BG62210B1 - Имидазодиазепини,метод за получаването им и тяхното използване - Google Patents

Имидазодиазепини,метод за получаването им и тяхното използване Download PDF

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Publication number
BG62210B1
BG62210B1 BG99505A BG9950595A BG62210B1 BG 62210 B1 BG62210 B1 BG 62210B1 BG 99505 A BG99505 A BG 99505A BG 9950595 A BG9950595 A BG 9950595A BG 62210 B1 BG62210 B1 BG 62210B1
Authority
BG
Bulgaria
Prior art keywords
mmol
dihydro
imidazo
oxadiazol
methylene chloride
Prior art date
Application number
BG99505A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG99505A (en
Inventor
Thierry Godel
Walter Hunkeler
Heinz Stadler
Ulrich Widmer
Original Assignee
F. Hoffmann- La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann- La Roche Ag filed Critical F. Hoffmann- La Roche Ag
Publication of BG99505A publication Critical patent/BG99505A/bg
Publication of BG62210B1 publication Critical patent/BG62210B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
BG99505A 1994-03-16 1995-03-16 Имидазодиазепини,метод за получаването им и тяхното използване BG62210B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH78394 1994-03-16
CH1095 1995-01-03

Publications (2)

Publication Number Publication Date
BG99505A BG99505A (en) 1996-01-31
BG62210B1 true BG62210B1 (bg) 1999-05-31

Family

ID=25683249

Family Applications (1)

Application Number Title Priority Date Filing Date
BG99505A BG62210B1 (bg) 1994-03-16 1995-03-16 Имидазодиазепини,метод за получаването им и тяхното използване

Country Status (27)

Country Link
US (1) US5665718A (da)
EP (1) EP0672666B1 (da)
JP (1) JP2690282B2 (da)
KR (1) KR100214800B1 (da)
CN (1) CN1036995C (da)
AT (1) ATE203536T1 (da)
AU (1) AU679608B2 (da)
BG (1) BG62210B1 (da)
CA (1) CA2143246C (da)
CZ (1) CZ288594B6 (da)
DE (1) DE59509432D1 (da)
DK (1) DK0672666T3 (da)
ES (1) ES2160646T3 (da)
FI (1) FI112487B (da)
GR (1) GR3037019T3 (da)
HU (1) HU219987B (da)
IL (1) IL112955A (da)
IS (1) IS4273A (da)
LV (1) LV11327B (da)
MA (1) MA23479A1 (da)
NO (1) NO303731B1 (da)
NZ (1) NZ270685A (da)
PH (1) PH31443A (da)
PT (1) PT672666E (da)
RO (1) RO117698B1 (da)
RU (1) RU2139873C1 (da)
SK (1) SK33995A3 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW349100B (en) * 1994-11-11 1999-01-01 Hoffmann La Roche Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines
US5905176A (en) * 1998-08-28 1999-05-18 Eastman Chemical Company Process for the production of cyclobutyl halides
ATE231865T1 (de) 1999-05-12 2003-02-15 Hoffmann La Roche Imidazodiazepinderivate
US7160880B1 (en) 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
US20060065608A1 (en) * 2004-09-29 2006-03-30 Choate Chris E Process and apparatus for generating useful biomass from organic waste streams
EP1841426B1 (en) * 2005-01-19 2011-04-27 Merck Sharp & Dohme Corp. Tertiary carbinamines having substituted heterocycles, which are active as inhibitors of beta-secretase, for the treatment of alzheimer's disease
EP1855679B1 (en) * 2005-01-19 2016-06-29 Merck Sharp & Dohme Corp. Aminomethyl beta-secretase inhibitors for the treatment of alzheimer's disease
US7595395B2 (en) * 2005-05-16 2009-09-29 Wisys Technology Foundation Gabaergic agents to treat memory deficits
KR20170091770A (ko) * 2006-07-10 2017-08-09 파이온 유케이 리미티드 속효형 벤조디아제핀 염 및 이의 중합체 형태
GB0613693D0 (en) * 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts (3)
US20100234359A1 (en) * 2007-08-20 2010-09-16 Evotec Neurosciences Gmbh Treatment of sleep disorders
WO2009024324A2 (en) * 2007-08-20 2009-02-26 Evotec Neurosciences Gmbh Treatment of sleep disorders
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
RU2503681C2 (ru) * 2008-09-30 2014-01-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Новое конденсированное производное аминодигидротиазина
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
UA115063C2 (uk) 2012-05-22 2017-09-11 ПАЙОН ЮКей ЛІМІТЕД Композиції, які містять бензодіазепіни короткої дії
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
HUE038169T2 (hu) 2013-09-06 2018-09-28 Aurigene Discovery Tech Ltd 1,2,4-Oxadiazol származékok mint immunomodulátorok
MY196130A (en) * 2015-03-10 2023-03-16 Aurigene Discovery Tech Ltd 1,2,4-Oxadiazole and Thiadiazole Compounds as Immunomodulators
CA2979161A1 (en) * 2015-03-10 2016-09-15 Aurigene Discovery Technologies Limited 3-substituted-1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
AU2017248683A1 (en) 2016-04-14 2018-10-25 Paion Uk Limited Orally inhaled and nasal benzodiazepines
WO2019061324A1 (en) 2017-09-29 2019-04-04 Curis Inc. CRYSTALLINE FORMS OF IMMUNOMODULATORS
CA3078872A1 (en) 2017-10-11 2019-04-18 Aurigene Discovery Technologies Limited Crystalline forms of 3-substituted 1,2,4-oxadiazole
SG11202003625VA (en) 2017-11-03 2020-05-28 Aurigene Discovery Tech Ltd Dual inhibitors of tim-3 and pd-1 pathways
JP7378395B2 (ja) 2017-11-06 2023-11-13 オーリジーン オンコロジー リミテッド 免疫調節のためのコンジョイントセラピー

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
CA1252462A (en) * 1984-01-19 1989-04-11 Walter Hunkeler Imidazodiazepine derivatives
AU587802B2 (en) * 1985-03-08 1989-08-31 Ferrosan A/S Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
DK476885D0 (da) * 1985-10-17 1985-10-17 Ferrosan As Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
US4622321A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
US4904654A (en) * 1989-07-26 1990-02-27 Merck & Co., Inc. 7-chloro-5,6-dihydro-3-(5-(2-hydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5a][1,4]benzodiazepine
US4939139A (en) * 1989-07-26 1990-07-03 Merck & Co., Inc. 7-chloro-5,6-dihydro-3-(5-(1,2-dihydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5A][1,4]benzodiazepine

Also Published As

Publication number Publication date
IS4273A (is) 1995-09-17
HU9500743D0 (en) 1995-04-28
KR950032199A (ko) 1995-12-20
DE59509432D1 (de) 2001-08-30
FI112487B (fi) 2003-12-15
EP0672666B1 (de) 2001-07-25
IL112955A0 (en) 1995-06-29
LV11327A (lv) 1996-06-20
LV11327B (en) 1996-10-20
RU95103921A (ru) 1996-12-10
EP0672666A3 (de) 1995-11-08
NO303731B1 (no) 1998-08-24
DK0672666T3 (da) 2001-11-12
SK33995A3 (en) 1995-10-11
RU2139873C1 (ru) 1999-10-20
MA23479A1 (fr) 1995-10-01
US5665718A (en) 1997-09-09
IL112955A (en) 1998-02-08
PT672666E (pt) 2002-01-30
CA2143246C (en) 2000-08-22
EP0672666A2 (de) 1995-09-20
HU219987B (hu) 2001-10-28
CA2143246A1 (en) 1995-09-17
FI951251A0 (fi) 1995-03-16
CZ66395A3 (en) 1995-10-18
GR3037019T3 (en) 2002-01-31
FI951251A (fi) 1995-09-17
BG99505A (en) 1996-01-31
NO950999L (no) 1995-09-18
JP2690282B2 (ja) 1997-12-10
CZ288594B6 (cs) 2001-07-11
JPH07258260A (ja) 1995-10-09
AU1476095A (en) 1995-09-28
ES2160646T3 (es) 2001-11-16
CN1036995C (zh) 1998-01-14
PH31443A (en) 1998-11-03
CN1111632A (zh) 1995-11-15
RO117698B1 (ro) 2002-06-28
NO950999D0 (no) 1995-03-15
ATE203536T1 (de) 2001-08-15
NZ270685A (en) 1996-05-28
KR100214800B1 (ko) 1999-08-02
HUT71817A (en) 1996-02-28
AU679608B2 (en) 1997-07-03

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