JPS5519052A - Production of adduct of n-benzyloxycarbonyl-l-aspartyl-l- phenylalanine methyl ester to methyl phenylalanate - Google Patents

Production of adduct of n-benzyloxycarbonyl-l-aspartyl-l- phenylalanine methyl ester to methyl phenylalanate

Info

Publication number
JPS5519052A
JPS5519052A JP9183578A JP9183578A JPS5519052A JP S5519052 A JPS5519052 A JP S5519052A JP 9183578 A JP9183578 A JP 9183578A JP 9183578 A JP9183578 A JP 9183578A JP S5519052 A JPS5519052 A JP S5519052A
Authority
JP
Japan
Prior art keywords
methyl
phenylalanate
adduct
benzyloxycarbonyl
aspartyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9183578A
Other languages
Japanese (ja)
Other versions
JPS6022919B2 (en
Inventor
Yoshikazu Isowa
Muneki Omori
Kaoru Mori
Tetsuya Ichikawa
Yuji Nonaka
Keiichi Kihara
Kiyotaka Koyama
Heijiro Sato
Shigesato Nishimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Sagami Chemical Research Institute
Tosoh Corp
Original Assignee
Ajinomoto Co Inc
Sagami Chemical Research Institute
Toyo Soda Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc, Sagami Chemical Research Institute, Toyo Soda Manufacturing Co Ltd filed Critical Ajinomoto Co Inc
Priority to JP53091835A priority Critical patent/JPS6022919B2/en
Publication of JPS5519052A publication Critical patent/JPS5519052A/en
Publication of JPS6022919B2 publication Critical patent/JPS6022919B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: Methyl phenylalanate is added to a dipeptide ester resulting from reaction of methyl phenylalanate and an aspaltic acid derivative to produce title compound useful as an intermediate of sweetening agent in high efficiency.
CONSTITUTION: The reaction between (A) N-benzyloxycarbonyl-aspaltic acid and (B) methyl phenylalanate is effected in an aqueous medium in the presence of a metal protease to form the adduct of (A) and (B), wherein when the concentration of (B) is kept over 10-1mol/l, the adduct of the dipeptide ester and (B) is separated, thus producting the adduct of N-benzyloxycarbonyl-L-aspaltyl-L-phenyl- alanin methyl ester and methyl phenylalanate.
COPYRIGHT: (C)1980,JPO&Japio
JP53091835A 1978-07-27 1978-07-27 Method for producing an addition compound of N-benzyloxycarbonyl-L-aspatyl-L-phenylalanine methyl ester and phenylalanine methyl ester Expired JPS6022919B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP53091835A JPS6022919B2 (en) 1978-07-27 1978-07-27 Method for producing an addition compound of N-benzyloxycarbonyl-L-aspatyl-L-phenylalanine methyl ester and phenylalanine methyl ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53091835A JPS6022919B2 (en) 1978-07-27 1978-07-27 Method for producing an addition compound of N-benzyloxycarbonyl-L-aspatyl-L-phenylalanine methyl ester and phenylalanine methyl ester

Publications (2)

Publication Number Publication Date
JPS5519052A true JPS5519052A (en) 1980-02-09
JPS6022919B2 JPS6022919B2 (en) 1985-06-04

Family

ID=14037642

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53091835A Expired JPS6022919B2 (en) 1978-07-27 1978-07-27 Method for producing an addition compound of N-benzyloxycarbonyl-L-aspatyl-L-phenylalanine methyl ester and phenylalanine methyl ester

Country Status (1)

Country Link
JP (1) JPS6022919B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57146595A (en) * 1981-02-02 1982-09-10 Searle & Co Production of amino protected-l- aspartyl-l-phenylalanine alkyl ester

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57146595A (en) * 1981-02-02 1982-09-10 Searle & Co Production of amino protected-l- aspartyl-l-phenylalanine alkyl ester

Also Published As

Publication number Publication date
JPS6022919B2 (en) 1985-06-04

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