ES2019545A6 - Procedimiento de preparacion de n-alquil aminoacidos, dipeptidos y aminocompuestos ciclicos. - Google Patents

Procedimiento de preparacion de n-alquil aminoacidos, dipeptidos y aminocompuestos ciclicos.

Info

Publication number
ES2019545A6
ES2019545A6 ES9000889A ES9000889A ES2019545A6 ES 2019545 A6 ES2019545 A6 ES 2019545A6 ES 9000889 A ES9000889 A ES 9000889A ES 9000889 A ES9000889 A ES 9000889A ES 2019545 A6 ES2019545 A6 ES 2019545A6
Authority
ES
Spain
Prior art keywords
preparation
cyclic
dipeptides
amino acids
amine compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9000889A
Other languages
English (en)
Inventor
Castellvi Juan Cabre
Nicolau Francisco E Palomo
Oller Jose Maria Solis
Coll Antonio Luis Palomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centro Marga Para la Investigacion SA
Original Assignee
Centro Marga Para la Investigacion SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centro Marga Para la Investigacion SA filed Critical Centro Marga Para la Investigacion SA
Priority to ES9000889A priority Critical patent/ES2019545A6/es
Publication of ES2019545A6 publication Critical patent/ES2019545A6/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

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  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE COMPUESTOS DE LA FORMULA (I) QUE CONSISTE EN LA REACCION DEL ANHIDRIDO TRIFLICO CON (R, S), (R) O (S) 2-TRIMETILSILILOXI-4-FENILBUTIRATOS (III), Y EL TRIFALTO (IV) RESULTANTE SE COMBINA CON UN DIPEPTIDO O AMINO COMPUESTO CICLICO (VI), DONDE RBS1, RBS2, RBS3 Y RBS4 TIENEN LA SIGNIFICACION DADA EN LA MEMORIA. FORMULA ALTERNATIVAMENTE UN COMPUESTO (I) SE OBTIENE DE LA COMBINACION DEL ANHIDRIDO TRIFLICO CON (R)-(2-TRIMETILSILILOXI-PROPIONIL)-L-PROLINA (III) (RBS2 Y RBS3 FORMAN UN CICLO) Y EL TRIFLATO (V) FORMADO SE HACE REACCIONAR CON EL ESTER ETILICO (R=CSI2HSI5) DEL AMINOACIDO PREFERENTEMENTE (S)-2-AMINO-4-FENILBUTIRICO. LOS COMPUESTOS DE FORMULA I SON DE INTERES COMO ANTIHIPERTENSIVOS.
ES9000889A 1990-03-29 1990-03-29 Procedimiento de preparacion de n-alquil aminoacidos, dipeptidos y aminocompuestos ciclicos. Expired - Fee Related ES2019545A6 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9000889A ES2019545A6 (es) 1990-03-29 1990-03-29 Procedimiento de preparacion de n-alquil aminoacidos, dipeptidos y aminocompuestos ciclicos.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9000889A ES2019545A6 (es) 1990-03-29 1990-03-29 Procedimiento de preparacion de n-alquil aminoacidos, dipeptidos y aminocompuestos ciclicos.

Publications (1)

Publication Number Publication Date
ES2019545A6 true ES2019545A6 (es) 1991-06-16

Family

ID=8266611

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9000889A Expired - Fee Related ES2019545A6 (es) 1990-03-29 1990-03-29 Procedimiento de preparacion de n-alquil aminoacidos, dipeptidos y aminocompuestos ciclicos.

Country Status (1)

Country Link
ES (1) ES2019545A6 (es)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002564A1 (en) * 1994-07-13 1996-02-01 Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. Process for the preparation of compounds having ace inhibitory action as well as novel compounds useful as starting materials or intermediates in said process
ES2136028A1 (es) * 1997-11-03 1999-11-01 Valles Rodoreda Martin Esteres del acido 2-(r)-fluorosulfoniloxi-4-fenibutirico, procedimiento para su obtencion y procedimiento para su utilizacion en la preparacion de carboxialquildipeptidos.
ES2212909A1 (es) * 2003-01-21 2004-08-01 Chemo Iberica, S.A. Procedimiento de obtencion de lisinopril con bajo contenido en cenizas.

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002564A1 (en) * 1994-07-13 1996-02-01 Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. Process for the preparation of compounds having ace inhibitory action as well as novel compounds useful as starting materials or intermediates in said process
ES2136028A1 (es) * 1997-11-03 1999-11-01 Valles Rodoreda Martin Esteres del acido 2-(r)-fluorosulfoniloxi-4-fenibutirico, procedimiento para su obtencion y procedimiento para su utilizacion en la preparacion de carboxialquildipeptidos.
ES2212909A1 (es) * 2003-01-21 2004-08-01 Chemo Iberica, S.A. Procedimiento de obtencion de lisinopril con bajo contenido en cenizas.

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000927