DE69433647D1 - Menschliche proteaseinhibitoren vom kunitztyp - Google Patents

Menschliche proteaseinhibitoren vom kunitztyp

Info

Publication number
DE69433647D1
DE69433647D1 DE69433647T DE69433647T DE69433647D1 DE 69433647 D1 DE69433647 D1 DE 69433647D1 DE 69433647 T DE69433647 T DE 69433647T DE 69433647 T DE69433647 T DE 69433647T DE 69433647 D1 DE69433647 D1 DE 69433647D1
Authority
DE
Germany
Prior art keywords
dna
human
dna segment
kunitz type
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69433647T
Other languages
English (en)
Other versions
DE69433647T2 (de
Inventor
A Sprecher
Walt Kisiel
C Foster
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of New Mexico UNM
Zymogenetics Inc
Original Assignee
University of New Mexico UNM
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of New Mexico UNM, Zymogenetics Inc filed Critical University of New Mexico UNM
Application granted granted Critical
Publication of DE69433647D1 publication Critical patent/DE69433647D1/de
Publication of DE69433647T2 publication Critical patent/DE69433647T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69433647T 1993-11-05 1994-11-02 Menschliche proteaseinhibitoren vom kunitztyp Expired - Fee Related DE69433647T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US147710 1980-05-08
US08/147,710 US5455338A (en) 1993-11-05 1993-11-05 DNA encoding novel human kunitz-type inhibitors and methods relating thereto
PCT/US1994/012609 WO1995012674A1 (en) 1993-11-05 1994-11-02 Human kunitz-type protease inhibitors

Publications (2)

Publication Number Publication Date
DE69433647D1 true DE69433647D1 (de) 2004-04-29
DE69433647T2 DE69433647T2 (de) 2004-08-05

Family

ID=22522614

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69433647T Expired - Fee Related DE69433647T2 (de) 1993-11-05 1994-11-02 Menschliche proteaseinhibitoren vom kunitztyp

Country Status (12)

Country Link
US (7) US5455338A (de)
EP (1) EP0726953B1 (de)
JP (1) JP3201527B2 (de)
KR (1) KR100243989B1 (de)
CN (1) CN1073159C (de)
AT (1) ATE262587T1 (de)
AU (1) AU685190B2 (de)
CA (1) CA2175797C (de)
DE (1) DE69433647T2 (de)
FI (1) FI961886A (de)
NO (1) NO961812L (de)
WO (1) WO1995012674A1 (de)

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US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
CA2202131A1 (en) * 1995-08-09 1997-02-20 Jun Utsumi Therapeutic agent for ophthalmic diseases
WO1997033996A2 (en) * 1996-03-11 1997-09-18 Bayer Corporation Human bikunin
DK1374891T3 (da) * 1998-12-22 2009-01-26 Bayer Ag Fremgangsmåde til fremskyndelse af hastigheden af mucociliær clearance
US20070140979A1 (en) * 1998-12-22 2007-06-21 Bayer Aktiengesellschaft Method for accelerating the rate of mucociliary clearance
AU6893100A (en) * 1999-08-02 2001-02-19 Avigen, Inc. Use of recombinant adeno-associated virus vector (raav) for the prevention of smooth muscle cell proliferation in vascular graft
US6180607B1 (en) 1999-08-05 2001-01-30 Christopher Davies Protein having proteinase inhibitor activity
US20040235715A1 (en) * 1999-11-12 2004-11-25 Bayer Corporation Method of producing glycosylated bikunin
US6355243B1 (en) * 1999-11-13 2002-03-12 Bayer Corporation Method of thrombolysis by local delivery of active plasmin
US6964764B2 (en) 1999-11-13 2005-11-15 Talecris Biotherapeutics, Inc. Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
US7544500B2 (en) * 1999-11-13 2009-06-09 Talecris Biotherapeutics, Inc. Process for the production of a reversibly inactive acidified plasmin composition
CA2403804A1 (en) * 2000-03-21 2001-09-27 Curagen Corporation Vegf-modulated genes and methods employing them
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US7064107B2 (en) * 2002-06-07 2006-06-20 Dyax Corp. Prevention and reduction of blood loss
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
US7244616B2 (en) 2003-06-27 2007-07-17 Bayer Pharmaceuticals Corporation Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells
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US7910550B2 (en) * 2004-04-16 2011-03-22 Stc.Unm Human kunitz-type inhibitor with enhanced antifibrinolytic activity
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
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AU2006330424B2 (en) 2005-12-29 2013-11-14 The Regents Of The University Of California Methods and compositions related to mutant Kunitz domain I of TFPI-2
US20070278239A1 (en) * 2006-05-17 2007-12-06 Michele Vogt Sipping lid closure device and method of use
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DE102007056231A1 (de) 2007-09-08 2009-03-12 Bayer Healthcare Ag Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI)
BRPI0816837B1 (pt) 2007-09-28 2022-10-18 Portola Pharmaceuticals, Inc Composições farmacêuticas, polipeptídeo isolado de duas cadeias e uso de uma composição farmacêutica
KR20160110544A (ko) * 2008-06-04 2016-09-21 그리폴스 테라퓨틱스 인코포레이티드 플라스민의 제조를 위한 조성물, 방법 및 키트
CA2747721C (en) 2008-12-19 2021-07-20 Baxter International Inc. Tfpi inhibitors and methods of use
BRPI0924058B1 (pt) 2008-12-22 2021-08-17 Novo Nordisk A/S Anticorpos monoclonais, seus usos, bem como composição farmacêutica
JP2013516389A (ja) * 2009-01-06 2013-05-13 ダイアックス コーポレーション カリクレイン阻害剤による粘膜炎治療
PT2403865E (pt) 2009-03-03 2015-11-18 Grifols Therapeutics Inc Métodos de preparação de plasminogénio
EP2414517B1 (de) 2009-03-30 2016-09-21 Portola Pharmaceuticals, Inc. Gegenmittel für faktor-xa-hemmer und verwendungsverfahren dafür
CN101588509B (zh) * 2009-06-23 2011-08-24 硅谷数模半导体（北京）有限公司 视频图像编码和解码方法
US9056106B2 (en) 2009-07-15 2015-06-16 Portola Pharmaceuticals, Inc. Unit dose formulation of antidotes for factor Xa inhibitors and methods of using the same
CA3021759A1 (en) 2010-01-06 2011-07-14 Dyax Corp. Plasma kallikrein binding proteins
MX2012010198A (es) 2010-03-01 2012-10-03 Bayer Healthcare Llc Anticuerpos monoclonales optimizados contra el inhibidor de la via del factor tisular (tfpi).
CN103025345B (zh) 2010-03-19 2016-01-20 巴克斯特国际公司 Tfpi抑制剂及使用方法
AU2012204202A1 (en) 2011-01-06 2013-07-11 Dyax Corp. Plasma kallikrein binding proteins
US11448657B2 (en) * 2011-01-18 2022-09-20 Rambam Med-Tech Methods and kits for assessing Heparanase procoagulant activity, compositions comprising Heparanase, and methods for the treatment of coagulation-related disorders
US8609355B2 (en) 2011-07-26 2013-12-17 Indicator Systems International, Inc. Assays for the detection of microbes
EP3626254A1 (de) 2012-03-16 2020-03-25 University Health Network Lösliches toso protein und dessen verwendung zur behandlung von autoimmunerkrankungen
AU2013235741C1 (en) 2012-03-21 2017-12-21 Takeda Pharmaceutical Company Limited TFPI inhibitors and methods of use
CA2904444A1 (en) * 2013-03-15 2014-09-18 The Regents Of The University Of California Dual reactivity potent kunitz inhibitor of fibrinolysis
KR20160127817A (ko) 2014-03-07 2016-11-04 유니버시티 헬스 네트워크 면역 반응을 변형시키기 위한 방법 및 조성물
KR102555955B1 (ko) 2014-03-27 2023-07-18 다케다 파머수티컬 컴패니 리미티드 당뇨병성 황반 부종의 치료를 위한 조성물 및 방법
US10287338B2 (en) 2015-07-10 2019-05-14 Miran NERSISSIAN Factor VIII protein compositions and methods of treating of hemophilia A
WO2017023863A1 (en) 2015-07-31 2017-02-09 Research Institute At Nationwide Children's Hospital Peptides and antibodies for the removal of biofilms
EP3365027B1 (de) 2015-10-14 2022-03-30 Research Institute at Nationwide Children's Hospital Hu-spezifische antikörper und deren verwendeng zur hemmung von biofilm
CO2018007151A2 (es) 2015-12-11 2018-09-20 Dyax Corp Inhibidores de calicreína plasmática y usos de los mismos para tratar ataque de angioedema hereditario
EP3565834A1 (de) 2017-01-04 2019-11-13 The Research Institute at Nationwide Children's Hospital Antikörperfragmente zur behandlung von biofilmbedingten erkrankungen
US11564982B2 (en) 2017-01-04 2023-01-31 Research Institute At Nationwide Children's Hospital DNABII vaccines and antibodies with enhanced activity
EP3595445A1 (de) 2017-03-15 2020-01-22 The Research Institute at Nationwide Children's Hospital Zusammensetzung und verfahren zur brechung bakterieller biofilme ohne begleitentzündung
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CN112206310B (zh) * 2020-09-23 2022-10-21 湖北医药学院 一组用于抑制补体的寄生绦虫多肽

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Also Published As

Publication number Publication date
DE69433647T2 (de) 2004-08-05
FI961886A (fi) 1996-07-03
US20020098560A1 (en) 2002-07-25
CA2175797A1 (en) 1995-05-11
KR960705850A (ko) 1996-11-08
NO961812L (no) 1996-07-05
US5728674A (en) 1998-03-17
EP0726953A1 (de) 1996-08-21
CN1139955A (zh) 1997-01-08
US20050004021A1 (en) 2005-01-06
US20040253686A1 (en) 2004-12-16
EP0726953B1 (de) 2004-03-24
US6656746B2 (en) 2003-12-02
AU8131294A (en) 1995-05-23
CN1073159C (zh) 2001-10-17
FI961886A0 (fi) 1996-05-03
US5455338A (en) 1995-10-03
US5914315A (en) 1999-06-22
JP3201527B2 (ja) 2001-08-20
US20070092948A1 (en) 2007-04-26
WO1995012674A1 (en) 1995-05-11
AU685190B2 (en) 1998-01-15
JPH09504696A (ja) 1997-05-13
CA2175797C (en) 2000-07-18
ATE262587T1 (de) 2004-04-15
US7541449B2 (en) 2009-06-02
NO961812D0 (no) 1996-05-03
KR100243989B1 (ko) 2000-02-01

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