KR890003404A - 수식형 tPA 함유 주사용 조성물 - Google Patents

수식형 tPA 함유 주사용 조성물 Download PDF

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Publication number
KR890003404A
KR890003404A KR1019880009479A KR880009479A KR890003404A KR 890003404 A KR890003404 A KR 890003404A KR 1019880009479 A KR1019880009479 A KR 1019880009479A KR 880009479 A KR880009479 A KR 880009479A KR 890003404 A KR890003404 A KR 890003404A
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KR
South Korea
Prior art keywords
amino acid
composition
modified tpa
composition containing
injectable composition
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Application number
KR1019880009479A
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English (en)
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KR910009366B1 (ko
Inventor
마사히로 가와하라
유우이찌로오 하야시
나오끼 아사까와
스미오 와다나베
야스오 미야께
Original Assignee
나이또오 하루오
에자이 가부시끼가이샤
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16406817&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR890003404(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 나이또오 하루오, 에자이 가부시끼가이샤 filed Critical 나이또오 하루오
Publication of KR890003404A publication Critical patent/KR890003404A/ko
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Publication of KR910009366B1 publication Critical patent/KR910009366B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

내용 없음

Description

수식형 tPA 함유 주사용 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 아미노산의 첨가가 전혀 없이 얻어진 대조품의 결과. 제2도는 L-아르기닌 염산염 3% 첨가의 결과. 제3도는 L-히스티딘 염산염 3% 첨가의 결과.

Claims (7)

  1. 수식형 tPA의 약리학적 유효량, 아미노산 또는 그의염 20mM이상 및 약리학적으로 허용되는 담체로 이루어진 주사용 조성물.
  2. 제1항에 있어서, 아미노산이 염기성 아미노산인 것을 특징으로 하는 조성물.
  3. 제1항에 있어서, 아미노산이 아르기닌, 히스티딘, 리신 및 오르니틴 중에서 채택된 것을 특징으로 하는 조성물.
  4. 제1항에 있어서, 아미노산이 산성 아미노산인 것을 특징으로 하는 조성물.
  5. 제1항에 있어서, 아미노산이 글루탐산 및 아스파라긴산 중에서 채택된 것을 특징으로 하는 조성물.
  6. 제1항에 있어서, 아미노산이 주성 아미노산인 것을 특징으로 하는 조성물.
  7. 제1항에 있어서, 아미노산이 글리신, 알라닌, 발린, 로이신, 세린 및 트레오닌 중에서 채택된 것을 특징으로 하는 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880009479A 1987-08-10 1988-07-27 수식형 tPA 함유 주사용 조성물 KR910009366B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP62-199381 1987-08-10
JP62199381A JP2708749B2 (ja) 1987-08-10 1987-08-10 修飾型ｔＰＡ含有注射用組成物

Publications (2)

Publication Number Publication Date
KR890003404A true KR890003404A (ko) 1989-04-14
KR910009366B1 KR910009366B1 (ko) 1991-11-14

Family

ID=16406817

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880009479A KR910009366B1 (ko) 1987-08-10 1988-07-27 수식형 tPA 함유 주사용 조성물

Country Status (11)

Country Link
US (1) US5425943A (ko)
EP (1) EP0303251B1 (ko)
JP (1) JP2708749B2 (ko)
KR (1) KR910009366B1 (ko)
AT (1) ATE84220T1 (ko)
CA (1) CA1338699C (ko)
DE (1) DE3877277T2 (ko)
DK (1) DK443988A (ko)
ES (1) ES2052651T3 (ko)
GR (1) GR3006748T3 (ko)
NO (1) NO178325C (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453363A (en) * 1985-10-23 1995-09-26 Boehringer Mannheim Gmbh Process for the activation of t-PA or Ing after genetic expression in prokaryotes
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
JP2520975B2 (ja) * 1989-09-21 1996-07-31 三井東圧化学株式会社 組織プラスミノ―ゲンアクチベ―タ―若しくはその誘導体を含有する血栓溶解剤
DE3939346A1 (de) * 1989-11-29 1991-06-06 Behringwerke Ag Arzneimitel zur subkutanen oder intramuskulaeren applikation enthaltend polypeptide
US6372716B1 (en) * 1994-04-26 2002-04-16 Genetics Institute, Inc. Formulations for factor IX
US5770700A (en) * 1996-01-25 1998-06-23 Genetics Institute, Inc. Liquid factor IX formulations
TW518219B (en) * 1996-04-26 2003-01-21 Chugai Pharmaceutical Co Ltd Erythropoietin solution preparation
DK0827751T3 (da) * 1996-09-06 2003-03-31 Chemo Sero Therapeut Res Inst Medicinsk præparat indeholdende vævsplasminogenaktivator og nicotinamid

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54147916A (en) * 1978-05-12 1979-11-19 Sumitomo Chem Co Ltd Preparation of urokinase injection
WO1984001786A1 (en) * 1982-10-28 1984-05-10 Beecham Group Plc Enzyme derivatives and their use in the treatment of thrombosis
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
DE3584902D1 (de) * 1984-02-29 1992-01-30 Asahi Chemical Ind Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren.
JPS60181028A (ja) * 1984-02-29 1985-09-14 Asahi Chem Ind Co Ltd 組織プラスミノ−ゲン・アクチベ−タ−の溶解補助法
JPS60184026A (ja) * 1984-03-01 1985-09-19 Asahi Chem Ind Co Ltd 組織プラスミノ−ゲン・アクチベ−タ−の溶解補助方法
GB8503358D0 (en) * 1985-02-09 1985-03-13 Beecham Group Plc Compounds
GB8508717D0 (en) * 1985-04-03 1985-05-09 Beecham Group Plc Composition
EP0199574B1 (en) * 1985-04-22 1991-10-23 Genentech, Inc. Human tissue plasminogen activator mutants, methods and intermediates therefor, and compositions using such mutants
US4916071A (en) * 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
NZ217331A (en) * 1985-08-26 1989-05-29 Lilly Co Eli Tissue plasminogen activator derivatives and genetically engineered product
US4960702A (en) * 1985-09-06 1990-10-02 Codon Methods for recovery of tissue plasminogen activator
JPH0811066B2 (ja) * 1985-09-30 1996-02-07 インテグレーテッド・ジエネティックス・インコーポレーテッド 組換えｄｎａが生産するヒト子宮プラスミノ−ゲンアクチベ−タ−
JPH0672105B2 (ja) * 1985-10-02 1994-09-14 持田製薬株式会社 血栓溶解剤及びその製法
JPS62120321A (ja) * 1985-11-20 1987-06-01 Eisai Co Ltd ｔＰＡ含有医薬組成物
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
ATE74379T1 (de) * 1985-12-23 1992-04-15 Chiron Corp Peptidplasminogenaktivatoren.
US4935237A (en) * 1988-03-21 1990-06-19 Genentech, Inc. Processes for the preparation of t-PA mutants
US4898826A (en) * 1987-12-10 1990-02-06 Invitron Corporation Method to solubilize tissue plasminogen activator

Also Published As

Publication number Publication date
KR910009366B1 (ko) 1991-11-14
ATE84220T1 (de) 1993-01-15
ES2052651T3 (es) 1994-07-16
DK443988A (da) 1989-02-11
EP0303251A2 (en) 1989-02-15
JP2708749B2 (ja) 1998-02-04
EP0303251B1 (en) 1993-01-07
JPS6442442A (en) 1989-02-14
DE3877277T2 (de) 1993-06-03
NO883520D0 (no) 1988-08-08
GR3006748T3 (ko) 1993-06-30
DE3877277D1 (de) 1993-02-18
EP0303251A3 (en) 1990-01-31
US5425943A (en) 1995-06-20
NO178325C (no) 1996-03-06
NO178325B (no) 1995-11-27
DK443988D0 (da) 1988-08-09
NO883520L (no) 1989-02-13
CA1338699C (en) 1996-11-12

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