DK653989A - Modificeret faktor vii/viia - Google Patents

Modificeret faktor vii/viia Download PDF

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Publication number
DK653989A
DK653989A DK653989A DK653989A DK653989A DK 653989 A DK653989 A DK 653989A DK 653989 A DK653989 A DK 653989A DK 653989 A DK653989 A DK 653989A DK 653989 A DK653989 A DK 653989A
Authority
DK
Denmark
Prior art keywords
viia
factor vii
modified factor
replacing
proteolytically
Prior art date
Application number
DK653989A
Other languages
English (en)
Other versions
DK653989D0 (da
DK161097C (da
DK161097B (da
Inventor
Else Marie Nicolaisen
Soeren Erik Bjoern
Finn Christoph Wiberg
Richard Woodbury
Original Assignee
Novo Nordisk As
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As, Zymogenetics Inc filed Critical Novo Nordisk As
Priority to DK653989A priority Critical patent/DK161097C/da
Publication of DK653989D0 publication Critical patent/DK653989D0/da
Publication of DK653989A publication Critical patent/DK653989A/da
Publication of DK161097B publication Critical patent/DK161097B/da
Application granted granted Critical
Publication of DK161097C publication Critical patent/DK161097C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
DK653989A 1987-06-25 1989-12-21 Modificeret faktor vii/viia, dna-sekvens, som koder herfor, ekspressionsvektor indeholdende en saadan dna-sekvens, celle, der er transformeret med en saadan vektor og fremgangsmaade til fremstilling af modificeret faktor vii/viia DK161097C (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK653989A DK161097C (da) 1987-06-25 1989-12-21 Modificeret faktor vii/viia, dna-sekvens, som koder herfor, ekspressionsvektor indeholdende en saadan dna-sekvens, celle, der er transformeret med en saadan vektor og fremgangsmaade til fremstilling af modificeret faktor vii/viia

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DK323587A DK323587D0 (da) 1987-06-25 1987-06-25 Protein
DK323587 1987-06-25
DK8800103 1988-06-24
PCT/DK1988/000103 WO1988010295A1 (en) 1987-06-25 1988-06-24 MODIFIED FACTOR VII/VIIa
DK653989A DK161097C (da) 1987-06-25 1989-12-21 Modificeret faktor vii/viia, dna-sekvens, som koder herfor, ekspressionsvektor indeholdende en saadan dna-sekvens, celle, der er transformeret med en saadan vektor og fremgangsmaade til fremstilling af modificeret faktor vii/viia
DK653989 1989-12-21

Publications (4)

Publication Number Publication Date
DK653989D0 DK653989D0 (da) 1989-12-21
DK653989A true DK653989A (da) 1989-12-21
DK161097B DK161097B (da) 1991-05-27
DK161097C DK161097C (da) 1991-11-11

Family

ID=8120606

Family Applications (2)

Application Number Title Priority Date Filing Date
DK323587A DK323587D0 (da) 1986-11-03 1987-06-25 Protein
DK653989A DK161097C (da) 1987-06-25 1989-12-21 Modificeret faktor vii/viia, dna-sekvens, som koder herfor, ekspressionsvektor indeholdende en saadan dna-sekvens, celle, der er transformeret med en saadan vektor og fremgangsmaade til fremstilling af modificeret faktor vii/viia

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK323587A DK323587D0 (da) 1986-11-03 1987-06-25 Protein

Country Status (7)

Country Link
EP (1) EP0370036B1 (da)
JP (1) JPH03500963A (da)
AT (1) ATE76900T1 (da)
CA (1) CA1339815C (da)
DE (1) DE3871798T2 (da)
DK (2) DK323587D0 (da)
WO (1) WO1988010295A1 (da)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580560A (en) * 1989-11-13 1996-12-03 Novo Nordisk A/S Modified factor VII/VIIa
AU7168591A (en) * 1989-12-29 1991-07-24 Zymogenetics Inc. Hybrid protein c
US5358932A (en) * 1989-12-29 1994-10-25 Zymogenetics, Inc. Hybrid protein C
ATE180834T1 (de) * 1990-01-29 1999-06-15 Zymogenetics Inc Antikoagulierende proteine
US6747003B1 (en) 1997-10-23 2004-06-08 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6693075B1 (en) * 1997-10-23 2004-02-17 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7247708B2 (en) 1997-10-23 2007-07-24 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
RU2278123C2 (ru) 2000-02-11 2006-06-20 Максиджен Холдингз Лтд. Молекулы, подобные фактору vii или viia
US7812132B2 (en) 2000-04-28 2010-10-12 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7220837B1 (en) 2000-04-28 2007-05-22 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6905683B2 (en) 2000-05-03 2005-06-14 Novo Nordisk Healthcare A/G Human coagulation factor VII variants
US20030211094A1 (en) 2001-06-26 2003-11-13 Nelsestuen Gary L. High molecular weight derivatives of vitamin k-dependent polypeptides
PL204888B1 (pl) * 2000-09-13 2010-02-26 Novo Nordisk Healthcare Ag Wariant polipeptydu czynnika VII, konstrukcja kwasu nukleinowego, rekombinowana komórka gospodarza, zwierzę transgeniczne, sposób wytwarzania wariantu polipeptydu czynnika VII, kompozycja farmaceutyczna i zastosowanie wariantu polipeptydu czynnika VII
MXPA03001984A (es) 2000-09-13 2003-08-29 Novo Nordisk Healthcare Ag Variantes de factor vii de coagulacion humano.
AU2002218029A1 (en) 2000-11-09 2002-05-21 The Scripps Research Institute Modified factor viia
ES2432967T3 (es) * 2001-03-22 2013-12-05 Novo Nordisk Health Care Ag Derivados del Factor VII de coagulación
ATE532858T1 (de) * 2001-09-27 2011-11-15 Novo Nordisk Healthcare Ag Menschliche gerinnungsfaktor-vii-polypeptide
US7052868B2 (en) 2001-09-27 2006-05-30 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
US6960657B2 (en) 2001-11-02 2005-11-01 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
JP2005512524A (ja) * 2001-11-02 2005-05-12 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト ヒト凝固第ｖｉｉ因子ポリペプチド
PT1499719E (pt) 2002-04-30 2011-02-09 Bayer Healthcare Llc Variantes polipeptídicas do factor vii ou viia
US6911323B2 (en) 2002-09-25 2005-06-28 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
DK1549677T3 (da) 2002-09-30 2011-07-18 Bayer Healthcare Llc FVII- eller FVIIa-varianter med forøget koagulationsaktivitet
ATE431403T1 (de) 2003-03-20 2009-05-15 Bayer Healthcare Llc Fvii oder fviia varianten
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
RU2373282C2 (ru) 2003-06-19 2009-11-20 Байер Хелткэр Ллк ВАРИАНТЫ ДОМЕНА GLA ФАКТОРА VII ИЛИ VIIa
ES2381110T3 (es) 2003-09-09 2012-05-23 Novo Nordisk Health Care Ag Polipéptidos de factor VII de coagulación
US20060040856A1 (en) 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
DE602005021509D1 (de) 2004-08-17 2010-07-08 Csl Behring Gmbh Modifizierte vitamin-k-abhängige polypeptide
JP5216580B2 (ja) 2005-05-25 2013-06-19 ノヴォ ノルディスク アー／エス グリコペグ化第ｉｘ因子
SG174077A1 (en) 2007-04-13 2011-09-29 Catalyst Biosciences Inc Modified factor vii polypetides and uses thereof
CN101778859B (zh) 2007-06-12 2014-03-26 诺和诺德公司 改良的用于生产核苷酸糖的方法
FR2917414B1 (fr) * 2007-06-15 2012-07-13 Lab Francais Du Fractionnement Facteur vii/viia humain modifie et composition pharmaceutique contenant celui-ci
TWI465247B (zh) 2008-04-11 2014-12-21 Catalyst Biosciences Inc 經修飾的因子ｖｉｉ多肽和其用途
AU2010258752B2 (en) 2009-06-09 2015-07-09 Prolong Pharmaceuticals, LLC Hemoglobin compositions
US20210069306A1 (en) 2019-08-15 2021-03-11 Catalyst Biosciences, Inc. Modified factor vii polypeptides for subcutaneous administration and on-demand treatment

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2461040A1 (fr) * 1979-07-09 1981-01-30 Inst Textile De France Procede et dispositif pour l'obtention d'un fil presentant sur sa longueur des zones de torsion alternativement de sens inverse
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
EP0201153A3 (en) * 1985-02-09 1987-10-07 Beecham Group Plc Modified enzyme and process for its preparation
GR860984B (en) * 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
DK43387A (da) * 1986-01-29 1987-07-30 Beecham Group Plc Fibrinolytisk enzym

Also Published As

Publication number Publication date
DE3871798T2 (de) 1993-05-13
ATE76900T1 (de) 1992-06-15
DK323587D0 (da) 1987-06-25
DK653989D0 (da) 1989-12-21
CA1339815C (en) 1998-04-14
EP0370036A1 (en) 1990-05-30
DK161097C (da) 1991-11-11
WO1988010295A1 (en) 1988-12-29
DE3871798D1 (de) 1992-07-09
DK161097B (da) 1991-05-27
EP0370036B1 (en) 1992-06-03
JPH03500963A (ja) 1991-03-07

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