444878A (en) * 1981-12-21 1984-04-24 Boston Biomedical Research Institute, Inc. Bispecific antibody determinants
WO1984003711A1 (en) * 1983-03-25 1984-09-27 Celltech Ltd A process for the production of a protein
GB8412517D0 (en) * 1984-05-16 1984-06-20 Nagai K Recombinant fusion proteins
GB8508340D0 (en) * 1985-03-29 1985-05-09 Creighton T E Production of protein
US4656255A (en) * 1985-09-09 1987-04-07 International Minerals & Chemical Corp. Protein recovery
CA1340522C (en) * 1987-03-10 1999-05-04 Heinz Dobeli Fusion proteins containing neighbouring histidines for improved purification
US5074977A (en) * 1987-05-05 1991-12-24 The Washington Technology Center Digital biosensors and method of using same
US4999422A (en) * 1988-04-15 1991-03-12 Biogen, N.V. Continuous method of refolding proteins
US5231168A (en) * 1988-09-16 1993-07-27 Statens Seruminstitut Malaria antigen
DE3835350A1 (de) * 1988-10-17 1990-04-19 Boehringer Mannheim Gmbh Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern
DK0432419T3 (da) * 1989-12-05 1994-11-14 American Cyanamid Co Fremgangsmåde til solubilisering og naturering af somatotropiner under anvendelse af lav urinstofkoncentration
US5324436A (en) * 1991-12-13 1994-06-28 The Administrators Of The Tulane Educational Fund Use of hydrate formation to control membrane mimetic systems
ATE241642T1 (de) * 1993-02-04 2003-06-15 Denzyme Aps Verbessertes verfahren zur rückfaltung der proteine

Also Published As

Publication number Publication date
US5739281A (en) 1998-04-14
NO952989L (no) 1995-10-03
CA2155335A1 (en) 1994-08-18
NZ261571A (en) 1997-03-24
CA2155335C (en) 2001-06-05
EP0686162B1 (en) 2003-05-28
WO1994018227A3 (en) 1994-10-13
ES2199959T3 (es) 2004-03-01
JP3695467B2 (ja) 2005-09-14
DE69432744T2 (de) 2004-03-25
ATE241642T1 (de) 2003-06-15
FI953705A (fi) 1995-08-03
US5917018A (en) 1999-06-29
WO1994018227A2 (en) 1994-08-18
AU6038094A (en) 1994-08-29
AU674568B2 (en) 1997-01-02
NO952989D0 (no) 1995-07-28
JPH08506243A (ja) 1996-07-09
FI113272B (fi) 2004-03-31
KR100310739B1 (ko) 2002-05-30
DE69432744D1 (de) 2003-07-03
EP0686162A1 (en) 1995-12-13
NO316274B1 (no) 2004-01-05
KR960701083A (ko) 1996-02-24
DK0686162T3 (da) 2003-09-22

Similar Documents

Publication Publication Date Title
FI953705A (fi) Parannettu proteiinien laskostamismenetelmä
CY1111322T1 (el) Προϊοντα υδρολυσης πρωτεϊνων εμπλουτισμενα σε πεπτιδια που εχουν ενα καρβοξυ-τερματικο υπολειμμα προλινης
ES2075155T3 (es) Separacion enzimatica de una secuencia de una proteina con amino terminal.
FI961886A (fi) Ihmisen Kunitz-tyyppiset proteaasi-inhibiittorit
DE3871798D1 (de) Modifizierter faktor vii/viia.
BG89942A (bg) Метод за получаване на протеолитични ензими
ATE110414T1 (de) System zur bearbeitung von hefe, welches eine zur bearbeitungsstelle benachbarte negativ geladene aminosäure beeinhaltet.
DE69210645D1 (de) Verfahren zur Herstellung von cysteinfreien Peptiden
WO2001004146A3 (en) Ecarin polypeptides, polynucleotides encoding ecarin, and methods for use thereof
FI20075338A (fi) gb350/220:n ei silmukoivia muutoksia
DK0642307T3 (da) Fremgangsmåde til fremstilling af et valleproteinhydrolysat og et valleproteinhydrolysat
DK0901526T3 (da) Cortistatin: neuropeptider, sammensætninger og metoder
WO2001096366A3 (de) Dipeptidische hemmstoffe für den gerinnungsfaktor xa
ES2134834T3 (es) Procedimiento para escindir proenzimas.
ATE515499T1 (de) Neue kristallform von 5-hydroxy-1-methylhydantoin
NO990316D0 (no) Frossenmat med antifrys-peptider
NO20030684D0 (no) Fremgangsmåter for å forbedre egenskaper av kjöttkvaliteten i produkter, samt et proteinhydrolysat fremstilt av et fiskemateriale
DE69623803T2 (de) Verwendung von KASEINFRAGMENTEn als WACHSTUMERFÖRDERer
ATE310013T1 (de) Herstellung von n-(n-(3,3-dimethylbutyl)-l-alpha- aspartyl)-l-phenylalanin-1-methylester durch verwendung vom l-alpha-aspartyl-l-phenylalanin-1- methylester als vorläufer
EP0945512A3 (en) Novel serine proteases
EA200300502A1 (ru) СПОСОБЫ КРУПНОМАСШТАБНОГО ПРОИЗВОДСТВА ВЫВЕДЕННЫХ ИЗ РЕКОМБИНАНТНОЙ ДНК МОЛЕКУЛ tPA ИЛИ K2S
RU94035681A (ru) Способ получения полипептида

Legal Events

Date Code Title Description
PC Transfer of assignment of patent

Owner name: ROCHE BIO DENMARK A/S

Free format text: ROCHE BIO DENMARK A/S

PC Transfer of assignment of patent

Owner name: BOREAN PHARMA APS

Free format text: BOREAN PHARMA APS

Owner name: F.HOFFMANN-LA ROCHE LTD.

Free format text: F.HOFFMANN-LA ROCHE LTD.

PC Transfer of assignment of patent

Owner name: F. HOFFMANN-LA ROCHE LTD.

Free format text: F. HOFFMANN-LA ROCHE LTD.

Owner name: ANAPHORE, INC.

Free format text: ANAPHORE, INC.

MM Patent lapsed