FI112778B - Menetelmä vesipitoisen lääkekoostumuksen valmistamiseksi, jolla on palautuva kuumakovettuva geeliytymisominaisuus - Google Patents

Menetelmä vesipitoisen lääkekoostumuksen valmistamiseksi, jolla on palautuva kuumakovettuva geeliytymisominaisuus Download PDF

Info

Publication number
FI112778B
FI112778B FI953575A FI953575A FI112778B FI 112778 B FI112778 B FI 112778B FI 953575 A FI953575 A FI 953575A FI 953575 A FI953575 A FI 953575A FI 112778 B FI112778 B FI 112778B
Authority
FI
Finland
Prior art keywords
agents
agent
sodium
hydrochloride
composition
Prior art date
Application number
FI953575A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI953575A0 (fi
FI953575A (fi
Inventor
Masanobu Takeuchi
Hiroki Maruyama
Hiroe Suzuki
Touru Oguma
Toshie Takahashi
Miyako Sasaki
Keiko Naitou
Masayoshi Goto
Original Assignee
Wakamoto Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wakamoto Pharma Co Ltd filed Critical Wakamoto Pharma Co Ltd
Publication of FI953575A0 publication Critical patent/FI953575A0/fi
Publication of FI953575A publication Critical patent/FI953575A/fi
Application granted granted Critical
Publication of FI112778B publication Critical patent/FI112778B/fi

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
FI953575A 1993-04-16 1995-07-26 Menetelmä vesipitoisen lääkekoostumuksen valmistamiseksi, jolla on palautuva kuumakovettuva geeliytymisominaisuus FI112778B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP11234593 1993-04-16
JP11234593 1993-04-16
PCT/JP1993/001636 WO1994023750A1 (en) 1993-04-16 1993-11-10 Reversible, thermally gelling water-base medicinal composition
JP9301636 1993-11-10

Publications (3)

Publication Number Publication Date
FI953575A0 FI953575A0 (fi) 1995-07-26
FI953575A FI953575A (fi) 1995-07-26
FI112778B true FI112778B (fi) 2004-01-15

Family

ID=14584369

Family Applications (1)

Application Number Title Priority Date Filing Date
FI953575A FI112778B (fi) 1993-04-16 1995-07-26 Menetelmä vesipitoisen lääkekoostumuksen valmistamiseksi, jolla on palautuva kuumakovettuva geeliytymisominaisuus

Country Status (17)

Country Link
US (1) US5624962A (ko)
EP (1) EP0694310B1 (ko)
KR (1) KR0162025B1 (ko)
CN (1) CN1048393C (ko)
AT (1) ATE189772T1 (ko)
AU (1) AU668447B2 (ko)
CA (1) CA2153234C (ko)
DE (1) DE69327878T2 (ko)
DK (1) DK0694310T3 (ko)
ES (1) ES2141775T3 (ko)
FI (1) FI112778B (ko)
HK (1) HK1017805A1 (ko)
HU (1) HU220864B1 (ko)
IL (1) IL107626A (ko)
NO (1) NO311635B1 (ko)
RU (1) RU2108112C1 (ko)
WO (1) WO1994023750A1 (ko)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436425B1 (en) 1988-11-16 2002-08-20 Mdv Technologies, Inc. Method and non-gelling composition for inhibiting post-surgical adhesions
US5346703A (en) 1990-08-07 1994-09-13 Mediventures, Inc. Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
AU703926B2 (en) * 1994-03-28 1999-04-01 Trustees Of Columbia University In The City Of New York, The Composition for inactivating irritants in fluids
KR100215739B1 (ko) * 1994-10-13 1999-08-16 오쿠다 기요아키 가역성열겔화 수용성 의약 조성물을 함유하는 동결건조 제제
DE19511322C2 (de) 1995-03-28 1999-09-02 Mann Gerhard Chem Pharm Fab Sterile Augengele mit einem Gehalt an mittelkettigen Triglyceriden und Verfahren zu deren Herstellung
US5843470A (en) 1995-10-06 1998-12-01 Mdv Technologies, Inc. Method and composition for inhibiting post-surgical adhesions
CA2232855C (en) * 1997-04-10 2007-10-09 Roche Consumer Health (Worldwide) Sa Pharmaceutical formulation
WO1998051281A1 (fr) * 1997-05-14 1998-11-19 Senju Pharmaceutical Co., Ltd. Preparations a base de suspensions aqueuses possedant d'excellentes proprietes de redispersion
CA2316248A1 (en) * 1997-12-23 1999-07-01 Alliance Pharmaceutical Corp. Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions
US6197347B1 (en) 1998-06-29 2001-03-06 Andrx Pharmaceuticals, Inc. Oral dosage for the controlled release of analgesic
ES2155027B1 (es) * 1999-05-24 2001-12-01 Univ Pais Vasco Geles para propositos multiples, reversibles y degradables.
IL146801A0 (en) * 1999-06-11 2002-07-25 Pro Duct Health Inc Gel composition for filling a breast milk duct prior to surgical excision of the duct or other breast tissue
US20020061281A1 (en) * 1999-07-06 2002-05-23 Osbakken Robert S. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
US6576224B1 (en) * 1999-07-06 2003-06-10 Sinuspharma, Inc. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
JP2001158750A (ja) * 1999-12-02 2001-06-12 Lion Corp 眼科用組成物及び抗アレルギー薬の持続性向上方法
JP3450805B2 (ja) 2000-08-08 2003-09-29 わかもと製薬株式会社 水性医薬組成物
US7420030B2 (en) 2000-09-08 2008-09-02 The Board Of Regents Of The University Of Texas System Aminopeptidase A (APA) targeting peptides for the treatment of cancer
AU2001291159A1 (en) * 2000-09-20 2002-04-02 Shahinian Jr., Lee Self-preserved nasal, inhalable, and topical ophthalmic preparations and medications
JP4820024B2 (ja) * 2001-01-10 2011-11-24 昭和薬品化工株式会社 局所麻酔用組成物
WO2003007979A1 (en) * 2001-07-18 2003-01-30 Board Of Regents, The University Of Texas System An anti-angiogenic state in mice and humans with retinal photorecptor cell degeneration
US20040048243A1 (en) * 2001-09-07 2004-03-11 Wadih Arap Methods and compositions for in vitro targeting
US6846846B2 (en) * 2001-10-23 2005-01-25 The Trustees Of Columbia University In The City Of New York Gentle-acting skin disinfectants
US7879365B2 (en) 2002-02-07 2011-02-01 The Trustees Of Columbia University In The City Of New York Zinc salt compositions for the prevention of dermal and mucosal irritation
AU2003216213B2 (en) 2002-02-07 2008-10-02 The Trustees Of Columbia University In The City Of New York Zinc salt compositions for the prevention of mucosal irritation from spermicides and microbicides
US7745425B2 (en) * 2002-02-07 2010-06-29 The Trustees Of Columbia University In The City Of New York Non-irritating compositions containing zinc salts
US20050089545A1 (en) * 2002-02-22 2005-04-28 Mitsuaki Kuwano Drug delivery system for the subconjunctival administration of fine grains
US20030211173A1 (en) * 2002-05-08 2003-11-13 Veach Tom C. Lubrication composition
AU2003264498A1 (en) * 2002-09-18 2004-04-08 Wakamoto Pharmaceutical Co., Ltd. Transparent and reversibly heat-gelling aqueous compositions
US7220431B2 (en) 2002-11-27 2007-05-22 Regents Of The University Of Minnesota Methods and compositions for applying pharmacologic agents to the ear
JP2004196787A (ja) * 2002-12-04 2004-07-15 Santen Pharmaceut Co Ltd 結膜下デポによるドラッグデリバリーシステム
KR20050086903A (ko) * 2002-12-10 2005-08-30 쇼와 야쿠힝 가코 가부시키가이샤 국소마취용 조성물
US20050085446A1 (en) * 2003-04-14 2005-04-21 Babu M.K. M. Fluoroquinolone formulations and methods of making and using the same
JP4669960B2 (ja) * 2003-06-03 2011-04-13 株式会社 メドレックス 局所麻酔薬を含有する口中用または咽頭部用製剤
BRPI0412675A (pt) 2003-07-17 2006-10-03 Univ Columbia composições antimicrobianas contendo combinações sinergìsticas de compostos de amÈnio quaternário e óleos essenciais e/ou constituintes
CN1835735B (zh) * 2003-08-20 2010-05-12 参天制药株式会社 微粒眼球筋膜下给药的药物释放系统
FR2860718B1 (fr) * 2003-10-09 2006-02-24 Jean Pascal Conduzorgues Nouvelle formulation et ses applications dans le domaines cosmetiques ou pharmaceutiques
JP2007517806A (ja) * 2004-01-15 2007-07-05 オーラル バイオサイエンス ピーティーワイ. リミテッド 口腔用麻酔ゲル
US7658947B2 (en) * 2004-06-25 2010-02-09 Kimberly-Clark Worldwide, Inc. Thermo-gelling composition
JP2007277095A (ja) * 2004-07-02 2007-10-25 Wakamoto Pharmaceut Co Ltd アジスロマイシン含有可逆性熱ゲル化水性組成物
US7459416B2 (en) * 2004-07-12 2008-12-02 Panasonic Corporation Fluid bearing unit and spindle motor using the same
EP2497460A1 (en) 2005-03-10 2012-09-12 3M Innovative Properties Co. Methods of reducing microbial contamination
JP4979258B2 (ja) * 2005-04-08 2012-07-18 ロート製薬株式会社 アシタザノラスト含有水性組成物
CN100463668C (zh) * 2005-05-09 2009-02-25 凌沛学 可逆性热凝胶化水性药物组合物
CN100430069C (zh) * 2005-07-28 2008-11-05 凌沛学 一种中药及其复方的可逆性热凝胶化水性药物组合物
PT1938820E (pt) * 2005-10-17 2010-04-01 Kowa Co Preparação líquida para aplicação externa contendo indometacina
EA008737B1 (ru) * 2005-12-07 2007-08-31 Леонид Андреевич Кожемякин Средство для профилактики и лечения конъюнктивитов и кератитов различной этиологии (варианты), способ его применения
US7759327B2 (en) * 2006-01-06 2010-07-20 The Trustees Of Columbia University In The City Of New York Compositions containing zinc salts for coating medical articles
US20070249546A1 (en) * 2006-04-22 2007-10-25 Sawaya Assad S Ophthalmic and related aqueous solutions containing antifungal agents, uses therefor and methods for preparing them
US20080108674A1 (en) * 2006-05-01 2008-05-08 Enturia, Inc. Cationic antiseptic and dye formulation
US20070254854A1 (en) * 2006-05-01 2007-11-01 Medi-Flex, Inc. Aqueous Antiseptic Solution and Compatible Anionic Dye for Staining Skin
US20070253909A1 (en) * 2006-05-01 2007-11-01 Medi-Flex, Inc. Aqueous Antiseptic Solution and Compatible Cationic Dye for Staining Skin
TW200808375A (en) * 2006-05-12 2008-02-16 Otsuka Pharma Co Ltd Hydrogel suspension and manufacturing process thereof
EA014780B1 (ru) * 2007-01-05 2011-02-28 Промед Экспортс Пвт. Лтд. Офтальмическая композиция
DE102007002073A1 (de) * 2007-01-09 2008-07-10 Matthias Habenicht Mittel zur Pflege und antimikrobiellen Behandlung der Haut
EP2172224A4 (en) * 2007-06-26 2013-01-16 Wakamoto Pharma Co Ltd AQUEOUS COMPOSITION
PT2193795E (pt) * 2007-08-29 2014-10-22 Wakamoto Pharma Co Ltd Composição farmacêutica aquosa contendo latanoprost
RU2600863C2 (ru) * 2007-12-10 2016-10-27 Сентисс Фарма Прайвит Лимитед Офтальмическая композиция, включающая фенилэфрин
RU2469726C2 (ru) * 2008-05-14 2012-12-20 Отономи, Инк. Композиции с контролируемым высвобождением на основе кортикостероидов для лечения ушных болезней
US10517839B2 (en) * 2008-06-09 2019-12-31 Cornell University Mast cell inhibition in diseases of the retina and vitreous
TW201023912A (en) * 2008-12-05 2010-07-01 Alcon Res Ltd Pharmaceutical suspension
WO2010101989A1 (en) * 2009-03-03 2010-09-10 Alcon Research, Ltd. PHARMACEUTICAL COMPOSITION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE
JP5583145B2 (ja) * 2009-03-03 2014-09-03 アルコン リサーチ, リミテッド レセプターチロシンキナーゼ阻害(RTKi)化合物の眼への送達のための薬学的組成物
AU2010221369B2 (en) * 2009-03-03 2014-03-13 Alcon Research, Ltd. Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (RTKi) compounds to the eye
US8299079B2 (en) 2009-05-22 2012-10-30 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
WO2010135731A1 (en) * 2009-05-22 2010-11-25 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
JP5870459B2 (ja) 2010-08-27 2016-03-01 わかもと製薬株式会社 点眼用水性組成物
TWI544922B (zh) 2011-05-19 2016-08-11 愛爾康研究有限公司 高濃度歐羅派特錠(olopatadine)眼用組成物
WO2013169458A1 (en) * 2012-05-11 2013-11-14 Bausch & Lomb Incorporated Pharmaceutical compositions and methods for treating, controlling, ameliorating, or reversing conditions of dry eye
RU2485939C1 (ru) * 2012-06-19 2013-06-27 Станислав Анатольевич Кедик Офтальмологический препарат в виде глазных капель, содержащий дисульфирам и таурин
US10507245B2 (en) 2012-07-19 2019-12-17 Luis Felipe Vejarano Restrepo Ophthalmic formulation and method for ameliorating presbyopia
RU2517033C1 (ru) * 2013-03-05 2014-05-27 федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Композиция для комплексного лечения больных с первичной открытоугольной глаукомой и заболеваниями глазной поверхности
CN103239390B (zh) * 2013-05-15 2014-08-06 中国人民解放军第三军医大学第二附属医院 托吡卡胺眼用温度敏感原位凝胶及其制备方法
CA2932158A1 (en) * 2013-12-20 2015-06-25 The Procter & Gamble Company Stable liquid medication containing diphenhydramine
JP6714247B2 (ja) * 2017-10-06 2020-06-24 有限会社ジーエヌコーポレーション 尿道狭窄治療剤および尿道狭窄治療方法
JP7368799B2 (ja) * 2018-05-29 2023-10-25 学校法人 神野学園 外用組成物
EP3886829A4 (en) * 2018-11-26 2021-12-22 AiViva Biopharma, Inc. PHARMACEUTICAL BIOSOLUBLE GELS FOR DRUG ADMINISTRATION

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3311577A (en) * 1965-03-29 1967-03-28 Burton Parsons Chemicals Inc Underwater contact lens solution
US4100271A (en) * 1976-02-26 1978-07-11 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4188373A (en) * 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
DE2714065A1 (de) * 1977-03-30 1978-10-12 Boehringer Mannheim Gmbh Instillationszubereitung
US4474753A (en) * 1983-05-16 1984-10-02 Merck & Co., Inc. Topical drug delivery system utilizing thermosetting gels
US4474752A (en) * 1983-05-16 1984-10-02 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4474751A (en) * 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US4478822A (en) * 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
FR2588189B1 (fr) * 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
GB2203039B (en) * 1987-03-02 1990-10-24 American Cyanamid Co Stable ophthalmic preparations containing acetazolamide
US5252318A (en) * 1990-06-15 1993-10-12 Allergan, Inc. Reversible gelation compositions and methods of use
US5077033A (en) * 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
MX9200339A (es) * 1991-01-28 1992-08-01 Hoechst Ag Preparado para la liberacion controlada de sustancias activas, que son apropiadas como terapeuticos o para mejorar el crecimiento y el aprovechamiento de los piensos en rumiantes
AU679937B2 (en) * 1992-11-18 1997-07-17 Johnson & Johnson Consumer Products, Inc. Extrudable compositions for topical or transdermal drug delivery

Also Published As

Publication number Publication date
DE69327878T2 (de) 2000-06-15
EP0694310B1 (en) 2000-02-16
AU5433394A (en) 1994-11-08
DE69327878D1 (de) 2000-03-23
KR960700075A (ko) 1996-01-19
KR0162025B1 (ko) 1998-12-01
IL107626A (en) 1997-09-30
NO311635B1 (no) 2001-12-27
DK0694310T3 (da) 2000-06-05
HK1017805A1 (en) 1999-11-26
NO953189L (no) 1995-08-14
FI953575A0 (fi) 1995-07-26
EP0694310A1 (en) 1996-01-31
ATE189772T1 (de) 2000-03-15
ES2141775T3 (es) 2000-04-01
HU220864B1 (en) 2002-06-29
WO1994023750A1 (en) 1994-10-27
IL107626A0 (en) 1994-02-27
CA2153234A1 (en) 1994-10-27
CN1097593A (zh) 1995-01-25
HU9502086D0 (en) 1995-09-28
AU668447B2 (en) 1996-05-02
HUT71676A (en) 1996-01-29
FI953575A (fi) 1995-07-26
EP0694310A4 (en) 1996-04-24
NO953189D0 (no) 1995-08-14
CA2153234C (en) 1999-02-16
RU2108112C1 (ru) 1998-04-10
CN1048393C (zh) 2000-01-19
US5624962A (en) 1997-04-29

Similar Documents

Publication Publication Date Title
FI112778B (fi) Menetelmä vesipitoisen lääkekoostumuksen valmistamiseksi, jolla on palautuva kuumakovettuva geeliytymisominaisuus
EP1312366B1 (en) Gelling aqueous pharmaceutical compositions
RU95122560A (ru) Водная лекарственная композиция, обладающая свойством обратимого терморегулируемого гелеобразования
US10561607B2 (en) Pharmaceutical compositions comprising gels and methods for fabricating thereof
CN100463668C (zh) 可逆性热凝胶化水性药物组合物
US5756552A (en) Lyophilized pharmaceutical preparations capable of providing aqueous drug composition having property of reversible thermosetting gelation
WO2005042026A1 (ja) 可逆性熱ゲル化水性組成物
KR20010012521A (ko) 방부 조성물
JPH11240838A (ja) アジスロマイシンによる眼感染症の治療法
MXPA98010124A (en) Procedure to treat ocular infections with azitromic
EP1189595B1 (en) Ophthalmic compositions in form of aqueous gels
EP1283043B1 (en) Ophthalmic solution
WO1999063968A1 (fr) Preparations aqueuses contenant des medicaments faiblement solubles
JP2729859B2 (ja) 可逆性熱ゲル化水性医薬組成物
JP4904687B2 (ja) 眼科用組成物
US20200155450A1 (en) Pharmaceutical compositions comprising gels and methods for fabricating thereof
CA3169401A1 (en) Xanthan-based ophthalmic topical formulations with a reduced dosage regimen
JP3504656B2 (ja) 水性医薬組成物
US20120028947A1 (en) Ophthalmic Compositions
US7645765B2 (en) Use of moxaverin for treating erectile dysfunction, forms of dementia or diseases associated to an arteriosclerotic occlusion
JPH0383931A (ja) 低刺激性grf経鼻投与製剤
JP2002037735A (ja) カフェイン類の安定化方法および粘膜適用組成物
CA2202520C (en) Lyophilized pharmaceutical preparations capable of providing aqueous drug composition having property of reversible thermosetting gelation
TW201330851A (zh) 用於鼻內施用唑吡坦(zolpidem)的治療組合物
JP2005247796A (ja) 点眼剤

Legal Events

Date Code Title Description
MM Patent lapsed