JPS57189694A - Optical resolving method of amino acid ester - Google Patents
Optical resolving method of amino acid esterInfo
- Publication number
- JPS57189694A JPS57189694A JP6748382A JP6748382A JPS57189694A JP S57189694 A JPS57189694 A JP S57189694A JP 6748382 A JP6748382 A JP 6748382A JP 6748382 A JP6748382 A JP 6748382A JP S57189694 A JPS57189694 A JP S57189694A
- Authority
- JP
- Japan
- Prior art keywords
- expressed
- ester
- aminocarboxylic
- adduct compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: To obtain the titled substance from an adduct compound, by reacting an N-substituted monoaminodicarboxylic acid with an aminocarboxylic ester in an aqueous medium in the presence of a proteolytic enzyme, and forming the adduct compound of the reaction product with the aminocarboxylic ester.
CONSTITUTION: An N-substituted monoaminodicarboxylic acid expressed by formulaI(R1 is aliphatic oxycarbonyl, benzoyl, etc.; n is 1 or 2) is reacted with the DL-form of an aminocarboxylic ester expressed by formula II (R2 is methyl, isobutyl, etc.; R3 is lower alkoxyl, benzyloxy, etc.) in an aqueous medium, e.g. an aqueous solution, in the presence of a proteolytic enzyme, e.g. metallic protease, at a pH of 5W8. The resultant dipeptide ester is converted into an adduct compound expressed by formula IV with an aminocarboxylic ester expressed by formula III, and the formed adduct compound is separated and decomposed with an acid to give the aimed aminocarboxylic ester expressed by foumula V of the D-form or rich in the D-form.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6748382A JPS5943159B2 (en) | 1982-04-23 | 1982-04-23 | Optical resolution method for amino acid esters |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6748382A JPS5943159B2 (en) | 1982-04-23 | 1982-04-23 | Optical resolution method for amino acid esters |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP727977A Division JPS5392729A (en) | 1977-01-27 | 1977-01-27 | Adduct of dipeptide derivatives and amino acid derivatives and process for their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57189694A true JPS57189694A (en) | 1982-11-22 |
JPS5943159B2 JPS5943159B2 (en) | 1984-10-19 |
Family
ID=13346264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6748382A Expired JPS5943159B2 (en) | 1982-04-23 | 1982-04-23 | Optical resolution method for amino acid esters |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5943159B2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1240947A (en) * | 1984-08-27 | 1988-08-23 | Louis E. Shipos | Ribbon cassette |
-
1982
- 1982-04-23 JP JP6748382A patent/JPS5943159B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS5943159B2 (en) | 1984-10-19 |
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