JPS5519051A - Production of adduct of n-benzyloxycarbonyl-l-aspartyl-l- phenylalanine methyl ester to methyl phenylalanate - Google Patents

Production of adduct of n-benzyloxycarbonyl-l-aspartyl-l- phenylalanine methyl ester to methyl phenylalanate

Info

Publication number
JPS5519051A
JPS5519051A JP9183478A JP9183478A JPS5519051A JP S5519051 A JPS5519051 A JP S5519051A JP 9183478 A JP9183478 A JP 9183478A JP 9183478 A JP9183478 A JP 9183478A JP S5519051 A JPS5519051 A JP S5519051A
Authority
JP
Japan
Prior art keywords
phenylalanate
methyl
benzyloxycarbonyl
adduct
aspartyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9183478A
Other languages
Japanese (ja)
Other versions
JPS6022918B2 (en
Inventor
Yoshikazu Isowa
Muneki Omori
Kaoru Mori
Tetsuya Ichikawa
Yuji Nonaka
Keiichi Kihara
Kiyotaka Koyama
Heijiro Sato
Shigesato Nishimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Sagami Chemical Research Institute
Tosoh Corp
Original Assignee
Ajinomoto Co Inc
Sagami Chemical Research Institute
Toyo Soda Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc, Sagami Chemical Research Institute, Toyo Soda Manufacturing Co Ltd filed Critical Ajinomoto Co Inc
Priority to JP9183478A priority Critical patent/JPS6022918B2/en
Publication of JPS5519051A publication Critical patent/JPS5519051A/en
Publication of JPS6022918B2 publication Critical patent/JPS6022918B2/en
Expired legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: The addition reaction of methyl phenylalanate to a dipeptide ester from aspaltic acid and methyl phenylalanate to efficiently produce title compound as an intermediate of sweetening agent.
CONSTITUTION: The reaction between (A) N-benzyloxycarbonyl aspaltic acid and (B) methyl phenylalanate is effected by standing them in an aqueous medium in the presence of a metal protease to form the dipeptide ester, to which further (B) methyl phenylalanate is added to produce the adduct.
COPYRIGHT: (C)1980,JPO&Japio
JP9183478A 1978-07-27 1978-07-27 Method for producing an addition compound of N-benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl-ester and phenylalanine methyl ester Expired JPS6022918B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9183478A JPS6022918B2 (en) 1978-07-27 1978-07-27 Method for producing an addition compound of N-benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl-ester and phenylalanine methyl ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9183478A JPS6022918B2 (en) 1978-07-27 1978-07-27 Method for producing an addition compound of N-benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl-ester and phenylalanine methyl ester

Publications (2)

Publication Number Publication Date
JPS5519051A true JPS5519051A (en) 1980-02-09
JPS6022918B2 JPS6022918B2 (en) 1985-06-04

Family

ID=14037616

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9183478A Expired JPS6022918B2 (en) 1978-07-27 1978-07-27 Method for producing an addition compound of N-benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl-ester and phenylalanine methyl ester

Country Status (1)

Country Link
JP (1) JPS6022918B2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57146595A (en) * 1981-02-02 1982-09-10 Searle & Co Production of amino protected-l- aspartyl-l-phenylalanine alkyl ester
US4587214A (en) * 1982-08-06 1986-05-06 Toyo Soda Manufacturing Co., Ltd. Process for preparation of aspartylphenylalanine alkyl esters
US5097060A (en) * 1982-04-12 1992-03-17 Ajinomoto Company Incorporated Process for crystallizing l-alpha-aspartyl-l-phenyl-alanine methyl ester

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57146595A (en) * 1981-02-02 1982-09-10 Searle & Co Production of amino protected-l- aspartyl-l-phenylalanine alkyl ester
US5097060A (en) * 1982-04-12 1992-03-17 Ajinomoto Company Incorporated Process for crystallizing l-alpha-aspartyl-l-phenyl-alanine methyl ester
US5744632A (en) * 1982-04-12 1998-04-28 Ajinomoto Company Incorporated Process for crystallizing L-α-aspartyl-L-phenylalanine methyl ester
US4587214A (en) * 1982-08-06 1986-05-06 Toyo Soda Manufacturing Co., Ltd. Process for preparation of aspartylphenylalanine alkyl esters

Also Published As

Publication number Publication date
JPS6022918B2 (en) 1985-06-04

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