NO303731B1 - Imidazodiazepiner - Google Patents

Imidazodiazepiner

Info

Publication number
NO303731B1
NO303731B1 NO950999A NO950999A NO303731B1 NO 303731 B1 NO303731 B1 NO 303731B1 NO 950999 A NO950999 A NO 950999A NO 950999 A NO950999 A NO 950999A NO 303731 B1 NO303731 B1 NO 303731B1
Authority
NO
Norway
Prior art keywords
formula
lower alkyl
atom
imidazodiazepine
imidazodiazepines
Prior art date
Application number
NO950999A
Other languages
English (en)
Other versions
NO950999L (no
NO950999D0 (no
Inventor
Thierry Godel
Walter Hunkeler
Heinz Stadler
Ulrich Widmer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO950999D0 publication Critical patent/NO950999D0/no
Publication of NO950999L publication Critical patent/NO950999L/no
Publication of NO303731B1 publication Critical patent/NO303731B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
NO950999A 1994-03-16 1995-03-15 Imidazodiazepiner NO303731B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH78394 1994-03-16
CH1095 1995-01-03

Publications (3)

Publication Number Publication Date
NO950999D0 NO950999D0 (no) 1995-03-15
NO950999L NO950999L (no) 1995-09-18
NO303731B1 true NO303731B1 (no) 1998-08-24

Family

ID=25683249

Family Applications (1)

Application Number Title Priority Date Filing Date
NO950999A NO303731B1 (no) 1994-03-16 1995-03-15 Imidazodiazepiner

Country Status (27)

Country Link
US (1) US5665718A (no)
EP (1) EP0672666B1 (no)
JP (1) JP2690282B2 (no)
KR (1) KR100214800B1 (no)
CN (1) CN1036995C (no)
AT (1) ATE203536T1 (no)
AU (1) AU679608B2 (no)
BG (1) BG62210B1 (no)
CA (1) CA2143246C (no)
CZ (1) CZ288594B6 (no)
DE (1) DE59509432D1 (no)
DK (1) DK0672666T3 (no)
ES (1) ES2160646T3 (no)
FI (1) FI112487B (no)
GR (1) GR3037019T3 (no)
HU (1) HU219987B (no)
IL (1) IL112955A (no)
IS (1) IS4273A (no)
LV (1) LV11327B (no)
MA (1) MA23479A1 (no)
NO (1) NO303731B1 (no)
NZ (1) NZ270685A (no)
PH (1) PH31443A (no)
PT (1) PT672666E (no)
RO (1) RO117698B1 (no)
RU (1) RU2139873C1 (no)
SK (1) SK33995A3 (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW349100B (en) * 1994-11-11 1999-01-01 Hoffmann La Roche Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines
US5905176A (en) * 1998-08-28 1999-05-18 Eastman Chemical Company Process for the production of cyclobutyl halides
ATE231865T1 (de) 1999-05-12 2003-02-15 Hoffmann La Roche Imidazodiazepinderivate
US7160880B1 (en) 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
US20060065608A1 (en) * 2004-09-29 2006-03-30 Choate Chris E Process and apparatus for generating useful biomass from organic waste streams
EP1841426B1 (en) * 2005-01-19 2011-04-27 Merck Sharp & Dohme Corp. Tertiary carbinamines having substituted heterocycles, which are active as inhibitors of beta-secretase, for the treatment of alzheimer's disease
EP1855679B1 (en) * 2005-01-19 2016-06-29 Merck Sharp & Dohme Corp. Aminomethyl beta-secretase inhibitors for the treatment of alzheimer's disease
US7595395B2 (en) * 2005-05-16 2009-09-29 Wisys Technology Foundation Gabaergic agents to treat memory deficits
KR20170091770A (ko) * 2006-07-10 2017-08-09 파이온 유케이 리미티드 속효형 벤조디아제핀 염 및 이의 중합체 형태
GB0613693D0 (en) * 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts (3)
US20100234359A1 (en) * 2007-08-20 2010-09-16 Evotec Neurosciences Gmbh Treatment of sleep disorders
WO2009024324A2 (en) * 2007-08-20 2009-02-26 Evotec Neurosciences Gmbh Treatment of sleep disorders
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
RU2503681C2 (ru) * 2008-09-30 2014-01-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Новое конденсированное производное аминодигидротиазина
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
UA115063C2 (uk) 2012-05-22 2017-09-11 ПАЙОН ЮКей ЛІМІТЕД Композиції, які містять бензодіазепіни короткої дії
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
HUE038169T2 (hu) 2013-09-06 2018-09-28 Aurigene Discovery Tech Ltd 1,2,4-Oxadiazol származékok mint immunomodulátorok
MY196130A (en) * 2015-03-10 2023-03-16 Aurigene Discovery Tech Ltd 1,2,4-Oxadiazole and Thiadiazole Compounds as Immunomodulators
CA2979161A1 (en) * 2015-03-10 2016-09-15 Aurigene Discovery Technologies Limited 3-substituted-1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
AU2017248683A1 (en) 2016-04-14 2018-10-25 Paion Uk Limited Orally inhaled and nasal benzodiazepines
WO2019061324A1 (en) 2017-09-29 2019-04-04 Curis Inc. CRYSTALLINE FORMS OF IMMUNOMODULATORS
CA3078872A1 (en) 2017-10-11 2019-04-18 Aurigene Discovery Technologies Limited Crystalline forms of 3-substituted 1,2,4-oxadiazole
SG11202003625VA (en) 2017-11-03 2020-05-28 Aurigene Discovery Tech Ltd Dual inhibitors of tim-3 and pd-1 pathways
JP7378395B2 (ja) 2017-11-06 2023-11-13 オーリジーン オンコロジー リミテッド 免疫調節のためのコンジョイントセラピー

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
CA1252462A (en) * 1984-01-19 1989-04-11 Walter Hunkeler Imidazodiazepine derivatives
AU587802B2 (en) * 1985-03-08 1989-08-31 Ferrosan A/S Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
DK476885D0 (da) * 1985-10-17 1985-10-17 Ferrosan As Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
US4622321A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
US4904654A (en) * 1989-07-26 1990-02-27 Merck & Co., Inc. 7-chloro-5,6-dihydro-3-(5-(2-hydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5a][1,4]benzodiazepine
US4939139A (en) * 1989-07-26 1990-07-03 Merck & Co., Inc. 7-chloro-5,6-dihydro-3-(5-(1,2-dihydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5A][1,4]benzodiazepine

Also Published As

Publication number Publication date
IS4273A (is) 1995-09-17
HU9500743D0 (en) 1995-04-28
KR950032199A (ko) 1995-12-20
DE59509432D1 (de) 2001-08-30
FI112487B (fi) 2003-12-15
EP0672666B1 (de) 2001-07-25
IL112955A0 (en) 1995-06-29
LV11327A (lv) 1996-06-20
LV11327B (en) 1996-10-20
RU95103921A (ru) 1996-12-10
EP0672666A3 (de) 1995-11-08
DK0672666T3 (da) 2001-11-12
SK33995A3 (en) 1995-10-11
RU2139873C1 (ru) 1999-10-20
MA23479A1 (fr) 1995-10-01
US5665718A (en) 1997-09-09
IL112955A (en) 1998-02-08
PT672666E (pt) 2002-01-30
CA2143246C (en) 2000-08-22
EP0672666A2 (de) 1995-09-20
HU219987B (hu) 2001-10-28
CA2143246A1 (en) 1995-09-17
FI951251A0 (fi) 1995-03-16
CZ66395A3 (en) 1995-10-18
GR3037019T3 (en) 2002-01-31
FI951251A (fi) 1995-09-17
BG99505A (en) 1996-01-31
NO950999L (no) 1995-09-18
JP2690282B2 (ja) 1997-12-10
CZ288594B6 (cs) 2001-07-11
JPH07258260A (ja) 1995-10-09
AU1476095A (en) 1995-09-28
ES2160646T3 (es) 2001-11-16
CN1036995C (zh) 1998-01-14
PH31443A (en) 1998-11-03
CN1111632A (zh) 1995-11-15
RO117698B1 (ro) 2002-06-28
NO950999D0 (no) 1995-03-15
ATE203536T1 (de) 2001-08-15
BG62210B1 (bg) 1999-05-31
NZ270685A (en) 1996-05-28
KR100214800B1 (ko) 1999-08-02
HUT71817A (en) 1996-02-28
AU679608B2 (en) 1997-07-03

Similar Documents

Publication Publication Date Title
ATE203536T1 (de) Imidazodiazepine
EP0256503A3 (en) Pyridinecarboxamide derivatives and their use as fungicide
ES8507135A1 (es) Procedimiento de preparar derivados benzofuran- o benzopirancar-boxamidicos
ES2068413T3 (es) Derivados de 4-fenilftalazina.
ES2046229T3 (es) Composicion antiulcerosa.
ES2060970T3 (es) Nuevos derivados de benzonaftiridina-1,8, su preparacion y las composiciones que les contienen.
DK391182A (da) Heterocycliske forbindelser, deres fremstilling og anvendelse
ES2077176T3 (es) Composiciones de goma.
GR1000887B (el) Νεα παραγωγα σπιροφουρανης.
DK0402033T3 (da) Carboxamidderivater
DK0623131T3 (da) Alkylderivater af trazodon med CNS-aktivitet
GR3008034T3 (no)
SE8103598L (sv) Antiinflammatoriska medel for yttre anvendning
ES479378A1 (es) Un procedimiento para la preparacion de compuestos de cefa- losporina.
PH18574A (en) Substituted 11-oxo-11h-pyrido 2,i-h -quinazoline derivatives,pharmaceutical compositions containing them and method of use thereof
FR2363629A1 (fr) Activateurs pour percomposes
EP0443474A3 (en) 1-phenoxycarbonyl-2-pyrrolidinone derivatives and nootropic agents
FI943360A (fi) Propoksibentseenijohdannaisia

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN SEPTEMBER 2002