DE3871798D1 - Modifizierter faktor vii/viia. - Google Patents
Modifizierter faktor vii/viia.Info
- Publication number
- DE3871798D1 DE3871798D1 DE8888905735T DE3871798T DE3871798D1 DE 3871798 D1 DE3871798 D1 DE 3871798D1 DE 8888905735 T DE8888905735 T DE 8888905735T DE 3871798 T DE3871798 T DE 3871798T DE 3871798 D1 DE3871798 D1 DE 3871798D1
- Authority
- DE
- Germany
- Prior art keywords
- viia
- factor vii
- modified factor
- proteolytically
- sensible
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6437—Coagulation factor VIIa (3.4.21.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK323587A DK323587D0 (da) | 1987-06-25 | 1987-06-25 | Protein |
PCT/DK1988/000103 WO1988010295A1 (en) | 1987-06-25 | 1988-06-24 | MODIFIED FACTOR VII/VIIa |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3871798D1 true DE3871798D1 (de) | 1992-07-09 |
DE3871798T2 DE3871798T2 (de) | 1993-05-13 |
Family
ID=8120606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8888905735T Expired - Lifetime DE3871798T2 (de) | 1987-06-25 | 1988-06-24 | Modifizierter faktor vii/viia. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0370036B1 (de) |
JP (1) | JPH03500963A (de) |
AT (1) | ATE76900T1 (de) |
CA (1) | CA1339815C (de) |
DE (1) | DE3871798T2 (de) |
DK (2) | DK323587D0 (de) |
WO (1) | WO1988010295A1 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5580560A (en) * | 1989-11-13 | 1996-12-03 | Novo Nordisk A/S | Modified factor VII/VIIa |
EP0506821B1 (de) * | 1989-12-29 | 1998-02-04 | Zymogenetics, Inc. | Hybrides protein c |
US5358932A (en) * | 1989-12-29 | 1994-10-25 | Zymogenetics, Inc. | Hybrid protein C |
ATE180834T1 (de) * | 1990-01-29 | 1999-06-15 | Zymogenetics Inc | Antikoagulierende proteine |
US6747003B1 (en) | 1997-10-23 | 2004-06-08 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
US6693075B1 (en) | 1997-10-23 | 2004-02-17 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
US7247708B2 (en) | 1997-10-23 | 2007-07-24 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
DK1257295T3 (da) | 2000-02-11 | 2009-08-10 | Bayer Healthcare Llc | Faktor VII eller VIIA-lignende molekyler |
US7220837B1 (en) | 2000-04-28 | 2007-05-22 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
US7812132B2 (en) | 2000-04-28 | 2010-10-12 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
US6905683B2 (en) | 2000-05-03 | 2005-06-14 | Novo Nordisk Healthcare A/G | Human coagulation factor VII variants |
US20030211094A1 (en) | 2001-06-26 | 2003-11-13 | Nelsestuen Gary L. | High molecular weight derivatives of vitamin k-dependent polypeptides |
RU2326126C2 (ru) | 2000-09-13 | 2008-06-10 | Ново Нордиск Хелт Кэр Аг | Полипептид фактора vii свертывания крови, его получение и применение |
IL154520A0 (en) * | 2000-09-13 | 2003-09-17 | Novo Nordisk As | Human coagulation factor vii variants |
AU2002218029A1 (en) | 2000-11-09 | 2002-05-21 | The Scripps Research Institute | Modified factor viia |
MXPA03008590A (es) * | 2001-03-22 | 2003-12-08 | Novo Nordisk Healthcare Ag | Derivados del factor vii de coagulacion. |
US7052868B2 (en) | 2001-09-27 | 2006-05-30 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
CN1602354A (zh) * | 2001-09-27 | 2005-03-30 | 诺和诺德医疗保健公司 | 人凝血因子ⅶ多肽 |
JP2005512524A (ja) * | 2001-11-02 | 2005-05-12 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | ヒト凝固第vii因子ポリペプチド |
US6960657B2 (en) | 2001-11-02 | 2005-11-01 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
RU2004134726A (ru) | 2002-04-30 | 2005-06-10 | Максиджен Холдингз Лтд. (Ky) | Варианты полипептида фактора vii или viia |
US6911323B2 (en) | 2002-09-25 | 2005-06-28 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
ATE505487T1 (de) | 2002-09-30 | 2011-04-15 | Bayer Healthcare Llc | Fvii- oder fviia-varianten mit erhöhter koagulationswirkung |
CA2519873C (en) | 2003-03-20 | 2012-12-18 | Maxygen Holdings Ltd. | Fvii or fviia variants |
US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
ES2338425T3 (es) | 2003-06-19 | 2010-05-07 | Bayer Healthcare Llc | Variantes de dominio de gla del factor vii o viia. |
ATE547519T1 (de) | 2003-09-09 | 2012-03-15 | Novo Nordisk Healthcare Ag | Gerinnungsfaktor-vii-polypeptide |
US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
CN101006175A (zh) | 2004-08-17 | 2007-07-25 | Csl百灵有限公司 | 经修饰的维生素k依赖性多肽 |
EP2975135A1 (de) | 2005-05-25 | 2016-01-20 | Novo Nordisk A/S | Glykopegylierter Faktor IX |
KR20100016462A (ko) | 2007-04-13 | 2010-02-12 | 카탈리스트 바이오사이언시즈, 인코포레이티드 | 변형 제vii 인자 폴리펩타이드 및 이의 용도 |
CA2690611C (en) | 2007-06-12 | 2015-12-08 | Novo Nordisk A/S | Improved process for the production of nucleotide sugars |
FR2917414B1 (fr) * | 2007-06-15 | 2012-07-13 | Lab Francais Du Fractionnement | Facteur vii/viia humain modifie et composition pharmaceutique contenant celui-ci |
TWI538916B (zh) | 2008-04-11 | 2016-06-21 | 介控生化科技公司 | 經修飾的因子vii多肽和其用途 |
PL3266463T3 (pl) | 2009-06-09 | 2024-03-18 | Prolong Pharmaceuticals, LLC | Kompozycje hemoglobiny |
US20210069306A1 (en) | 2019-08-15 | 2021-03-11 | Catalyst Biosciences, Inc. | Modified factor vii polypeptides for subcutaneous administration and on-demand treatment |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2461040A1 (fr) * | 1979-07-09 | 1981-01-30 | Inst Textile De France | Procede et dispositif pour l'obtention d'un fil presentant sur sa longueur des zones de torsion alternativement de sens inverse |
US4753879A (en) * | 1984-08-27 | 1988-06-28 | Biogen N.V. | Modified tissue plasminogen activators |
EP0201153A3 (de) * | 1985-02-09 | 1987-10-07 | Beecham Group Plc | Modifiziertes Enzym und Verfahren zu dessen Herstellung |
GR860984B (en) * | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
DK43387A (da) * | 1986-01-29 | 1987-07-30 | Beecham Group Plc | Fibrinolytisk enzym |
-
1987
- 1987-06-25 DK DK323587A patent/DK323587D0/da not_active Application Discontinuation
-
1988
- 1988-06-24 EP EP88905735A patent/EP0370036B1/de not_active Expired - Lifetime
- 1988-06-24 JP JP63505496A patent/JPH03500963A/ja active Pending
- 1988-06-24 DE DE8888905735T patent/DE3871798T2/de not_active Expired - Lifetime
- 1988-06-24 AT AT88905735T patent/ATE76900T1/de not_active IP Right Cessation
- 1988-06-24 WO PCT/DK1988/000103 patent/WO1988010295A1/en active IP Right Grant
- 1988-06-27 CA CA000570535A patent/CA1339815C/en not_active Expired - Fee Related
-
1989
- 1989-12-21 DK DK653989A patent/DK161097C/da not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA1339815C (en) | 1998-04-14 |
DK653989A (da) | 1989-12-21 |
WO1988010295A1 (en) | 1988-12-29 |
JPH03500963A (ja) | 1991-03-07 |
DK161097B (da) | 1991-05-27 |
ATE76900T1 (de) | 1992-06-15 |
DK161097C (da) | 1991-11-11 |
EP0370036A1 (de) | 1990-05-30 |
DK653989D0 (da) | 1989-12-21 |
DK323587D0 (da) | 1987-06-25 |
EP0370036B1 (de) | 1992-06-03 |
DE3871798T2 (de) | 1993-05-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE76900T1 (de) | Modifizierter faktor vii/viia. | |
DK105489D0 (da) | Polypeptid | |
HUT54213A (en) | Process for the enzymatic removal of n-terminal sequence of proteins | |
ES8802235A1 (es) | Procedimiento para preparar un polipeptido | |
ATE142258T1 (de) | Menschlicher gefässpermeabilitätsfaktor | |
DE3856265D1 (de) | Varianten des pankreatischen Rinder-Trypsininhibitors, deren Herstellung und Verwendung | |
KR880701105A (ko) | 신규 응혈촉진 단백질 | |
ATE92107T1 (de) | N-terminale fragmente von menschliches serumalbumin enthaltenden fusionsproteinen. | |
ES8801674A1 (es) | Un procedimiento para la preparacion de una proteina que presenta actividad procoagulante. | |
DE69129865D1 (de) | Osteogene peptide | |
ES548617A0 (es) | Procedimiento para disociar peptidos y proteinas en el enla-ce metionilo | |
EP0423224A4 (en) | Leader sequence inducing a post-translational modification of polypeptides in bacteria, and gene therefor | |
ATE144535T1 (de) | Plättchen blockierende peptide | |
DE59810198D1 (de) | Myc-bindende Zinkfinger-Proteine, ihre Herstellung und ihre Verwendung | |
ATE146188T1 (de) | Substituierungsanaloge von magaininpeptiden | |
NO893452D0 (no) | Rekombinant naturlig dreper-celleaktivator. | |
BR9809416A (pt) | Processo para clivagem de proteìnas de fusão | |
ZA896980B (en) | Peptide compounds | |
ES2168282T3 (es) | D-hidantoinasa recombinante, procedimiento para su preparacion y utilizacion. | |
DK262986A (da) | Peptidmateriale med thymushumoral aktivitet | |
ATE124955T1 (de) | Substrat-peptide. | |
FR2569111B1 (fr) | Nouveaux medicaments contenant des tripeptides | |
AU637589B2 (en) | Ancrod proteins, their production and use | |
DK0563385T3 (da) | Thrombolytisk peptid, fremstilling deraf og thrombolytisk middel | |
DE59209915D1 (de) | Verfahren zur Herstellung von Polypeptiden mit Prourokinase-Aktivität |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de | ||
8370 | Indication related to discontinuation of the patent is to be deleted | ||
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: NOVO NORDISK HEALTH CARE AG, ZUERICH, CH Owner name: ZYMOGENETICS, INC., SEATTLE, WASH., US |