ES8706622A1 - Procedimiento para preparar alfa-aminoacidos sustituidos - Google Patents

Procedimiento para preparar alfa-aminoacidos sustituidos

Info

Publication number
ES8706622A1
ES8706622A1 ES555560A ES555560A ES8706622A1 ES 8706622 A1 ES8706622 A1 ES 8706622A1 ES 555560 A ES555560 A ES 555560A ES 555560 A ES555560 A ES 555560A ES 8706622 A1 ES8706622 A1 ES 8706622A1
Authority
ES
Spain
Prior art keywords
amino acids
group
preparation
ester
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES555560A
Other languages
English (en)
Other versions
ES555560A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848408059A external-priority patent/GB8408059D0/en
Priority claimed from GB848421091A external-priority patent/GB8421091D0/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES555560A0 publication Critical patent/ES555560A0/es
Publication of ES8706622A1 publication Critical patent/ES8706622A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

METODO DE PREPARAR ALFA-AMINOACIDOS SUSTITUIDOS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) PARA OBTENER ALFA-AMINOACIDOS SUSTITUIDOS DE FORMULA (I) DONDE M Y N, INDEPENDIENTEMENTE UNA DE OTRA SON 1, 2 O 3; R1 ES H O UN RADICAL CAPAZ DE FORMAR UN ESTER; A ES UN GRUPO AMINO EVENTUALMENTE SUSTITUIDO; X ELEVADO A V ES UN GRUPO ACIDO QUE CONTIENE FOSFORO, EN EL QUE EL FOSFORO ESTA UNIDO DIRECTAMENTE AL GRUPO -(CH2)N- O A UN ESTER ALQUILICO DEL MISMO. TIENEN UTILIDAD PARA PREPARAR COMPOSICIONES FARMACEUTICAS.
ES555560A 1984-03-29 1986-05-30 Procedimiento para preparar alfa-aminoacidos sustituidos Expired ES8706622A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848408059A GB8408059D0 (en) 1984-03-29 1984-03-29 Organic compounds
GB848421091A GB8421091D0 (en) 1984-08-20 1984-08-20 Organic compounds

Publications (2)

Publication Number Publication Date
ES555560A0 ES555560A0 (es) 1987-07-01
ES8706622A1 true ES8706622A1 (es) 1987-07-01

Family

ID=26287523

Family Applications (3)

Application Number Title Priority Date Filing Date
ES541689A Expired ES8704957A1 (es) 1984-03-29 1985-03-28 Procedimiento para preparar alfa-aminoacidos sustituidos
ES555560A Expired ES8706622A1 (es) 1984-03-29 1986-05-30 Procedimiento para preparar alfa-aminoacidos sustituidos
ES555559A Expired ES8802015A1 (es) 1984-03-29 1986-05-30 Procedimiento para preparar alfa-aminoacidos sustituidos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES541689A Expired ES8704957A1 (es) 1984-03-29 1985-03-28 Procedimiento para preparar alfa-aminoacidos sustituidos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES555559A Expired ES8802015A1 (es) 1984-03-29 1986-05-30 Procedimiento para preparar alfa-aminoacidos sustituidos

Country Status (16)

Country Link
AU (1) AU4042585A (es)
BE (1) BE902040A (es)
DE (1) DE3510858A1 (es)
DK (1) DK139185A (es)
ES (3) ES8704957A1 (es)
FI (1) FI851234L (es)
FR (1) FR2562076A1 (es)
GB (1) GB2156818B (es)
GR (1) GR850770B (es)
HU (1) HUT40447A (es)
IL (1) IL74734A0 (es)
IT (1) IT1199964B (es)
LU (1) LU85826A1 (es)
NL (1) NL8500847A (es)
PT (1) PT80178B (es)
SE (1) SE8501548L (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906621A (en) * 1985-05-24 1990-03-06 Ciba-Geigy Corporation Certain 2-carboxypiperidyl-alkylene phosphonic acids and esters thereof useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade
US5217963A (en) * 1985-05-24 1993-06-08 Ciba-Geigy Corporation Certain phosphonic acid quinoline-2-carboxylic acids, esters or amides useful for treatment of disorders responsive to N-methyl D-aspartate receptor blockade
US4746653A (en) * 1986-02-28 1988-05-24 Ciba-Geigy Corporation Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals
US5175153A (en) * 1987-11-30 1992-12-29 Warner-Lambert Company Substituted alpha-amino acids having pharmaceutical activity
IT1216096B (it) * 1988-03-15 1990-02-22 Farmaceutica Italiana S P A S L_piroglutamil_l_cisteina, dipeptide ad elevata attivita'anticatarattogena e composizioni farmaceutiche che lo contengono.
WO1990003399A1 (en) * 1988-09-30 1990-04-05 Australian Commercial Research & Development Limited Amino acid transport proteins, amino acid analogues, assay apparatus, uses thereof for treatment and diagnosis of cancer
US5179085A (en) * 1989-03-15 1993-01-12 Warner-Lambert Company N-substituted α-amino acids and derivatives thereof having pharmaceutical activity
US5500419A (en) * 1989-09-19 1996-03-19 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
JPH03236315A (ja) * 1989-12-05 1991-10-22 Nippon Oil & Fats Co Ltd 抗精神病薬
US5238958A (en) * 1990-02-26 1993-08-24 Warner-Lambert Company Substituted α-amino acids having selected acidic moieties for use as excitatory amino acid antagonists in pharmaceuticals
IT1249650B (it) * 1991-05-29 1995-03-09 Poli Ind Chimica Spa N-(5-tioxo-l-prolil)-l-cisteina e suoi derivati, loro preparazione ed impiego terapeutico
IT1256178B (it) * 1992-11-30 1995-11-29 Lorenzo Ferrari Composti ad attivita' terapeutica utili per il trattamento di malattieconnesse ad una carenza di glutatione, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
DE4433555B4 (de) * 1994-09-07 2005-04-28 Guenther Oehme Wasserlösliche chirale und achirale Phosphine, Verfahren zu ihrer Herstellung und ihre Verwendung
DE10045831A1 (de) * 2000-09-14 2002-04-04 Gruenenthal Gmbh Thio-Aminosäuren
DK1317426T3 (da) 2000-09-14 2006-01-09 Gruenenthal Gmbh Betal-thio-aminosyrer
WO2003024423A1 (en) * 2001-09-18 2003-03-27 Vasogen Ireland Limited Apoptosis-mimicking synthetic entities and use thereof in medical treatment
EP3427729A1 (en) 2017-07-13 2019-01-16 Paris Sciences et Lettres - Quartier Latin Probenecid for use in treating epileptic diseases, disorders or conditions
KR20200052329A (ko) 2017-09-08 2020-05-14 에프. 호프만-라 로슈 아게 질량 분석법용의 설폭사이드 기반 시약

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2104079B (en) * 1981-08-14 1985-08-21 London Polytech New aminoacid isomers, their production and their medicinal use

Also Published As

Publication number Publication date
PT80178B (en) 1987-03-20
FR2562076A1 (fr) 1985-10-04
ES8704957A1 (es) 1987-04-16
HUT40447A (en) 1986-12-28
IT8547877A0 (it) 1985-03-27
ES555560A0 (es) 1987-07-01
IL74734A0 (en) 1985-06-30
SE8501548D0 (sv) 1985-03-28
GB2156818A (en) 1985-10-16
PT80178A (en) 1985-04-01
ES8802015A1 (es) 1988-03-16
LU85826A1 (fr) 1985-12-12
GB2156818B (en) 1987-10-21
DK139185D0 (da) 1985-03-27
SE8501548L (sv) 1985-09-30
DE3510858A1 (de) 1985-10-10
FI851234L (fi) 1985-09-30
IT8547877A1 (it) 1986-09-27
GR850770B (es) 1985-07-23
BE902040A (fr) 1985-09-30
DK139185A (da) 1985-09-30
NL8500847A (nl) 1985-10-16
ES555559A0 (es) 1988-03-16
FI851234A0 (fi) 1985-03-27
IT1199964B (it) 1989-01-05
AU4042585A (en) 1985-10-03
ES541689A0 (es) 1987-04-16
GB8507794D0 (en) 1985-05-01

Similar Documents

Publication Publication Date Title
ES8802015A1 (es) Procedimiento para preparar alfa-aminoacidos sustituidos
ES2012521A6 (es) Procedimiento para preparar acidos alfa-amino-alfa-(3-alquilfenil)alquiletanoiocos, esteres y amidas de los mismos.
ZA944884B (en) Derivatives of valproic acid amides and 2-valproenoic acid amides method of making and use thereof as anticonvulsant agent
EP0200218A3 (en) New tetrapyrrole therapeutic agents
IL88810A (en) 1, 2, 3, 4, 6, 7, 8, 12b-octahydro 7-(mercaptomethyl)- 6-oxopyrido (2,1-a) (2)- benzazepine-4-carboxylic acid, esters thereof and pharmaceutical compositions containing same
ES8608486A1 (es) Un procedimiento para preparar un compuesto de carboximida
GB8601368D0 (en) Hydroxamic acids
GR79751B (es)
IL71933A0 (en) Cephalosporin derivatives,their production and pharmaceutical composition containing them
AU2015088A (en) New sulphur compounds, processes for the preparation thereof and pharmaceutical compositions containing them
ATE92315T1 (de) Aminosaeurederivate enthaltende antikonvulsive zusammensetzungen und verwendung dieser aminosaeurederivate.
GR3006748T3 (es)
RO92794A (ro) Procedeu pentru prepararea unor esteri de acid 2-brom-4-metilimidazol-5-carboxilic
YU226283A (en) Process for preparing new benzazepine derivatives
FR2574078B1 (fr) Procede de production d'amides d'acides carboxyliques persilyles
GB8410992D0 (en) Process
HU9300181D0 (en) Alpha-aryl-alpha-hydroxi-beta-imidazolinyl-propionic acid amide
PT81256A (en) Process for the preparation of 1,2,3,4,6,7,12,12b-octahydroindolo/2,3-a/quinolizin-1-yl-alkanecarboxylic acid amides and their therapeutically useful acid addition salts pharmaceutical compositions containing them
RO84689A2 (ro) Procedeu de preparare a acidului 4-(n-metil n-tosil)aminobenzoic si aesterului etilic al acestuia
FR2521131B1 (fr) Procede d'hydrogenolyse d'esters d'acides carboxyliques