FI961886A - Ihmisen Kunitz-tyyppiset proteaasi-inhibiittorit - Google Patents

Ihmisen Kunitz-tyyppiset proteaasi-inhibiittorit Download PDF

Info

Publication number
FI961886A
FI961886A FI961886A FI961886A FI961886A FI 961886 A FI961886 A FI 961886A FI 961886 A FI961886 A FI 961886A FI 961886 A FI961886 A FI 961886A FI 961886 A FI961886 A FI 961886A
Authority
FI
Finland
Prior art keywords
dna
human kunitz
protease inhibitors
dna segment
type protease
Prior art date
Application number
FI961886A
Other languages
English (en)
Swedish (sv)
Other versions
FI961886A0 (fi
Inventor
Cindy A Sprecher
Walter Kisiel
Donald C Foster
Original Assignee
Zymogenetics Inc
Univ New Mexico
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc, Univ New Mexico filed Critical Zymogenetics Inc
Publication of FI961886A0 publication Critical patent/FI961886A0/fi
Publication of FI961886A publication Critical patent/FI961886A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FI961886A 1993-11-05 1996-05-03 Ihmisen Kunitz-tyyppiset proteaasi-inhibiittorit FI961886A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/147,710 US5455338A (en) 1993-11-05 1993-11-05 DNA encoding novel human kunitz-type inhibitors and methods relating thereto
PCT/US1994/012609 WO1995012674A1 (en) 1993-11-05 1994-11-02 Human kunitz-type protease inhibitors

Publications (2)

Publication Number Publication Date
FI961886A0 FI961886A0 (fi) 1996-05-03
FI961886A true FI961886A (fi) 1996-07-03

Family

ID=22522614

Family Applications (1)

Application Number Title Priority Date Filing Date
FI961886A FI961886A (fi) 1993-11-05 1996-05-03 Ihmisen Kunitz-tyyppiset proteaasi-inhibiittorit

Country Status (12)

Country Link
US (7) US5455338A (fi)
EP (1) EP0726953B1 (fi)
JP (1) JP3201527B2 (fi)
KR (1) KR100243989B1 (fi)
CN (1) CN1073159C (fi)
AT (1) ATE262587T1 (fi)
AU (1) AU685190B2 (fi)
CA (1) CA2175797C (fi)
DE (1) DE69433647T2 (fi)
FI (1) FI961886A (fi)
NO (1) NO961812L (fi)
WO (1) WO1995012674A1 (fi)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455338A (en) * 1993-11-05 1995-10-03 Zymogenetics, Inc. DNA encoding novel human kunitz-type inhibitors and methods relating thereto
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
DE69618560T2 (de) * 1995-08-09 2002-08-14 Toray Industries, Inc. Medikament gegen ophthalmische erkrankungen
KR100356956B1 (ko) 1996-03-11 2003-03-15 베이어 코오포레이숀 사람비쿠닌
JP3819239B2 (ja) * 1998-12-22 2006-09-06 バイエル アクチェンゲゼルシャフト 粘膜線毛クリアランスの速度を促進する方法
US20070140979A1 (en) * 1998-12-22 2007-06-21 Bayer Aktiengesellschaft Method for accelerating the rate of mucociliary clearance
WO2001009360A1 (en) * 1999-08-02 2001-02-08 Avigen, Inc. USE OF RECOMBINANT ADENO-ASSOCIATED VIRUS VECTOR (rAAV) FOR THE PREVENTION OF SMOOTH MUSCLE CELL PROLIFERATION IN A VASCULAR GRAFT
US6180607B1 (en) 1999-08-05 2001-01-30 Christopher Davies Protein having proteinase inhibitor activity
US20040235715A1 (en) * 1999-11-12 2004-11-25 Bayer Corporation Method of producing glycosylated bikunin
US6355243B1 (en) * 1999-11-13 2002-03-12 Bayer Corporation Method of thrombolysis by local delivery of active plasmin
US7544500B2 (en) * 1999-11-13 2009-06-09 Talecris Biotherapeutics, Inc. Process for the production of a reversibly inactive acidified plasmin composition
US6964764B2 (en) 1999-11-13 2005-11-15 Talecris Biotherapeutics, Inc. Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
WO2001070174A2 (en) * 2000-03-21 2001-09-27 Curagen Corporation Vegf-modulated genes and methods employing them
US6781817B2 (en) 2000-10-02 2004-08-24 Biosource, Inc. Fringe-field capacitor electrode for electrochemical device
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
AU2003243394B2 (en) 2002-06-07 2008-06-12 Takeda Pharmaceutical Company Limited Prevention and reduction of blood loss
US7244616B2 (en) 2003-06-27 2007-07-17 Bayer Pharmaceuticals Corporation Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells
US7432238B2 (en) * 2004-04-16 2008-10-07 Stc.Unm Human Kunitz-type inhibitor with enhanced antifibrinolytic activity
US7910550B2 (en) * 2004-04-16 2011-03-22 Stc.Unm Human kunitz-type inhibitor with enhanced antifibrinolytic activity
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
CA2597325A1 (en) * 2005-03-10 2006-09-21 Genentech, Inc. Methods and compositions for modulating vascular integrity
EP2653542B1 (en) 2005-12-29 2016-06-29 The Regents of The University of California Methods and compositions related to mutant kunitz domain I of TFPI-2
DK1981519T3 (en) 2005-12-29 2018-02-19 Dyax Corp protease inhibition
US20070278239A1 (en) * 2006-05-17 2007-12-06 Michele Vogt Sipping lid closure device and method of use
AU2008289005A1 (en) * 2007-08-21 2009-02-26 Genzyme Corporation Treatment with kallikrein inhibitors
DE102007056231A1 (de) 2007-09-08 2009-03-12 Bayer Healthcare Ag Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI)
BRPI0816837B1 (pt) 2007-09-28 2022-10-18 Portola Pharmaceuticals, Inc Composições farmacêuticas, polipeptídeo isolado de duas cadeias e uso de uma composição farmacêutica
BRPI0913397B8 (pt) * 2008-06-04 2021-05-25 Grifols Therapeutics Inc método para preparar plasmina
JP5739816B2 (ja) 2008-12-19 2015-06-24 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ Ｔｆｐｉインヒビターおよび使用法
PL2379600T5 (pl) 2008-12-22 2021-03-08 Novo Nordisk A/S Przeciwciała przeciwko inhibitorowi szlaku czynnika tkankowego
US8637454B2 (en) * 2009-01-06 2014-01-28 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
JP5789521B2 (ja) 2009-03-03 2015-10-07 グリフオルス・セラピユーテイクス・インコーポレーテツドＧｒｉｆｏｌｓ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． プラスミノーゲンを製造するための組成物、方法およびキット；ならびにそれから製造されるプラスミン
ES2607935T3 (es) 2009-03-30 2017-04-04 Portola Pharmaceuticals, Inc. Antídotos para inhibidores del factor Xa y procedimientos de uso de los mismos
CN101588509B (zh) * 2009-06-23 2011-08-24 硅谷数模半导体（北京）有限公司 视频图像编码和解码方法
CA2767858C (en) 2009-07-15 2019-02-12 Portola Pharmaceuticals, Inc. Unit dose formulation of antidotes for factor xa inhibitors and methods of using the same
LT3459564T (lt) 2010-01-06 2022-03-10 Takeda Pharmaceutical Company Limited Plazmos kalikreiną surišantys baltymai
KR101807894B1 (ko) 2010-03-01 2017-12-12 바이엘 헬스케어 엘엘씨 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 최적화된 모노클로날 항체
NZ603028A (en) 2010-03-19 2014-11-28 Baxter Healthcare Sa Tfpi inhibitors and methods of use
KR102320178B1 (ko) 2011-01-06 2021-11-02 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 결합 단백질
US11448657B2 (en) * 2011-01-18 2022-09-20 Rambam Med-Tech Methods and kits for assessing Heparanase procoagulant activity, compositions comprising Heparanase, and methods for the treatment of coagulation-related disorders
WO2013016449A2 (en) 2011-07-26 2013-01-31 Indicator Systems International, Inc. Assays for the detection of microbes
CN104394880B (zh) 2012-03-16 2020-08-28 大学保健网络 用于调节toso活性的方法和组合物
KR102263685B1 (ko) 2012-03-21 2021-06-11 다케다 야쿠힌 고교 가부시키가이샤 Tfpi 저해제 및 사용 방법
CN105377888A (zh) * 2013-03-15 2016-03-02 加利福尼亚大学董事会 纤维蛋白溶解的双反应性的有效的Kunitz抑制剂
AU2015225867B2 (en) 2014-03-07 2020-02-06 University Health Network Methods and compositions for modifying the immune response
EP3122782A4 (en) 2014-03-27 2017-09-13 Dyax Corp. Compositions and methods for treatment of diabetic macular edema
US10287338B2 (en) 2015-07-10 2019-05-14 Miran NERSISSIAN Factor VIII protein compositions and methods of treating of hemophilia A
AU2016303688B2 (en) 2015-07-31 2023-06-15 Research Institute At Nationwide Children's Hospital Peptides and antibodies for the removal of biofilms
EP3365027B1 (en) 2015-10-14 2022-03-30 Research Institute at Nationwide Children's Hospital Hu specific antibodies and their use in inhibiting biofilm
AU2016366557B2 (en) 2015-12-11 2024-01-25 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
WO2018129078A1 (en) 2017-01-04 2018-07-12 Research Institute At Nationwide Children's Hospital Dnabii vaccines and antibodies with enhanced activity
US12098188B2 (en) 2017-01-04 2024-09-24 Research Institute At Nationwide Children's Hospital Antibody fragments for the treatment of biofilm-related disorders
CA3056088A1 (en) 2017-03-15 2018-09-20 Research Institute At Nationwide Children's Hospital Composition and methods for disruption of bacterial biofilms without accompanying inflammation
CN114401986A (zh) 2019-07-08 2022-04-26 国家儿童医院研究所 破坏生物膜的抗体组合物
CN112206310B (zh) * 2020-09-23 2022-10-21 湖北医药学院 一组用于抑制补体的寄生绦虫多肽

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU199883B (en) * 1984-09-21 1990-03-28 Boehringer Ingelheim Int Process for producing anticoagulant proteins and pharmaceutical compositions comprising same
US5011912A (en) * 1986-12-19 1991-04-30 Immunex Corporation Hybridoma and monoclonal antibody for use in an immunoaffinity purification system
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors
IL87171A (en) * 1987-11-23 1995-08-31 Monsanto Co ANDC of human tissue factor inhibitor
DK408089D0 (da) * 1989-08-18 1989-08-18 Novo Nordisk As Proteiner
US5557518A (en) * 1994-04-28 1996-09-17 Citibank, N.A. Trusted agents for open electronic commerce
IL104325A (en) * 1992-01-07 2000-10-31 Novo Nordisk As Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above
IL104324A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Variant of human kunitz-type protease inhibitor
US5276015A (en) * 1992-03-18 1994-01-04 Washington University Method of inhibiting microvascular thrombosis
US5884292A (en) * 1993-05-06 1999-03-16 Pitney Bowes Inc. System for smart card funds refill
US5455338A (en) * 1993-11-05 1995-10-03 Zymogenetics, Inc. DNA encoding novel human kunitz-type inhibitors and methods relating thereto
US5578808A (en) * 1993-12-22 1996-11-26 Datamark Services, Inc. Data card that can be used for transactions involving separate card issuers
US5854975A (en) * 1994-12-23 1998-12-29 Freedom Wireless, Inc. Prepaid security cellular telecommunications system
US5722067A (en) * 1994-12-23 1998-02-24 Freedom Wireless, Inc. Security cellular telecommunications system
US5903633A (en) * 1995-03-27 1999-05-11 Smarttalk Teleservices, Inc. Method and apparatus for prepaid phone card activation and billing
US5684291A (en) * 1995-06-01 1997-11-04 American Express Trs Refundable prepaid telephone card
US5778313A (en) * 1995-12-08 1998-07-07 Cellexis International, Inc. Pre-paid cellular telephone system
US5892827A (en) * 1996-06-14 1999-04-06 Catalina Marketing International, Inc. Method and apparatus for generating personal identification numbers for use in consumer transactions
US5845259A (en) * 1996-06-27 1998-12-01 Electronic Consumer Concepts, L.L.C. Electronic coupon dispensing system
US5991749A (en) * 1996-09-11 1999-11-23 Morrill, Jr.; Paul H. Wireless telephony for collecting tolls, conducting financial transactions, and authorizing other activities
US5828740A (en) * 1996-11-14 1998-10-27 Sprint Communications Co., L.P. Prepaid calling card external/adjunct database processor
US5991380A (en) * 1997-10-21 1999-11-23 At&T Corp. Universal telecommunications services account
US6035025A (en) * 1998-01-07 2000-03-07 National Telemanagement Corporation System and method for a prepaid bundled telecommunications account
US7249054B2 (en) * 1998-06-18 2007-07-24 Keil Dean S System and method for debit account transactions
AU5898099A (en) * 1998-08-25 2000-03-14 Accompany Inc. On-line marketing system and method
US20030163425A1 (en) * 2002-02-26 2003-08-28 Cannon Thomas Calvin System for executing high-volume electronic bill payments

Also Published As

Publication number Publication date
KR960705850A (ko) 1996-11-08
CA2175797A1 (en) 1995-05-11
NO961812D0 (no) 1996-05-03
DE69433647D1 (de) 2004-04-29
EP0726953B1 (en) 2004-03-24
NO961812L (no) 1996-07-05
CN1139955A (zh) 1997-01-08
US6656746B2 (en) 2003-12-02
US20020098560A1 (en) 2002-07-25
US5728674A (en) 1998-03-17
US20040253686A1 (en) 2004-12-16
ATE262587T1 (de) 2004-04-15
US5455338A (en) 1995-10-03
AU8131294A (en) 1995-05-23
AU685190B2 (en) 1998-01-15
WO1995012674A1 (en) 1995-05-11
US7541449B2 (en) 2009-06-02
US20050004021A1 (en) 2005-01-06
CN1073159C (zh) 2001-10-17
US5914315A (en) 1999-06-22
FI961886A0 (fi) 1996-05-03
JPH09504696A (ja) 1997-05-13
US20070092948A1 (en) 2007-04-26
JP3201527B2 (ja) 2001-08-20
KR100243989B1 (ko) 2000-02-01
CA2175797C (en) 2000-07-18
DE69433647T2 (de) 2004-08-05
EP0726953A1 (en) 1996-08-21

Similar Documents

Publication Publication Date Title
FI961886A (fi) Ihmisen Kunitz-tyyppiset proteaasi-inhibiittorit
WO1994012637A3 (en) Novel human amyloid protein precursor homologue and kunitz-type inhibitors
DK0663010T3 (da) Fremgangsmåde til forøgelse af sekretion af overudtrykte proteiner
ES2153037T3 (es) Lacasas purificadas de scytalidium y acidos nucleicos que las codifican.
FI934811A (fi) Stabiliserade enzymer och detergentfoereningar
PT737207E (pt) Inibidores de plasmina humana derivados de dominios kunitz
PT765394E (pt) Lacases myceliophthora purificadas e acidos nucleicos que as codificam
ATE322279T1 (de) Pneumokokkengene, ihre fragmente, ihre expressionsprodukte und die verwendung der gene, fragmente und produkte
DE69942861D1 (de) Ldcam genannte moleküle
DE3587875D1 (de) Rekombinantverfahren zur herstellung von serinproteaseinhibitoren, sowie dns-sequenzen dazu.
DE69535696D1 (de) Tripeptidyl-aminopeptidase
ATE474926T1 (de) Verwendung von clya hemolysin fur ausscheidung von fusionprotein
NO974035D0 (no) En ny vestfaktor og en genetisk sekvens som koder for denne
DE59912185D1 (de) Verwendung von hsp70 protein
DK0981631T3 (da) Polypeptider, som har aminopeptidase-aktivitet, og nukleinsyrer, som koder for samme
NO20055210L (no) Inhibitorproteiner av en protease og anvendelse derav
ATE264913T1 (de) Protease-resistente analoge des thrombomodulin
NO972313L (no) Peptider som er i stand til å binde til GAP-protein-SH3-området, nukleotid-sekvenser som koder for dette samt fremstilling og bruk derav
DK0904356T3 (da) Aspergillus Oryzae 5-aminolevulinsyre-synthaser og nukleinsyrer, der koder disse
NO930428D0 (no) Proteinstrukturen til plantetoksingelonin
ATE340257T1 (de) Histonedeacetylase 9
DK0629238T3 (da) Autotaxin:Motilitetsstimulerende protein, som er nyttigt til cancerdiagnose og terapi
BR9815277A (pt) Fragmento de ácido nucléico isolado, gene quimérico, célula hospedeira transformada, homólogo de soja, método para alterar o nìvel de expressão de um homólogo do ativador de transcrição pvalf de phaseolus vulgaris em uma célula vegetal, método de obtenção de um fragmento de ácido nucléico e produto
DK0788549T3 (da) Regulerende nukleinsyresekvenser og anvendelser
ATE213773T1 (de) In apoptosis beteiligte cysteine protease cmh-1 und dns-sequenzen dafür