FI112487B - Imidatsobentso- ja -tieno[1,4]diatsepiinit - Google Patents

Imidatsobentso- ja -tieno[1,4]diatsepiinit Download PDF

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Publication number
FI112487B
FI112487B FI951251A FI951251A FI112487B FI 112487 B FI112487 B FI 112487B FI 951251 A FI951251 A FI 951251A FI 951251 A FI951251 A FI 951251A FI 112487 B FI112487 B FI 112487B
Authority
FI
Finland
Prior art keywords
imidazo
dihydro
mmol
oxadiazol
methyl
Prior art date
Application number
FI951251A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI951251A0 (fi
FI951251A (fi
Inventor
Heinz Stadler
Walter Hunkeler
Ulrich Widmer
Thierry Godel
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI951251A0 publication Critical patent/FI951251A0/fi
Publication of FI951251A publication Critical patent/FI951251A/fi
Application granted granted Critical
Publication of FI112487B publication Critical patent/FI112487B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI951251A 1994-03-16 1995-03-16 Imidatsobentso- ja -tieno[1,4]diatsepiinit FI112487B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH78394 1994-03-16
CH78394 1994-03-16
CH1095 1995-01-03
CH1095 1995-01-03

Publications (3)

Publication Number Publication Date
FI951251A0 FI951251A0 (fi) 1995-03-16
FI951251A FI951251A (fi) 1995-09-17
FI112487B true FI112487B (fi) 2003-12-15

Family

ID=25683249

Family Applications (1)

Application Number Title Priority Date Filing Date
FI951251A FI112487B (fi) 1994-03-16 1995-03-16 Imidatsobentso- ja -tieno[1,4]diatsepiinit

Country Status (27)

Country Link
US (1) US5665718A (da)
EP (1) EP0672666B1 (da)
JP (1) JP2690282B2 (da)
KR (1) KR100214800B1 (da)
CN (1) CN1036995C (da)
AT (1) ATE203536T1 (da)
AU (1) AU679608B2 (da)
BG (1) BG62210B1 (da)
CA (1) CA2143246C (da)
CZ (1) CZ288594B6 (da)
DE (1) DE59509432D1 (da)
DK (1) DK0672666T3 (da)
ES (1) ES2160646T3 (da)
FI (1) FI112487B (da)
GR (1) GR3037019T3 (da)
HU (1) HU219987B (da)
IL (1) IL112955A (da)
IS (1) IS4273A (da)
LV (1) LV11327B (da)
MA (1) MA23479A1 (da)
NO (1) NO303731B1 (da)
NZ (1) NZ270685A (da)
PH (1) PH31443A (da)
PT (1) PT672666E (da)
RO (1) RO117698B1 (da)
RU (1) RU2139873C1 (da)
SK (1) SK33995A3 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW349100B (en) * 1994-11-11 1999-01-01 Hoffmann La Roche Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines
US5905176A (en) * 1998-08-28 1999-05-18 Eastman Chemical Company Process for the production of cyclobutyl halides
JP3706307B2 (ja) * 1999-05-12 2005-10-12 エフ．ホフマン−ラ ロシュ アーゲー イミダゾジアゼピン誘導体
US7160880B1 (en) * 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
US20060065608A1 (en) * 2004-09-29 2006-03-30 Choate Chris E Process and apparatus for generating useful biomass from organic waste streams
US8338614B2 (en) * 2005-01-19 2012-12-25 Merck, Sharp & Dohme Corp. Tertiary carbinamines having substituted heterocycles which are active as β-secretase inhibitors for the treatment of alzheimer's disease
CN101106994A (zh) * 2005-01-19 2008-01-16 默克公司 用于治疗阿尔茨海默氏病的氨基甲基β-分泌酶抑制剂
US7595395B2 (en) * 2005-05-16 2009-09-29 Wisys Technology Foundation Gabaergic agents to treat memory deficits
GB0613693D0 (en) * 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts (3)
KR20090045233A (ko) 2006-07-10 2009-05-07 파이온 유케이 리미티드 속효형 벤조디아제핀 염 및 이의 중합체 형태
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
KR101589314B1 (ko) * 2007-08-20 2016-01-28 에보텍 인터내셔널 게엠베하 수면 장애의 치료
WO2009024324A2 (en) * 2007-08-20 2009-02-26 Evotec Neurosciences Gmbh Treatment of sleep disorders
RU2503681C2 (ru) * 2008-09-30 2014-01-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Новое конденсированное производное аминодигидротиазина
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
CN104968348B (zh) 2012-05-22 2018-04-17 Paion英国有限公司 包含短效苯二氮杂*类化合物的组合物
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
ES2788848T3 (es) 2013-09-06 2020-10-23 Aurigene Discovery Tech Ltd Derivados de 1,2,4-oxadiazol como inmunomoduladores
EA034708B1 (ru) 2015-03-10 2020-03-10 Ауриджен Дискавери Текнолоджис Лимитед 1,2,4-оксадиазольные и тиадиазольные соединения в качестве иммуномодуляторов
CA2979161A1 (en) * 2015-03-10 2016-09-15 Aurigene Discovery Technologies Limited 3-substituted-1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
BR112018071082A2 (pt) 2016-04-14 2019-02-05 Paion Uk Ltd benzodiazepinas nasais e inaladas oralmente
WO2019061324A1 (en) 2017-09-29 2019-04-04 Curis Inc. CRYSTALLINE FORMS OF IMMUNOMODULATORS
KR20200068659A (ko) 2017-10-11 2020-06-15 오리진 디스커버리 테크놀로지스 리미티드 3-치환된 1,2,4-옥사다이아졸의 결정질 형태
JP7378394B2 (ja) 2017-11-03 2023-11-13 オーリジーン オンコロジー リミテッド Ｔｉｍ－３およびｐｄ－１経路の二重阻害剤
EP3706798A1 (en) 2017-11-06 2020-09-16 Aurigene Discovery Technologies Limited Conjoint therapies for immunomodulation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
NZ210850A (en) * 1984-01-19 1988-10-28 Hoffmann La Roche Imidazodiazepine derivatives and pharmaceutical compositions
AU587802B2 (en) * 1985-03-08 1989-08-31 Ferrosan A/S Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
DK476885D0 (da) * 1985-10-17 1985-10-17 Ferrosan As Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
US4622320A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
US4939139A (en) * 1989-07-26 1990-07-03 Merck & Co., Inc. 7-chloro-5,6-dihydro-3-(5-(1,2-dihydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5A][1,4]benzodiazepine
US4904654A (en) * 1989-07-26 1990-02-27 Merck & Co., Inc. 7-chloro-5,6-dihydro-3-(5-(2-hydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5a][1,4]benzodiazepine

Also Published As

Publication number Publication date
CN1036995C (zh) 1998-01-14
AU679608B2 (en) 1997-07-03
FI951251A0 (fi) 1995-03-16
NZ270685A (en) 1996-05-28
HUT71817A (en) 1996-02-28
DK0672666T3 (da) 2001-11-12
NO950999D0 (no) 1995-03-15
EP0672666A2 (de) 1995-09-20
EP0672666A3 (de) 1995-11-08
RU95103921A (ru) 1996-12-10
CA2143246A1 (en) 1995-09-17
JPH07258260A (ja) 1995-10-09
LV11327B (en) 1996-10-20
CA2143246C (en) 2000-08-22
RU2139873C1 (ru) 1999-10-20
BG99505A (en) 1996-01-31
CN1111632A (zh) 1995-11-15
KR950032199A (ko) 1995-12-20
RO117698B1 (ro) 2002-06-28
BG62210B1 (bg) 1999-05-31
HU9500743D0 (en) 1995-04-28
PT672666E (pt) 2002-01-30
IL112955A (en) 1998-02-08
NO950999L (no) 1995-09-18
NO303731B1 (no) 1998-08-24
CZ66395A3 (en) 1995-10-18
LV11327A (lv) 1996-06-20
HU219987B (hu) 2001-10-28
GR3037019T3 (en) 2002-01-31
AU1476095A (en) 1995-09-28
US5665718A (en) 1997-09-09
PH31443A (en) 1998-11-03
MA23479A1 (fr) 1995-10-01
ES2160646T3 (es) 2001-11-16
SK33995A3 (en) 1995-10-11
DE59509432D1 (de) 2001-08-30
JP2690282B2 (ja) 1997-12-10
CZ288594B6 (cs) 2001-07-11
IS4273A (is) 1995-09-17
FI951251A (fi) 1995-09-17
KR100214800B1 (ko) 1999-08-02
ATE203536T1 (de) 2001-08-15
IL112955A0 (en) 1995-06-29
EP0672666B1 (de) 2001-07-25

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MA Patent expired