DK0672666T3 - Imidazodiazepiner - Google Patents

Imidazodiazepiner

Info

Publication number
DK0672666T3
DK0672666T3 DK95103028T DK95103028T DK0672666T3 DK 0672666 T3 DK0672666 T3 DK 0672666T3 DK 95103028 T DK95103028 T DK 95103028T DK 95103028 T DK95103028 T DK 95103028T DK 0672666 T3 DK0672666 T3 DK 0672666T3
Authority
DK
Denmark
Prior art keywords
formula
lower alkyl
imidazodiazepines
atom
substd
Prior art date
Application number
DK95103028T
Other languages
English (en)
Inventor
Thierry Godel
Walter Hunkeler
Heinz Stadler
Ulrich Widmer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK0672666T3 publication Critical patent/DK0672666T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK95103028T 1994-03-16 1995-03-03 Imidazodiazepiner DK0672666T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH78394 1994-03-16
CH1095 1995-01-03

Publications (1)

Publication Number Publication Date
DK0672666T3 true DK0672666T3 (da) 2001-11-12

Family

ID=25683249

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95103028T DK0672666T3 (da) 1994-03-16 1995-03-03 Imidazodiazepiner

Country Status (27)

Country Link
US (1) US5665718A (da)
EP (1) EP0672666B1 (da)
JP (1) JP2690282B2 (da)
KR (1) KR100214800B1 (da)
CN (1) CN1036995C (da)
AT (1) ATE203536T1 (da)
AU (1) AU679608B2 (da)
BG (1) BG62210B1 (da)
CA (1) CA2143246C (da)
CZ (1) CZ288594B6 (da)
DE (1) DE59509432D1 (da)
DK (1) DK0672666T3 (da)
ES (1) ES2160646T3 (da)
FI (1) FI112487B (da)
GR (1) GR3037019T3 (da)
HU (1) HU219987B (da)
IL (1) IL112955A (da)
IS (1) IS4273A (da)
LV (1) LV11327B (da)
MA (1) MA23479A1 (da)
NO (1) NO303731B1 (da)
NZ (1) NZ270685A (da)
PH (1) PH31443A (da)
PT (1) PT672666E (da)
RO (1) RO117698B1 (da)
RU (1) RU2139873C1 (da)
SK (1) SK33995A3 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW349100B (en) * 1994-11-11 1999-01-01 Hoffmann La Roche Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines
US5905176A (en) * 1998-08-28 1999-05-18 Eastman Chemical Company Process for the production of cyclobutyl halides
KR100451610B1 (ko) * 1999-05-12 2004-10-06 에프. 호프만-라 로슈 아게 이미다조디아제핀 유도체
US7160880B1 (en) * 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
US20060065608A1 (en) * 2004-09-29 2006-03-30 Choate Chris E Process and apparatus for generating useful biomass from organic waste streams
ATE506951T1 (de) * 2005-01-19 2011-05-15 Merck Sharp & Dohme Als inhibitoren von beta-secretase aktive tertiäre carbinamine mit substituierten heterocyclen zur behandlung der alzheimer- krankheit
US7820674B2 (en) * 2005-01-19 2010-10-26 Merck, Sharp & Dohme Corp. Aminomethyl beta-secretase inhibitors for the treatment of alzheimer's disease
EP1888594A2 (en) * 2005-05-16 2008-02-20 Wisys Technology Foundation, Inc. Gabaergic agents to treat memory deficits
GB0613693D0 (en) * 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts (3)
KR20090045233A (ko) * 2006-07-10 2009-05-07 파이온 유케이 리미티드 속효형 벤조디아제핀 염 및 이의 중합체 형태
CA2696703C (en) 2007-08-20 2016-07-26 Evotec Neurosciences Gmbh Treatment of sleep disorders
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
WO2009024324A2 (en) * 2007-08-20 2009-02-26 Evotec Neurosciences Gmbh Treatment of sleep disorders
RU2503681C2 (ru) * 2008-09-30 2014-01-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Новое конденсированное производное аминодигидротиазина
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
US20150148338A1 (en) 2012-05-22 2015-05-28 Paion Uk Limited Compositions comprising short-acting benzodiazepines
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
CA2922607C (en) 2013-09-06 2022-08-30 Aurigene Discovery Technologies Limited 1,2,4-oxadiazole derivatives as immunomodulators
WO2016142833A1 (en) 2015-03-10 2016-09-15 Aurigene Discovery Technologies Limited 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
CA2979161A1 (en) * 2015-03-10 2016-09-15 Aurigene Discovery Technologies Limited 3-substituted-1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
EP3442539A1 (en) 2016-04-14 2019-02-20 Paion UK Limited Orally inhaled and nasal benzodiazepines
WO2019061324A1 (en) 2017-09-29 2019-04-04 Curis Inc. CRYSTALLINE FORMS OF IMMUNOMODULATORS
EP3694841A1 (en) 2017-10-11 2020-08-19 Aurigene Discovery Technologies Limited Crystalline forms of 3-substituted 1,2,4-oxadiazole
JP7378394B2 (ja) 2017-11-03 2023-11-13 オーリジーン オンコロジー リミテッド Ｔｉｍ－３およびｐｄ－１経路の二重阻害剤
EA202090749A1 (ru) 2017-11-06 2020-08-19 Ориджен Дискавери Текнолоджис Лимитед Способы совместной терапии для иммуномодуляции

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
NZ210850A (en) * 1984-01-19 1988-10-28 Hoffmann La Roche Imidazodiazepine derivatives and pharmaceutical compositions
AU587802B2 (en) * 1985-03-08 1989-08-31 Ferrosan A/S Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
DK476885D0 (da) * 1985-10-17 1985-10-17 Ferrosan As Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
US4622320A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
US4939139A (en) * 1989-07-26 1990-07-03 Merck & Co., Inc. 7-chloro-5,6-dihydro-3-(5-(1,2-dihydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5A][1,4]benzodiazepine
US4904654A (en) * 1989-07-26 1990-02-27 Merck & Co., Inc. 7-chloro-5,6-dihydro-3-(5-(2-hydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5a][1,4]benzodiazepine

Also Published As

Publication number Publication date
CZ288594B6 (cs) 2001-07-11
EP0672666B1 (de) 2001-07-25
CN1036995C (zh) 1998-01-14
KR950032199A (ko) 1995-12-20
KR100214800B1 (ko) 1999-08-02
HUT71817A (en) 1996-02-28
RU95103921A (ru) 1996-12-10
DE59509432D1 (de) 2001-08-30
NO303731B1 (no) 1998-08-24
PH31443A (en) 1998-11-03
IL112955A (en) 1998-02-08
US5665718A (en) 1997-09-09
FI112487B (fi) 2003-12-15
CA2143246C (en) 2000-08-22
SK33995A3 (en) 1995-10-11
NZ270685A (en) 1996-05-28
LV11327B (en) 1996-10-20
CN1111632A (zh) 1995-11-15
IS4273A (is) 1995-09-17
CZ66395A3 (en) 1995-10-18
AU679608B2 (en) 1997-07-03
MA23479A1 (fr) 1995-10-01
NO950999D0 (no) 1995-03-15
AU1476095A (en) 1995-09-28
LV11327A (lv) 1996-06-20
GR3037019T3 (en) 2002-01-31
FI951251A (fi) 1995-09-17
CA2143246A1 (en) 1995-09-17
RU2139873C1 (ru) 1999-10-20
HU219987B (hu) 2001-10-28
NO950999L (no) 1995-09-18
JPH07258260A (ja) 1995-10-09
BG99505A (en) 1996-01-31
PT672666E (pt) 2002-01-30
IL112955A0 (en) 1995-06-29
BG62210B1 (bg) 1999-05-31
RO117698B1 (ro) 2002-06-28
EP0672666A2 (de) 1995-09-20
JP2690282B2 (ja) 1997-12-10
EP0672666A3 (de) 1995-11-08
ATE203536T1 (de) 2001-08-15
HU9500743D0 (en) 1995-04-28
ES2160646T3 (es) 2001-11-16
FI951251A0 (fi) 1995-03-16

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