ES2053589T3 - Nuevos compuestos de cistina, su fabricacion y empleo. - Google Patents

Nuevos compuestos de cistina, su fabricacion y empleo.

Info

Publication number
ES2053589T3
ES2053589T3 ES87890244T ES87890244T ES2053589T3 ES 2053589 T3 ES2053589 T3 ES 2053589T3 ES 87890244 T ES87890244 T ES 87890244T ES 87890244 T ES87890244 T ES 87890244T ES 2053589 T3 ES2053589 T3 ES 2053589T3
Authority
ES
Spain
Prior art keywords
group
amino acid
organic
independently
another
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87890244T
Other languages
English (en)
Inventor
Dr Rainer Naderer
Dr Klaus Langer
Dr Lothar Buxbaum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kabi Pharmacia GmbH
Original Assignee
Kabi Pharmacia GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Pharmacia GmbH filed Critical Kabi Pharmacia GmbH
Application granted granted Critical
Publication of ES2053589T3 publication Critical patent/ES2053589T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)

Abstract

SE PRESENTAN NUEVOS COMPUESTOS DE CISTINA DE FORMULA GENERAL (I), EN LA QUE AS (AMINOACIDOS) INDEPENDIENTEMENTE UNO DE OTRO, SIGNIFICA L-AMINOACIDO, EN ESPECIAL GLICINA, ALANINA, PROLINA, TRONINA, SERINA, VALINA, ARGININA, LISINA U ORNITINA, LOS R1 SON, INDEPENDIENTEMENTE UNO DE OTRO UN RESTO ACILO DE UN ACIDO ORGANICO CON 2-5 ATOMOS DE C, PREFERENTEMENTE ACETILO, PROPIONILO, SUCCINILO O HIDROXISUCCINILO, O UN L-AMINOACIDO, QUE SE UNE CON EL GRUPO AMINO DEL AMINOACIDO AS SOBRE SU GRUPO CARBOXILO DE TIPO AMIDA, LOS AMINOACIDOS PREFERIDOS CITADOS PARA AS TAMBIEN SE PREFIEREN PARA LOS AMINOACIDOS DE R1, O LOS DE R1 JUNTOS FORMAN EL RESTO ACILO DE UN ACIDO DICARBOXILICO ORGANICO CON PREFERENCIA AL RESTO DE ACIDO SUCCINICO O MALICO. LOS R2,INDEPENDIENTEMENTE UNO DE OTRO SON UN RESTO ALCOXI CON 1-4 ATOMOS DE C, CON PREFERENCIA A METOXI O ETOXI, UN RESTO HIDROXI, DE DONDE EN EL CASO DEL SIGNIFICADO DE R2= GRUPOS CARBOXILO CON H PUEDEN EXISTIR COMO TALES O COMO SAL ORGANICA O INORGANICA, PREFERENTEMENTE CON NAOH O KOH, BASES ORGANICAS O AMINOACIDOS BASICOA COMO L-LISINA, L-ORNITINA, L-ARGININA O L-HISTIDINA. PROCEDIMIENTO PARA SU OBTENCION Y COMPOSICION DE NUTRIENTES OBTENIDOS.
ES87890244T 1986-11-07 1987-11-04 Nuevos compuestos de cistina, su fabricacion y empleo. Expired - Lifetime ES2053589T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0298086A AT402931B (de) 1986-11-07 1986-11-07 Verfahren zur herstellung von neuen cystinverbindungen und derenverwendung

Publications (1)

Publication Number Publication Date
ES2053589T3 true ES2053589T3 (es) 1994-08-01

Family

ID=3543430

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87890244T Expired - Lifetime ES2053589T3 (es) 1986-11-07 1987-11-04 Nuevos compuestos de cistina, su fabricacion y empleo.

Country Status (6)

Country Link
US (1) US4801579A (es)
EP (1) EP0267179B1 (es)
JP (1) JPS63233999A (es)
AT (2) AT402931B (es)
DE (1) DE3784215D1 (es)
ES (1) ES2053589T3 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5102871A (en) * 1989-04-24 1992-04-07 Kyowa Hakko Kogyo Co., Ltd. Nutrient composition
SE9103572D0 (sv) * 1991-11-29 1991-11-29 Astra Ab Organic salts of n,n'-diacetyl cystine
PT2238842E (pt) * 2004-09-09 2015-04-08 Nestec Sa Produtos nutricionais possuindo qualidade melhorada e métodos e sistemas em relação a estes
WO2011035005A2 (en) * 2009-09-16 2011-03-24 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for reducing the risk of agent-induced liver toxicity
US11260005B2 (en) 2016-12-21 2022-03-01 Conopco, Inc. Personal care compositions with glutathione precursor comprising 4-substituted resorcinols and amino acids
EA201991185A1 (ru) 2016-12-21 2020-01-13 Юнилевер Н.В. Композиции для личной гигиены, содержащие цистин
CN110099672B (zh) 2016-12-21 2022-05-24 联合利华知识产权控股有限公司 具有氨基酸和烟酰胺化合物的局部皮肤增亮添加剂和组合物
US10751267B2 (en) * 2016-12-21 2020-08-25 Conopco, Inc. Personal care compositions comprising poorly soluble compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1768777A1 (de) * 1968-06-28 1971-07-08 Hoechst Ag Cysteinhaltige Peptide und deren Derivate und ein Verfahren zu ihrer Herstellung
DE1917939C3 (de) * 1969-04-09 1981-04-09 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung cystinhaltiger Peptide
CH517705A (de) * 1969-12-16 1972-01-15 Ciba Geigy Ag Verfahren zur Herstellung von Cystin-haltigen Peptiden
BE785933A (fr) * 1971-07-07 1973-01-08 Ciba Geigy Procede de preparation de peptides contenant de la cystine
SE399880B (sv) * 1973-05-24 1978-03-06 Ciba Geigy Ag Sett att framstella peptider, som innehaller mer en en disulfidbindning
US4284624A (en) * 1980-05-02 1981-08-18 E. R. Squibb & Sons, Inc. Mixed disulfides
JPS62195356A (ja) * 1986-02-20 1987-08-28 Seiwa Kasei:Kk シスチン誘導体及びその塩
JPH01501706A (ja) * 1986-10-24 1989-06-15 プリマー　カビ　ゲーエムベーハー　ウント　コ．カーゲー 経口投与及び腸管外投与用のｎ，ｎ′―ビス―ｌ―アミノ酸―ｌ―シスチン―ペプタイドを含有するアミノ酸製剤

Also Published As

Publication number Publication date
EP0267179A3 (en) 1990-02-28
DE3784215D1 (de) 1993-03-25
AT402931B (de) 1997-09-25
ATE85798T1 (de) 1993-03-15
JPS63233999A (ja) 1988-09-29
EP0267179A2 (de) 1988-05-11
ATA298086A (de) 1997-02-15
US4801579A (en) 1989-01-31
EP0267179B1 (de) 1993-02-17

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